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The map label for this gene is folD [H]

Identifier: 55981089

GI number: 55981089

Start: 1065895

End: 1066743

Strand: Reverse

Name: folD [H]

Synonym: TTHA1120

Alternate gene names: 55981089

Gene position: 1066743-1065895 (Counterclockwise)

Preceding gene: 55981090

Following gene: 55981088

Centisome position: 57.67

GC content: 69.85

Gene sequence:

>849_bases
GTGGCGGCCCAGGTGCTTTCGGGACACGAGGCGGCGGAGGCGGTCTACGAGGAGATCCGCGCCCGGCTACGTAGCCTTTC
CTTCACGCCATCCCTGCGGGTGATCCGGCTCGGGGAGGACCCGGCCTCGGTGGCCTACGTGCGGCTTAAGGACAAGCGGG
CGCGGGCTTTGGGGTACCGAAGCCAGGTGGAGGTCTACCCGGAGGACCTCCCCGAGGAGGCCCTTCTGGAAAGGATCGCC
GCCCTCAACGCCGACGAGGAGGTGGACGGGATCCTGGTCCAGCTTCCCCTCCCCCCGCACATCCGCACCCAGCGGGTCCT
CGAGGCCATCCACCCCTTGAAGGACGTGGACGGTTTCCACCCCCTGAACGTGGGGCGGCTTTGGAGCGGGGGAAAGGGGC
TTTTCCCCTGCACCCCCCTAGGGGTGGTCCGTCTCCTCAAGCACTACGGGGTGGACCTTAGGGGCAAGGAGGTGGTGGTG
GTGGGGCGGTCCAACATCGTGGGAAAGCCCCTGGCGGGGCTTCTTCTGCGGGAGGACGCCACCGTGACCCTGGCCCACTC
CAAGACCCAGGACCTGCCCGAGGTCACCCGGAGGGCCCAGGTCCTGGTGGTGGCCGTGGGCCGGCCCCACCTGGTGCGGA
AGGAGTGGGTGCGGGAGGGGGCCATCGTGGTGGACGTGGGCGTGAACCGCGTGGAGGGGAGGCTTCTCGGCGACGTGCAC
CCCGAGGTGGCCGAGGTGGCCTTCGCCCTCACCCCCGTGCCGGGCGGGGTGGGGCCCATGACCGTGGCCATGCTCATGGG
GAACACCCTCGAGGCCGCCCTCTTGAGGCGCCATGGAGCTTCTGGCTAA

Upstream 100 bases:

>100_bases
CGGCGGCGAGCACTCGGGGAGCTTCGTCAACGGGGTCCTCGCCCGGGTCTACCGCCGGGTGGCGGCCGGGGAGCTGAAGA
CGGTGGCCAAGGAGGCTTAG

Downstream 100 bases:

>100_bases
CGCCGTTTTCTGGACGGCGGTCCTCGCCAACCTCACCGCCCAGACCCTCAAGCTCCTCCTCTACTACTTCCTGGAGGGGC
GCTTCCAGTGGCACCGCTTC

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MAAQVLSGHEAAEAVYEEIRARLRSLSFTPSLRVIRLGEDPASVAYVRLKDKRARALGYRSQVEVYPEDLPEEALLERIA
ALNADEEVDGILVQLPLPPHIRTQRVLEAIHPLKDVDGFHPLNVGRLWSGGKGLFPCTPLGVVRLLKHYGVDLRGKEVVV
VGRSNIVGKPLAGLLLREDATVTLAHSKTQDLPEVTRRAQVLVVAVGRPHLVRKEWVREGAIVVDVGVNRVEGRLLGDVH
PEVAEVAFALTPVPGGVGPMTVAMLMGNTLEAALLRRHGASG

Sequences:

>Translated_282_residues
MAAQVLSGHEAAEAVYEEIRARLRSLSFTPSLRVIRLGEDPASVAYVRLKDKRARALGYRSQVEVYPEDLPEEALLERIA
ALNADEEVDGILVQLPLPPHIRTQRVLEAIHPLKDVDGFHPLNVGRLWSGGKGLFPCTPLGVVRLLKHYGVDLRGKEVVV
VGRSNIVGKPLAGLLLREDATVTLAHSKTQDLPEVTRRAQVLVVAVGRPHLVRKEWVREGAIVVDVGVNRVEGRLLGDVH
PEVAEVAFALTPVPGGVGPMTVAMLMGNTLEAALLRRHGASG
>Mature_281_residues
AAQVLSGHEAAEAVYEEIRARLRSLSFTPSLRVIRLGEDPASVAYVRLKDKRARALGYRSQVEVYPEDLPEEALLERIAA
LNADEEVDGILVQLPLPPHIRTQRVLEAIHPLKDVDGFHPLNVGRLWSGGKGLFPCTPLGVVRLLKHYGVDLRGKEVVVV
GRSNIVGKPLAGLLLREDATVTLAHSKTQDLPEVTRRAQVLVVAVGRPHLVRKEWVREGAIVVDVGVNRVEGRLLGDVHP
EVAEVAFALTPVPGGVGPMTVAMLMGNTLEAALLRRHGASG

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=292, Percent_Identity=43.1506849315069, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI94721354, Length=292, Percent_Identity=44.5205479452055, Blast_Score=204, Evalue=6e-53,
Organism=Homo sapiens, GI222418558, Length=292, Percent_Identity=43.8356164383562, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI36796743, Length=211, Percent_Identity=26.0663507109005, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1786741, Length=280, Percent_Identity=47.8571428571429, Blast_Score=242, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17568735, Length=296, Percent_Identity=42.5675675675676, Blast_Score=217, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6319558, Length=285, Percent_Identity=43.5087719298246, Blast_Score=219, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6321643, Length=296, Percent_Identity=40.8783783783784, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322933, Length=278, Percent_Identity=27.3381294964029, Blast_Score=93, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24645718, Length=287, Percent_Identity=43.9024390243902, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17137370, Length=287, Percent_Identity=43.9024390243902, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI62472483, Length=287, Percent_Identity=43.9024390243902, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI45551871, Length=287, Percent_Identity=43.9024390243902, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17136816, Length=292, Percent_Identity=43.8356164383562, Blast_Score=211, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17136818, Length=292, Percent_Identity=43.8356164383562, Blast_Score=211, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 30608; Mature: 30477

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQVLSGHEAAEAVYEEIRARLRSLSFTPSLRVIRLGEDPASVAYVRLKDKRARALGYR
CCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECHHHHHHCCC
SQVEVYPEDLPEEALLERIAALNADEEVDGILVQLPLPPHIRTQRVLEAIHPLKDVDGFH
CCEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCC
PLNVGRLWSGGKGLFPCTPLGVVRLLKHYGVDLRGKEVVVVGRSNIVGKPLAGLLLREDA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHEEECCC
TVTLAHSKTQDLPEVTRRAQVLVVAVGRPHLVRKEWVREGAIVVDVGVNRVEGRLLGDVH
EEEEECCCCCCHHHHHHCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCEEECCCC
PEVAEVAFALTPVPGGVGPMTVAMLMGNTLEAALLRRHGASG
HHHHHHHHEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
AAQVLSGHEAAEAVYEEIRARLRSLSFTPSLRVIRLGEDPASVAYVRLKDKRARALGYR
CCCHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECHHHHHHCCC
SQVEVYPEDLPEEALLERIAALNADEEVDGILVQLPLPPHIRTQRVLEAIHPLKDVDGFH
CCEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCC
PLNVGRLWSGGKGLFPCTPLGVVRLLKHYGVDLRGKEVVVVGRSNIVGKPLAGLLLREDA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHEEECCC
TVTLAHSKTQDLPEVTRRAQVLVVAVGRPHLVRKEWVREGAIVVDVGVNRVEGRLLGDVH
EEEEECCCCCCHHHHHHCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCEEECCCC
PEVAEVAFALTPVPGGVGPMTVAMLMGNTLEAALLRRHGASG
HHHHHHHHEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA