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The map label for this gene is pdp [H]

Identifier: 55981740

GI number: 55981740

Start: 1659112

End: 1660383

Strand: Reverse

Name: pdp [H]

Synonym: TTHA1771

Alternate gene names: 55981740

Gene position: 1660383-1659112 (Counterclockwise)

Preceding gene: 55981742

Following gene: 55981739

Centisome position: 89.76

GC content: 70.91

Gene sequence:

>1272_bases
ATGAACCCCGTGGCCTTCATCCGGGAGAAGCGGGAAGGGAAAAAGCACCGCCGGGAGGACCTCGAGGCCTTCCTCCTCGG
CTACCTGCGGGACGAGGTTCCGGACTACCAGGTTTCCGCCTGGCTCATGGCGGCCTTTCTGCGGGGGCTGGACCCCGAGG
AGACCCTCTGGCTCACCGAGACCATGGCCCGCTCGGGGAAGGTTCTGGACCTTTCCGGCCTTCCCCACCCCGTGGACAAG
CACTCCTCGGGGGGCGTGGGGGACAAGGTGAGCCTGGTGGTGGGGCCGATCCTCGCCGCAAGCGGGTGCACCTTCGCCAA
GATGTCGGGCCGGGGCCTGGCCCACACCGGGGGAACCATAGACAAGCTGGAGTCGGTGCCGGGCTGGCGAGGGGAGATGA
CGGAGGCGGAGTTTTTGGAGAGGGCGCGGAGGGTGGGCCTCGTCATCGCCGCCCAAAGCCCGGACCTCGCCCCCCTGGAC
GGGAAGCTCTACGCCCTCCGCGACGTGACCGCCACGGTGGAGAGCGTGCCCTTGATCGCGAGCTCCATCATGAGCAAGAA
GCTCGCCGCCGGGGCGCGGAGCATTGTCTTGGACGTGAAGGTGGGCCGGGGGGCCTTCATGAAGACCCTGGAGGAGGCCC
GGCTTTTGGCCAAGACCATGGTGGCCATCGGCCAGGGGGCGGGAAGGCGGGTGAGGGCCCTCCTCACCTCCATGGAGGCC
CCCCTGGGGCGGGCGGTGGGGAACGCCATAGAGGTGCGGGAGGCCATAGAGGCCCTCAAAGGGGAGGGCCCCGGGGACCT
TCTGGAGGTGGCCCTGGCCCTGGCGGAGGAGGCCTTAAGGCTTGAGGGGCTGGACCCCGCCCTCGCCCGGAAGGCCCTGG
AGGGCGGGGCGGCCTTGGAGAAGTTCCGGGCCTTCCTCGAGGCCCAGGGGGGGGACCCCCGGGCGGTGGAGGACTTCTCC
CTTTTGCCCCTCGCCGAGGAGCACCCCCTCCGTGCCGAGCGGGAGGGCGTGGTGCGGGAGGTGGACGCCTACAAGGTGGG
CCTCGCCGTCCTCGCCCTGGGCGGGGGGCGGAAGCGGAAGGGGGAGCCCATTGACCACGGGGTGGGGGTCTACCTGCTCA
AGAAGCCCGGGGACCGGGTGGAGCGGGGGGAGGCCTTGGCCTTGGTCTACCACCGGAGGCGGGGCCTGGAGGAGGCCCTT
GGGCACCTGCGCGAGGCCTACGCCCTAGGGGAGGAGGCGCACCCCGCCCCCTTGGTCCTGGAGGCCATCTAG

Upstream 100 bases:

>100_bases
TGCCAAAAGCTCCACGTCCCGTATCCCCCGGAAGAGCCTTTCGTACTCCTCCAGCCCGAACCGGTACCGGGTGGCCATGG
CCTTAGCGTAGCATGGGCCC

Downstream 100 bases:

>100_bases
GTACCCCACCCGGTGGCGCAACCAGGGGGTGAACCCAGAAAGCGGGTCCCCGGGCCCAGACCGGGGCCGCCCCGCGCCGA
CCCCGGGCGCGGGCGCTTGG

Product: pyrimidine-nucleoside (thymidine) phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNPVAFIREKREGKKHRREDLEAFLLGYLRDEVPDYQVSAWLMAAFLRGLDPEETLWLTETMARSGKVLDLSGLPHPVDK
HSSGGVGDKVSLVVGPILAASGCTFAKMSGRGLAHTGGTIDKLESVPGWRGEMTEAEFLERARRVGLVIAAQSPDLAPLD
GKLYALRDVTATVESVPLIASSIMSKKLAAGARSIVLDVKVGRGAFMKTLEEARLLAKTMVAIGQGAGRRVRALLTSMEA
PLGRAVGNAIEVREAIEALKGEGPGDLLEVALALAEEALRLEGLDPALARKALEGGAALEKFRAFLEAQGGDPRAVEDFS
LLPLAEEHPLRAEREGVVREVDAYKVGLAVLALGGGRKRKGEPIDHGVGVYLLKKPGDRVERGEALALVYHRRRGLEEAL
GHLREAYALGEEAHPAPLVLEAI

Sequences:

>Translated_423_residues
MNPVAFIREKREGKKHRREDLEAFLLGYLRDEVPDYQVSAWLMAAFLRGLDPEETLWLTETMARSGKVLDLSGLPHPVDK
HSSGGVGDKVSLVVGPILAASGCTFAKMSGRGLAHTGGTIDKLESVPGWRGEMTEAEFLERARRVGLVIAAQSPDLAPLD
GKLYALRDVTATVESVPLIASSIMSKKLAAGARSIVLDVKVGRGAFMKTLEEARLLAKTMVAIGQGAGRRVRALLTSMEA
PLGRAVGNAIEVREAIEALKGEGPGDLLEVALALAEEALRLEGLDPALARKALEGGAALEKFRAFLEAQGGDPRAVEDFS
LLPLAEEHPLRAEREGVVREVDAYKVGLAVLALGGGRKRKGEPIDHGVGVYLLKKPGDRVERGEALALVYHRRRGLEEAL
GHLREAYALGEEAHPAPLVLEAI
>Mature_423_residues
MNPVAFIREKREGKKHRREDLEAFLLGYLRDEVPDYQVSAWLMAAFLRGLDPEETLWLTETMARSGKVLDLSGLPHPVDK
HSSGGVGDKVSLVVGPILAASGCTFAKMSGRGLAHTGGTIDKLESVPGWRGEMTEAEFLERARRVGLVIAAQSPDLAPLD
GKLYALRDVTATVESVPLIASSIMSKKLAAGARSIVLDVKVGRGAFMKTLEEARLLAKTMVAIGQGAGRRVRALLTSMEA
PLGRAVGNAIEVREAIEALKGEGPGDLLEVALALAEEALRLEGLDPALARKALEGGAALEKFRAFLEAQGGDPRAVEDFS
LLPLAEEHPLRAEREGVVREVDAYKVGLAVLALGGGRKRKGEPIDHGVGVYLLKKPGDRVERGEALALVYHRRRGLEEAL
GHLREAYALGEEAHPAPLVLEAI

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=421, Percent_Identity=44.1805225653207, Blast_Score=274, Evalue=9e-74,
Organism=Homo sapiens, GI4503445, Length=421, Percent_Identity=44.1805225653207, Blast_Score=274, Evalue=9e-74,
Organism=Homo sapiens, GI166158922, Length=421, Percent_Identity=44.1805225653207, Blast_Score=274, Evalue=9e-74,
Organism=Escherichia coli, GI1790842, Length=400, Percent_Identity=42.25, Blast_Score=273, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 45371; Mature: 45371

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPVAFIREKREGKKHRREDLEAFLLGYLRDEVPDYQVSAWLMAAFLRGLDPEETLWLTE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
TMARSGKVLDLSGLPHPVDKHSSGGVGDKVSLVVGPILAASGCTFAKMSGRGLAHTGGTI
HHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCH
DKLESVPGWRGEMTEAEFLERARRVGLVIAAQSPDLAPLDGKLYALRDVTATVESVPLIA
HHHHCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHH
SSIMSKKLAAGARSIVLDVKVGRGAFMKTLEEARLLAKTMVAIGQGAGRRVRALLTSMEA
HHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
PLGRAVGNAIEVREAIEALKGEGPGDLLEVALALAEEALRLEGLDPALARKALEGGAALE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHH
KFRAFLEAQGGDPRAVEDFSLLPLAEEHPLRAEREGVVREVDAYKVGLAVLALGGGRKRK
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCC
GEPIDHGVGVYLLKKPGDRVERGEALALVYHRRRGLEEALGHLREAYALGEEAHPAPLVL
CCCCCCCCEEEEECCCCCCHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEE
EAI
ECC
>Mature Secondary Structure
MNPVAFIREKREGKKHRREDLEAFLLGYLRDEVPDYQVSAWLMAAFLRGLDPEETLWLTE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
TMARSGKVLDLSGLPHPVDKHSSGGVGDKVSLVVGPILAASGCTFAKMSGRGLAHTGGTI
HHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCH
DKLESVPGWRGEMTEAEFLERARRVGLVIAAQSPDLAPLDGKLYALRDVTATVESVPLIA
HHHHCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHH
SSIMSKKLAAGARSIVLDVKVGRGAFMKTLEEARLLAKTMVAIGQGAGRRVRALLTSMEA
HHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
PLGRAVGNAIEVREAIEALKGEGPGDLLEVALALAEEALRLEGLDPALARKALEGGAALE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHH
KFRAFLEAQGGDPRAVEDFSLLPLAEEHPLRAEREGVVREVDAYKVGLAVLALGGGRKRK
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCC
GEPIDHGVGVYLLKKPGDRVERGEALALVYHRRRGLEEALGHLREAYALGEEAHPAPLVL
CCCCCCCCEEEEECCCCCCHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEE
EAI
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA