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The map label for this gene is moeZ [H]

Identifier: 55981313

GI number: 55981313

Start: 1285820

End: 1286635

Strand: Reverse

Name: moeZ [H]

Synonym: TTHA1344

Alternate gene names: 55981313

Gene position: 1286635-1285820 (Counterclockwise)

Preceding gene: 55981314

Following gene: 55981312

Centisome position: 69.56

GC content: 70.59

Gene sequence:

>816_bases
ATGCGCTGGACGAAGGAGGAGCTTGACCGGTACCACCGGCAGATGATCCTGCCCCAGGTGGGCCCTGAGGGGCAGGAGCG
GCTGAAACGGGCCTCGGTGGTGGTGGTGGGGGCCGGAGGGCTCGGGGTCCCCGTCCTCCAGTACCTGGTGGCGGCCGGGG
TGGGGCGGGTGGGGGTGGTGGAGATGGACCGGGTGGAGGTGTCCAACCTCCACCGCCAGGTGCTCTACACCACCGAGGAC
GTGGGCGAGCCCAAGGCCCTGGTGGCCCAGAAGCGGCTCCAGGCCCTGAACCCCCTGGTCCGGGTGGAGGCCTACCCGGT
GCGCCTCACCTCGGAGAACGCCCTGGAGATCCTCAGGCCCTACGACCTCGTGGTGGACGCCTCGGACAACTTCCCCACCC
GCTACCTGGTGAACGACGCCGCCGTCCTCCTCGGCAAGCCCCTGGTCTTTGGGGCCATCTACCAGTTTGACGGCCAGGTG
GCCGTCTTCCACCACCCCACCCTCCATGGGGAGATGGGGCCGTGCTACCGCTGCCTCTTCCCCAAGCCGCCCCCGCCCGG
GGCGGTGCCCTCCTGCGCCGAGGCTGGGGTCTTCGGGGTTCTGCCGGCGGTGGTGGGGAGCCTGATGGCCGCCGAGGCCC
TCAAGGTTCTTTTGGGGATCGGTAAGCCCCTGGCGGGACACCTCCTGCTCTACGACGCCCTCGAGGCCGGCTTCCGCAAG
CTCACGGTGCGGCGCAACCCCCGTTGCCCCGTCTGCGGGGACGAGCCCACCCAGAGGGAGCTCGTGGACTACGAGGCCTT
CTGCGGCCTGGGCTGA

Upstream 100 bases:

>100_bases
TTCCCTGGGCCAGTCGGGCGAAGGAAACCGGAAGAAAGGGTATGAGGCCGCATGGGGGTCCCGAAGGAAGGCTTCCCAGG
CCAGAAGGGCAAGAGAGGGT

Downstream 100 bases:

>100_bases
GGCTACTCCTCCCCGCGGGCGAAGGGGTATGATGCACTCGGTGCACCCCTGGGGTGCGGACAAGGAGGCAGCATGGAAGT
GGCACGCGGTCTGGAAGGCG

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MRWTKEELDRYHRQMILPQVGPEGQERLKRASVVVVGAGGLGVPVLQYLVAAGVGRVGVVEMDRVEVSNLHRQVLYTTED
VGEPKALVAQKRLQALNPLVRVEAYPVRLTSENALEILRPYDLVVDASDNFPTRYLVNDAAVLLGKPLVFGAIYQFDGQV
AVFHHPTLHGEMGPCYRCLFPKPPPPGAVPSCAEAGVFGVLPAVVGSLMAAEALKVLLGIGKPLAGHLLLYDALEAGFRK
LTVRRNPRCPVCGDEPTQRELVDYEAFCGLG

Sequences:

>Translated_271_residues
MRWTKEELDRYHRQMILPQVGPEGQERLKRASVVVVGAGGLGVPVLQYLVAAGVGRVGVVEMDRVEVSNLHRQVLYTTED
VGEPKALVAQKRLQALNPLVRVEAYPVRLTSENALEILRPYDLVVDASDNFPTRYLVNDAAVLLGKPLVFGAIYQFDGQV
AVFHHPTLHGEMGPCYRCLFPKPPPPGAVPSCAEAGVFGVLPAVVGSLMAAEALKVLLGIGKPLAGHLLLYDALEAGFRK
LTVRRNPRCPVCGDEPTQRELVDYEAFCGLG
>Mature_271_residues
MRWTKEELDRYHRQMILPQVGPEGQERLKRASVVVVGAGGLGVPVLQYLVAAGVGRVGVVEMDRVEVSNLHRQVLYTTED
VGEPKALVAQKRLQALNPLVRVEAYPVRLTSENALEILRPYDLVVDASDNFPTRYLVNDAAVLLGKPLVFGAIYQFDGQV
AVFHHPTLHGEMGPCYRCLFPKPPPPGAVPSCAEAGVFGVLPAVVGSLMAAEALKVLLGIGKPLAGHLLLYDALEAGFRK
LTVRRNPRCPVCGDEPTQRELVDYEAFCGLG

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=267, Percent_Identity=49.812734082397, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI4885649, Length=152, Percent_Identity=33.5526315789474, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI38045942, Length=182, Percent_Identity=30.2197802197802, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI38045948, Length=163, Percent_Identity=36.1963190184049, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI38045944, Length=185, Percent_Identity=30.2702702702703, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI13376212, Length=264, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI38327032, Length=248, Percent_Identity=27.0161290322581, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787048, Length=251, Percent_Identity=40.2390438247012, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI87082356, Length=244, Percent_Identity=42.2131147540984, Blast_Score=180, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17540406, Length=269, Percent_Identity=43.8661710037175, Blast_Score=249, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI193203301, Length=172, Percent_Identity=29.0697674418605, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71984476, Length=183, Percent_Identity=31.1475409836066, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321903, Length=275, Percent_Identity=43.6363636363636, Blast_Score=218, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6320598, Length=183, Percent_Identity=26.2295081967213, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325323, Length=176, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24582879, Length=270, Percent_Identity=45.5555555555556, Blast_Score=260, Evalue=6e-70,
Organism=Drosophila melanogaster, GI24660640, Length=158, Percent_Identity=34.1772151898734, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28573937, Length=148, Percent_Identity=31.7567567567568, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20129973, Length=181, Percent_Identity=28.1767955801105, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 29499; Mature: 29499

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWTKEELDRYHRQMILPQVGPEGQERLKRASVVVVGAGGLGVPVLQYLVAAGVGRVGVV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCCCCEE
EMDRVEVSNLHRQVLYTTEDVGEPKALVAQKRLQALNPLVRVEAYPVRLTSENALEILRP
EEHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCHHHEEEEEEEEECCCCHHHHHCC
YDLVVDASDNFPTRYLVNDAAVLLGKPLVFGAIYQFDGQVAVFHHPTLHGEMGPCYRCLF
EEEEEECCCCCCCEEECCCHHHHHCCHHHHHHHEEECCEEEEEECCCCCCCCCCCEEECC
PKPPPPGAVPSCAEAGVFGVLPAVVGSLMAAEALKVLLGIGKPLAGHLLLYDALEAGFRK
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHE
LTVRRNPRCPVCGDEPTQRELVDYEAFCGLG
EEECCCCCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MRWTKEELDRYHRQMILPQVGPEGQERLKRASVVVVGAGGLGVPVLQYLVAAGVGRVGVV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCCCCEE
EMDRVEVSNLHRQVLYTTEDVGEPKALVAQKRLQALNPLVRVEAYPVRLTSENALEILRP
EEHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCHHHEEEEEEEEECCCCHHHHHCC
YDLVVDASDNFPTRYLVNDAAVLLGKPLVFGAIYQFDGQVAVFHHPTLHGEMGPCYRCLF
EEEEEECCCCCCCEEECCCHHHHHCCHHHHHHHEEECCEEEEEECCCCCCCCCCCEEECC
PKPPPPGAVPSCAEAGVFGVLPAVVGSLMAAEALKVLLGIGKPLAGHLLLYDALEAGFRK
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHE
LTVRRNPRCPVCGDEPTQRELVDYEAFCGLG
EEECCCCCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]