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The map label for this gene is ypdA [H]

Identifier: 55981184

GI number: 55981184

Start: 1156338

End: 1157318

Strand: Reverse

Name: ypdA [H]

Synonym: TTHA1215

Alternate gene names: 55981184

Gene position: 1157318-1156338 (Counterclockwise)

Preceding gene: 55981194

Following gene: 55981183

Centisome position: 62.57

GC content: 70.54

Gene sequence:

>981_bases
ATGGTGGACGTCCTCGTGGTGGGCGCGGGTCCCGTGGGGCTTTGCGCCGCCCTTTGGGCCAAGCGGCTCGGCCTCTCCCA
CCTGGTCCTGGAGCGGGGCACGGTGGCGGAGACCGTCTACCGCTTTCCCCGGGACATGGTCTTCTTCTCCGAGGCCAAGA
ACATTGAGATCGGGGGCCATCCCTTGGTCGCCCAAGGCCCCAAGCCCACCCGCAAGGAGGCCCTCCTCTACTACCAGCGG
GTGGCGGAGCGGGAGGGGCTAAGCGTCCTCACCTACACCGAGGTCCTGAGCATCCGGGGCCGGGAGGGGGCCTTCCAGGT
CCTGGCCAAAGACCGCAAGGGGGAGCGGGCCTTCTCGGCCCGGTACGTGGTGGTGGCCACGGGCTACTTCGGGAACCCGA
ACCGCCTGGGCGTCCCGGGGGAGGACCTCCCCCACGTCCTCCACCGCTACGAGGAGGCCGCCCCCTTCTTCGGGCGGGAG
GTGGCGGTGGTGGGGGGGTCCAACTCGGCGGTGGAGGCGGCCTTGGACCTCTACCGCGGCGGGGCGAGGGTCACCCTCGT
CCACCGGGGAAAGTGGGTCCGGCCCTCGGTGAAGTACTGGCTCCTCCCCGACTTTGAGAACCGGGTCAAGGAGGGGAGCA
TCCGGGCGGTCATGGAGGCCCGGGTGGAGGCCATCACCCCGGAGGGGCTTTGGCTTTCTAGGCCCTCTGGGCGGGAGTTC
CTGCCCGCCGACTTCGTGGTGGTTCTCATCGGCTACCGGGCGGAAGACCGCCTCCTTAGGGAGGCGGGGGTGGCCTACGA
GGGGGAGAGGCCCTGGCTTTCCCCGGAGTGGGAGACCTCCGTTCCCGGCCTCTTCGCCGTGGGCTCCTGCGCCTACGGGC
CCGACACCCGCTCCGTCTTCATTGAGAACGGCCGGGAGCACGCTAGGGCCGCCCTCACCGCCATCGCCGCCCGGGTGCGG
GGCTTGACACCGAGGCCTTAG

Upstream 100 bases:

>100_bases
CAAGCTTCAGGCCAGGAGGTCCGAGGACGCGGCCCAAGCGTCTGGGCCCTTGTGAGCCACCCCACGGGGGAGGCCCGTCC
GTTGCCGTAAACTCAGGGCC

Downstream 100 bases:

>100_bases
GGGGCTATCCTTAGCGGCAAGATGCGTTCCGGGCTCGCCCTATCCCTAGCCCTGGTCCTAATCGTAGGGCCAGCGGGGGG
TAGGGCGTAGCGCTTTAGGG

Product: thioredoxin reductase

Products: an alcohol; H2O; NAD [C]

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MVDVLVVGAGPVGLCAALWAKRLGLSHLVLERGTVAETVYRFPRDMVFFSEAKNIEIGGHPLVAQGPKPTRKEALLYYQR
VAEREGLSVLTYTEVLSIRGREGAFQVLAKDRKGERAFSARYVVVATGYFGNPNRLGVPGEDLPHVLHRYEEAAPFFGRE
VAVVGGSNSAVEAALDLYRGGARVTLVHRGKWVRPSVKYWLLPDFENRVKEGSIRAVMEARVEAITPEGLWLSRPSGREF
LPADFVVVLIGYRAEDRLLREAGVAYEGERPWLSPEWETSVPGLFAVGSCAYGPDTRSVFIENGREHARAALTAIAARVR
GLTPRP

Sequences:

>Translated_326_residues
MVDVLVVGAGPVGLCAALWAKRLGLSHLVLERGTVAETVYRFPRDMVFFSEAKNIEIGGHPLVAQGPKPTRKEALLYYQR
VAEREGLSVLTYTEVLSIRGREGAFQVLAKDRKGERAFSARYVVVATGYFGNPNRLGVPGEDLPHVLHRYEEAAPFFGRE
VAVVGGSNSAVEAALDLYRGGARVTLVHRGKWVRPSVKYWLLPDFENRVKEGSIRAVMEARVEAITPEGLWLSRPSGREF
LPADFVVVLIGYRAEDRLLREAGVAYEGERPWLSPEWETSVPGLFAVGSCAYGPDTRSVFIENGREHARAALTAIAARVR
GLTPRP
>Mature_326_residues
MVDVLVVGAGPVGLCAALWAKRLGLSHLVLERGTVAETVYRFPRDMVFFSEAKNIEIGGHPLVAQGPKPTRKEALLYYQR
VAEREGLSVLTYTEVLSIRGREGAFQVLAKDRKGERAFSARYVVVATGYFGNPNRLGVPGEDLPHVLHRYEEAAPFFGRE
VAVVGGSNSAVEAALDLYRGGARVTLVHRGKWVRPSVKYWLLPDFENRVKEGSIRAVMEARVEAITPEGLWLSRPSGREF
LPADFVVVLIGYRAEDRLLREAGVAYEGERPWLSPEWETSVPGLFAVGSCAYGPDTRSVFIENGREHARAALTAIAARVR
GLTPRP

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.6.4.- [C]

Molecular weight: Translated: 35940; Mature: 35940

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDVLVVGAGPVGLCAALWAKRLGLSHLVLERGTVAETVYRFPRDMVFFSEAKNIEIGGH
CEEEEEECCCHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHCCCCEEEEECCCCEEECCC
PLVAQGPKPTRKEALLYYQRVAEREGLSVLTYTEVLSIRGREGAFQVLAKDRKGERAFSA
EEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCHHHHHHCCCCCCCHHHE
RYVVVATGYFGNPNRLGVPGEDLPHVLHRYEEAAPFFGREVAVVGGSNSAVEAALDLYRG
EEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCC
GARVTLVHRGKWVRPSVKYWLLPDFENRVKEGSIRAVMEARVEAITPEGLWLSRPSGREF
CCEEEEEECCCCCCCCCEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCC
LPADFVVVLIGYRAEDRLLREAGVAYEGERPWLSPEWETSVPGLFAVGSCAYGPDTRSVF
CCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEE
IENGREHARAALTAIAARVRGLTPRP
ECCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVDVLVVGAGPVGLCAALWAKRLGLSHLVLERGTVAETVYRFPRDMVFFSEAKNIEIGGH
CEEEEEECCCHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHCCCCEEEEECCCCEEECCC
PLVAQGPKPTRKEALLYYQRVAEREGLSVLTYTEVLSIRGREGAFQVLAKDRKGERAFSA
EEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCHHHHHHCCCCCCCHHHE
RYVVVATGYFGNPNRLGVPGEDLPHVLHRYEEAAPFFGREVAVVGGSNSAVEAALDLYRG
EEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCC
GARVTLVHRGKWVRPSVKYWLLPDFENRVKEGSIRAVMEARVEAITPEGLWLSRPSGREF
CCEEEEEECCCCCCCCCEEEECCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCC
LPADFVVVLIGYRAEDRLLREAGVAYEGERPWLSPEWETSVPGLFAVGSCAYGPDTRSVF
CCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEE
IENGREHARAALTAIAARVRGLTPRP
ECCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ROOH; Proton; NADH [C]

Specific reaction: ROOH + Proton + NADH = an alcohol + H2O + NAD [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]