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The map label for this gene is hisA [H]

Identifier: 55981134

GI number: 55981134

Start: 1108414

End: 1109121

Strand: Direct

Name: hisA [H]

Synonym: TTHA1165

Alternate gene names: 55981134

Gene position: 1108414-1109121 (Clockwise)

Preceding gene: 55981133

Following gene: 55981135

Centisome position: 59.92

GC content: 74.58

Gene sequence:

>708_bases
ATGCGCCTCATCCCGGCGGTGGACCTGAAGTCGGGCAAGGCGGTGCGCCTCTACGAGGGGGACCCCGCCCGGGAGACCCC
CTACGGGGACCCGGTGGAGGCCGCGCTGCGCTTCCAGGAGGAAGGGGCCACCCTCCTCCACCTGGTGGACCTGGACCGCG
CCCTGGGCACGGGGGAGAACCGGGAGGTGGTGCGCCGGGTGGCGGCCTCCCTCTCCATCCCCTTCCAGCTCGCGGGGGGC
ATCCGGAGCCTCGAGGCCCTGCAGGAGGCCCTCTCCCTGGGGGCGAGCCGGGCGGTGGTGGGCACGGTGGCCGTGAAGGA
CCCGGGGCTTCTGGCGCGGATGCTGGAAGCGGTGGGCCCGGACCGCCTGGCCGTGGCCCTGGACGCCCGGGGCCTGGAGG
TGGTGGTCTCGGGCTGGCAGGAGGCCGTCTCCGCCTCCGCCCTGGACCTCCTCCGGGCCTGGGCGGAAATGGGGGTGCGG
ACCCTCCTCTACACCGACGTCCGCCGGGACGGGACCCTCTTGGGCCTGGACCGGGAGGTGGTGGCCCGGGTGCGGGCGGC
CTGGCCCTACGAGCTCATCGTGGGGGGAGGGATCGCCTCCCCGGAGGACCTCCACCTGCTCCAGGCCCTGGGCGTGGACG
GCGCTTTGGTGGGCAAGGCCCTCTACGAGGGCCGGATCCGGCTAAAGGAGGCGTCATGGCGCTCGTGA

Upstream 100 bases:

>100_bases
AAAGCTCTGGAGGGGCTTTTTGACGCCGTCCTCATCGGCACGAGCTTGATGCGGGCGCCCGATCTGGAGGCCGCCTTAAG
GGAGCTTGTAGGATAGGACC

Downstream 100 bases:

>100_bases
ACTGGCTCCTTTTGGTGTCGGGGCTTCTCGTGGCGGGCACGGGGCTTTACCTCTACGGGACCTACCCCTTCCTCGCCCTC
CCCACCCCCTGGGGCCCCTG

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MRLIPAVDLKSGKAVRLYEGDPARETPYGDPVEAALRFQEEGATLLHLVDLDRALGTGENREVVRRVAASLSIPFQLAGG
IRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVGPDRLAVALDARGLEVVVSGWQEAVSASALDLLRAWAEMGVR
TLLYTDVRRDGTLLGLDREVVARVRAAWPYELIVGGGIASPEDLHLLQALGVDGALVGKALYEGRIRLKEASWRS

Sequences:

>Translated_235_residues
MRLIPAVDLKSGKAVRLYEGDPARETPYGDPVEAALRFQEEGATLLHLVDLDRALGTGENREVVRRVAASLSIPFQLAGG
IRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVGPDRLAVALDARGLEVVVSGWQEAVSASALDLLRAWAEMGVR
TLLYTDVRRDGTLLGLDREVVARVRAAWPYELIVGGGIASPEDLHLLQALGVDGALVGKALYEGRIRLKEASWRS
>Mature_235_residues
MRLIPAVDLKSGKAVRLYEGDPARETPYGDPVEAALRFQEEGATLLHLVDLDRALGTGENREVVRRVAASLSIPFQLAGG
IRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVGPDRLAVALDARGLEVVVSGWQEAVSASALDLLRAWAEMGVR
TLLYTDVRRDGTLLGLDREVVARVRAAWPYELIVGGGIASPEDLHLLQALGVDGALVGKALYEGRIRLKEASWRS

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=36.6255144032922, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1788336, Length=244, Percent_Identity=30.327868852459, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 25150; Mature: 25150

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIPAVDLKSGKAVRLYEGDPARETPYGDPVEAALRFQEEGATLLHLVDLDRALGTGEN
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEHHHHHCCCCC
REVVRRVAASLSIPFQLAGGIRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVGP
HHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHCCC
DRLAVALDARGLEVVVSGWQEAVSASALDLLRAWAEMGVRTLLYTDVRRDGTLLGLDREV
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEECCHHH
VARVRAAWPYELIVGGGIASPEDLHLLQALGVDGALVGKALYEGRIRLKEASWRS
HHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCEEEECCCCCC
>Mature Secondary Structure
MRLIPAVDLKSGKAVRLYEGDPARETPYGDPVEAALRFQEEGATLLHLVDLDRALGTGEN
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEHHHHHCCCCC
REVVRRVAASLSIPFQLAGGIRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVGP
HHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHCCC
DRLAVALDARGLEVVVSGWQEAVSASALDLLRAWAEMGVRTLLYTDVRRDGTLLGLDREV
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEECCHHH
VARVRAAWPYELIVGGGIASPEDLHLLQALGVDGALVGKALYEGRIRLKEASWRS
HHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA