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The map label for this gene is coaBC [H]

Identifier: 55981529

GI number: 55981529

Start: 1484019

End: 1485209

Strand: Reverse

Name: coaBC [H]

Synonym: TTHA1560

Alternate gene names: 55981529

Gene position: 1485209-1484019 (Counterclockwise)

Preceding gene: 55981530

Following gene: 55981528

Centisome position: 80.29

GC content: 73.64

Gene sequence:

>1191_bases
GTGGCCCGGGTCCTGGTGGCGGTGACGGGGGGGGTGGCCGCGGTGAAGGCCCCCCACCTCCTCCGCCTCCTGCGCCGGGA
GGGGCACGAGGTGCGGGCCCTCGCCACCCCCAGGGCCCTGGAGTTCGTCACCCCCCTCTCCCTGGCCGTGGCCTCCGGGG
GCGAGGTGGCCACGGAGGAGGCCTGGTTCCGGCCCGACGGGAGGGCCCTCCACATTGAGCTCGCCCGCTGGGCCGAGGTG
GTCCTGGTGGCCCCCGCCACCGCCGACGCCCTGGCCAAGGCCGCTTTGGGGCTCGCCGACGACCTCCTCTCCGCCACCCT
CCTCGCCGGGGCCAAACGGGTGGCCTGGGCCCCGGCCATGAACGAGGCCATGTGGCTCGCCCCCCAGACCCAGGCCCACG
TCAGGCGGCTGGAGGAGCTGGGGCACGCCTTCTTCGGCCCGGCCTACGGCCCCTTGGCCGCCGTGGGGGAGGGGGAGGGA
TGGGGGCGGATGCTGGAGCCCGAGGAGCTTGTGGAGCGGTTACGGGCTTTCCTCGCGCCCAAGGACCTCTCGGGCCTCCG
CCTCCTCGTCTCCGCCGGGCCCACCCGGGAGTACCTGGACCCGGTGCGCTTCCTCTCCAACCCCTCCTCGGGCCGGATGG
GCTACGCCGTGGCCGAGGCCGCCCGGGACCGGGGGGCGGAGGTGGTCCTGGTCTCCGGGCCCACCGCGCTTCCCGACCCC
TGGGGCGTGGAGGTGGTCCGGGTGGAGAGCGCCCTGGAGATGCGAAAGGCCCTCCTGGACCGCTACCCCTGGGCCCAGGC
GGTGGTCATGGCCGCCGCGGTGGCGGACTACCGGCCCGCCGAGACCCTAAAGGACAAGGAGCCCAAGGCCGAGGCGGAAA
AGCTCCTCCGCCTCGTGCCCAACCCCGACATCCTCCGCGAGCTCGGGGAGAGGAAGGAGGGGCGGGTGCTCGTGGGCTTC
GCCATGGAGACCCGGGAGGGCCTGGAGCGGGCCCGGGGGAAGCTCGCCCGCAAGAACCTGGACCTGATCGCCTTGAACTA
CGTGGGGCGGGAGGGGGTGGGCTTCGGGAGCCCCGAGAACGAGGTGACCCTGATCCTGCGGGACGGCCGGGTGGTGGAGC
TTCCCCGGCTTTCCAAGCGGGAGGTGGCCCACCGTATACTGGATTTCGTCAAGGAGCTCTGGAAGCGATAG

Upstream 100 bases:

>100_bases
CACGGGCCGGTTGGTCTTCGGCGAGAACCTGGTGCCCGAGGACCGGCTCCAAAAGGAGATGGAGCGGCTCTACCCGGTGG
AGCGGGAGGAGTAGCGCGCC

Downstream 100 bases:

>100_bases
GAGCCGCGTATGGGCAACAAGGCGGAACGGCACCGCGCCATCCAGGAGATCGTCCGCCGGGAGGAGATCGGCACCCAGAA
GGAGCTGGTGGAGAGGCTGC

Product: DNA/pantothenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MARVLVAVTGGVAAVKAPHLLRLLRREGHEVRALATPRALEFVTPLSLAVASGGEVATEEAWFRPDGRALHIELARWAEV
VLVAPATADALAKAALGLADDLLSATLLAGAKRVAWAPAMNEAMWLAPQTQAHVRRLEELGHAFFGPAYGPLAAVGEGEG
WGRMLEPEELVERLRAFLAPKDLSGLRLLVSAGPTREYLDPVRFLSNPSSGRMGYAVAEAARDRGAEVVLVSGPTALPDP
WGVEVVRVESALEMRKALLDRYPWAQAVVMAAAVADYRPAETLKDKEPKAEAEKLLRLVPNPDILRELGERKEGRVLVGF
AMETREGLERARGKLARKNLDLIALNYVGREGVGFGSPENEVTLILRDGRVVELPRLSKREVAHRILDFVKELWKR

Sequences:

>Translated_396_residues
MARVLVAVTGGVAAVKAPHLLRLLRREGHEVRALATPRALEFVTPLSLAVASGGEVATEEAWFRPDGRALHIELARWAEV
VLVAPATADALAKAALGLADDLLSATLLAGAKRVAWAPAMNEAMWLAPQTQAHVRRLEELGHAFFGPAYGPLAAVGEGEG
WGRMLEPEELVERLRAFLAPKDLSGLRLLVSAGPTREYLDPVRFLSNPSSGRMGYAVAEAARDRGAEVVLVSGPTALPDP
WGVEVVRVESALEMRKALLDRYPWAQAVVMAAAVADYRPAETLKDKEPKAEAEKLLRLVPNPDILRELGERKEGRVLVGF
AMETREGLERARGKLARKNLDLIALNYVGREGVGFGSPENEVTLILRDGRVVELPRLSKREVAHRILDFVKELWKR
>Mature_395_residues
ARVLVAVTGGVAAVKAPHLLRLLRREGHEVRALATPRALEFVTPLSLAVASGGEVATEEAWFRPDGRALHIELARWAEVV
LVAPATADALAKAALGLADDLLSATLLAGAKRVAWAPAMNEAMWLAPQTQAHVRRLEELGHAFFGPAYGPLAAVGEGEGW
GRMLEPEELVERLRAFLAPKDLSGLRLLVSAGPTREYLDPVRFLSNPSSGRMGYAVAEAARDRGAEVVLVSGPTALPDPW
GVEVVRVESALEMRKALLDRYPWAQAVVMAAAVADYRPAETLKDKEPKAEAEKLLRLVPNPDILRELGERKEGRVLVGFA
METREGLERARGKLARKNLDLIALNYVGREGVGFGSPENEVTLILRDGRVVELPRLSKREVAHRILDFVKELWKR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=179, Percent_Identity=37.4301675977654, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI87082301, Length=395, Percent_Identity=43.0379746835443, Blast_Score=248, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI17560194, Length=142, Percent_Identity=32.3943661971831, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=27.6595744680851, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43205; Mature: 43073

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVLVAVTGGVAAVKAPHLLRLLRREGHEVRALATPRALEFVTPLSLAVASGGEVATEE
CCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEECCC
AWFRPDGRALHIELARWAEVVLVAPATADALAKAALGLADDLLSATLLAGAKRVAWAPAM
CEECCCCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCC
NEAMWLAPQTQAHVRRLEELGHAFFGPAYGPLAAVGEGEGWGRMLEPEELVERLRAFLAP
CCCEEECCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
KDLSGLRLLVSAGPTREYLDPVRFLSNPSSGRMGYAVAEAARDRGAEVVLVSGPTALPDP
CCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCC
WGVEVVRVESALEMRKALLDRYPWAQAVVMAAAVADYRPAETLKDKEPKAEAEKLLRLVP
CCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHCC
NPDILRELGERKEGRVLVGFAMETREGLERARGKLARKNLDLIALNYVGREGVGFGSPEN
CHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
EVTLILRDGRVVELPRLSKREVAHRILDFVKELWKR
CEEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARVLVAVTGGVAAVKAPHLLRLLRREGHEVRALATPRALEFVTPLSLAVASGGEVATEE
CEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEECCC
AWFRPDGRALHIELARWAEVVLVAPATADALAKAALGLADDLLSATLLAGAKRVAWAPAM
CEECCCCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCC
NEAMWLAPQTQAHVRRLEELGHAFFGPAYGPLAAVGEGEGWGRMLEPEELVERLRAFLAP
CCCEEECCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
KDLSGLRLLVSAGPTREYLDPVRFLSNPSSGRMGYAVAEAARDRGAEVVLVSGPTALPDP
CCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCC
WGVEVVRVESALEMRKALLDRYPWAQAVVMAAAVADYRPAETLKDKEPKAEAEKLLRLVP
CCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHCC
NPDILRELGERKEGRVLVGFAMETREGLERARGKLARKNLDLIALNYVGREGVGFGSPEN
CHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
EVTLILRDGRVVELPRLSKREVAHRILDFVKELWKR
CEEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]