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The map label for this gene is hisI [H]

Identifier: 55981414

GI number: 55981414

Start: 1372979

End: 1373623

Strand: Direct

Name: hisI [H]

Synonym: TTHA1445

Alternate gene names: 55981414

Gene position: 1372979-1373623 (Clockwise)

Preceding gene: 55981413

Following gene: 55981415

Centisome position: 74.23

GC content: 66.36

Gene sequence:

>645_bases
ATGGACCTTTCCGCCGTCCGCTTTGACGAAAAGGGCCTCGTCCCCGTGGTGGTCCAAGACGCCCGCACCGGGGAGGTCCT
CACCCTGGCCTACGCCAACCGGGAGGCTTTGGAGGAGACCCTAAGGACCCGGCGGAGCACCTTCTTTAGCCGAAGCCGCC
AGGCGCTTTGGCGCAAGGGGGAGACCTCGGGGCACACCCAGGAGGTGGTGGAGGTTCTTTTGGACTGCGACGGGGACGCC
GTGGTCTACCGGGTCCTCCCCCAAGGCCCCGCCTGCCACACGGGGGAGAGGACCTGCTTCCACCGGGCCCTCCTTGAAGG
GGAGAAGGACCTCGGCTTCGTGGTGGGCCAGGTCTACGCCACCATCAAGGAGCGCCTAAGGACCCTCCCCGAGGGAAGCT
ACGTGGCCCGGATGCACCAAGCAGGCCTGGACCGGATCCTAAAGAAGATCGGGGAGGAAGCGGGGGAGGTGATCCTCGCC
GCCAAGAACCAAAACCCCGAGGAGCTTCGCCACGAAGCGGCGGACCTCCTCTTCCACCTCCTCCTCACCCTGGCGGAGCT
CGGCCTCACCCCCGAGGACCTGGCGAAGACCCTCTGGGAGCGGCACCGGCCGCGAAGCCCTTATGATGGAAGCCATGGAA
ATTGA

Upstream 100 bases:

>100_bases
GCCTTGGCCGCAAGCGTCTTCCACTTTGGCGAGATCCCCATTCCCAAGCTTAAGCGCTACCTCGCGGAAAAAGGCGTCCA
CGTGCGGCTAGACTAGGGGC

Downstream 100 bases:

>100_bases
ACGCCGGCTGGTCCTCGAGGTCGTCCGGGTCACGGAGCAAGCGGCCCTGGCCGCGAGCCGCTTCGCGGGCAAGGGGGACA
AGGAAGCGGTGGACGAAGCG

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MDLSAVRFDEKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGETSGHTQEVVEVLLDCDGDA
VVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYATIKERLRTLPEGSYVARMHQAGLDRILKKIGEEAGEVILA
AKNQNPEELRHEAADLLFHLLLTLAELGLTPEDLAKTLWERHRPRSPYDGSHGN

Sequences:

>Translated_214_residues
MDLSAVRFDEKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGETSGHTQEVVEVLLDCDGDA
VVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYATIKERLRTLPEGSYVARMHQAGLDRILKKIGEEAGEVILA
AKNQNPEELRHEAADLLFHLLLTLAELGLTPEDLAKTLWERHRPRSPYDGSHGN
>Mature_214_residues
MDLSAVRFDEKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGETSGHTQEVVEVLLDCDGDA
VVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYATIKERLRTLPEGSYVARMHQAGLDRILKKIGEEAGEVILA
AKNQNPEELRHEAADLLFHLLLTLAELGLTPEDLAKTLWERHRPRSPYDGSHGN

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=196, Percent_Identity=42.3469387755102, Blast_Score=152, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319819, Length=204, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23997; Mature: 23997

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSAVRFDEKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKG
CCCCCCEECCCCCCEEEEECCCCCCEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
ETSGHTQEVVEVLLDCDGDAVVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYA
CCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
TIKERLRTLPEGSYVARMHQAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAADLLFHL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH
LLTLAELGLTPEDLAKTLWERHRPRSPYDGSHGN
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDLSAVRFDEKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKG
CCCCCCEECCCCCCEEEEECCCCCCEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
ETSGHTQEVVEVLLDCDGDAVVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYA
CCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
TIKERLRTLPEGSYVARMHQAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAADLLFHL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH
LLTLAELGLTPEDLAKTLWERHRPRSPYDGSHGN
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA