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The map label for this gene is dapA [H]

Identifier: 55980926

GI number: 55980926

Start: 903075

End: 903974

Strand: Direct

Name: dapA [H]

Synonym: TTHA0957

Alternate gene names: 55980926

Gene position: 903075-903974 (Clockwise)

Preceding gene: 55980924

Following gene: 55980927

Centisome position: 48.82

GC content: 68.22

Gene sequence:

>900_bases
ATGTTCCGCGGTTCCATACCGCCCCTACCCACACCCTTTCGGCGCGGCCGGTTGGACGAGGAGGCCCTAAGGCGCCTCGT
GGAGCGGGTCGTCCAGGGGGGCTCCCACGGCGTGAGCGTGGGGGGCACCACGGGCGAGCCCGGCACCCAGACCCTGGAGG
AGAGGAAGCGGGCCATAGAGGTCGTCCTGGACCAGGTGGCGGGCCGCGTTCCCGTGATCCCGGGGACCGGGGCGCTTCGC
CTGGAGGAGACCCTGGAGCTCACCCGCTTCGCCAAGGAGGCCGGGGCCCAGGGGGCCATGGTCATCGTCCCCTACTACGT
CAAGCCCAACCAGGAGGGGCTTTACCGCTACTTCGCCGAGGTGGCGAGGACCGTCCCCGACTTTCCCCTCCTCATCTACA
ACATCCCGGGAAGGGCCGGGGTGGAGATCGCCCCCAAGACCGTGGGGCGCTTGAGGCGGGACTTCCCCAACATCGTGGGC
CTCAAGCACTCCTCCAAGGACCTGGAGTACCTCTCCCACCTCTTTTTGGAGGCGGGGCGGGACTTTCTCGTCTTCTGCGG
CCTGGAAAGCCTCACCCTCCCCATGATGAGCCTGGGGGCGGTGGGGACCATCGCCGCCACCGCCAACTGGCTCCCCAAGG
AGGTGGCCCTCCTCTGCGAAAAGGCCCTCGCCGGGGACTACCAGGGGGCGCGGGAACTCCACTTCCACCTCCTCGAGGCC
AACGAGGCCATCTTCTGGGACACGAACCCCATCCCCTTAAAAACCGTCCTCTCCTGGATGGGGCTACTGGAAAAGGAGTG
GCGGCCCCCCTTGGGCCCCACCACCCCGGAGGTGGAGGAGAGGCTCAGGCGGATGGCCGAGCGCTACGGCCTCCTCCCCA
AGGAGAAGGAGGCGGCGTGA

Upstream 100 bases:

>100_bases
GGTTTTGTGCGAAAAGACAAACTCTTCCGCGTTTTTGTCTAAGCCGCCGGTTGCCCCCGGCGGCCCGCCCCCGCATCCTG
GGAGGCGAAAGGAGCCCAGC

Downstream 100 bases:

>100_bases
AGCTCGCCCGGTTTCTCGCCAAGGGAAGGGTCCACCAGGGGGTTTACCGGGAAGGCCTCCTCCTGGACGAGGCGGGGGAG
GCCCACAGGCCCGAGGACGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MFRGSIPPLPTPFRRGRLDEEALRRLVERVVQGGSHGVSVGGTTGEPGTQTLEERKRAIEVVLDQVAGRVPVIPGTGALR
LEETLELTRFAKEAGAQGAMVIVPYYVKPNQEGLYRYFAEVARTVPDFPLLIYNIPGRAGVEIAPKTVGRLRRDFPNIVG
LKHSSKDLEYLSHLFLEAGRDFLVFCGLESLTLPMMSLGAVGTIAATANWLPKEVALLCEKALAGDYQGARELHFHLLEA
NEAIFWDTNPIPLKTVLSWMGLLEKEWRPPLGPTTPEVEERLRRMAERYGLLPKEKEAA

Sequences:

>Translated_299_residues
MFRGSIPPLPTPFRRGRLDEEALRRLVERVVQGGSHGVSVGGTTGEPGTQTLEERKRAIEVVLDQVAGRVPVIPGTGALR
LEETLELTRFAKEAGAQGAMVIVPYYVKPNQEGLYRYFAEVARTVPDFPLLIYNIPGRAGVEIAPKTVGRLRRDFPNIVG
LKHSSKDLEYLSHLFLEAGRDFLVFCGLESLTLPMMSLGAVGTIAATANWLPKEVALLCEKALAGDYQGARELHFHLLEA
NEAIFWDTNPIPLKTVLSWMGLLEKEWRPPLGPTTPEVEERLRRMAERYGLLPKEKEAA
>Mature_299_residues
MFRGSIPPLPTPFRRGRLDEEALRRLVERVVQGGSHGVSVGGTTGEPGTQTLEERKRAIEVVLDQVAGRVPVIPGTGALR
LEETLELTRFAKEAGAQGAMVIVPYYVKPNQEGLYRYFAEVARTVPDFPLLIYNIPGRAGVEIAPKTVGRLRRDFPNIVG
LKHSSKDLEYLSHLFLEAGRDFLVFCGLESLTLPMMSLGAVGTIAATANWLPKEVALLCEKALAGDYQGARELHFHLLEA
NEAIFWDTNPIPLKTVLSWMGLLEKEWRPPLGPTTPEVEERLRRMAERYGLLPKEKEAA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=284, Percent_Identity=28.5211267605634, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI13540533, Length=241, Percent_Identity=28.6307053941909, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1788823, Length=294, Percent_Identity=34.0136054421769, Blast_Score=184, Evalue=4e-48,
Organism=Escherichia coli, GI1786463, Length=252, Percent_Identity=34.1269841269841, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87082415, Length=299, Percent_Identity=31.7725752508361, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1789620, Length=289, Percent_Identity=27.3356401384083, Blast_Score=115, Evalue=3e-27,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR012691 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 33177; Mature: 33177

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRGSIPPLPTPFRRGRLDEEALRRLVERVVQGGSHGVSVGGTTGEPGTQTLEERKRAIE
CCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHH
VVLDQVAGRVPVIPGTGALRLEETLELTRFAKEAGAQGAMVIVPYYVKPNQEGLYRYFAE
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHH
VARTVPDFPLLIYNIPGRAGVEIAPKTVGRLRRDFPNIVGLKHSSKDLEYLSHLFLEAGR
HHHHCCCCCEEEEECCCCCCCEECHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCCC
DFLVFCGLESLTLPMMSLGAVGTIAATANWLPKEVALLCEKALAGDYQGARELHFHLLEA
CEEEEECCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHEEC
NEAIFWDTNPIPLKTVLSWMGLLEKEWRPPLGPTTPEVEERLRRMAERYGLLPKEKEAA
CCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFRGSIPPLPTPFRRGRLDEEALRRLVERVVQGGSHGVSVGGTTGEPGTQTLEERKRAIE
CCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHH
VVLDQVAGRVPVIPGTGALRLEETLELTRFAKEAGAQGAMVIVPYYVKPNQEGLYRYFAE
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHH
VARTVPDFPLLIYNIPGRAGVEIAPKTVGRLRRDFPNIVGLKHSSKDLEYLSHLFLEAGR
HHHHCCCCCEEEEECCCCCCCEECHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCCC
DFLVFCGLESLTLPMMSLGAVGTIAATANWLPKEVALLCEKALAGDYQGARELHFHLLEA
CEEEEECCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHEEC
NEAIFWDTNPIPLKTVLSWMGLLEKEWRPPLGPTTPEVEERLRRMAERYGLLPKEKEAA
CCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA