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The map label for this gene is macA [H]

Identifier: 55980975

GI number: 55980975

Start: 952501

End: 953814

Strand: Direct

Name: macA [H]

Synonym: TTHA1006

Alternate gene names: 55980975

Gene position: 952501-953814 (Clockwise)

Preceding gene: 55980974

Following gene: 55980976

Centisome position: 51.49

GC content: 72.22

Gene sequence:

>1314_bases
ATGCGCGCCCGGCGGCTCCTCTGGATCCCCCTTCTCGCCGTTCTGGTCGCCCTCGGCTTCTTCCTCCTCCGCCCGAAACC
GGAGGAAAACCAGGCGACCGCCTTCCAAGTGGTGGAGGCGACGCGGGGCGACCTCCGGGTGACCGTCTCCGGCTACGGCT
GGCTCTCCCCCTGGGAGACCCTGGAGGTCCGCCCCGAGATCACGGGGACCCTGGTCTGGCTCGCCGAGGAAGGCCAGGAG
GTGCAAGAAGGCGAGGTCGTGGCGCGGCTGGACCCCACCCCCTTCGCCCGGGCCCTCGCCGAGGCCGAGGCGGAGGTGCG
CCGCCAGGAGGCCAACCTGGAAAACGCCCGCCTCGAGGGGCAAAGCGCCCTCGCCTCGCTTACGGCCTCGGTGAAAAGCG
CCGAGATCGCCTACGCGAACGCCAAGCAGGACCTGGAAACCGCCCGGCAGAACCTCGAGGCCACCCGGATCGTCTACGAG
GCGGGCGGGACGAGCCGCCAGGACCTCCTCGCCGCCGAGGCCGCCTACGCCGCCGCCGAGCGGGCCCTGGAGAACGCCGA
GGCGGCCCTGGCCGCCCAGCGGAAGGCCTTGAACCTCCGCGAAGCCCAGCTCGCCAAGGAGCTTGAAGCCCTGCAGGAGG
CCCTCCGGCAAGCCCAGCTCACCCTGGCCTCCGCGAGGGAGGACCTAGAGGCGGTGGAGGTCAAGGCTCCCTTCTCCGGG
GTCGTCCTGTCCCAAGAGGCGAGCCTCGGCGCCCAGGTCTCCCCAGAGACCGCCCTCCTCACCCTGGGCGACCTCTCCGC
CTTCCGCCTCGTGCTCCAGGTGGACGAGACCGAGATCGGAAAGGTCCAGGTGGGGCAGAAGGTGGCCGTCACCCTGGACG
GCCTCCCCGGCGAAACCCTGGAAGGGGAGGTGGTGGCCAAAAGCCCGAAGGCAGAACTGGTCAACAACATCCCCGTCTTT
GAGGTCACCGTCCGCCTCCCCGCCGACCCCCGCCTCCGCCCCGGGATGAGCGCCGACGGGGAGATCGTCGTCCAGGAGGC
CAAGGACGTCATCCTCCTGCCCAAGGGGGCCGTGCGCCGGGGGCCCAGGGGAGCGTCCGTCACCGTCCTGCGCCCCGACG
GCTCCACGGAGACGGTGCCGGTGCGCCTGGGCCTCGAGGACAGCACCCGGGTCGCCGTCCTCGAGGGCCTCCAAGAGGGG
GACCAGGTGGTCCTCCCCCAGGGAACAGGGGGCTCCCGTGGCACGGGAAGCCCTGGCTCCGCTCGGCCCGGCCCCACAAC
CCCCATCCCCTTCGGGCCCCCGCCCGGGAGGTGA

Upstream 100 bases:

>100_bases
ACTTTGCCCTCCTCCAGGCGAAAAACGCCTACCTGAGGGCCTTGGCCGCCCTGAGCGTGGCCGCCGGGGTTGACCTCACG
GGCCTCTTGGAGGTGGAGTG

Downstream 100 bases:

>100_bases
GGATGCTCCTCGCGCTCAAAGGGATCCGAAAGGTCTACCGCATGGGCGAGGTGGCCTTTTCCGCCCTGAAGGGCGTGGAC
CTCGAGGTGGAGGAAGGGGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MRARRLLWIPLLAVLVALGFFLLRPKPEENQATAFQVVEATRGDLRVTVSGYGWLSPWETLEVRPEITGTLVWLAEEGQE
VQEGEVVARLDPTPFARALAEAEAEVRRQEANLENARLEGQSALASLTASVKSAEIAYANAKQDLETARQNLEATRIVYE
AGGTSRQDLLAAEAAYAAAERALENAEAALAAQRKALNLREAQLAKELEALQEALRQAQLTLASAREDLEAVEVKAPFSG
VVLSQEASLGAQVSPETALLTLGDLSAFRLVLQVDETEIGKVQVGQKVAVTLDGLPGETLEGEVVAKSPKAELVNNIPVF
EVTVRLPADPRLRPGMSADGEIVVQEAKDVILLPKGAVRRGPRGASVTVLRPDGSTETVPVRLGLEDSTRVAVLEGLQEG
DQVVLPQGTGGSRGTGSPGSARPGPTTPIPFGPPPGR

Sequences:

>Translated_437_residues
MRARRLLWIPLLAVLVALGFFLLRPKPEENQATAFQVVEATRGDLRVTVSGYGWLSPWETLEVRPEITGTLVWLAEEGQE
VQEGEVVARLDPTPFARALAEAEAEVRRQEANLENARLEGQSALASLTASVKSAEIAYANAKQDLETARQNLEATRIVYE
AGGTSRQDLLAAEAAYAAAERALENAEAALAAQRKALNLREAQLAKELEALQEALRQAQLTLASAREDLEAVEVKAPFSG
VVLSQEASLGAQVSPETALLTLGDLSAFRLVLQVDETEIGKVQVGQKVAVTLDGLPGETLEGEVVAKSPKAELVNNIPVF
EVTVRLPADPRLRPGMSADGEIVVQEAKDVILLPKGAVRRGPRGASVTVLRPDGSTETVPVRLGLEDSTRVAVLEGLQEG
DQVVLPQGTGGSRGTGSPGSARPGPTTPIPFGPPPGR
>Mature_437_residues
MRARRLLWIPLLAVLVALGFFLLRPKPEENQATAFQVVEATRGDLRVTVSGYGWLSPWETLEVRPEITGTLVWLAEEGQE
VQEGEVVARLDPTPFARALAEAEAEVRRQEANLENARLEGQSALASLTASVKSAEIAYANAKQDLETARQNLEATRIVYE
AGGTSRQDLLAAEAAYAAAERALENAEAALAAQRKALNLREAQLAKELEALQEALRQAQLTLASAREDLEAVEVKAPFSG
VVLSQEASLGAQVSPETALLTLGDLSAFRLVLQVDETEIGKVQVGQKVAVTLDGLPGETLEGEVVAKSPKAELVNNIPVF
EVTVRLPADPRLRPGMSADGEIVVQEAKDVILLPKGAVRRGPRGASVTVLRPDGSTETVPVRLGLEDSTRVAVLEGLQEG
DQVVLPQGTGGSRGTGSPGSARPGPTTPIPFGPPPGR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=424, Percent_Identity=26.1792452830189, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082036, Length=364, Percent_Identity=24.4505494505494, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790519, Length=250, Percent_Identity=30, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 46457; Mature: 46457

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARRLLWIPLLAVLVALGFFLLRPKPEENQATAFQVVEATRGDLRVTVSGYGWLSPWET
CCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEECCCCCEEEEEECCCCCCCCCC
LEVRPEITGTLVWLAEEGQEVQEGEVVARLDPTPFARALAEAEAEVRRQEANLENARLEG
EEECCCCCEEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHCCH
QSALASLTASVKSAEIAYANAKQDLETARQNLEATRIVYEAGGTSRQDLLAAEAAYAAAE
HHHHHHHHHHHHHCEEEECCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
RALENAEAALAAQRKALNLREAQLAKELEALQEALRQAQLTLASAREDLEAVEVKAPFSG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEECCCCC
VVLSQEASLGAQVSPETALLTLGDLSAFRLVLQVDETEIGKVQVGQKVAVTLDGLPGETL
EEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCEEECCCEEEEEECCCCCCCC
EGEVVAKSPKAELVNNIPVFEVTVRLPADPRLRPGMSADGEIVVQEAKDVILLPKGAVRR
CCCEEECCCHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEECCCHHCC
GPRGASVTVLRPDGSTETVPVRLGLEDSTRVAVLEGLQEGDQVVLPQGTGGSRGTGSPGS
CCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
ARPGPTTPIPFGPPPGR
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRARRLLWIPLLAVLVALGFFLLRPKPEENQATAFQVVEATRGDLRVTVSGYGWLSPWET
CCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEECCCCCEEEEEECCCCCCCCCC
LEVRPEITGTLVWLAEEGQEVQEGEVVARLDPTPFARALAEAEAEVRRQEANLENARLEG
EEECCCCCEEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHCCH
QSALASLTASVKSAEIAYANAKQDLETARQNLEATRIVYEAGGTSRQDLLAAEAAYAAAE
HHHHHHHHHHHHHCEEEECCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
RALENAEAALAAQRKALNLREAQLAKELEALQEALRQAQLTLASAREDLEAVEVKAPFSG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEECCCCC
VVLSQEASLGAQVSPETALLTLGDLSAFRLVLQVDETEIGKVQVGQKVAVTLDGLPGETL
EEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCEEECCCEEEEEECCCCCCCC
EGEVVAKSPKAELVNNIPVFEVTVRLPADPRLRPGMSADGEIVVQEAKDVILLPKGAVRR
CCCEEECCCHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEECCCHHCC
GPRGASVTVLRPDGSTETVPVRLGLEDSTRVAVLEGLQEGDQVVLPQGTGGSRGTGSPGS
CCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCC
ARPGPTTPIPFGPPPGR
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]