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The map label for this gene is mprA [H]

Identifier: 55981471

GI number: 55981471

Start: 1430910

End: 1431593

Strand: Direct

Name: mprA [H]

Synonym: TTHA1502

Alternate gene names: 55981471

Gene position: 1430910-1431593 (Clockwise)

Preceding gene: 55981470

Following gene: 55981472

Centisome position: 77.36

GC content: 65.06

Gene sequence:

>684_bases
ATGGGAGGCATGGAGCCGCCCCTGATCCTCATCGTGGAGGACGAGAAGGACATCGCCCGCTTCATTGAGCTTGAGCTCCA
GGCCGAGGGCTACCGCACCGAGGTGGCCCACGACGGGATCACCGGGCTTTCCAAGTTCCGGGAGGTGAGCCCCAACCTGG
TGATCCTGGACCTGATGCTCCCCGTGATGGACGGGATTGAGGTGGCCAAGCGCATCCGCAAGACCTCCAACGTCCCCATC
CTCATCCTCACCGCCAAGGACCGCGTGGAGGACAAGGTGGCGGGCCTGGACGCGGGGGCCGACGACTACCTGGTGAAGCC
CTTCTCCATAGAAGAGCTCCTCGCCCGGGTCAGGGCCCACCTCCGCCGGGTCACCCCGGCCATCACCGGGGAGATCCGGG
TGGCGGACCTCATCATCAACCTCGAGGGCCGGGAGGTCTTCCGGGGAAACCGCCGCATTGAACTCTCCAACAAGGAGTTT
GAGCTTCTGGAGCTCCTCGCCAAAAACCCCGGCAAGGTCTTCAGCCGCTACGAGATTGAGGAGAAGGTCTGGCCCGGCTA
CCAAGGGGGAAGCAACGTGGTGGACGTCTACATCGGCTACCTGCGCAAGAAGCTGGAGGCGGGGGGGGAGCGCCGCCTCA
TCCACACGGTGCGGGGCGTGGGGTACGTCCTCAGGGAGGACTGA

Upstream 100 bases:

>100_bases
CCACGGGGTGTGGCACGTCCTCGTCCTCCTGGGAAGCCTCTTTATGTACCTGGCGGTCTTGAGCCTCTACACCTAGCTTT
CTCATGAGAAAGTAAGTACC

Downstream 100 bases:

>100_bases
GCCCAAGCCTAGCCTCCCGGCATGACCCTTAGGACCCGGATCACCCTCCTCACGGCGGGGCTCCTCCTCGTGGCCTTTTT
GGTCCTCGGCTTCGCCCTGG

Product: response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MGGMEPPLILIVEDEKDIARFIELELQAEGYRTEVAHDGITGLSKFREVSPNLVILDLMLPVMDGIEVAKRIRKTSNVPI
LILTAKDRVEDKVAGLDAGADDYLVKPFSIEELLARVRAHLRRVTPAITGEIRVADLIINLEGREVFRGNRRIELSNKEF
ELLELLAKNPGKVFSRYEIEEKVWPGYQGGSNVVDVYIGYLRKKLEAGGERRLIHTVRGVGYVLRED

Sequences:

>Translated_227_residues
MGGMEPPLILIVEDEKDIARFIELELQAEGYRTEVAHDGITGLSKFREVSPNLVILDLMLPVMDGIEVAKRIRKTSNVPI
LILTAKDRVEDKVAGLDAGADDYLVKPFSIEELLARVRAHLRRVTPAITGEIRVADLIINLEGREVFRGNRRIELSNKEF
ELLELLAKNPGKVFSRYEIEEKVWPGYQGGSNVVDVYIGYLRKKLEAGGERRLIHTVRGVGYVLRED
>Mature_226_residues
GGMEPPLILIVEDEKDIARFIELELQAEGYRTEVAHDGITGLSKFREVSPNLVILDLMLPVMDGIEVAKRIRKTSNVPIL
ILTAKDRVEDKVAGLDAGADDYLVKPFSIEELLARVRAHLRRVTPAITGEIRVADLIINLEGREVFRGNRRIELSNKEFE
LLELLAKNPGKVFSRYEIEEKVWPGYQGGSNVVDVYIGYLRKKLEAGGERRLIHTVRGVGYVLRED

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=42.0091324200913, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI87082012, Length=215, Percent_Identity=40.4651162790698, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=38.3928571428571, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=41.743119266055, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=39.0134529147982, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=37.8854625550661, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=35.3211009174312, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=40.6392694063927, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=38.1818181818182, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=34.4978165938865, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.9344978165939, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=34.3478260869565, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=30.7359307359307, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1788550, Length=142, Percent_Identity=30.9859154929577, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=29.1304347826087, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790437, Length=129, Percent_Identity=34.8837209302326, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788191, Length=116, Percent_Identity=35.3448275862069, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=29.5652173913043, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787487, Length=109, Percent_Identity=32.1100917431193, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25605; Mature: 25474

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGMEPPLILIVEDEKDIARFIELELQAEGYRTEVAHDGITGLSKFREVSPNLVILDLML
CCCCCCCEEEEEECCHHHHHHHHHEEECCCCEEHHHHCCHHHHHHHHHCCCCEEEHHHHH
PVMDGIEVAKRIRKTSNVPILILTAKDRVEDKVAGLDAGADDYLVKPFSIEELLARVRAH
HHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHH
LRRVTPAITGEIRVADLIINLEGREVFRGNRRIELSNKEFELLELLAKNPGKVFSRYEIE
HHHHCHHHCCCEEEEEEEEECCCCHHHCCCCEEEECCCHHHHHHHHHCCCCHHHHHEEHH
EKVWPGYQGGSNVVDVYIGYLRKKLEAGGERRLIHTVRGVGYVLRED
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEECC
>Mature Secondary Structure 
GGMEPPLILIVEDEKDIARFIELELQAEGYRTEVAHDGITGLSKFREVSPNLVILDLML
CCCCCCEEEEEECCHHHHHHHHHEEECCCCEEHHHHCCHHHHHHHHHCCCCEEEHHHHH
PVMDGIEVAKRIRKTSNVPILILTAKDRVEDKVAGLDAGADDYLVKPFSIEELLARVRAH
HHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHH
LRRVTPAITGEIRVADLIINLEGREVFRGNRRIELSNKEFELLELLAKNPGKVFSRYEIE
HHHHCHHHCCCEEEEEEEEECCCCHHHCCCCEEEECCCHHHHHHHHHCCCCHHHHHEEHH
EKVWPGYQGGSNVVDVYIGYLRKKLEAGGERRLIHTVRGVGYVLRED
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA