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The map label for this gene is cobB [H]

Identifier: 55981361

GI number: 55981361

Start: 1327678

End: 1328442

Strand: Reverse

Name: cobB [H]

Synonym: TTHA1392

Alternate gene names: 55981361

Gene position: 1328442-1327678 (Counterclockwise)

Preceding gene: 55981365

Following gene: 55981359

Centisome position: 71.82

GC content: 70.98

Gene sequence:

>765_bases
ATGGAGCGGTTGGAGGAAGCCCGGAAGCGCCTGGAGGAGGCGAGGCGGGTGGCGGTCCTCACGGGGGCGGGCATCTCCAA
GCCCTCCGGCATCCCCACCTTCCGGGACGCCGAGGGGCTTTGGAAAAACTTCAACCCCCTGGACTACGCCACCCCCGAGG
CCTACGCCCGGGACCCGGAGAAGGTCTGGGCCTGGTACGCCTGGCGCATCCAGAAGGTGCGGGAGGCCAAGCCCAACCCG
GCCCACTACGCCCTAGTGGAGCTGGAGAGGCGCATCCTCTCCCGGGGGGGAAGCTTCCTCCTCGTCACCCAGAACGTGGA
CGGCCTTCACGCCCTCGCGGGAAGCCAGAACCTGGTGGAGCTCCACGGCAACCTCCTCAGGGCCCGGTGCGAGGCCTGCG
GGAAGCGGTTTCCCTTGCCGGAGGCCTTCGCCCCGCCCCCCTTCTGCCCGGCCTGCGGCCACCGGGCCCGGCCCGATGTG
GTCTGGTTCGGGGAGTTTCTGCCGGAAGGGGCTTGGGAGAGGGCGGAAAGGGCCTTCGCCGAGGCCGACTTCGCCTTGGT
GGTGGGCACCAGCGCCGAGGTGGAGCCCGCGGCCTCCTTGGGCCGGATCGCCTTCGCCTCGGGGGCCTACCTGGTGGAGG
TGAACCCCGAGCCCACCCCCCTCACCCCCCTGGCCCACCTCTCCTTGCGGACGGGGGCGGTGGAGGGGATGGCGCTACTC
CTCCCTCCTTCCCCGGAAGACCAGGCGGAAGGGCACCTCTCTTAG

Upstream 100 bases:

>100_bases
GAGAAGGAGGCTCGGGTAGCCCCGCTCCACGGCCTTCCGGTCCGCCTCCCGCATGGCCTCGGGGGTGAAGAGCCTCATGG
GTTAAGGATACGATGGGGCC

Downstream 100 bases:

>100_bases
GCCCAGGTCCTCGCCGATGCGGTTTTTCAGGTAGTTCTCAAAGGCCCGGGTGACGAACTCCGGGTGGTTCACGAAGAAGA
CGAAGGTGGGCGGGGCCACC

Product: Sir2 family protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MERLEEARKRLEEARRVAVLTGAGISKPSGIPTFRDAEGLWKNFNPLDYATPEAYARDPEKVWAWYAWRIQKVREAKPNP
AHYALVELERRILSRGGSFLLVTQNVDGLHALAGSQNLVELHGNLLRARCEACGKRFPLPEAFAPPPFCPACGHRARPDV
VWFGEFLPEGAWERAERAFAEADFALVVGTSAEVEPAASLGRIAFASGAYLVEVNPEPTPLTPLAHLSLRTGAVEGMALL
LPPSPEDQAEGHLS

Sequences:

>Translated_254_residues
MERLEEARKRLEEARRVAVLTGAGISKPSGIPTFRDAEGLWKNFNPLDYATPEAYARDPEKVWAWYAWRIQKVREAKPNP
AHYALVELERRILSRGGSFLLVTQNVDGLHALAGSQNLVELHGNLLRARCEACGKRFPLPEAFAPPPFCPACGHRARPDV
VWFGEFLPEGAWERAERAFAEADFALVVGTSAEVEPAASLGRIAFASGAYLVEVNPEPTPLTPLAHLSLRTGAVEGMALL
LPPSPEDQAEGHLS
>Mature_254_residues
MERLEEARKRLEEARRVAVLTGAGISKPSGIPTFRDAEGLWKNFNPLDYATPEAYARDPEKVWAWYAWRIQKVREAKPNP
AHYALVELERRILSRGGSFLLVTQNVDGLHALAGSQNLVELHGNLLRARCEACGKRFPLPEAFAPPPFCPACGHRARPDV
VWFGEFLPEGAWERAERAFAEADFALVVGTSAEVEPAASLGRIAFASGAYLVEVNPEPTPLTPLAHLSLRTGAVEGMALL
LPPSPEDQAEGHLS

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=229, Percent_Identity=39.7379912663755, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI13787215, Length=247, Percent_Identity=36.8421052631579, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI6912664, Length=247, Percent_Identity=36.8421052631579, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI6912662, Length=276, Percent_Identity=31.5217391304348, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI6912660, Length=206, Percent_Identity=38.3495145631068, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI63054862, Length=196, Percent_Identity=38.265306122449, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI13775602, Length=206, Percent_Identity=34.9514563106796, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13775600, Length=206, Percent_Identity=34.9514563106796, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI300797705, Length=199, Percent_Identity=33.6683417085427, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI300797577, Length=245, Percent_Identity=30.6122448979592, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7657575, Length=222, Percent_Identity=28.3783783783784, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI300797597, Length=236, Percent_Identity=31.3559322033898, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI308199517, Length=213, Percent_Identity=44.6009389671362, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17567771, Length=264, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71990482, Length=254, Percent_Identity=27.9527559055118, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71990487, Length=256, Percent_Identity=28.125, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17541892, Length=210, Percent_Identity=28.0952380952381, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17505510, Length=238, Percent_Identity=24.7899159663866, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320163, Length=245, Percent_Identity=23.6734693877551, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324599, Length=282, Percent_Identity=26.241134751773, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24648389, Length=211, Percent_Identity=31.7535545023697, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24645650, Length=247, Percent_Identity=26.3157894736842, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28571445, Length=206, Percent_Identity=31.0679611650485, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17137536, Length=229, Percent_Identity=28.3842794759825, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27867; Mature: 27867

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLEEARKRLEEARRVAVLTGAGISKPSGIPTFRDAEGLWKNFNPLDYATPEAYARDPE
CHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHCCCHH
KVWAWYAWRIQKVREAKPNPAHYALVELERRILSRGGSFLLVTQNVDGLHALAGSQNLVE
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCHHHH
LHGNLLRARCEACGKRFPLPEAFAPPPFCPACGHRARPDVVWFGEFLPEGAWERAERAFA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHH
EADFALVVGTSAEVEPAASLGRIAFASGAYLVEVNPEPTPLTPLAHLSLRTGAVEGMALL
HCCEEEEEECCCCCCHHHHHCCEEEECCEEEEEECCCCCCCCHHHHHHHHCCCCCCEEEE
LPPSPEDQAEGHLS
ECCCCCCCCCCCCC
>Mature Secondary Structure
MERLEEARKRLEEARRVAVLTGAGISKPSGIPTFRDAEGLWKNFNPLDYATPEAYARDPE
CHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHCCCHH
KVWAWYAWRIQKVREAKPNPAHYALVELERRILSRGGSFLLVTQNVDGLHALAGSQNLVE
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCHHHH
LHGNLLRARCEACGKRFPLPEAFAPPPFCPACGHRARPDVVWFGEFLPEGAWERAERAFA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHH
EADFALVVGTSAEVEPAASLGRIAFASGAYLVEVNPEPTPLTPLAHLSLRTGAVEGMALL
HCCEEEEEECCCCCCHHHHHCCEEEECCEEEEEECCCCCCCCHHHHHHHHCCCCCCEEEE
LPPSPEDQAEGHLS
ECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA