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The map label for this gene is yngG [H]

Identifier: 55981495

GI number: 55981495

Start: 1452112

End: 1452972

Strand: Direct

Name: yngG [H]

Synonym: TTHA1526

Alternate gene names: 55981495

Gene position: 1452112-1452972 (Clockwise)

Preceding gene: 55981494

Following gene: 55981499

Centisome position: 78.5

GC content: 69.92

Gene sequence:

>861_bases
GTGAAGGCGAGCGTGCGGTGGGTGGAGTGCCCCAGGGACGCTTGGCAGGGCTTCTCCCGCTTCATCCCCACGGAGGAGAA
GGTGGCCTTCCTCAACGAGCTCCTGGAGGCCGGGTTCGCCCACCTGGACCTCACGAGCTTCGTCTCCCCCAAGTGGGTGC
CCCAGATGCAAGACGCCGAAGAGGTGCTCAAGGCCCTCCCCCCGCCCAACGGGCGCACCTACCTCGCCATCGTGGCCAAC
GAGAAGGGCCTGGAAAGGGCCCTCGCCGCCCCCAACCTCACCCACGTGGGCTACCCCTTCTCCCTCTCCGAGACCTTCCA
GCAAAGGAACACTAACCGCTCCATAGAGGCCTCCTGGCCCCTGGTGGGGGCCATGGTGGAGAGGACAGAGGGGCGGCTCG
GCCTCGTGGTCTACCTCTCCATGGCCTTCGGCAACCCCTACGGGGACCCCTGGAGCGTGGAGGCCGTCCTCGAGGCCCTC
GCCCGGCTTAAGGAAATGGGCGTGCGGGAGATCGCCCTCGCCGACACCTACGGGGTGGCGGAACCCGAGCGGATTCATGA
GGTCTTGAAGGCCGCCGTGGCCCGCTTTGGCCCGGAAGGCCTCGGGGCCCACCTCCACGCCCGGCCCGAGGGGGCCTTGG
CCAAGGTGGAGGCGGTCCTTGCGGCGGGGGTCACCTGGCTCGAGGGGGCCCTGGCGGGGGTGGGGGGGTGCCCCTTCGCC
GGGGACGAGCTCGTGGGCAACCTCCCCACGGAGGTCGTCCTCCCCCATCTGGAGAAGCGGGGCCTCGCCACGGGAGTAGA
CCTAAGCCGCCTCCCCCTTCTCGCGGAGGAGGCGGCGCGGCTTAAGGCCCTTTACGCCTGA

Upstream 100 bases:

>100_bases
AGGAGATCGCCCGCCTCCTCTCCGGGGCCTACACCCAGGCGGCTTTGGCCCACGCCCGGGAGCTTCTGGAGGCCCAGGGC
GCCCTTTAGGAGGTGGAAGC

Downstream 100 bases:

>100_bases
AAGGTGAGGACGATCTTCCCCCGCCCGTGCCCGGAGTCCATGCGGGCGTGGGCCTTCCTCAGGTTCTCCAGGCTGAAGGG
GAGGACCTCGGCGATGAGGG

Product: hydroxymethylglutaryl-CoA lyase like protein

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKASVRWVECPRDAWQGFSRFIPTEEKVAFLNELLEAGFAHLDLTSFVSPKWVPQMQDAEEVLKALPPPNGRTYLAIVAN
EKGLERALAAPNLTHVGYPFSLSETFQQRNTNRSIEASWPLVGAMVERTEGRLGLVVYLSMAFGNPYGDPWSVEAVLEAL
ARLKEMGVREIALADTYGVAEPERIHEVLKAAVARFGPEGLGAHLHARPEGALAKVEAVLAAGVTWLEGALAGVGGCPFA
GDELVGNLPTEVVLPHLEKRGLATGVDLSRLPLLAEEAARLKALYA

Sequences:

>Translated_286_residues
MKASVRWVECPRDAWQGFSRFIPTEEKVAFLNELLEAGFAHLDLTSFVSPKWVPQMQDAEEVLKALPPPNGRTYLAIVAN
EKGLERALAAPNLTHVGYPFSLSETFQQRNTNRSIEASWPLVGAMVERTEGRLGLVVYLSMAFGNPYGDPWSVEAVLEAL
ARLKEMGVREIALADTYGVAEPERIHEVLKAAVARFGPEGLGAHLHARPEGALAKVEAVLAAGVTWLEGALAGVGGCPFA
GDELVGNLPTEVVLPHLEKRGLATGVDLSRLPLLAEEAARLKALYA
>Mature_286_residues
MKASVRWVECPRDAWQGFSRFIPTEEKVAFLNELLEAGFAHLDLTSFVSPKWVPQMQDAEEVLKALPPPNGRTYLAIVAN
EKGLERALAAPNLTHVGYPFSLSETFQQRNTNRSIEASWPLVGAMVERTEGRLGLVVYLSMAFGNPYGDPWSVEAVLEAL
ARLKEMGVREIALADTYGVAEPERIHEVLKAAVARFGPEGLGAHLHARPEGALAKVEAVLAAGVTWLEGALAGVGGCPFA
GDELVGNLPTEVVLPHLEKRGLATGVDLSRLPLLAEEAARLKALYA

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=269, Percent_Identity=37.1747211895911, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI109150422, Length=272, Percent_Identity=34.9264705882353, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI109150427, Length=272, Percent_Identity=34.9264705882353, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI260654708, Length=268, Percent_Identity=27.9850746268657, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17510563, Length=264, Percent_Identity=34.0909090909091, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24582381, Length=275, Percent_Identity=34.5454545454545, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 30940; Mature: 30940

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKASVRWVECPRDAWQGFSRFIPTEEKVAFLNELLEAGFAHLDLTSFVSPKWVPQMQDAE
CCCCCCCEECCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHH
EVLKALPPPNGRTYLAIVANEKGLERALAAPNLTHVGYPFSLSETFQQRNTNRSIEASWP
HHHHHCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEECCCC
LVGAMVERTEGRLGLVVYLSMAFGNPYGDPWSVEAVLEALARLKEMGVREIALADTYGVA
HHHHHHHHCCCCEEHHEEEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHEEHHHCCCCC
EPERIHEVLKAAVARFGPEGLGAHLHARPEGALAKVEAVLAAGVTWLEGALAGVGGCPFA
CHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GDELVGNLPTEVVLPHLEKRGLATGVDLSRLPLLAEEAARLKALYA
CHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKASVRWVECPRDAWQGFSRFIPTEEKVAFLNELLEAGFAHLDLTSFVSPKWVPQMQDAE
CCCCCCCEECCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHH
EVLKALPPPNGRTYLAIVANEKGLERALAAPNLTHVGYPFSLSETFQQRNTNRSIEASWP
HHHHHCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEECCCC
LVGAMVERTEGRLGLVVYLSMAFGNPYGDPWSVEAVLEALARLKEMGVREIALADTYGVA
HHHHHHHHCCCCEEHHEEEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHEEHHHCCCCC
EPERIHEVLKAAVARFGPEGLGAHLHARPEGALAKVEAVLAAGVTWLEGALAGVGGCPFA
CHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GDELVGNLPTEVVLPHLEKRGLATGVDLSRLPLLAEEAARLKALYA
CHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]