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The map label for this gene is qor [C]

Identifier: 55981496

GI number: 55981496

Start: 1452963

End: 1453919

Strand: Reverse

Name: qor [C]

Synonym: TTHA1527

Alternate gene names: 55981496

Gene position: 1453919-1452963 (Counterclockwise)

Preceding gene: 55981497

Following gene: 55981492

Centisome position: 78.6

GC content: 71.79

Gene sequence:

>957_bases
ATGCGCGCGGTGGTGCTCAAGGGCTTCGGCGGGTTGGAGATGCTGGAGGAGCGGGACCTCCCGGTGCCCGAGCCCGGGCC
CGGGGAGGTCTTGGTGCGGAACCTGGCCGTGGCCGTGAACCCCGTGGACGCCAAGATCCGGGCGGCGGGGCGCTGGGCGG
GGGTGGAGCCCCCCTTCGTCCTGGGCTACGACGCCGCCGGCGTCGTGGCCAAGGTGGGCCCCGGGGTGAAGGACCTTAAG
GAGGGGGACGAGGTCTACTACACCCCCGAGATCTTCGGGAACCCCCACGGCACCTACGCCGAGTACACCCCCGTGCCCGC
GGGGATCGTGGCCAAGAAGCCCAAGAACCTCTCCTTCGCCGAGGCCGCCGCCATTCCCTTGGCGGGGGGTACCGCCTGGG
AGGCGGTGGTGCGCCGCCTGGCCGTGCGCCCGGGGGAGACGGTGCTGGTGATGGGCGGGGCGGGGGGCGTGGGCTCCTTC
GCCGTCCAGTTCGCCAAGGCGGCGGGGGCCTACGTGATCGCCACGGCGAGCGCGGAAAACCTCCCGGTGCTCAAGGAGCT
CGGGGCCGACCTCGCCCTGGACTACCGGGGCCCCTGGGCGGAGGAGGTCCTCAAGGCCACGGAGGGCCAGGGGGTGGACG
CCGCCTTTGAGACCGCCGGGGAGAGCCTGGTGGAGCGGGTCATCCCCGTGGTGCGCCCCTTCGGCCGCATCGCCACCATC
CTCCCCCCGCAGGGGAACCTCTCCGGGCTTTACACCAAGAACCAGACCCTCTACGGCGTCTTCCTCACGCGGGAGAGGAA
GCGCCTTCTGGAGATGCGCCCCCTCTTTGAGCGGGGCCTGGCGAGGCCCCTCATCGCCGAGGTCCTCCCCTTCAGCCTGG
AGAACCTGAGGAAGGCCCACGCCCGCATGGACTCCGGGCACGGGCGGGGGAAGATCGTCCTCACCTTTCAGGCGTAA

Upstream 100 bases:

>100_bases
CCCACGGACCCCGGGATCTACCTCAAGCGGGCGGCCTAGGAAGCTTCTTCACAAAAGGGGGCCTAGACCCCCCTTTAAGG
TTTTTGAGGGGGGTGAGCCG

Downstream 100 bases:

>100_bases
AGGGCCTTAAGCCGCGCCGCCTCCTCCGCGAGAAGGGGGAGGCGGCTTAGGTCTACTCCCGTGGCGAGGCCCCGCTTCTC
CAGATGGGGGAGGACGACCT

Product: NADPH-quinone reductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MRAVVLKGFGGLEMLEERDLPVPEPGPGEVLVRNLAVAVNPVDAKIRAAGRWAGVEPPFVLGYDAAGVVAKVGPGVKDLK
EGDEVYYTPEIFGNPHGTYAEYTPVPAGIVAKKPKNLSFAEAAAIPLAGGTAWEAVVRRLAVRPGETVLVMGGAGGVGSF
AVQFAKAAGAYVIATASAENLPVLKELGADLALDYRGPWAEEVLKATEGQGVDAAFETAGESLVERVIPVVRPFGRIATI
LPPQGNLSGLYTKNQTLYGVFLTRERKRLLEMRPLFERGLARPLIAEVLPFSLENLRKAHARMDSGHGRGKIVLTFQA

Sequences:

>Translated_318_residues
MRAVVLKGFGGLEMLEERDLPVPEPGPGEVLVRNLAVAVNPVDAKIRAAGRWAGVEPPFVLGYDAAGVVAKVGPGVKDLK
EGDEVYYTPEIFGNPHGTYAEYTPVPAGIVAKKPKNLSFAEAAAIPLAGGTAWEAVVRRLAVRPGETVLVMGGAGGVGSF
AVQFAKAAGAYVIATASAENLPVLKELGADLALDYRGPWAEEVLKATEGQGVDAAFETAGESLVERVIPVVRPFGRIATI
LPPQGNLSGLYTKNQTLYGVFLTRERKRLLEMRPLFERGLARPLIAEVLPFSLENLRKAHARMDSGHGRGKIVLTFQA
>Mature_318_residues
MRAVVLKGFGGLEMLEERDLPVPEPGPGEVLVRNLAVAVNPVDAKIRAAGRWAGVEPPFVLGYDAAGVVAKVGPGVKDLK
EGDEVYYTPEIFGNPHGTYAEYTPVPAGIVAKKPKNLSFAEAAAIPLAGGTAWEAVVRRLAVRPGETVLVMGGAGGVGSF
AVQFAKAAGAYVIATASAENLPVLKELGADLALDYRGPWAEEVLKATEGQGVDAAFETAGESLVERVIPVVRPFGRIATI
LPPQGNLSGLYTKNQTLYGVFLTRERKRLLEMRPLFERGLARPLIAEVLPFSLENLRKAHARMDSGHGRGKIVLTFQA

