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The map label for this gene is merA [H]

Identifier: 55981122

GI number: 55981122

Start: 1098696

End: 1100069

Strand: Reverse

Name: merA [H]

Synonym: TTHA1153

Alternate gene names: 55981122

Gene position: 1100069-1098696 (Counterclockwise)

Preceding gene: 55981123

Following gene: 55981120

Centisome position: 59.47

GC content: 73.29

Gene sequence:

>1374_bases
ATGACCTACGACCTCCTCATCGTGGGCTCGGGCTCCGCCGGGGTGGCGGCGGCCCTGGAGGCGAGCGCCCTCGGGGCCAA
GGCGGCCGTGGTGGAGGCGGGGGTTTTGGGGGGGACCTGCGTCAACGTGGGGTGCGTGCCCTCCAAGTACCTCCTCCGGG
CGGCCGACGCCTTCCACCGGGCGGGCCACCCCGCCTTCCCCGGCCTCCGCACGGAGGCCCTGGGGGTGGACTGGAAAGCC
CTCCTCGCGGGCAAGGAGGGCCTGATCGCGGCCCTCAGGAAGGAGAAGTACCAGGAGGTTCTGGAGGCGGCCGGGGTTCC
CGTGCTCCGGGGGAGGGCCCGCTTCCTGGACGGGGAAAGGATGGAGGTAGAGGGGCGGGAGGTCTTGGCCGGGCGGTACC
TCCTCGCCACCGGGGCGAGGCCCTTCCTTCCGCCCATCCCCGGCCTCCAGGAGAGCGCGCCCTGGACCTACCTCGAGGCC
CTCTCCGCCCCCGCCCTTCCCGAAAGCCTCCTGGTGGTGGGGGGTGGGCCCATCGGGCTTGAGCTCGCCCAGGCCTTCGC
CAGGCTTGGGAGCCGGGTGACGGTCCTCGAGGCCCTGCCCGAGGTCCTGCCCCAGGAGGACCGGGAGCTTGCCCGGCTCC
TCCGGGGCTACCTGGAGGAGGAGGGCCTTAGGGTCCACACCGGGGTCCGGGTGGAGGCCGTGGCCCGGGAAGGGGCCTTC
CGCGTCCGGACCGACCGGGGGGTTTTTGAGGCGGAGAGGCTCCTTGTGGCCACGGGGAGGAGGCCGGACCTGGAAGGGCT
CGGCCTGGAGCGGGCGGGCGTGGAGCGGGACGAGCGGGGCTTCCTCCGGCTGGACCCCAGCCTGCGCACCACCAACCCCC
GGGTCTACGCCGCCGGGGACGCGGCGGGGCTTCCCCAGTTCGTCTACGTGGCCGCCCAGTCGGGCAGGGTGGCGGCCCGC
AACGCCTTGGGGGTAAAGGCGCCCCTGGACCTCGCCGCCCTCCCCCGGGTCACCTTCACCGACCCCGCCCTGGCCGCGGT
GGGCCTCACGGAGGAGGAGGCGAGGAGGCGGTACGGCGCGGGGGTGCGGGCGGCCACCCTTCCCCTTTCCCAGGTGCCCA
AGGCCCTCACCGCCCGCGACACCCGGGGGGCCTTCAAGATCGTGGTGGACGAAGAGGGCACGGTCCTCGGCCTCCACGTC
CTGGCCCACGAGGCGGGGGACGTCATCCAGGAGGGCATCCTGGCGGTGAAGTACGGCTTCGGCTACCGGGACCTCATAGA
CACCTTCCACCCCTACCTGACCCTGGCCGAGGGGATAAGGCTCGTGGCCCAGGCCCTGGACGCCGATCCCAAAAAGCTTT
CCTGCTGCGCCTGA

Upstream 100 bases:

>100_bases
GCATCAAGGTGCCCGGGATCCACGGCGCGGGGTGCATCCGCAGGGTGGAGCGGGTGGCCGGGGTGGAGAAGGCGTGGATG
GGCTACCCGGGGGAGGCCCT

Downstream 100 bases:

>100_bases
CTACACCACCCACCTTCCCCGGCGCATGAGGGGAGTGCGGGTGCCGTCCTCGTAAAGCCCGTCCACGTCCATCTCCTCGG
AGCCGATCATCCAGTCCACG

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTYDLLIVGSGSAGVAAALEASALGAKAAVVEAGVLGGTCVNVGCVPSKYLLRAADAFHRAGHPAFPGLRTEALGVDWKA
LLAGKEGLIAALRKEKYQEVLEAAGVPVLRGRARFLDGERMEVEGREVLAGRYLLATGARPFLPPIPGLQESAPWTYLEA
LSAPALPESLLVVGGGPIGLELAQAFARLGSRVTVLEALPEVLPQEDRELARLLRGYLEEEGLRVHTGVRVEAVAREGAF
RVRTDRGVFEAERLLVATGRRPDLEGLGLERAGVERDERGFLRLDPSLRTTNPRVYAAGDAAGLPQFVYVAAQSGRVAAR
NALGVKAPLDLAALPRVTFTDPALAAVGLTEEEARRRYGAGVRAATLPLSQVPKALTARDTRGAFKIVVDEEGTVLGLHV
LAHEAGDVIQEGILAVKYGFGYRDLIDTFHPYLTLAEGIRLVAQALDADPKKLSCCA

Sequences:

>Translated_457_residues
MTYDLLIVGSGSAGVAAALEASALGAKAAVVEAGVLGGTCVNVGCVPSKYLLRAADAFHRAGHPAFPGLRTEALGVDWKA
LLAGKEGLIAALRKEKYQEVLEAAGVPVLRGRARFLDGERMEVEGREVLAGRYLLATGARPFLPPIPGLQESAPWTYLEA
LSAPALPESLLVVGGGPIGLELAQAFARLGSRVTVLEALPEVLPQEDRELARLLRGYLEEEGLRVHTGVRVEAVAREGAF
RVRTDRGVFEAERLLVATGRRPDLEGLGLERAGVERDERGFLRLDPSLRTTNPRVYAAGDAAGLPQFVYVAAQSGRVAAR
NALGVKAPLDLAALPRVTFTDPALAAVGLTEEEARRRYGAGVRAATLPLSQVPKALTARDTRGAFKIVVDEEGTVLGLHV
LAHEAGDVIQEGILAVKYGFGYRDLIDTFHPYLTLAEGIRLVAQALDADPKKLSCCA
>Mature_456_residues
TYDLLIVGSGSAGVAAALEASALGAKAAVVEAGVLGGTCVNVGCVPSKYLLRAADAFHRAGHPAFPGLRTEALGVDWKAL
LAGKEGLIAALRKEKYQEVLEAAGVPVLRGRARFLDGERMEVEGREVLAGRYLLATGARPFLPPIPGLQESAPWTYLEAL
SAPALPESLLVVGGGPIGLELAQAFARLGSRVTVLEALPEVLPQEDRELARLLRGYLEEEGLRVHTGVRVEAVAREGAFR
VRTDRGVFEAERLLVATGRRPDLEGLGLERAGVERDERGFLRLDPSLRTTNPRVYAAGDAAGLPQFVYVAAQSGRVAARN
ALGVKAPLDLAALPRVTFTDPALAAVGLTEEEARRRYGAGVRAATLPLSQVPKALTARDTRGAFKIVVDEEGTVLGLHVL
AHEAGDVIQEGILAVKYGFGYRDLIDTFHPYLTLAEGIRLVAQALDADPKKLSCCA

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=29.9349240780911, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI50301238, Length=457, Percent_Identity=30.8533916849015, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI22035672, Length=497, Percent_Identity=30.3822937625755, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI291045266, Length=468, Percent_Identity=28.8461538461538, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI33519430, Length=464, Percent_Identity=29.7413793103448, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI33519428, Length=464, Percent_Identity=29.7413793103448, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI33519426, Length=464, Percent_Identity=29.7413793103448, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI148277065, Length=464, Percent_Identity=29.7413793103448, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI148277071, Length=464, Percent_Identity=29.7413793103448, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI291045268, Length=466, Percent_Identity=27.8969957081545, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=31.2775330396476, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI87081717, Length=450, Percent_Identity=30.4444444444444, Blast_Score=204, Evalue=9e-54,
Organism=Escherichia coli, GI1789915, Length=427, Percent_Identity=33.0210772833724, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=26.2582056892779, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789065, Length=218, Percent_Identity=32.1100917431193, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=30.2832244008715, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17557007, Length=491, Percent_Identity=29.1242362525458, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71983429, Length=367, Percent_Identity=32.425068119891, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI71983419, Length=367, Percent_Identity=32.425068119891, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71982272, Length=457, Percent_Identity=29.7592997811816, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17559934, Length=199, Percent_Identity=27.1356783919598, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=490, Percent_Identity=31.4285714285714, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6325166, Length=459, Percent_Identity=30.0653594771242, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325240, Length=483, Percent_Identity=26.7080745341615, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21358499, Length=456, Percent_Identity=30.4824561403509, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24640553, Length=492, Percent_Identity=31.0975609756098, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24640549, Length=491, Percent_Identity=30.7535641547862, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24640551, Length=493, Percent_Identity=30.8316430020284, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17737741, Length=490, Percent_Identity=30.4081632653061, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 48477; Mature: 48346

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYDLLIVGSGSAGVAAALEASALGAKAAVVEAGVLGGTCVNVGCVPSKYLLRAADAFHR
CCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHH
AGHPAFPGLRTEALGVDWKALLAGKEGLIAALRKEKYQEVLEAAGVPVLRGRARFLDGER
CCCCCCCCCCCHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHCCCCE
MEVEGREVLAGRYLLATGARPFLPPIPGLQESAPWTYLEALSAPALPESLLVVGGGPIGL
EEECCCHHHHCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHH
ELAQAFARLGSRVTVLEALPEVLPQEDRELARLLRGYLEEEGLRVHTGVRVEAVAREGAF
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCEEEEECCCCCE
RVRTDRGVFEAERLLVATGRRPDLEGLGLERAGVERDERGFLRLDPSLRTTNPRVYAAGD
EEECCCCHHHHHHEEEECCCCCCCCCCCCHHCCCCCCCCCCEEECCCCCCCCCEEEECCC
AAGLPQFVYVAAQSGRVAARNALGVKAPLDLAALPRVTFTDPALAAVGLTEEEARRRYGA
CCCCCEEEEEEECCCCEEECCCCCCCCCCCHHHCCCCEECCCHHHEECCCHHHHHHHHCC
GVRAATLPLSQVPKALTARDTRGAFKIVVDEEGTVLGLHVLAHEAGDVIQEGILAVKYGF
CCEEEECCHHHCCHHHHCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHCCEEEEECC
GYRDLIDTFHPYLTLAEGIRLVAQALDADPKKLSCCA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TYDLLIVGSGSAGVAAALEASALGAKAAVVEAGVLGGTCVNVGCVPSKYLLRAADAFHR
CEEEEEEECCCCCHHHHHHHHHCCCHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHH
AGHPAFPGLRTEALGVDWKALLAGKEGLIAALRKEKYQEVLEAAGVPVLRGRARFLDGER
CCCCCCCCCCCHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHCCCCE
MEVEGREVLAGRYLLATGARPFLPPIPGLQESAPWTYLEALSAPALPESLLVVGGGPIGL
EEECCCHHHHCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHH
ELAQAFARLGSRVTVLEALPEVLPQEDRELARLLRGYLEEEGLRVHTGVRVEAVAREGAF
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCEEEEECCCCCE
RVRTDRGVFEAERLLVATGRRPDLEGLGLERAGVERDERGFLRLDPSLRTTNPRVYAAGD
EEECCCCHHHHHHEEEECCCCCCCCCCCCHHCCCCCCCCCCEEECCCCCCCCCEEEECCC
AAGLPQFVYVAAQSGRVAARNALGVKAPLDLAALPRVTFTDPALAAVGLTEEEARRRYGA
CCCCCEEEEEEECCCCEEECCCCCCCCCCCHHHCCCCEECCCHHHEECCCHHHHHHHHCC
GVRAATLPLSQVPKALTARDTRGAFKIVVDEEGTVLGLHVLAHEAGDVIQEGILAVKYGF
CCEEEECCHHHCCHHHHCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHCCEEEEECC
GYRDLIDTFHPYLTLAEGIRLVAQALDADPKKLSCCA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2067577 [H]