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The map label for this gene is phoP [H]

Identifier: 55981691

GI number: 55981691

Start: 1617531

End: 1618208

Strand: Direct

Name: phoP [H]

Synonym: TTHA1722

Alternate gene names: 55981691

Gene position: 1617531-1618208 (Clockwise)

Preceding gene: 55981690

Following gene: 55981692

Centisome position: 87.45

GC content: 66.96

Gene sequence:

>678_bases
ATGAAGGTCCTTTTGGTGGACGACGACCCGGCCATCCTCGAGGTCCTCGGGGCCTTTCTGAGGGGGGCCGGGTTTGAGGT
CTTGGAGGCGGAGGACGGGGAAAAGGCCTTGGAACTCTTTCCCCAGGCCGATCTGGTCATCCTGGACCTGATGCTCCCCA
AGGTGGGAGGCCTCGAGGTGGCCCGCCTCATCCGCCAGGAGCGCCCCGAGCTTCCCCTCCTCATCCTCACCGCCAAGGGG
GAGGAGGAGGACCGGGTTCTGGGCCTGGAGCTTGGGGCGGACGATTACGTGGTCAAGCCCTTCAGCCCCAGGGAGGTGGT
GGCCCGGGTCAAGGCCCTGTTGCGCCGGGCCGGGCTAAGGGAGGAGCTCGTCTACGGTCCCTTGCGCCTCCTCCCCACCC
GGCGGGAGGCCTACCTGGCGGGAAAGCCCCTCCCCCTCTCCCGGCTGGAGTTTGACCTCCTCTTAACCCTCGCCCAGCAC
CCGGGGGTGGTTTTCAGCCGGGAGAGGCTTTTGGAAAGGGTCTGGGGGCCCGGCTTCCCCGGGGTGGACCGGGTGGTGGA
CGTCCACATCGCCGCCCTTCGGAAGAAGCTCGGGGACGATCCGGAAAACCCCCGCTTCATTGAAACGGTGCGGGGCGTGG
GTTACCGCTTCAAGGACCCGGATGCGCCTCTTCCTTAA

Upstream 100 bases:

>100_bases
CCCCGGAAAGGCGGGACCGGGCCTTGGAGGTGCTGAGGGAGCGGTACGCCCGGGGGGAGATTGACAAGGAGACCTTTGAG
CGGATGAAGCGGGACCTCGC

Downstream 100 bases:

>100_bases
ACTCTTCCTGAGCCACCTCCTGGTGGCCCTCCTCGCCCTTTTGCTCCTCCTGCTGCTGGCGGAGGCCTTCGCCCCCGCCT
TCTACCGGGGGCACGTGGAG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKVLLVDDDPAILEVLGAFLRGAGFEVLEAEDGEKALELFPQADLVILDLMLPKVGGLEVARLIRQERPELPLLILTAKG
EEEDRVLGLELGADDYVVKPFSPREVVARVKALLRRAGLREELVYGPLRLLPTRREAYLAGKPLPLSRLEFDLLLTLAQH
PGVVFSRERLLERVWGPGFPGVDRVVDVHIAALRKKLGDDPENPRFIETVRGVGYRFKDPDAPLP

Sequences:

>Translated_225_residues
MKVLLVDDDPAILEVLGAFLRGAGFEVLEAEDGEKALELFPQADLVILDLMLPKVGGLEVARLIRQERPELPLLILTAKG
EEEDRVLGLELGADDYVVKPFSPREVVARVKALLRRAGLREELVYGPLRLLPTRREAYLAGKPLPLSRLEFDLLLTLAQH
PGVVFSRERLLERVWGPGFPGVDRVVDVHIAALRKKLGDDPENPRFIETVRGVGYRFKDPDAPLP
>Mature_225_residues
MKVLLVDDDPAILEVLGAFLRGAGFEVLEAEDGEKALELFPQADLVILDLMLPKVGGLEVARLIRQERPELPLLILTAKG
EEEDRVLGLELGADDYVVKPFSPREVVARVKALLRRAGLREELVYGPLRLLPTRREAYLAGKPLPLSRLEFDLLLTLAQH
PGVVFSRERLLERVWGPGFPGVDRVVDVHIAALRKKLGDDPENPRFIETVRGVGYRFKDPDAPLP

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=43.6123348017621, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=40.0881057268723, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=43.4977578475336, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=44, Blast_Score=157, Evalue=4e-40,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=42.8571428571429, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=39.647577092511, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=41.3636363636364, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=37.2727272727273, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=35.3711790393013, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=39.5454545454545, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=35.1351351351351, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=34.9775784753363, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=34.051724137931, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=33.4782608695652, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1788550, Length=126, Percent_Identity=30.952380952381, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790437, Length=103, Percent_Identity=36.8932038834951, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=36.9369369369369, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788191, Length=124, Percent_Identity=32.258064516129, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25090; Mature: 25090

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLLVDDDPAILEVLGAFLRGAGFEVLEAEDGEKALELFPQADLVILDLMLPKVGGLEV
CEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCCCHHHHHHHHCCCCCHHH
ARLIRQERPELPLLILTAKGEEEDRVLGLELGADDYVVKPFSPREVVARVKALLRRAGLR
HHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCEEECCCCHHHHHHHHHHHHHHCCCH
EELVYGPLRLLPTRREAYLAGKPLPLSRLEFDLLLTLAQHPGVVFSRERLLERVWGPGFP
HHHHHCCHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCC
GVDRVVDVHIAALRKKLGDDPENPRFIETVRGVGYRFKDPDAPLP
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCCC
>Mature Secondary Structure
MKVLLVDDDPAILEVLGAFLRGAGFEVLEAEDGEKALELFPQADLVILDLMLPKVGGLEV
CEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCCCHHHHHHHHCCCCCHHH
ARLIRQERPELPLLILTAKGEEEDRVLGLELGADDYVVKPFSPREVVARVKALLRRAGLR
HHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCEEECCCCHHHHHHHHHHHHHHCCCH
EELVYGPLRLLPTRREAYLAGKPLPLSRLEFDLLLTLAQHPGVVFSRERLLERVWGPGFP
HHHHHCCHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCC
GVDRVVDVHIAALRKKLGDDPENPRFIETVRGVGYRFKDPDAPLP
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]