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=357, Percent_Identity=30.2521008403361, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI194239674, Length=330, Percent_Identity=30.3030303030303, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI13236495, Length=330, Percent_Identity=30.3030303030303, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI28557745, Length=325, Percent_Identity=32.3076923076923, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI194239676, Length=321, Percent_Identity=32.0872274143302, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI22538446, Length=345, Percent_Identity=30.1449275362319, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI22538444, Length=345, Percent_Identity=30.1449275362319, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI24308257, Length=236, Percent_Identity=31.7796610169492, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI156627571, Length=236, Percent_Identity=35.1694915254237, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI18379349, Length=349, Percent_Identity=30.3724928366762, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI34577061, Length=359, Percent_Identity=28.4122562674095, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4501933, Length=358, Percent_Identity=27.0949720670391, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI41872631, Length=222, Percent_Identity=30.1801801801802, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI90669511, Length=208, Percent_Identity=30.2884615384615, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790485, Length=320, Percent_Identity=30.3125, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87081918, Length=320, Percent_Identity=27.5, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507255, Length=327, Percent_Identity=30.5810397553517, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71987554, Length=380, Percent_Identity=30.2631578947368, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17562876, Length=330, Percent_Identity=28.1818181818182, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=255, Percent_Identity=30.1960784313725, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319520, Length=333, Percent_Identity=30.9309309309309, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319621, Length=339, Percent_Identity=28.3185840707965, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=336, Percent_Identity=27.0833333333333, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=27.0833333333333, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=335, Percent_Identity=26.865671641791, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319945, Length=231, Percent_Identity=30.7359307359307, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323493, Length=232, Percent_Identity=30.6034482758621, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324195, Length=240, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581341, Length=363, Percent_Identity=30.0275482093664, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24581339, Length=363, Percent_Identity=30.0275482093664, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 33785; Mature: 33785

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVLKGFGGLEMLEERDLPVPEPGPGEVLVRNLAVAVNPVDAKIRAAGRWAGVEPPFV
CCEEEEECCCCHHHHHHCCCCCCCCCCHHHHHHHHHEEECCCCCEEEECCCCCCCCCCEE
LGYDAAGVVAKVGPGVKDLKEGDEVYYTPEIFGNPHGTYAEYTPVPAGIVAKKPKNLSFA
EECCCCCHHHHCCCCHHHHHCCCCEEECHHHCCCCCCCCCCCCCCCCCCEECCCCCCCHH
EAAAIPLAGGTAWEAVVRRLAVRPGETVLVMGGAGGVGSFAVQFAKAAGAYVIATASAEN
HHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEECCCCC
LPVLKELGADLALDYRGPWAEEVLKATEGQGVDAAFETAGESLVERVIPVVRPFGRIATI
CCHHHHCCCCEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
LPPQGNLSGLYTKNQTLYGVFLTRERKRLLEMRPLFERGLARPLIAEVLPFSLENLRKAH
ECCCCCCCEEEECCCEEEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHH
ARMDSGHGRGKIVLTFQA
HHCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MRAVVLKGFGGLEMLEERDLPVPEPGPGEVLVRNLAVAVNPVDAKIRAAGRWAGVEPPFV
CCEEEEECCCCHHHHHHCCCCCCCCCCHHHHHHHHHEEECCCCCEEEECCCCCCCCCCEE
LGYDAAGVVAKVGPGVKDLKEGDEVYYTPEIFGNPHGTYAEYTPVPAGIVAKKPKNLSFA
EECCCCCHHHHCCCCHHHHHCCCCEEECHHHCCCCCCCCCCCCCCCCCCEECCCCCCCHH
EAAAIPLAGGTAWEAVVRRLAVRPGETVLVMGGAGGVGSFAVQFAKAAGAYVIATASAEN
HHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEECCCCC
LPVLKELGADLALDYRGPWAEEVLKATEGQGVDAAFETAGESLVERVIPVVRPFGRIATI
CCHHHHCCCCEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
LPPQGNLSGLYTKNQTLYGVFLTRERKRLLEMRPLFERGLARPLIAEVLPFSLENLRKAH
ECCCCCCCEEEECCCEEEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHH
ARMDSGHGRGKIVLTFQA
HHCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA