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The map label for this gene is argC

Identifier: 55981166

GI number: 55981166

Start: 1141606

End: 1142643

Strand: Reverse

Name: argC

Synonym: TTHA1197

Alternate gene names: 55981166

Gene position: 1142643-1141606 (Counterclockwise)

Preceding gene: 55981167

Following gene: 55981165

Centisome position: 61.77

GC content: 69.36

Gene sequence:

>1038_bases
GTGGGGATCCTGGGGGCCTCGGGGTACGGGGGGGCGGAGCTTTTGCGGCTCCTCAAGGCCCACCCCGAGGTGGAGCTCGT
GGGGTTTTCCAGCCGCAAGTACGAGGGAAGGCCCCTGGAGGCCGCCTGGCCCCAGCTTTGGGACGGAAGGCTCTTCGCCG
CCCAAGAGGAGGTCCTAGAGCGGGCGGAGGTGGTCTTCCTCGCCCTTCCCAACGGGCTTTCCATGGAGATCGCCCCCGAG
GCCCTTAAGGCGGGGAAGCGGGTGGTGGACCTCTCCGGGGACTTCCGCCTGCCCCCCGAGGTCTACGAGGCTTGGTACCG
CATCCCCCATAAGAGCCCTGACCTCTACCGGGAAGCGGTCTACGGCCTTCCCGAGCTCCACCGGGAGGAGCTTAAGGGGG
CGAGGCTCGTGGCCAACCCGGGTTGCTACGTGACCGCCGCCACCTTGGCCCTCGCGCCCTTGGCGGCGGAAGGGGTCCTG
AAGGGGGCCTTCGTGGTGGGCCTGAGCGGGGTCTCGGGGGCGGGGCGGGAGGCCGAGGGCACCGCCTTCGCCGAGGTCAA
CGAGAACCTCAAGCCCTACAAGGCGGGGGGCACCCACCGGCACATCCCCGAGATGGAGCGGAACCTGGGGAGGATTTTGG
CCCAGGGGAGGCGCGTCCGCACCCACGGGGAGGCGAGGGCGGTGCGGCTTTCCTTCACCCCCCACCTGGTGCCCATGACC
CGGGGGATCCTGGTCACCGCCGAGGCGGAGGTGGAGGGCGCTTGGAGCCAGGAGAGCCTAGAGGCGCTTTACCGGGACTT
CTACGCCGGGGAGCCTTTCGTGCGGGTCCTTAAGGGGCTTCCCGAGACCAAGGCCACCCTGGGGAGCAACCGGGTGGACG
TGAGGCCCCTCTACGAGGAGAGGACGGGGCGGGTTTTGGTCTTCGCCGCCCTGGACAACCTGGTGAAGGGCATGGCGGGG
CAGGCGGTGCAGAACCTCAACCTGATGCTGGGCCTTCCCGAGGAGACGGCGCTTCCCAAGGAGGGGTTATGGCCGTGA

Upstream 100 bases:

>100_bases
CGGAGGAAGACCACTACCGGGAGCAGATCTGGGTGAGGCCTGGGGAGAGGGTCTCCCCCCTCGCCTTTCCCGAGGCCTTC
TTGGAGGTGCCGTGGTAAGG

Downstream 100 bases:

>100_bases
GGCTTCCCAGGGGCTTTAGGGCGGGGGCCACCCGGGCGGGGATCAAGCCCTCGGGAAGGCCCGACCTCGCCCTTTTGGTC
TCCGGCTTGCCCGCGGCCTG

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MGILGASGYGGAELLRLLKAHPEVELVGFSSRKYEGRPLEAAWPQLWDGRLFAAQEEVLERAEVVFLALPNGLSMEIAPE
ALKAGKRVVDLSGDFRLPPEVYEAWYRIPHKSPDLYREAVYGLPELHREELKGARLVANPGCYVTAATLALAPLAAEGVL
KGAFVVGLSGVSGAGREAEGTAFAEVNENLKPYKAGGTHRHIPEMERNLGRILAQGRRVRTHGEARAVRLSFTPHLVPMT
RGILVTAEAEVEGAWSQESLEALYRDFYAGEPFVRVLKGLPETKATLGSNRVDVRPLYEERTGRVLVFAALDNLVKGMAG
QAVQNLNLMLGLPEETALPKEGLWP

Sequences:

>Translated_345_residues
MGILGASGYGGAELLRLLKAHPEVELVGFSSRKYEGRPLEAAWPQLWDGRLFAAQEEVLERAEVVFLALPNGLSMEIAPE
ALKAGKRVVDLSGDFRLPPEVYEAWYRIPHKSPDLYREAVYGLPELHREELKGARLVANPGCYVTAATLALAPLAAEGVL
KGAFVVGLSGVSGAGREAEGTAFAEVNENLKPYKAGGTHRHIPEMERNLGRILAQGRRVRTHGEARAVRLSFTPHLVPMT
RGILVTAEAEVEGAWSQESLEALYRDFYAGEPFVRVLKGLPETKATLGSNRVDVRPLYEERTGRVLVFAALDNLVKGMAG
QAVQNLNLMLGLPEETALPKEGLWP
>Mature_344_residues
GILGASGYGGAELLRLLKAHPEVELVGFSSRKYEGRPLEAAWPQLWDGRLFAAQEEVLERAEVVFLALPNGLSMEIAPEA
LKAGKRVVDLSGDFRLPPEVYEAWYRIPHKSPDLYREAVYGLPELHREELKGARLVANPGCYVTAATLALAPLAAEGVLK
GAFVVGLSGVSGAGREAEGTAFAEVNENLKPYKAGGTHRHIPEMERNLGRILAQGRRVRTHGEARAVRLSFTPHLVPMTR
GILVTAEAEVEGAWSQESLEALYRDFYAGEPFVRVLKGLPETKATLGSNRVDVRPLYEERTGRVLVFAALDNLVKGMAGQ
AVQNLNLMLGLPEETALPKEGLWP

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=350, Percent_Identity=35.7142857142857, Blast_Score=164, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6320913, Length=358, Percent_Identity=29.8882681564246, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC_THET2 (P96136)

Other databases:

- EMBL:   Y10525
- EMBL:   Y18353
- EMBL:   AE017221
- RefSeq:   YP_004809.1
- ProteinModelPortal:   P96136
- SMR:   P96136
- STRING:   P96136
- GeneID:   2775222
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0002
- HOGENOM:   HBG294213
- OMA:   VCRIAVH
- PhylomeDB:   P96136
- ProtClustDB:   PRK00436
- BioCyc:   TTHE262724:TT_C0836-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR023013
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.38

Molecular weight: Translated: 37635; Mature: 37504

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS01224 ARGC

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGILGASGYGGAELLRLLKAHPEVELVGFSSRKYEGRPLEAAWPQLWDGRLFAAQEEVLE
CCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHCCCEEHHHHHHHHH
RAEVVFLALPNGLSMEIAPEALKAGKRVVDLSGDFRLPPEVYEAWYRIPHKSPDLYREAV
HHCEEEEECCCCCCEEECHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
YGLPELHREELKGARLVANPGCYVTAATLALAPLAAEGVLKGAFVVGLSGVSGAGREAEG
HCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCC
TAFAEVNENLKPYKAGGTHRHIPEMERNLGRILAQGRRVRTHGEARAVRLSFTPHLVPMT
CEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCCC
RGILVTAEAEVEGAWSQESLEALYRDFYAGEPFVRVLKGLPETKATLGSNRVDVRPLYEE
CCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHCCCCCEECCHHHC
RTGRVLVFAALDNLVKGMAGQAVQNLNLMLGLPEETALPKEGLWP
CCCCEEEEHHHHHHHHHHHHHHHHCCEEEEECCHHHCCCCCCCCC
>Mature Secondary Structure 
GILGASGYGGAELLRLLKAHPEVELVGFSSRKYEGRPLEAAWPQLWDGRLFAAQEEVLE
CCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHCCCEEHHHHHHHHH
RAEVVFLALPNGLSMEIAPEALKAGKRVVDLSGDFRLPPEVYEAWYRIPHKSPDLYREAV
HHCEEEEECCCCCCEEECHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
YGLPELHREELKGARLVANPGCYVTAATLALAPLAAEGVLKGAFVVGLSGVSGAGREAEG
HCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCC
TAFAEVNENLKPYKAGGTHRHIPEMERNLGRILAQGRRVRTHGEARAVRLSFTPHLVPMT
CEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCCC
RGILVTAEAEVEGAWSQESLEALYRDFYAGEPFVRVLKGLPETKATLGSNRVDVRPLYEE
CCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHCCCCCEECCHHHC
RTGRVLVFAALDNLVKGMAGQAVQNLNLMLGLPEETALPKEGLWP
CCCCEEEEHHHHHHHHHHHHHHHHCCEEEEECCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9493385; 11004195