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The map label for this gene is dnaX [H]

Identifier: 55981921

GI number: 55981921

Start: 1828653

End: 1830242

Strand: Direct

Name: dnaX [H]

Synonym: TTHA1952

Alternate gene names: 55981921

Gene position: 1828653-1830242 (Clockwise)

Preceding gene: 55981918

Following gene: 55981922

Centisome position: 98.86

GC content: 72.14

Gene sequence:

>1590_bases
GTGAGCGCCCTCTACCGCCGCTTCCGCCCCCTCACCTTCCAGGAGGTGGTGGGGCAGGAGCACGTGAAGGAGCCCCTCCT
CAAGGCCATCCGGGAGGGGAGGCTCGCCCAGGCCTACCTCTTCTCCGGGCCCAGGGGCGTGGGCAAGACCACCACGGCGA
GGCTCCTCGCCATGGCGGTGGGGTGCCAGGGGGAAGACCCCCCTTGCGGGGTCTGCCCCCACTGCCAGGCGGTGCAGAGG
GGCGCCCACCCGGACGTGGTGGAGATTGACGCCGCCAGCAACAACTCCGTGGAGGACGTGCGGGAGCTGAGGGAAAGGAT
CCACCTCGCCCCCCTCTCTGCCCCCAGGAAGGTCTTCATCCTGGACGAGGCCCACATGCTCTCCAAAAGCGCCTTCAACG
CCCTCCTCAAGACCCTGGAGGAGCCCCCGCCCCACGTCCTCTTCGTCTTCGCCACCACCGAGCCCGAGAGGATGCCCCCC
ACCATCCTCTCCCGCACCCAGCACTTCCGCTTCCGCCGCCTCACGGAGGAGGAGATCGCCTTTAAGCTCCGGCGCATCCT
GGAGGCCGTGGGGCGGGAGGCGGAGGAGGAGGCCCTCCTCCTCCTCGCCCGCCTGGCGGACGGGGCCCTTAGGGACGCGG
AAAGCCTCCTGGAGCGCTTCCTCCTCCTGGAAGGCCCCCTCACCCGGAAGGAGGTGGAGCGCGCCCTAGGCCTCCCCCCC
AGGGAGGCCCTGGCCGAGATCGCCGCCTCCCTCGCGAGGGGGAAAACGGCGGAGGCCCTGGGCCTCGCCCGGCGCCTCTA
CGGGGAAGGGTACGCCCCGAGGAGCCTGGTCTCGGGCCTTTTGGAGGTGTTCCGGGAAGGCCTCTACGCCGCCTTCGGCC
TCGCGGGAACCCCCCTTCCCGCCCCGCCCCAGGCCCTGATCGCCGCCATGACCGCCCTGGACGAGGCCATGGAGCGCCTC
GCCCGCCGCTCCGACGCCTTAAGCCTGGAGGTGGCCCTCCTGGAGGCGGGAAGGGCCCTGGCCGCCGAGGCCCTGCCCCA
GCCCACGGGCGCTCCCTCCCCAGAGGTCGGCCCCAAGCCGGAAAGCCCCCCGGCCCCGGAACCCCCAAGGCCCGAGGAGG
CGCCCGACCTGCGGGAGCGGTGGCGGGCCTTCCTCGAGGCCCTCAGGCCCACCCTACGGGCCTTCGTGCGGGAGGCCCGC
CCGGAGGTCCGGGAAGGCCAGCTCTGCCTCGCTTTCCCCGAGGACAAGGCCTTCCACTACCGCAAGGCCTCGGAACAGAA
GGCGAGGCTCCTCCCCCTGGCCCAGGCCCATTTCGGGGTGGAGGAGGTCGTCCTCGTCCTGGAGGGAGAAAAAAAAAGCC
TGAGCCCAAGGCCCCGCCCGGCCCCACCTCCTGAAGCGCCCGCACCCCCGGGCCCTCCCGAGGAGGAGGTAGAGGCGGAG
GAAGCGGCGGAGGAGGCCCCGGAGGAGGCCTTGAGGCGGGTGGTCCGCCTCCTGGGGGGGCGGGTGCTCTGGGTGCGGCG
GCCCAGGACCCGGGAGGCGCCGGAGGAGGAACCCCTGAGCCAAGACGAGATAGGGGGTACTGGTATATAA

Upstream 100 bases:

>100_bases
GCCCCTCCCGTGCGCCCCTTTACCCAGGCCGCCACCTCCTCCAGGGGGGCCTTGGCGTGCAAGGAGAGGAAGCTCCGCAC
CACGCCCTATACTAGCCCTT

Downstream 100 bases:

>100_bases
TGGGGGCATGACGCGGACCACCGACCTCGGACAAGAGACCGTGGACAACATCCTCAAGCGCCTCCGCCGTATTGAGGGCC
AGGTGCGGGGGCTCCAGAAG

Product: DNA polymerase III holoenzyme subunit tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MSALYRRFRPLTFQEVVGQEHVKEPLLKAIREGRLAQAYLFSGPRGVGKTTTARLLAMAVGCQGEDPPCGVCPHCQAVQR
GAHPDVVEIDAASNNSVEDVRELRERIHLAPLSAPRKVFILDEAHMLSKSAFNALLKTLEEPPPHVLFVFATTEPERMPP
TILSRTQHFRFRRLTEEEIAFKLRRILEAVGREAEEEALLLLARLADGALRDAESLLERFLLLEGPLTRKEVERALGLPP
REALAEIAASLARGKTAEALGLARRLYGEGYAPRSLVSGLLEVFREGLYAAFGLAGTPLPAPPQALIAAMTALDEAMERL
ARRSDALSLEVALLEAGRALAAEALPQPTGAPSPEVGPKPESPPAPEPPRPEEAPDLRERWRAFLEALRPTLRAFVREAR
PEVREGQLCLAFPEDKAFHYRKASEQKARLLPLAQAHFGVEEVVLVLEGEKKSLSPRPRPAPPPEAPAPPGPPEEEVEAE
EAAEEAPEEALRRVVRLLGGRVLWVRRPRTREAPEEEPLSQDEIGGTGI

Sequences:

>Translated_529_residues
MSALYRRFRPLTFQEVVGQEHVKEPLLKAIREGRLAQAYLFSGPRGVGKTTTARLLAMAVGCQGEDPPCGVCPHCQAVQR
GAHPDVVEIDAASNNSVEDVRELRERIHLAPLSAPRKVFILDEAHMLSKSAFNALLKTLEEPPPHVLFVFATTEPERMPP
TILSRTQHFRFRRLTEEEIAFKLRRILEAVGREAEEEALLLLARLADGALRDAESLLERFLLLEGPLTRKEVERALGLPP
REALAEIAASLARGKTAEALGLARRLYGEGYAPRSLVSGLLEVFREGLYAAFGLAGTPLPAPPQALIAAMTALDEAMERL
ARRSDALSLEVALLEAGRALAAEALPQPTGAPSPEVGPKPESPPAPEPPRPEEAPDLRERWRAFLEALRPTLRAFVREAR
PEVREGQLCLAFPEDKAFHYRKASEQKARLLPLAQAHFGVEEVVLVLEGEKKSLSPRPRPAPPPEAPAPPGPPEEEVEAE
EAAEEAPEEALRRVVRLLGGRVLWVRRPRTREAPEEEPLSQDEIGGTGI
>Mature_528_residues
SALYRRFRPLTFQEVVGQEHVKEPLLKAIREGRLAQAYLFSGPRGVGKTTTARLLAMAVGCQGEDPPCGVCPHCQAVQRG
AHPDVVEIDAASNNSVEDVRELRERIHLAPLSAPRKVFILDEAHMLSKSAFNALLKTLEEPPPHVLFVFATTEPERMPPT
ILSRTQHFRFRRLTEEEIAFKLRRILEAVGREAEEEALLLLARLADGALRDAESLLERFLLLEGPLTRKEVERALGLPPR
EALAEIAASLARGKTAEALGLARRLYGEGYAPRSLVSGLLEVFREGLYAAFGLAGTPLPAPPQALIAAMTALDEAMERLA
RRSDALSLEVALLEAGRALAAEALPQPTGAPSPEVGPKPESPPAPEPPRPEEAPDLRERWRAFLEALRPTLRAFVREARP
EVREGQLCLAFPEDKAFHYRKASEQKARLLPLAQAHFGVEEVVLVLEGEKKSLSPRPRPAPPPEAPAPPGPPEEEVEAEE
AAEEAPEEALRRVVRLLGGRVLWVRRPRTREAPEEEPLSQDEIGGTGI

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=295, Percent_Identity=27.1186440677966, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI31881687, Length=295, Percent_Identity=27.1186440677966, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI31563534, Length=283, Percent_Identity=23.321554770318, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI6677723, Length=248, Percent_Identity=25.4032258064516, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI194306571, Length=248, Percent_Identity=25.4032258064516, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI194306567, Length=248, Percent_Identity=25.4032258064516, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1786676, Length=262, Percent_Identity=46.5648854961832, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1787119, Length=224, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787341, Length=152, Percent_Identity=34.8684210526316, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=296, Percent_Identity=25, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324039, Length=212, Percent_Identity=29.7169811320755, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=286, Percent_Identity=21.3286713286713, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17647857, Length=283, Percent_Identity=24.7349823321555, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI18859927, Length=229, Percent_Identity=27.5109170305677, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921076, Length=259, Percent_Identity=23.9382239382239, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 58163; Mature: 58032

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALYRRFRPLTFQEVVGQEHVKEPLLKAIREGRLAQAYLFSGPRGVGKTTTARLLAMAV
CCHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHH
GCQGEDPPCGVCPHCQAVQRGAHPDVVEIDAASNNSVEDVRELRERIHLAPLSAPRKVFI
CCCCCCCCCCCCCCHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEE
LDEAHMLSKSAFNALLKTLEEPPPHVLFVFATTEPERMPPTILSRTQHFRFRRLTEEEIA
ECHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHH
FKLRRILEAVGREAEEEALLLLARLADGALRDAESLLERFLLLEGPLTRKEVERALGLPP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCH
REALAEIAASLARGKTAEALGLARRLYGEGYAPRSLVSGLLEVFREGLYAAFGLAGTPLP
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
APPQALIAAMTALDEAMERLARRSDALSLEVALLEAGRALAAEALPQPTGAPSPEVGPKP
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCC
ESPPAPEPPRPEEAPDLRERWRAFLEALRPTLRAFVREARPEVREGQLCLAFPEDKAFHY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHH
RKASEQKARLLPLAQAHFGVEEVVLVLEGEKKSLSPRPRPAPPPEAPAPPGPPEEEVEAE
HHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EAAEEAPEEALRRVVRLLGGRVLWVRRPRTREAPEEEPLSQDEIGGTGI
HHHHHCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SALYRRFRPLTFQEVVGQEHVKEPLLKAIREGRLAQAYLFSGPRGVGKTTTARLLAMAV
CHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHH
GCQGEDPPCGVCPHCQAVQRGAHPDVVEIDAASNNSVEDVRELRERIHLAPLSAPRKVFI
CCCCCCCCCCCCCCHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEE
LDEAHMLSKSAFNALLKTLEEPPPHVLFVFATTEPERMPPTILSRTQHFRFRRLTEEEIA
ECHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHH
FKLRRILEAVGREAEEEALLLLARLADGALRDAESLLERFLLLEGPLTRKEVERALGLPP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCH
REALAEIAASLARGKTAEALGLARRLYGEGYAPRSLVSGLLEVFREGLYAAFGLAGTPLP
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
APPQALIAAMTALDEAMERLARRSDALSLEVALLEAGRALAAEALPQPTGAPSPEVGPKP
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCC
ESPPAPEPPRPEEAPDLRERWRAFLEALRPTLRAFVREARPEVREGQLCLAFPEDKAFHY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHH
RKASEQKARLLPLAQAHFGVEEVVLVLEGEKKSLSPRPRPAPPPEAPAPPGPPEEEVEAE
HHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EAAEEAPEEALRRVVRLLGGRVLWVRRPRTREAPEEEPLSQDEIGGTGI
HHHHHCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]