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The map label for this gene is relA [H]

Identifier: 55981686

GI number: 55981686

Start: 1611926

End: 1614109

Strand: Direct

Name: relA [H]

Synonym: TTHA1717

Alternate gene names: 55981686

Gene position: 1611926-1614109 (Clockwise)

Preceding gene: 55981685

Following gene: 55981687

Centisome position: 87.14

GC content: 69.28

Gene sequence:

>2184_bases
GTGGTCGGCGCGGATCTCGGCCTCTGGAACCGCCTGGAACCCGCCTTGGCCTACCTCGCTCCCGAGGAACGGGCCAAAGT
GCGGGAGGCCTATCGCTTCGCCGAGGAGGCCCACCGGGGGCAGCTACGGCGAAGCGGGGAGCCCTACATCACCCACCCCG
TGGCCGTGGCCGAGATTCTGGCCGGCCTGCAGATGGACGCCGACACGGTGGCCGCGGGCCTCCTCCACGACACCCTGGAG
GACTGCGGGGTGGCGCCCGAGGAGCTGGAGCGCCGCTTCGGCCCCACGGTGCGCCGCATCGTGGAGGGGGAGACCAAGGT
CAGCAAGCTCTACAAGCTGGCGAACCTCGAGGGGGAGGAGAGGCGGGCGGAGGACCTCCGCCAGATGTTCATCGCCATGG
CGGAGGACGTGCGCATCATCATCGTCAAGCTGGCGGACCGCCTGCACAACCTCCGCACCCTGGAGCACATGCCCCCCGAG
AAGCAGAAGCGGATCGCCCAGGAAACCCTGGAGATCTACGCCCCCCTCGCCCACCGCCTGGGGATGGGCCAGCTCAAGTG
GGAGCTGGAGGACCTCTCCTTCCGCTACCTCCACCCCGAGGCCTTCGCCAGCCTGTCCGCCCGGATCCAGGCCACCCAGG
AGGCCAGGGAGCGCCTCATCCAGAGGGCCATCCACCTCCTCCAGGAGACCCTGGCCCGGGACGAGCTCCTCCAGAGCCAG
CTCCAGGGCTTTGAGGTGACCGGGCGCCCCAAGCACCTCTACTCCATCTGGAAGAAGATGGAGCGGGAGGGGAAGACCCT
GGAGCAGATCTACGACCTCCTGGCGGTCCGGGTCATCCTTGACCCCAAGCCCGCGCCCACCCGGGAAAGCCAGGCCCTAA
GGGAGAAGCAGGTCTGCTACCACGTCCTCGGCCTGGTCCACGCCCTCTGGCAGCCCATCCCCGGCCGGGTCAAGGACTAC
ATCGCCGTGCCCAAGCCCAACGGCTACCAGAGCCTCCACACCACGGTGATCGCCCTCGAGGGCCTGCCCCTGGAGGTGCA
GATCCGCACCCGGGAGATGCACCGCGTGGCCGAGTACGGCATCGCCGCCCACTGGCTCTATAAGGAGGGGCTCACCGACC
CCGAGGAGGTCAAGCGGCGGGTCTCCTGGCTGAAGAGCATCCAGGAGTGGCAGAAGGAGTTCTCCAGCTCCCGGGAGTTC
GTGGAGGCGGTGACCAAGGACCTCCTCGGCGGCCGGGTCTTCGTCTTCACCCCCAAGGGCCGCATCATCAACCTGCCCAA
GGGGGCGACCCCCGTGGACTTCGCCTACCACATCCACACCGAGGTGGGCCACCACATGGTGGGGGCCAAGGTCAACGGCC
GCATCGTCCCCCTCTCCTACGAGCTCCAAAACGGGGAGATCGTGGAGATCCTCACCAGCAAGAACGCCCACCCCTCCAAG
GGCTGGCTGGAGTTCGCCAAGACCCGGAGCGCCAAGAGCAAGATCCGCCAGTACTTCCGCGCCCAGGAGCGCCAGGAGAC
CCTGGAAAAGGGCCAGCACCTCCTGGAGCGGTACCTCAAGCGCCGGGGCCTGCCCAAGCCCACGGACAGCCAGCTGGAGG
AGGCGGCCAAACGCCTCTCCCTTCCCCCCTCCCCGGAGGAGCTCTACCTGGCCCTGGCCCTGAACCGCCTCACCCCCCGG
CAGGTGGCGGAAAAGCTCTATCCCAAGGCCCTCCTCAAGCCGGAGAAGCCCAAGCCCCAGGCCCGCAACGAGTGGGGCAT
CCGGCTGGAGCAGGACCTGCAGGCCCCCATCCGCCTCGCCTCCTGCTGCGAGCCCATGAAGGGCGACCCCATCCTCGGGT
TCGTGACCCGGGGCCGTGGGGTCACGGTCCACCGGGCCGACTGCCCCAACCTCCGCCGCCTCCTCCAGGGGCCGGAGGCG
GACCGGGTGATCGGGGCCTACTGGGAAGGGGTGGGAGGGAAGGTGGTGGTCCTCGAGGTCCTGGCCCAAGACCGGGCCGG
CCTCCTCCGGGACGTGATGCAGGTGGTGGCCGAGGCGGGGAAGAGCGCCCTCGGCTCCGAAACCCGGGTTTTGGGCCCTC
TGGCCCGGATCCGGCTCCGCCTGGCGGTCCAGGACGGGGAGGAGGAGCGGATCCTCCAGGCGGTGCAGAAGGTGTCCGGG
GTCAAAGAGGCGCGCTGGGCCTGA

