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The map label for this gene is bhbA [H]

Identifier: 55981215

GI number: 55981215

Start: 1179669

End: 1181213

Strand: Direct

Name: bhbA [H]

Synonym: TTHA1246

Alternate gene names: 55981215

Gene position: 1179669-1181213 (Clockwise)

Preceding gene: 55981214

Following gene: 55981216

Centisome position: 63.77

GC content: 68.03

Gene sequence:

>1545_bases
ATGGAAGGCCTCTTTGAGTCCCTCCCCGAGGGGTACCGGGAGAAGCTCGGCCGGCCCGGGGAGTACCCCTTCACCCGGGG
GATCTACCCCCGGATGTACCTGGAAAGGCTCTGGACCATGCGCCAGTACGCGGGCTTCTCCACCGCCGAGGAGTCCAACG
CCCGCTACCGCTACCTCCTCTCCCAGGGCCAGACGGGGCTGTCCGTGGCCTTTGACCTCCCCACCCAGCTCGGCCTGGAC
CCCGACCACCCCATGAGCGTGGGGGAGGTGGGGCGGGTGGGGGTGTCCATCGCCACCCTGGAGGACATGCAGAAGCTCTT
TGACGGCATCCCCCTGGACCAGGTCTCCACCAGCATGACCATCAACGCCCCGGCCATGATGCTCCTCGCCCTCTACCTCC
TCGTGGCCGAGGCGCAGGGGGTGCCCTGGGACAAGGTCTCGGGGACGGTGCAGAACGACATCCTCAAGGAGTACTTCGCC
CGCGGCACCTACATCTACCCGCCCGGCCCCTCCATGCGCCTCGTGACCGACATCTTTGAGTTCTGCGCCGCGCACGTCCC
CCGGTGGAACACCATCAGCATCTCCGGCTACCACATCCGCGAGGCGGGGTCCACCGCCGCCCAGGAGATCGCCTTCACCC
TGGCGGACGCCAAGGCCTACGTGCGGGCCGCCTTGGAGCGGGGCCTGGACGTGGACCGCTTCGCCCCGAGGCTTTCCTTC
TTCTTCGCCGCCCACGGGGACATCTTTGAGGAGGCCGCCAAGTTCCGGGCGGCAAGGCGCCTTTGGGCAAGGATCATGCG
GGAGGAGTTCGGGGCCAAGGACCCGAAAAGCTGGATGCTCCGCTTCCACACCCAGACCGGGGGCTCCACCCTCACGGCGC
AGGAACCCCTCAACAACGTGGTGCGCACCGCCTACCAGGCCCTGGCGGCGGTGCTCGGGGGGACGCAGAGCCTCCACACC
AACGCCTACGACGAGGCCCTGGGCCTGCCCACGGAGAAGAGCGCCCTCCTCGCCCTCCGCACCCAGCAGATCCTGGCCTA
CGAGAGCGGGGTCACCCGGGCCATAGACCCCCTAGGGGGGAGCTTCTACGTGGAGCACCTCACGGACAAGCTGGAACGGG
AGGCGGAGCAGATTCTGCGGGAGATTGACGCCCTTGGGGGCGCGGTGGCCGCGGTGGAGGCGGGCTACTTCCAGAGGGCC
CTCGAGGAGTCCGCCTGGCAGTTCCAGAAGGAGGTGGAGGAGGGCAAGAGGGTGATCGTGGGGGTGAACCGCTTCTTTGA
CCCCAATAGCCCCCTCAACGAACCCGTCCCCGTGCAGCGGATTGACCCCGAGCTCCACGAAAGGCGCAAGCGGGAGCTCG
CCGCCTTCAAAGCCAATCGGGATGGGGAAAGCGTAAGGGTCGGCCTAGAGAGGCTAAGGGAGGCGGCAAGGGGCGAGGAG
AACCTCTTCCCCTACGTGCTGGAGGCCTTCCGGCGCCGGGCCACCCTGGGGGAGGTCTGCGGGGTTCTTAGGGAGGAGTG
GGGCGAGTACCAGCCCCCCCGGTGA

Upstream 100 bases:

>100_bases
GCTGGCCGCCTACAGCCTCCTCCTCCCTCCCCTCCTCGCCGTCCTCGGGGCCCTCCTCCTCTTCACCCTCCTCCTCGGCC
TCCTGCGGTAAAACTAAGGC

Downstream 100 bases:

>100_bases
GGAGGGCCATGGAAGGCGAAGCCGAGCTCTGGAACTTTTTGGAGAGGCACCTGAGGAGCATCTACGAGGGCGACTGGGCC
ACGTACGAGGCCACCACCCA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MEGLFESLPEGYREKLGRPGEYPFTRGIYPRMYLERLWTMRQYAGFSTAEESNARYRYLLSQGQTGLSVAFDLPTQLGLD
PDHPMSVGEVGRVGVSIATLEDMQKLFDGIPLDQVSTSMTINAPAMMLLALYLLVAEAQGVPWDKVSGTVQNDILKEYFA
RGTYIYPPGPSMRLVTDIFEFCAAHVPRWNTISISGYHIREAGSTAAQEIAFTLADAKAYVRAALERGLDVDRFAPRLSF
FFAAHGDIFEEAAKFRAARRLWARIMREEFGAKDPKSWMLRFHTQTGGSTLTAQEPLNNVVRTAYQALAAVLGGTQSLHT
NAYDEALGLPTEKSALLALRTQQILAYESGVTRAIDPLGGSFYVEHLTDKLEREAEQILREIDALGGAVAAVEAGYFQRA
LEESAWQFQKEVEEGKRVIVGVNRFFDPNSPLNEPVPVQRIDPELHERRKRELAAFKANRDGESVRVGLERLREAARGEE
NLFPYVLEAFRRRATLGEVCGVLREEWGEYQPPR

Sequences:

>Translated_514_residues
MEGLFESLPEGYREKLGRPGEYPFTRGIYPRMYLERLWTMRQYAGFSTAEESNARYRYLLSQGQTGLSVAFDLPTQLGLD
PDHPMSVGEVGRVGVSIATLEDMQKLFDGIPLDQVSTSMTINAPAMMLLALYLLVAEAQGVPWDKVSGTVQNDILKEYFA
RGTYIYPPGPSMRLVTDIFEFCAAHVPRWNTISISGYHIREAGSTAAQEIAFTLADAKAYVRAALERGLDVDRFAPRLSF
FFAAHGDIFEEAAKFRAARRLWARIMREEFGAKDPKSWMLRFHTQTGGSTLTAQEPLNNVVRTAYQALAAVLGGTQSLHT
NAYDEALGLPTEKSALLALRTQQILAYESGVTRAIDPLGGSFYVEHLTDKLEREAEQILREIDALGGAVAAVEAGYFQRA
LEESAWQFQKEVEEGKRVIVGVNRFFDPNSPLNEPVPVQRIDPELHERRKRELAAFKANRDGESVRVGLERLREAARGEE
NLFPYVLEAFRRRATLGEVCGVLREEWGEYQPPR
>Mature_514_residues
MEGLFESLPEGYREKLGRPGEYPFTRGIYPRMYLERLWTMRQYAGFSTAEESNARYRYLLSQGQTGLSVAFDLPTQLGLD
PDHPMSVGEVGRVGVSIATLEDMQKLFDGIPLDQVSTSMTINAPAMMLLALYLLVAEAQGVPWDKVSGTVQNDILKEYFA
RGTYIYPPGPSMRLVTDIFEFCAAHVPRWNTISISGYHIREAGSTAAQEIAFTLADAKAYVRAALERGLDVDRFAPRLSF
FFAAHGDIFEEAAKFRAARRLWARIMREEFGAKDPKSWMLRFHTQTGGSTLTAQEPLNNVVRTAYQALAAVLGGTQSLHT
NAYDEALGLPTEKSALLALRTQQILAYESGVTRAIDPLGGSFYVEHLTDKLEREAEQILREIDALGGAVAAVEAGYFQRA
LEESAWQFQKEVEEGKRVIVGVNRFFDPNSPLNEPVPVQRIDPELHERRKRELAAFKANRDGESVRVGLERLREAARGEE
NLFPYVLEAFRRRATLGEVCGVLREEWGEYQPPR

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=495, Percent_Identity=48.6868686868687, Blast_Score=471, Evalue=1e-133,
Organism=Escherichia coli, GI1789284, Length=495, Percent_Identity=50.7070707070707, Blast_Score=485, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI25144500, Length=493, Percent_Identity=48.2758620689655, Blast_Score=483, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 57689; Mature: 57689

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGLFESLPEGYREKLGRPGEYPFTRGIYPRMYLERLWTMRQYAGFSTAEESNARYRYLL
CCCHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
SQGQTGLSVAFDLPTQLGLDPDHPMSVGEVGRVGVSIATLEDMQKLFDGIPLDQVSTSMT
HCCCCCCEEEEECCHHCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCHHHHCCCEE
INAPAMMLLALYLLVAEAQGVPWDKVSGTVQNDILKEYFARGTYIYPPGPSMRLVTDIFE
ECHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
FCAAHVPRWNTISISGYHIREAGSTAAQEIAFTLADAKAYVRAALERGLDVDRFAPRLSF
HHHHCCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FFAAHGDIFEEAAKFRAARRLWARIMREEFGAKDPKSWMLRFHTQTGGSTLTAQEPLNNV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCCEEEHHHHHHHH
VRTAYQALAAVLGGTQSLHTNAYDEALGLPTEKSALLALRTQQILAYESGVTRAIDPLGG
HHHHHHHHHHHHCCCHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCC
SFYVEHLTDKLEREAEQILREIDALGGAVAAVEAGYFQRALEESAWQFQKEVEEGKRVIV
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
GVNRFFDPNSPLNEPVPVQRIDPELHERRKRELAAFKANRDGESVRVGLERLREAARGEE
EHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
NLFPYVLEAFRRRATLGEVCGVLREEWGEYQPPR
CCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEGLFESLPEGYREKLGRPGEYPFTRGIYPRMYLERLWTMRQYAGFSTAEESNARYRYLL
CCCHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
SQGQTGLSVAFDLPTQLGLDPDHPMSVGEVGRVGVSIATLEDMQKLFDGIPLDQVSTSMT
HCCCCCCEEEEECCHHCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCHHHHCCCEE
INAPAMMLLALYLLVAEAQGVPWDKVSGTVQNDILKEYFARGTYIYPPGPSMRLVTDIFE
ECHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHH
FCAAHVPRWNTISISGYHIREAGSTAAQEIAFTLADAKAYVRAALERGLDVDRFAPRLSF
HHHHCCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FFAAHGDIFEEAAKFRAARRLWARIMREEFGAKDPKSWMLRFHTQTGGSTLTAQEPLNNV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCCEEEHHHHHHHH
VRTAYQALAAVLGGTQSLHTNAYDEALGLPTEKSALLALRTQQILAYESGVTRAIDPLGG
HHHHHHHHHHHHCCCHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCC
SFYVEHLTDKLEREAEQILREIDALGGAVAAVEAGYFQRALEESAWQFQKEVEEGKRVIV
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
GVNRFFDPNSPLNEPVPVQRIDPELHERRKRELAAFKANRDGESVRVGLERLREAARGEE
EHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
NLFPYVLEAFRRRATLGEVCGVLREEWGEYQPPR
CCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]