Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 55981484

GI number: 55981484

Start: 1440498

End: 1441187

Strand: Direct

Name: purC [H]

Synonym: TTHA1515

Alternate gene names: 55981484

Gene position: 1440498-1441187 (Clockwise)

Preceding gene: 55981482

Following gene: 55981485

Centisome position: 77.88

GC content: 65.8

Gene sequence:

>690_bases
ATGGAGAAGCTCTACGAGGGCAAGGCCAAGGTGCTCTACCGGGAAGGCCCGGACACCTTAAGGGTCTACTTCAAGGACGA
GGCCACCGCCTTCAACGCGCAAAAACGGGGGGTGATCCCGGGCAAGGGCGTGGTGAACAACAAGGTCTCGGCGGCCCTCT
TCCGCTACCTCGAGGCCCACGGGGTCAAGACCCACTTCCTGGAGGAGGTCTCCGACCGGGAGATGCGGGTGAGGCGGGTG
GAGATCCTTCCCCTGGAGGTGATCCTCCGCTTTAGGGCCGCGGGAAGCTTCGCCCGGCGCTACGGCCTAAAGGAGGGGAC
CCCGCTGAAGATGCCCCTTCTGGAGTTCTCCCTCAAAAACGACGCCCTGGGGGACCCCTTGATCTGCGAAAACGCCGTCC
TGGCCCTGGGGCTCACCACAGAGGGGGAGCTGGAAGGGGTGAAGGCCGCCACGCTCCGGGTGGGGGACCTCCTCAAGGCC
TTCTTCGCCGAGCGGGGCCTAGAGCTCGTGGACTTCAAGCTGGAGTTCGGGAAGGTGGGCGGGGAGATCCTCCTCGCCGA
CGAGATCAGCCCCGACACCATGCGCCTTTGGGACGAGAAGGGGGAGCCTTTGGACAAGGACCGCTTCCGCAAGGACCTAG
GCGGCGTGGAGGAGGCCTACCGGGAGGTGCTCCGGCGGGTCCTGGGGTAG

Upstream 100 bases:

>100_bases
CCGGGCGGGCGAGGTCCAGCACCAAGGGCACACCCCCATTGTGGCACAAGGCCCCTTACAATGGGGGGAGAAGGGCCCAA
GCGCCCCTTTGAGGAGAGGC

Downstream 100 bases:

>100_bases
ACTTGGGCCATATGCCGCGCTACCAGGCCACCCTGCTCATTGAGCTGAAGAAGGGCATCCTGGACCCCCAGGGCCGGGCG
GTGGAGGGGGTGCTGAAGGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MEKLYEGKAKVLYREGPDTLRVYFKDEATAFNAQKRGVIPGKGVVNNKVSAALFRYLEAHGVKTHFLEEVSDREMRVRRV
EILPLEVILRFRAAGSFARRYGLKEGTPLKMPLLEFSLKNDALGDPLICENAVLALGLTTEGELEGVKAATLRVGDLLKA
FFAERGLELVDFKLEFGKVGGEILLADEISPDTMRLWDEKGEPLDKDRFRKDLGGVEEAYREVLRRVLG

Sequences:

>Translated_229_residues
MEKLYEGKAKVLYREGPDTLRVYFKDEATAFNAQKRGVIPGKGVVNNKVSAALFRYLEAHGVKTHFLEEVSDREMRVRRV
EILPLEVILRFRAAGSFARRYGLKEGTPLKMPLLEFSLKNDALGDPLICENAVLALGLTTEGELEGVKAATLRVGDLLKA
FFAERGLELVDFKLEFGKVGGEILLADEISPDTMRLWDEKGEPLDKDRFRKDLGGVEEAYREVLRRVLG
>Mature_229_residues
MEKLYEGKAKVLYREGPDTLRVYFKDEATAFNAQKRGVIPGKGVVNNKVSAALFRYLEAHGVKTHFLEEVSDREMRVRRV
EILPLEVILRFRAAGSFARRYGLKEGTPLKMPLLEFSLKNDALGDPLICENAVLALGLTTEGELEGVKAATLRVGDLLKA
FFAERGLELVDFKLEFGKVGGEILLADEISPDTMRLWDEKGEPLDKDRFRKDLGGVEEAYREVLRRVLG

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=222, Percent_Identity=32.4324324324324, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI5453539, Length=222, Percent_Identity=32.4324324324324, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI119220559, Length=229, Percent_Identity=31.0043668122271, Blast_Score=107, Evalue=8e-24,
Organism=Escherichia coli, GI1788820, Length=227, Percent_Identity=42.7312775330396, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17531275, Length=238, Percent_Identity=34.0336134453782, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319326, Length=230, Percent_Identity=25.2173913043478, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24583917, Length=243, Percent_Identity=28.8065843621399, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18860083, Length=235, Percent_Identity=29.3617021276596, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 25758; Mature: 25758

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLYEGKAKVLYREGPDTLRVYFKDEATAFNAQKRGVIPGKGVVNNKVSAALFRYLEAH
CCCCCCCCEEEEEECCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GVKTHFLEEVSDREMRVRRVEILPLEVILRFRAAGSFARRYGLKEGTPLKMPLLEFSLKN
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEECCC
DALGDPLICENAVLALGLTTEGELEGVKAATLRVGDLLKAFFAERGLELVDFKLEFGKVG
CCCCCCCEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCC
GEILLADEISPDTMRLWDEKGEPLDKDRFRKDLGGVEEAYREVLRRVLG
CEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKLYEGKAKVLYREGPDTLRVYFKDEATAFNAQKRGVIPGKGVVNNKVSAALFRYLEAH
CCCCCCCCEEEEEECCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GVKTHFLEEVSDREMRVRRVEILPLEVILRFRAAGSFARRYGLKEGTPLKMPLLEFSLKN
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEECCC
DALGDPLICENAVLALGLTTEGELEGVKAATLRVGDLLKAFFAERGLELVDFKLEFGKVG
CCCCCCCEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCC
GEILLADEISPDTMRLWDEKGEPLDKDRFRKDLGGVEEAYREVLRRVLG
CEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]