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The map label for this gene is prs [H]

Identifier: 55981518

GI number: 55981518

Start: 1475779

End: 1476702

Strand: Reverse

Name: prs [H]

Synonym: TTHA1549

Alternate gene names: 55981518

Gene position: 1476702-1475779 (Counterclockwise)

Preceding gene: 55981519

Following gene: 55981516

Centisome position: 79.83

GC content: 69.91

Gene sequence:

>924_bases
ATGGAAATCCGGCTCTTCTCGGGGAGCGCCCACCCCGACTTGGCCCGGCGGGTGGCGGAGGCCCTGGGGGTGCCCTTGGG
CAAGGCCCTGGTGGACCGCTTTCCCGACGGGGAGGTGCGGGTCAGGCTTCTTGAGAGCGTCCGCGGGGAGGACGTCTACC
TCATCCAGCCCACCTGCCCCCCGGTGAACGACCACCTGATGGAGCTCCTCCTCCTCGCCGACGCCGCCAGGCGGAGCTCG
GCGGGGCGCATCAACGCCGTCATCCCCTACTTCGGCTACGCCCGCCAGGACAAGCAGACGGAGGGGCGCGAGCCCATCAG
CGCCAGGCTGGTGGCGGGGCTTTTGGAGAGGGTGGGGGTGGAGCGGGTCATCGCCATTGACCTCCACGCCCCCCAGATCC
AGGGCTTCTTTGACATCCCCGTGGACCACCTCTCCGCCGTGCGCCTCTTCGCCCGCTACCTCCGGGAAAAGGGGTACGTG
GAAAACGCCGTGGTGGTCTCCCCGGACGCGGGCCGGGCCGAGGAGGCGAGAAGGCTTGCGGAAAGGCTCGGCCTTCCCCT
CGCCATGCTGGCCAAAAGGCGCCTCGGGCCCCGGGAGACCTCCGTGACCTACGTCATCGGCGACGTGGAGGGGAAAAGGC
CCATCCTGGTGGACGACATCGTCTCCACCGGGGGGACGATAAGGCGGGGGGTGGAGGCCCTCCTCCAGGCGGGGGCCCTC
CCCGAGGTGGTGGTCATGGCCACCCACGCCGTCCTGGTGGGGGGGGCCAAGGAGAACCTCGCCCACCCCGCCGTCCGCGA
GGTGGTGTTCACCGACACCATCCCCCTAAAGGACGGGGGCTACACGGTGCTCTCCACCGCCGAGCTTCTGGCCCAGGCCA
TCCGCCACGTCCACACCAACCAGTCGGTGAGCGCCCTCATCTGA

Upstream 100 bases:

>100_bases
CGGGGAGGGGGCGGCCTTGGACTTCCAGGCCTTTTTGCGGGAGGCCGCAAGGCGCCTTGGGCTCCTCGCCCGGGCCCTGG
TAGAGTGAGGAGGGGGTTCC

Downstream 100 bases:

>100_bases
GGTGCGCCCGCACATGGGCCCGGACCAAGGCTTGGGGAGGCCCTTTTGGGGCGCAGGTGGTGTCAGGCGGGCTCCTCCTC
GGCCAGGGCCGCCTTGAGGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MEIRLFSGSAHPDLARRVAEALGVPLGKALVDRFPDGEVRVRLLESVRGEDVYLIQPTCPPVNDHLMELLLLADAARRSS
AGRINAVIPYFGYARQDKQTEGREPISARLVAGLLERVGVERVIAIDLHAPQIQGFFDIPVDHLSAVRLFARYLREKGYV
ENAVVVSPDAGRAEEARRLAERLGLPLAMLAKRRLGPRETSVTYVIGDVEGKRPILVDDIVSTGGTIRRGVEALLQAGAL
PEVVVMATHAVLVGGAKENLAHPAVREVVFTDTIPLKDGGYTVLSTAELLAQAIRHVHTNQSVSALI

Sequences:

>Translated_307_residues
MEIRLFSGSAHPDLARRVAEALGVPLGKALVDRFPDGEVRVRLLESVRGEDVYLIQPTCPPVNDHLMELLLLADAARRSS
AGRINAVIPYFGYARQDKQTEGREPISARLVAGLLERVGVERVIAIDLHAPQIQGFFDIPVDHLSAVRLFARYLREKGYV
ENAVVVSPDAGRAEEARRLAERLGLPLAMLAKRRLGPRETSVTYVIGDVEGKRPILVDDIVSTGGTIRRGVEALLQAGAL
PEVVVMATHAVLVGGAKENLAHPAVREVVFTDTIPLKDGGYTVLSTAELLAQAIRHVHTNQSVSALI
>Mature_307_residues
MEIRLFSGSAHPDLARRVAEALGVPLGKALVDRFPDGEVRVRLLESVRGEDVYLIQPTCPPVNDHLMELLLLADAARRSS
AGRINAVIPYFGYARQDKQTEGREPISARLVAGLLERVGVERVIAIDLHAPQIQGFFDIPVDHLSAVRLFARYLREKGYV
ENAVVVSPDAGRAEEARRLAERLGLPLAMLAKRRLGPRETSVTYVIGDVEGKRPILVDDIVSTGGTIRRGVEALLQAGAL
PEVVVMATHAVLVGGAKENLAHPAVREVVFTDTIPLKDGGYTVLSTAELLAQAIRHVHTNQSVSALI

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=312, Percent_Identity=44.5512820512821, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI4506127, Length=312, Percent_Identity=43.2692307692308, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI84875539, Length=315, Percent_Identity=44.4444444444444, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=42.443729903537, Blast_Score=251, Evalue=4e-67,
Organism=Homo sapiens, GI4506133, Length=339, Percent_Identity=34.8082595870207, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI194018537, Length=346, Percent_Identity=35.5491329479769, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI310128524, Length=137, Percent_Identity=32.8467153284672, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310115209, Length=137, Percent_Identity=32.8467153284672, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310118259, Length=137, Percent_Identity=32.8467153284672, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310119946, Length=137, Percent_Identity=32.8467153284672, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=46.0063897763578, Blast_Score=269, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=42.6282051282051, Blast_Score=247, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=42.6282051282051, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17554704, Length=313, Percent_Identity=42.4920127795527, Blast_Score=244, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71989924, Length=312, Percent_Identity=42.6282051282051, Blast_Score=243, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=30.5637982195846, Blast_Score=154, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=42.1221864951768, Blast_Score=244, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6319403, Length=311, Percent_Identity=42.443729903537, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=40.3846153846154, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6322667, Length=194, Percent_Identity=41.2371134020619, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=95, Percent_Identity=43.1578947368421, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=42.1725239616613, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI45551540, Length=336, Percent_Identity=39.2857142857143, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=33.4269662921348, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=33.4269662921348, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=33.4269662921348, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=33.4269662921348, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651462, Length=191, Percent_Identity=40.8376963350785, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24651464, Length=191, Percent_Identity=40.8376963350785, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45552010, Length=191, Percent_Identity=40.8376963350785, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33324; Mature: 33324

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRLFSGSAHPDLARRVAEALGVPLGKALVDRFPDGEVRVRLLESVRGEDVYLIQPTCP
CEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCC
PVNDHLMELLLLADAARRSSAGRINAVIPYFGYARQDKQTEGREPISARLVAGLLERVGV
CHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
ERVIAIDLHAPQIQGFFDIPVDHLSAVRLFARYLREKGYVENAVVVSPDAGRAEEARRLA
CEEEEEEECCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHH
ERLGLPLAMLAKRRLGPRETSVTYVIGDVEGKRPILVDDIVSTGGTIRRGVEALLQAGAL
HHHCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCEEHHHHHHCCCHHHHHHHHHHHCCCC
PEVVVMATHAVLVGGAKENLAHPAVREVVFTDTIPLKDGGYTVLSTAELLAQAIRHVHTN
CHHHHHHHHHHEECCCHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
QSVSALI
CCHHHCC
>Mature Secondary Structure
MEIRLFSGSAHPDLARRVAEALGVPLGKALVDRFPDGEVRVRLLESVRGEDVYLIQPTCP
CEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCC
PVNDHLMELLLLADAARRSSAGRINAVIPYFGYARQDKQTEGREPISARLVAGLLERVGV
CHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
ERVIAIDLHAPQIQGFFDIPVDHLSAVRLFARYLREKGYVENAVVVSPDAGRAEEARRLA
CEEEEEEECCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHH
ERLGLPLAMLAKRRLGPRETSVTYVIGDVEGKRPILVDDIVSTGGTIRRGVEALLQAGAL
HHHCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCEEHHHHHHCCCHHHHHHHHHHHCCCC
PEVVVMATHAVLVGGAKENLAHPAVREVVFTDTIPLKDGGYTVLSTAELLAQAIRHVHTN
CHHHHHHHHHHEECCCHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
QSVSALI
CCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]