Upstream 100 bases:

>100_bases
GCCCCCTGGAGGGGGCACGAGGCCGTGGCCCTGGTGGAGCCCGAGGCCTTGGACCCCTTCTTGAAGGCCCTCTCCGGGTA
GGGGTGCTACACTAAAAGTA

Downstream 100 bases:

>100_bases
GGCCACCCCATGCCGGCTTGCGCCAGCATGGGGCCCCGGTAAAGGGGCTTCCTCGGGCTAAGTGGCTGCGCGTTGATTTC
GCAACACGGGTTGCCCGCAA

Product: guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 727; Mature: 727

Protein sequence:

>727_residues
MVGADLGLWNRLEPALAYLAPEERAKVREAYRFAEEAHRGQLRRSGEPYITHPVAVAEILAGLQMDADTVAAGLLHDTLE
DCGVAPEELERRFGPTVRRIVEGETKVSKLYKLANLEGEERRAEDLRQMFIAMAEDVRIIIVKLADRLHNLRTLEHMPPE
KQKRIAQETLEIYAPLAHRLGMGQLKWELEDLSFRYLHPEAFASLSARIQATQEARERLIQRAIHLLQETLARDELLQSQ
LQGFEVTGRPKHLYSIWKKMEREGKTLEQIYDLLAVRVILDPKPAPTRESQALREKQVCYHVLGLVHALWQPIPGRVKDY
IAVPKPNGYQSLHTTVIALEGLPLEVQIRTREMHRVAEYGIAAHWLYKEGLTDPEEVKRRVSWLKSIQEWQKEFSSSREF
VEAVTKDLLGGRVFVFTPKGRIINLPKGATPVDFAYHIHTEVGHHMVGAKVNGRIVPLSYELQNGEIVEILTSKNAHPSK
GWLEFAKTRSAKSKIRQYFRAQERQETLEKGQHLLERYLKRRGLPKPTDSQLEEAAKRLSLPPSPEELYLALALNRLTPR
QVAEKLYPKALLKPEKPKPQARNEWGIRLEQDLQAPIRLASCCEPMKGDPILGFVTRGRGVTVHRADCPNLRRLLQGPEA
DRVIGAYWEGVGGKVVVLEVLAQDRAGLLRDVMQVVAEAGKSALGSETRVLGPLARIRLRLAVQDGEEERILQAVQKVSG
VKEARWA

Sequences:

>Translated_727_residues
MVGADLGLWNRLEPALAYLAPEERAKVREAYRFAEEAHRGQLRRSGEPYITHPVAVAEILAGLQMDADTVAAGLLHDTLE
DCGVAPEELERRFGPTVRRIVEGETKVSKLYKLANLEGEERRAEDLRQMFIAMAEDVRIIIVKLADRLHNLRTLEHMPPE
KQKRIAQETLEIYAPLAHRLGMGQLKWELEDLSFRYLHPEAFASLSARIQATQEARERLIQRAIHLLQETLARDELLQSQ
LQGFEVTGRPKHLYSIWKKMEREGKTLEQIYDLLAVRVILDPKPAPTRESQALREKQVCYHVLGLVHALWQPIPGRVKDY
IAVPKPNGYQSLHTTVIALEGLPLEVQIRTREMHRVAEYGIAAHWLYKEGLTDPEEVKRRVSWLKSIQEWQKEFSSSREF
VEAVTKDLLGGRVFVFTPKGRIINLPKGATPVDFAYHIHTEVGHHMVGAKVNGRIVPLSYELQNGEIVEILTSKNAHPSK
GWLEFAKTRSAKSKIRQYFRAQERQETLEKGQHLLERYLKRRGLPKPTDSQLEEAAKRLSLPPSPEELYLALALNRLTPR
QVAEKLYPKALLKPEKPKPQARNEWGIRLEQDLQAPIRLASCCEPMKGDPILGFVTRGRGVTVHRADCPNLRRLLQGPEA
DRVIGAYWEGVGGKVVVLEVLAQDRAGLLRDVMQVVAEAGKSALGSETRVLGPLARIRLRLAVQDGEEERILQAVQKVSG
VKEARWA
>Mature_727_residues
MVGADLGLWNRLEPALAYLAPEERAKVREAYRFAEEAHRGQLRRSGEPYITHPVAVAEILAGLQMDADTVAAGLLHDTLE
DCGVAPEELERRFGPTVRRIVEGETKVSKLYKLANLEGEERRAEDLRQMFIAMAEDVRIIIVKLADRLHNLRTLEHMPPE
KQKRIAQETLEIYAPLAHRLGMGQLKWELEDLSFRYLHPEAFASLSARIQATQEARERLIQRAIHLLQETLARDELLQSQ
LQGFEVTGRPKHLYSIWKKMEREGKTLEQIYDLLAVRVILDPKPAPTRESQALREKQVCYHVLGLVHALWQPIPGRVKDY
IAVPKPNGYQSLHTTVIALEGLPLEVQIRTREMHRVAEYGIAAHWLYKEGLTDPEEVKRRVSWLKSIQEWQKEFSSSREF
VEAVTKDLLGGRVFVFTPKGRIINLPKGATPVDFAYHIHTEVGHHMVGAKVNGRIVPLSYELQNGEIVEILTSKNAHPSK
GWLEFAKTRSAKSKIRQYFRAQERQETLEKGQHLLERYLKRRGLPKPTDSQLEEAAKRLSLPPSPEELYLALALNRLTPR
QVAEKLYPKALLKPEKPKPQARNEWGIRLEQDLQAPIRLASCCEPMKGDPILGFVTRGRGVTVHRADCPNLRRLLQGPEA
DRVIGAYWEGVGGKVVVLEVLAQDRAGLLRDVMQVVAEAGKSALGSETRVLGPLARIRLRLAVQDGEEERILQAVQKVSG
VKEARWA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=143, Percent_Identity=41.958041958042, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1790082, Length=646, Percent_Identity=41.1764705882353, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI1789147, Length=710, Percent_Identity=36.6197183098592, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI25143118, Length=136, Percent_Identity=36.0294117647059, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82539; Mature: 82539

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGADLGLWNRLEPALAYLAPEERAKVREAYRFAEEAHRGQLRRSGEPYITHPVAVAEIL
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHH
AGLQMDADTVAAGLLHDTLEDCGVAPEELERRFGPTVRRIVEGETKVSKLYKLANLEGEE
HCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHCCHHHHHHHHHHHCCCCHH
RRAEDLRQMFIAMAEDVRIIIVKLADRLHNLRTLEHMPPEKQKRIAQETLEIYAPLAHRL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
GMGQLKWELEDLSFRYLHPEAFASLSARIQATQEARERLIQRAIHLLQETLARDELLQSQ
CCCHHEEEHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQGFEVTGRPKHLYSIWKKMEREGKTLEQIYDLLAVRVILDPKPAPTRESQALREKQVCY
HCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
HVLGLVHALWQPIPGRVKDYIAVPKPNGYQSLHTTVIALEGLPLEVQIRTREMHRVAEYG
HHHHHHHHHHCCCCCCHHHCEECCCCCCCHHHHHHHEEECCCCEEEEEHHHHHHHHHHHH
IAAHWLYKEGLTDPEEVKRRVSWLKSIQEWQKEFSSSREFVEAVTKDLLGGRVFVFTPKG
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
RIINLPKGATPVDFAYHIHTEVGHHMVGAKVNGRIVPLSYELQNGEIVEILTSKNAHPSK
CEEECCCCCCCCHHHEEEHHHHCCCEECCEECCEEEEEEEEECCCCEEEEEECCCCCCCH
GWLEFAKTRSAKSKIRQYFRAQERQETLEKGQHLLERYLKRRGLPKPTDSQLEEAAKRLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
LPPSPEELYLALALNRLTPRQVAEKLYPKALLKPEKPKPQARNEWGIRLEQDLQAPIRLA
CCCCHHHHHHHHHHHCCCHHHHHHHHCHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHH
SCCEPMKGDPILGFVTRGRGVTVHRADCPNLRRLLQGPEADRVIGAYWEGVGGKVVVLEV
HHCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHH
LAQDRAGLLRDVMQVVAEAGKSALGSETRVLGPLARIRLRLAVQDGEEERILQAVQKVSG
HHHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHC
VKEARWA
CHHHCCC
>Mature Secondary Structure
MVGADLGLWNRLEPALAYLAPEERAKVREAYRFAEEAHRGQLRRSGEPYITHPVAVAEIL
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHH
AGLQMDADTVAAGLLHDTLEDCGVAPEELERRFGPTVRRIVEGETKVSKLYKLANLEGEE
HCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHCCHHHHHHHHHHHCCCCHH
RRAEDLRQMFIAMAEDVRIIIVKLADRLHNLRTLEHMPPEKQKRIAQETLEIYAPLAHRL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
GMGQLKWELEDLSFRYLHPEAFASLSARIQATQEARERLIQRAIHLLQETLARDELLQSQ
CCCHHEEEHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQGFEVTGRPKHLYSIWKKMEREGKTLEQIYDLLAVRVILDPKPAPTRESQALREKQVCY
HCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
HVLGLVHALWQPIPGRVKDYIAVPKPNGYQSLHTTVIALEGLPLEVQIRTREMHRVAEYG
HHHHHHHHHHCCCCCCHHHCEECCCCCCCHHHHHHHEEECCCCEEEEEHHHHHHHHHHHH
IAAHWLYKEGLTDPEEVKRRVSWLKSIQEWQKEFSSSREFVEAVTKDLLGGRVFVFTPKG
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
RIINLPKGATPVDFAYHIHTEVGHHMVGAKVNGRIVPLSYELQNGEIVEILTSKNAHPSK
CEEECCCCCCCCHHHEEEHHHHCCCEECCEECCEEEEEEEEECCCCEEEEEECCCCCCCH
GWLEFAKTRSAKSKIRQYFRAQERQETLEKGQHLLERYLKRRGLPKPTDSQLEEAAKRLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
LPPSPEELYLALALNRLTPRQVAEKLYPKALLKPEKPKPQARNEWGIRLEQDLQAPIRLA
CCCCHHHHHHHHHHHCCCHHHHHHHHCHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHH
SCCEPMKGDPILGFVTRGRGVTVHRADCPNLRRLLQGPEADRVIGAYWEGVGGKVVVLEV
HHCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHH
LAQDRAGLLRDVMQVVAEAGKSALGSETRVLGPLARIRLRLAVQDGEEERILQAVQKVSG
HHHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHC
VKEARWA
CHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]