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The map label for this gene is patB [H]

Identifier: 55981589

GI number: 55981589

Start: 1535572

End: 1536636

Strand: Direct

Name: patB [H]

Synonym: TTHA1620

Alternate gene names: 55981589

Gene position: 1535572-1536636 (Clockwise)

Preceding gene: 55981588

Following gene: 55981591

Centisome position: 83.02

GC content: 72.96

Gene sequence:

>1065_bases
ATGGACCTGCCTCCCCGCACCGGCTCCCTCAAGTGGGGCACCTACCCCGAGGACGTCCTCCCCCTCTGGGTGGCGGACAT
GGACTTCCCCCCGGCCGAGGCGATCCAGCAAGCCCTCGCCGAGCGGGCCCGGGGCTTTCTCGGCTACCCGCCCCGGGAGG
GGGACCGGGAGCTCAGGGAGCTGATCCTGGAGGCCCTGGGCCTCGAGGCGGAGCTCGCCTTCATGCCCGGGGTGGTGGTG
GGGCTCTACGCCGCCGTGGCCGCCTTCACCGCCCCGGGCCAGGGGGTCCTCACCCAGGTCCCCATCTACCCGCCCTTCCT
CGCCGCCATCCGGGACCAGCGCCGCACCGTCCTCGCCAACCCCTTGCGGGAGACCCCGGAAGGCTACCGGCTGGACCTCG
CGGGGCTGGAGCGCCTGGCCTTCGCCACCCGCCTCCTCCTCTTCTGCCACCCCCACAACCCCACGGGCCGGGTCTTCGGC
GAGGAGGAGCTCGCCGCCCTGGCCCAGATCGCCCGCAGGCACGACCTCATCGTGGTCTCCGACGAGCTCCACGCCCCCCT
CACCTACGAGAAGCCCCACGTCCCCCTGGCCCGCTTCCTCCCGGAAAGGACCCTCACCCTGGTGGGCCCGGGGAAGACCT
ACAACCTGGCGGGCCTGCCCATCGGGGCGGTCCTCGGCCCCAAGCCCCTGGTGGAGGCCGTGAAGCGCCACCTGCCCCAC
GTCTTCCCCAACGTCCTGGCCATGGCCGCCTGGAAGGCGGCCCTGAAGGAAGGGGGGCCCTGGCTTAAGGCCACCCTGGA
GCAGCTTCGGGCCAACCGGGACCGGGTGGCGGCCTGGGCCAAGGCGCGGGGGCTCGGCCACCACCCGCCGGAGGGAACCT
ACCTGGCCTGGATCCAGACCCCCTTCCCCAAGGCCGCCGCGTACTTCCTGGAGCGGGCCCGGGTGGCCCTGAACCCGGGG
GAGAGCTTCGGCCGGGGGTACGACACCTACGTCCGGCTCAACTTCGCCACCTACCCCGAGGTGCTGGAAGAGGCCCTGCG
GCGGCTGGACGGGGCCCTAAAGTAA

Upstream 100 bases:

>100_bases
GAGGCCGTCAAGGGGGCGGTGCGGGCCCTGGTGGACCGGCTCGAGGCCCACGGGCTGGAGGTGGTCCAGGACCACACCTG
AGGCCGGGTAAGATAAGCCC

Downstream 100 bases:

>100_bases
GCCCCCCCCCTGGGGGAACCCAGGGGGGTTAAGGCCTCACGCCCTTACTGGACCACCTCAATGGGGATCCGCCTGGCGCG
CGCCTCGGCCACCTTGGGCA

Product: aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MDLPPRTGSLKWGTYPEDVLPLWVADMDFPPAEAIQQALAERARGFLGYPPREGDRELRELILEALGLEAELAFMPGVVV
GLYAAVAAFTAPGQGVLTQVPIYPPFLAAIRDQRRTVLANPLRETPEGYRLDLAGLERLAFATRLLLFCHPHNPTGRVFG
EEELAALAQIARRHDLIVVSDELHAPLTYEKPHVPLARFLPERTLTLVGPGKTYNLAGLPIGAVLGPKPLVEAVKRHLPH
VFPNVLAMAAWKAALKEGGPWLKATLEQLRANRDRVAAWAKARGLGHHPPEGTYLAWIQTPFPKAAAYFLERARVALNPG
ESFGRGYDTYVRLNFATYPEVLEEALRRLDGALK

Sequences:

>Translated_354_residues
MDLPPRTGSLKWGTYPEDVLPLWVADMDFPPAEAIQQALAERARGFLGYPPREGDRELRELILEALGLEAELAFMPGVVV
GLYAAVAAFTAPGQGVLTQVPIYPPFLAAIRDQRRTVLANPLRETPEGYRLDLAGLERLAFATRLLLFCHPHNPTGRVFG
EEELAALAQIARRHDLIVVSDELHAPLTYEKPHVPLARFLPERTLTLVGPGKTYNLAGLPIGAVLGPKPLVEAVKRHLPH
VFPNVLAMAAWKAALKEGGPWLKATLEQLRANRDRVAAWAKARGLGHHPPEGTYLAWIQTPFPKAAAYFLERARVALNPG
ESFGRGYDTYVRLNFATYPEVLEEALRRLDGALK
>Mature_354_residues
MDLPPRTGSLKWGTYPEDVLPLWVADMDFPPAEAIQQALAERARGFLGYPPREGDRELRELILEALGLEAELAFMPGVVV
GLYAAVAAFTAPGQGVLTQVPIYPPFLAAIRDQRRTVLANPLRETPEGYRLDLAGLERLAFATRLLLFCHPHNPTGRVFG
EEELAALAQIARRHDLIVVSDELHAPLTYEKPHVPLARFLPERTLTLVGPGKTYNLAGLPIGAVLGPKPLVEAVKRHLPH
VFPNVLAMAAWKAALKEGGPWLKATLEQLRANRDRVAAWAKARGLGHHPPEGTYLAWIQTPFPKAAAYFLERARVALNPG
ESFGRGYDTYVRLNFATYPEVLEEALRRLDGALK

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=286, Percent_Identity=26.5734265734266, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI56713254, Length=286, Percent_Identity=26.5734265734266, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI95147551, Length=255, Percent_Identity=29.0196078431373, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI169881279, Length=255, Percent_Identity=29.0196078431373, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI169881281, Length=117, Percent_Identity=34.1880341880342, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787909, Length=362, Percent_Identity=28.4530386740331, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786816, Length=285, Percent_Identity=27.719298245614, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788722, Length=308, Percent_Identity=26.9480519480519, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788627, Length=178, Percent_Identity=28.6516853932584, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=229, Percent_Identity=30.5676855895196, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71994472, Length=229, Percent_Identity=30.5676855895196, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17567369, Length=168, Percent_Identity=26.1904761904762, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17567663, Length=205, Percent_Identity=26.8292682926829, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=217, Percent_Identity=29.9539170506912, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573069, Length=246, Percent_Identity=24.390243902439, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646114, Length=246, Percent_Identity=24.390243902439, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573067, Length=246, Percent_Identity=24.390243902439, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573065, Length=246, Percent_Identity=24.390243902439, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 39079; Mature: 39079

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLPPRTGSLKWGTYPEDVLPLWVADMDFPPAEAIQQALAERARGFLGYPPREGDRELRE
CCCCCCCCCCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
LILEALGLEAELAFMPGVVVGLYAAVAAFTAPGQGVLTQVPIYPPFLAAIRDQRRTVLAN
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHC
PLRETPEGYRLDLAGLERLAFATRLLLFCHPHNPTGRVFGEEELAALAQIARRHDLIVVS
HHHCCCCCCEEEHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEE
DELHAPLTYEKPHVPLARFLPERTLTLVGPGKTYNLAGLPIGAVLGPKPLVEAVKRHLPH
CCCCCCCCCCCCCCCHHHHCCCCEEEEECCCCEEEECCCCHHHHCCCHHHHHHHHHHCCH
VFPNVLAMAAWKAALKEGGPWLKATLEQLRANRDRVAAWAKARGLGHHPPEGTYLAWIQT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEEC
PFPKAAAYFLERARVALNPGESFGRGYDTYVRLNFATYPEVLEEALRRLDGALK
CCHHHHHHHHHHHHHEECCCHHHCCCCCEEEEEEECHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDLPPRTGSLKWGTYPEDVLPLWVADMDFPPAEAIQQALAERARGFLGYPPREGDRELRE
CCCCCCCCCCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
LILEALGLEAELAFMPGVVVGLYAAVAAFTAPGQGVLTQVPIYPPFLAAIRDQRRTVLAN
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHC
PLRETPEGYRLDLAGLERLAFATRLLLFCHPHNPTGRVFGEEELAALAQIARRHDLIVVS
HHHCCCCCCEEEHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEE
DELHAPLTYEKPHVPLARFLPERTLTLVGPGKTYNLAGLPIGAVLGPKPLVEAVKRHLPH
CCCCCCCCCCCCCCCHHHHCCCCEEEEECCCCEEEECCCCHHHHCCCHHHHHHHHHHCCH
VFPNVLAMAAWKAALKEGGPWLKATLEQLRANRDRVAAWAKARGLGHHPPEGTYLAWIQT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEEC
PFPKAAAYFLERARVALNPGESFGRGYDTYVRLNFATYPEVLEEALRRLDGALK
CCHHHHHHHHHHHHHEECCCHHHCCCCCEEEEEEECHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]