Click here to switch to the map view.

The map label for this gene is cofH [H]

Identifier: 55981061

GI number: 55981061

Start: 1038295

End: 1039437

Strand: Direct

Name: cofH [H]

Synonym: TTHA1092

Alternate gene names: 55981061

Gene position: 1038295-1039437 (Clockwise)

Preceding gene: 55981059

Following gene: 55981065

Centisome position: 56.13

GC content: 67.54

Gene sequence:

>1143_bases
ATGAAGGGCATGGACGTCCTGGAGAAGGCCGTGGCCGGGGAGCGGCTTTCCGAGGCCGAGGTCCTAAGCCTCTTTGACCT
CCCCTTGCCCGAGCTCGCCGCCGCCGCCCACGAGGTGCGGCTTAAGAAGACCGACCCCGAGGTGGTGACCTTCCTCATTG
ACCGGAACATCAACTACACCAACGTCTGCACCGTGGCCTGCGCCTTCTGCGCCTTTTACCGCACCAAAAGGCAGAAGGAC
GCCTACACCCTGAGCTACGAGGAGATCGCGAGGAAAGTGGAGGAGCTCTACCAGGTGGGGGGCAGGCGGATCCTCATGCA
GGGGGGCGTGAACCCGGAGCTTCCCCTAGTGTGGTACCTGGACCTCCTCCGCTACCTCAAAAGCCGCTTCCCCGACCTTC
GCATAGACGCCTTCAGCCCCGAGGAGATCCTGGGCCTAGAACGCCTCACGGGCCTTAGGGCGGAGGCGATCCTTGAAAAG
CTAAAGGAAGCGGGCCTGGACGGCCTGCCCGGGGCCGGGGCGGAGATTTTGGTGGACGAGGTCCGCCTGAAGGCGGCCCC
CGCCCGGATCCGGACGGCGGACTGGTACCGCATCGTGGACGCCGCCCAGGCCCTGGGGCTTTACACCCTCGCCACCATGG
TCATCGGCTTCGGAGAAGGCCCCAAGGAGCGCACCGCCCACCTCCTGGGCCTTCGCGCCCAGCAGGACAGGGCCCTGGAG
CGCTATGAGAACGGCTTCGCCGCCTTCGCCCTGTGGACCCTTCAGGTGGAGCACACCCGCTTAAAGGGCAAGGCCCCAGG
GGCCACGGCCCACGAGTACCTGAAGACCCTCGCCGTCGCCCGCCTCGCCCTGGACAACTTCGCCCACTTCCAGGCCTCCT
GGCCCACCCTGGGCTTCAAGGTGGCCCAGGCGGCCCTCTACTACGGAGCCGACGACTTCGGGAGCACCATGCTGGAGGAG
AACGTGGTCTCGGCCGCGGGAGGGCACGGGCGCACCCACGCCACGGTGCGCCAGATCGTGCGCCACATCGTGGACGCGGG
GTTTAAGCCGGCGGAACGGGACCCCCTCTACCGCATCCTCCGCTACCCCGACGCCGAGGCCATCCTCAGCGAGCCCGAGC
CCGTGGAGCTCCCCCTCGCCTAA

Upstream 100 bases:

>100_bases
GGATGACGTTGAGGTTCTCGGGCTTCTCAATGGGAATAAGCTTGAGTTCCATGCCCCGATTTTACCGAAGGCCACCTTGA
CCCGGGAAAGCGGGTGTAGG

Downstream 100 bases:

>100_bases
GGGCAGTTCCCCGAGCGGTAGAGGTCGTAGTCGGTGTAGACCGAGGCCTGGTAGGGATCGCCTCCCCGCCGGGCATCGTA
GCCGTTCCAGCCGTGCTTCA

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKGMDVLEKAVAGERLSEAEVLSLFDLPLPELAAAAHEVRLKKTDPEVVTFLIDRNINYTNVCTVACAFCAFYRTKRQKD
AYTLSYEEIARKVEELYQVGGRRILMQGGVNPELPLVWYLDLLRYLKSRFPDLRIDAFSPEEILGLERLTGLRAEAILEK
LKEAGLDGLPGAGAEILVDEVRLKAAPARIRTADWYRIVDAAQALGLYTLATMVIGFGEGPKERTAHLLGLRAQQDRALE
RYENGFAAFALWTLQVEHTRLKGKAPGATAHEYLKTLAVARLALDNFAHFQASWPTLGFKVAQAALYYGADDFGSTMLEE
NVVSAAGGHGRTHATVRQIVRHIVDAGFKPAERDPLYRILRYPDAEAILSEPEPVELPLA

Sequences:

>Translated_380_residues
MKGMDVLEKAVAGERLSEAEVLSLFDLPLPELAAAAHEVRLKKTDPEVVTFLIDRNINYTNVCTVACAFCAFYRTKRQKD
AYTLSYEEIARKVEELYQVGGRRILMQGGVNPELPLVWYLDLLRYLKSRFPDLRIDAFSPEEILGLERLTGLRAEAILEK
LKEAGLDGLPGAGAEILVDEVRLKAAPARIRTADWYRIVDAAQALGLYTLATMVIGFGEGPKERTAHLLGLRAQQDRALE
RYENGFAAFALWTLQVEHTRLKGKAPGATAHEYLKTLAVARLALDNFAHFQASWPTLGFKVAQAALYYGADDFGSTMLEE
NVVSAAGGHGRTHATVRQIVRHIVDAGFKPAERDPLYRILRYPDAEAILSEPEPVELPLA
>Mature_380_residues
MKGMDVLEKAVAGERLSEAEVLSLFDLPLPELAAAAHEVRLKKTDPEVVTFLIDRNINYTNVCTVACAFCAFYRTKRQKD
AYTLSYEEIARKVEELYQVGGRRILMQGGVNPELPLVWYLDLLRYLKSRFPDLRIDAFSPEEILGLERLTGLRAEAILEK
LKEAGLDGLPGAGAEILVDEVRLKAAPARIRTADWYRIVDAAQALGLYTLATMVIGFGEGPKERTAHLLGLRAQQDRALE
RYENGFAAFALWTLQVEHTRLKGKAPGATAHEYLKTLAVARLALDNFAHFQASWPTLGFKVAQAALYYGADDFGSTMLEE
NVVSAAGGHGRTHATVRQIVRHIVDAGFKPAERDPLYRILRYPDAEAILSEPEPVELPLA

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR020050
- InterPro:   IPR005244
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 42206; Mature: 42206

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGMDVLEKAVAGERLSEAEVLSLFDLPLPELAAAAHEVRLKKTDPEVVTFLIDRNINYT
CCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHEECCCCHHHEEEEEECCCCHH
NVCTVACAFCAFYRTKRQKDAYTLSYEEIARKVEELYQVGGRRILMQGGVNPELPLVWYL
HHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
DLLRYLKSRFPDLRIDAFSPEEILGLERLTGLRAEAILEKLKEAGLDGLPGAGAEILVDE
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
VRLKAAPARIRTADWYRIVDAAQALGLYTLATMVIGFGEGPKERTAHLLGLRAQQDRALE
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
RYENGFAAFALWTLQVEHTRLKGKAPGATAHEYLKTLAVARLALDNFAHFQASWPTLGFK
HHHCCEEEEEEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VAQAALYYGADDFGSTMLEENVVSAAGGHGRTHATVRQIVRHIVDAGFKPAERDPLYRIL
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
RYPDAEAILSEPEPVELPLA
HCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKGMDVLEKAVAGERLSEAEVLSLFDLPLPELAAAAHEVRLKKTDPEVVTFLIDRNINYT
CCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHEECCCCHHHEEEEEECCCCHH
NVCTVACAFCAFYRTKRQKDAYTLSYEEIARKVEELYQVGGRRILMQGGVNPELPLVWYL
HHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
DLLRYLKSRFPDLRIDAFSPEEILGLERLTGLRAEAILEKLKEAGLDGLPGAGAEILVDE
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
VRLKAAPARIRTADWYRIVDAAQALGLYTLATMVIGFGEGPKERTAHLLGLRAQQDRALE
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
RYENGFAAFALWTLQVEHTRLKGKAPGATAHEYLKTLAVARLALDNFAHFQASWPTLGFK
HHHCCEEEEEEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VAQAALYYGADDFGSTMLEENVVSAAGGHGRTHATVRQIVRHIVDAGFKPAERDPLYRIL
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
RYPDAEAILSEPEPVELPLA
HCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA