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The map label for this gene is ftsI [H]

Identifier: 55981047

GI number: 55981047

Start: 1024681

End: 1026000

Strand: Direct

Name: ftsI [H]

Synonym: TTHA1078

Alternate gene names: 55981047

Gene position: 1024681-1026000 (Clockwise)

Preceding gene: 55981046

Following gene: 55981048

Centisome position: 55.4

GC content: 72.5

Gene sequence:

>1320_bases
ATGACCGCAGGCCGGGAGCGGGTCCACCTCGTGGTCCTCGGCTTCCTCGCCTACGTGGCCCTCCTCGCCCTCGGGGTCTA
CACCCTGGCCCTCCACCCCCCGAGGATCCAGCCCGCGCCCCCCCCGCCCCCGCCGCCTCGAGGGGGGCTTTACGCCGCCG
ACGGCACCCCCCTCGCCCTCACCCTGGAGGGGAAGCGGCTCCACCCCTTGGGGCGGAGCGCGAGCCAGCTCCTGGGCTTC
GGGGAGCGGGCCTCGGGCCGGGGCCTGGAGGGGCTGGAGCGGGACCTCAACGCCTCCTTGAGCGAGGGGCGGTCCTACAC
CCTGACCCTGGAGCCCTTCGTCCAAGCCCTGGCGGAAAGGGCCCTTTGGCGCGGGCTAGAGGAAAGCCGCGCGGACTACG
GGAGCGCCGTGGTCATGGACGCAGAGGGGCGCCTCCTCGCCGTGGCCAACGGCCCCCCCTTTGACCCCGATGCCCCGAGG
AAAAGCCCTGAAGAGGACATCTCCTGGCGCAACCACGCCTTCCTCGTCCCCTTGGAACCGGGGTCCACGGCCAAGACCCT
CACCGCCGCCATGCTCCTGGAGGAGGGCGCCGCCACCCTCGCCACCCGGGTGGAGGCCCCCATGCGGAGGGAGCTTGAGG
GCTGGACCATACGGGACATCGTCCCCCACCCCCCCGTCCTGACCCTGGAGGAGGTGCTCCGCTACTCCTCCAACGTGGGC
ATCAGCCTCCTCGCCGAACGCCTCCCCAAGGAAACCTTCTTCGCCTACATGGAAGCCCTGGGCCTCACCCGCACCGACCT
CCTGCCGGGCATCCGGGTGGCGGCCCCCCTCTTCCAACCCCCCGAGAAGTGGAGCCGGGTGGCCTACGCCAACCACACCT
TCGGCCAGGGCTTCCTCATCACCCCCCTGCACCTGGCCGCCGCCTACGGGGCCCTGGTGGACGGGGTCTACCGGACCCCT
GTCCTCCTCAAGGGAACGGAGGGCCGTTCCTGGCGCGTCTTCTCCCCAGCCACGGCCCAGGCCCTGCGGGAGGCCCTGGC
CCGCGTGGCCGTGCCCACAGCCCACCTTCCGGGCTACCGCCTCGGGGGCAAGACGGGCACCGCCCAGGTGGTGGTGAACG
GGCGCTACTCCCAGGAGGTGTTCACCGCCTGGTTCGCCGGGTTCGTCCCCGCCGACCGCCCCCGGTTCACCGTGGTGGTC
GCCGTCCACCACCCCAAAACCCGGATCCACGGGAGCCAGGTGGCCGCCCCCATCTTCCGGGAGATCGCCGCCGGGCTCTT
GGCCTGGGCGGGCCTGCCCCCCTATGCTGAAGGGCGGTGA

Upstream 100 bases:

>100_bases
CCCTCGTCATGGAGAAGTGGCGCCTCCTCCGCCCCGAGCGCCTCCTGGCCTGGGCGGAGGAGGAAGGGTTCGTCCCCATG
AGCCTGGGGAGGTGGTCCCG

Downstream 100 bases:

>100_bases
GGATGTTGTGCAAGGGACGCATGTTAGGGAACTAACGCCGGAGTGGGTGGCCCGGGCCGTGGGGGGACGGCTCCATCCGG
GCGGAGGGCCGGTGCGGGAC

Product: penicillin-binding protein

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTAGRERVHLVVLGFLAYVALLALGVYTLALHPPRIQPAPPPPPPPRGGLYAADGTPLALTLEGKRLHPLGRSASQLLGF
GERASGRGLEGLERDLNASLSEGRSYTLTLEPFVQALAERALWRGLEESRADYGSAVVMDAEGRLLAVANGPPFDPDAPR
KSPEEDISWRNHAFLVPLEPGSTAKTLTAAMLLEEGAATLATRVEAPMRRELEGWTIRDIVPHPPVLTLEEVLRYSSNVG
ISLLAERLPKETFFAYMEALGLTRTDLLPGIRVAAPLFQPPEKWSRVAYANHTFGQGFLITPLHLAAAYGALVDGVYRTP
VLLKGTEGRSWRVFSPATAQALREALARVAVPTAHLPGYRLGGKTGTAQVVVNGRYSQEVFTAWFAGFVPADRPRFTVVV
AVHHPKTRIHGSQVAAPIFREIAAGLLAWAGLPPYAEGR

Sequences:

>Translated_439_residues
MTAGRERVHLVVLGFLAYVALLALGVYTLALHPPRIQPAPPPPPPPRGGLYAADGTPLALTLEGKRLHPLGRSASQLLGF
GERASGRGLEGLERDLNASLSEGRSYTLTLEPFVQALAERALWRGLEESRADYGSAVVMDAEGRLLAVANGPPFDPDAPR
KSPEEDISWRNHAFLVPLEPGSTAKTLTAAMLLEEGAATLATRVEAPMRRELEGWTIRDIVPHPPVLTLEEVLRYSSNVG
ISLLAERLPKETFFAYMEALGLTRTDLLPGIRVAAPLFQPPEKWSRVAYANHTFGQGFLITPLHLAAAYGALVDGVYRTP
VLLKGTEGRSWRVFSPATAQALREALARVAVPTAHLPGYRLGGKTGTAQVVVNGRYSQEVFTAWFAGFVPADRPRFTVVV
AVHHPKTRIHGSQVAAPIFREIAAGLLAWAGLPPYAEGR
>Mature_438_residues
TAGRERVHLVVLGFLAYVALLALGVYTLALHPPRIQPAPPPPPPPRGGLYAADGTPLALTLEGKRLHPLGRSASQLLGFG
ERASGRGLEGLERDLNASLSEGRSYTLTLEPFVQALAERALWRGLEESRADYGSAVVMDAEGRLLAVANGPPFDPDAPRK
SPEEDISWRNHAFLVPLEPGSTAKTLTAAMLLEEGAATLATRVEAPMRRELEGWTIRDIVPHPPVLTLEEVLRYSSNVGI
SLLAERLPKETFFAYMEALGLTRTDLLPGIRVAAPLFQPPEKWSRVAYANHTFGQGFLITPLHLAAAYGALVDGVYRTPV
LLKGTEGRSWRVFSPATAQALREALARVAVPTAHLPGYRLGGKTGTAQVVVNGRYSQEVFTAWFAGFVPADRPRFTVVVA
VHHPKTRIHGSQVAAPIFREIAAGLLAWAGLPPYAEGR

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=419, Percent_Identity=29.8329355608592, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 47455; Mature: 47324

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAGRERVHLVVLGFLAYVALLALGVYTLALHPPRIQPAPPPPPPPRGGLYAADGTPLAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEE
TLEGKRLHPLGRSASQLLGFGERASGRGLEGLERDLNASLSEGRSYTLTLEPFVQALAER
EECCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHCCHHHCCCEEEEEHHHHHHHHHHH
ALWRGLEESRADYGSAVVMDAEGRLLAVANGPPFDPDAPRKSPEEDISWRNHAFLVPLEP
HHHCCHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEEECC
GSTAKTLTAAMLLEEGAATLATRVEAPMRRELEGWTIRDIVPHPPVLTLEEVLRYSSNVG
CCCHHHHHHHHHHHHCHHHHHHHHCCHHHHHCCCCEEECCCCCCCCCCHHHHHHHCCCCC
ISLLAERLPKETFFAYMEALGLTRTDLLPGIRVAAPLFQPPEKWSRVAYANHTFGQGFLI
HHHHHHHCCHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCHHHHHHEEECCCCCCCCEEE
TPLHLAAAYGALVDGVYRTPVLLKGTEGRSWRVFSPATAQALREALARVAVPTAHLPGYR
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCE
LGGKTGTAQVVVNGRYSQEVFTAWFAGFVPADRPRFTVVVAVHHPKTRIHGSQVAAPIFR
ECCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHCCCHHHHHHHHH
EIAAGLLAWAGLPPYAEGR
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TAGRERVHLVVLGFLAYVALLALGVYTLALHPPRIQPAPPPPPPPRGGLYAADGTPLAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEE
TLEGKRLHPLGRSASQLLGFGERASGRGLEGLERDLNASLSEGRSYTLTLEPFVQALAER
EECCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHCCHHHCCCEEEEEHHHHHHHHHHH
ALWRGLEESRADYGSAVVMDAEGRLLAVANGPPFDPDAPRKSPEEDISWRNHAFLVPLEP
HHHCCHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEEECC
GSTAKTLTAAMLLEEGAATLATRVEAPMRRELEGWTIRDIVPHPPVLTLEEVLRYSSNVG
CCCHHHHHHHHHHHHCHHHHHHHHCCHHHHHCCCCEEECCCCCCCCCCHHHHHHHCCCCC
ISLLAERLPKETFFAYMEALGLTRTDLLPGIRVAAPLFQPPEKWSRVAYANHTFGQGFLI
HHHHHHHCCHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCHHHHHHEEECCCCCCCCEEE
TPLHLAAAYGALVDGVYRTPVLLKGTEGRSWRVFSPATAQALREALARVAVPTAHLPGYR
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCE
LGGKTGTAQVVVNGRYSQEVFTAWFAGFVPADRPRFTVVVAVHHPKTRIHGSQVAAPIFR
ECCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHCCCHHHHHHHHH
EIAAGLLAWAGLPPYAEGR
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]