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The map label for this gene is serA [H]

Identifier: 55980921

GI number: 55980921

Start: 897366

End: 898931

Strand: Direct

Name: serA [H]

Synonym: TTHA0952

Alternate gene names: 55980921

Gene position: 897366-898931 (Clockwise)

Preceding gene: 55980915

Following gene: 55980922

Centisome position: 48.51

GC content: 70.18

Gene sequence:

>1566_bases
ATGTGGAGGGTCCTGGTCTCGGACGACATGCGCCTGGGGGAGGTGCGGTACCCGGGGGTGATCCTGGACTACCGCCCGGG
GATCGGCCGGGAGGAGCTTTTGGAGATCATCCCCGCTTACGATGCCCTCATCACCCGAAGCCGCACCCGGGTGGACGCGG
AGCTTCTCCAGAGGGGGAAGCGCCTTAAGGTGGTGGGCCGGGGCGGGGTTGGGGTGGACAACGTGGACCTCGAGGCGGCA
AGCCGCCTCGGGATCCTGGTGGTGAACGTCCCCGAGGCCAACACCCGCTCCGCCGCCGAGCTCGCCTTCGGCCTCCTCCT
CGCCGCCGCCCGGGGCATCGCCCTTTCCGACCGGAAGCTGCGCCAGGGGGAGTGGGACCGGAAGTTCCTGGGGCTTGAGC
TCAAGGGAAAGACCCTGGGGATCGTGGGCCTGGGCCGCATCGGCAGCCAGGTGGCCCGCTTCGCCAAGGGGTTTGAGATG
CGGGTTCTGGCCTACGACCCCTACATCCCCAAGGCCCGGGCGGAAAGCCTCGGGGTGGAGCTTTTGGAAAACCTCGAGGA
CCTTCTCCGGCAGAGCCACTTCCTCACCGTCCACACCCCCCTCACCGAGGAGACCCGGGGGATGATCGGCCGGAGGGAGC
TCTACCTGCTTCCCCGGGGGGCGGTGGTGGTGAACGCGGCCCGGGGCGGGATCATAGACGAGAAGGCCCTCCTCGAGGTC
CTGGAGGAGGGCCACCTCTTCGCCGTGGGCCTGGACGTCTTCGCCGAGGAGCCGCCTCCCAAGGACCACCCCCTCATCCA
CCACCCCAGGGTGGTCCACACCGCCCACCTGGGGGCGAACACCCTCGAGGCCCAGGAAAGGGTGGGGGAGGCCATCTTGG
AAAGGGTGGTGCGCACCTTGGAGGGGGACCTCTCCTACGCCCTGAACACCGGGTTTGACCCCGAGGCCCTGGAGGCCTTG
AAGGGCTTCCTCCCCCTGGGGGAGGCCTTGGGCAAGCTCCTCGCCCAGATCACCCGGGGCCGCCCCGAGGCCCTGGAGGT
GCGTTTCCTGGGCCAGTTTGAGAAGGATCCCGAGCCCATCGCCAGCGCCGTGGCCAAGGGCCTCCTCGCCCGGGTCCTGG
GGGAGGGGGCGGTGAACCTGGTCTCGGCGAGGCCCCTCCTCAAGGACCGGGGCATCCACCTCACCACCCTGCGCTCCGAG
GAGGCGGGGGAGTACACCCGGCTCGTGGAGGCCAGGCTCTCCACCGACCAGGAGGAGCGGCGGGCCCGGGGGGTGGTGAT
CGGGGGAAGGCCCCGCCTCGTGGGCATTGACGACTACGCCCTGGAGGTGGTGCCCGAGGGGTACATGCTGGTCTGCGTCA
ACTACGACCGCCCCGGGGTGGTGGGCCAGGTGGGGACCCTCTTGGGGGAGGCGGGGGTGAACATCGCCGGGATGCAGCTC
GGGCGGGACGTGCCGGGCGGCCGGGCCCTCTTCGTACTCACCGTGGACCAGAAGCCCTCCCCCGAGGTCCTGGAGGCCTT
GAGGGCCCTTCCCGTCTTGGAGCGGGTGGACCTGGTGGAGCTGTAG

Upstream 100 bases:

>100_bases
AGGGTAATGCGCATGGCCGCACCTTCGCGAGAGAGGATACCACGGGTGTAGTGTAGGGGGGAAGTTGCCCTGGGCCCCGC
TTGGTGCTACTTTTGGCCCT

Downstream 100 bases:

>100_bases
CCGCAAGGGGAGAGAAAAAGCACGAGCGGGAGTAATCGTGAAGTTTATCACATATCGCCCCTCTGAGTTCCGAGTGTTCA
CACTTGACCAAACTTTCCGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MWRVLVSDDMRLGEVRYPGVILDYRPGIGREELLEIIPAYDALITRSRTRVDAELLQRGKRLKVVGRGGVGVDNVDLEAA
SRLGILVVNVPEANTRSAAELAFGLLLAAARGIALSDRKLRQGEWDRKFLGLELKGKTLGIVGLGRIGSQVARFAKGFEM
RVLAYDPYIPKARAESLGVELLENLEDLLRQSHFLTVHTPLTEETRGMIGRRELYLLPRGAVVVNAARGGIIDEKALLEV
LEEGHLFAVGLDVFAEEPPPKDHPLIHHPRVVHTAHLGANTLEAQERVGEAILERVVRTLEGDLSYALNTGFDPEALEAL
KGFLPLGEALGKLLAQITRGRPEALEVRFLGQFEKDPEPIASAVAKGLLARVLGEGAVNLVSARPLLKDRGIHLTTLRSE
EAGEYTRLVEARLSTDQEERRARGVVIGGRPRLVGIDDYALEVVPEGYMLVCVNYDRPGVVGQVGTLLGEAGVNIAGMQL
GRDVPGGRALFVLTVDQKPSPEVLEALRALPVLERVDLVEL

Sequences:

>Translated_521_residues
MWRVLVSDDMRLGEVRYPGVILDYRPGIGREELLEIIPAYDALITRSRTRVDAELLQRGKRLKVVGRGGVGVDNVDLEAA
SRLGILVVNVPEANTRSAAELAFGLLLAAARGIALSDRKLRQGEWDRKFLGLELKGKTLGIVGLGRIGSQVARFAKGFEM
RVLAYDPYIPKARAESLGVELLENLEDLLRQSHFLTVHTPLTEETRGMIGRRELYLLPRGAVVVNAARGGIIDEKALLEV
LEEGHLFAVGLDVFAEEPPPKDHPLIHHPRVVHTAHLGANTLEAQERVGEAILERVVRTLEGDLSYALNTGFDPEALEAL
KGFLPLGEALGKLLAQITRGRPEALEVRFLGQFEKDPEPIASAVAKGLLARVLGEGAVNLVSARPLLKDRGIHLTTLRSE
EAGEYTRLVEARLSTDQEERRARGVVIGGRPRLVGIDDYALEVVPEGYMLVCVNYDRPGVVGQVGTLLGEAGVNIAGMQL
GRDVPGGRALFVLTVDQKPSPEVLEALRALPVLERVDLVEL
>Mature_521_residues
MWRVLVSDDMRLGEVRYPGVILDYRPGIGREELLEIIPAYDALITRSRTRVDAELLQRGKRLKVVGRGGVGVDNVDLEAA
SRLGILVVNVPEANTRSAAELAFGLLLAAARGIALSDRKLRQGEWDRKFLGLELKGKTLGIVGLGRIGSQVARFAKGFEM
RVLAYDPYIPKARAESLGVELLENLEDLLRQSHFLTVHTPLTEETRGMIGRRELYLLPRGAVVVNAARGGIIDEKALLEV
LEEGHLFAVGLDVFAEEPPPKDHPLIHHPRVVHTAHLGANTLEAQERVGEAILERVVRTLEGDLSYALNTGFDPEALEAL
KGFLPLGEALGKLLAQITRGRPEALEVRFLGQFEKDPEPIASAVAKGLLARVLGEGAVNLVSARPLLKDRGIHLTTLRSE
EAGEYTRLVEARLSTDQEERRARGVVIGGRPRLVGIDDYALEVVPEGYMLVCVNYDRPGVVGQVGTLLGEAGVNIAGMQL
GRDVPGGRALFVLTVDQKPSPEVLEALRALPVLERVDLVEL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=424, Percent_Identity=40.0943396226415, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI145580578, Length=271, Percent_Identity=35.0553505535055, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4557499, Length=271, Percent_Identity=35.0553505535055, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI61743967, Length=286, Percent_Identity=32.8671328671329, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4557497, Length=286, Percent_Identity=32.8671328671329, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI145580575, Length=271, Percent_Identity=35.0553505535055, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI6912396, Length=238, Percent_Identity=32.7731092436975, Blast_Score=117, Evalue=4e-26,
Organism=Escherichia coli, GI1789279, Length=329, Percent_Identity=32.8267477203647, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082289, Length=261, Percent_Identity=32.9501915708812, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1787645, Length=264, Percent_Identity=31.8181818181818, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788660, Length=276, Percent_Identity=29.3478260869565, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI87081824, Length=253, Percent_Identity=30.8300395256917, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=312, Percent_Identity=41.6666666666667, Blast_Score=240, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI25147481, Length=281, Percent_Identity=28.4697508896797, Blast_Score=122, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=279, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322116, Length=279, Percent_Identity=32.6164874551971, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6324055, Length=257, Percent_Identity=30.7392996108949, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=283, Percent_Identity=30.0353356890459, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324980, Length=179, Percent_Identity=30.1675977653631, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=174, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=42.3841059602649, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI62472511, Length=216, Percent_Identity=38.4259259259259, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646446, Length=278, Percent_Identity=35.2517985611511, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24646448, Length=278, Percent_Identity=35.2517985611511, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24646452, Length=278, Percent_Identity=35.2517985611511, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24646450, Length=278, Percent_Identity=35.2517985611511, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI28574286, Length=285, Percent_Identity=32.280701754386, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24585516, Length=279, Percent_Identity=28.673835125448, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28571528, Length=281, Percent_Identity=30.2491103202847, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28574284, Length=284, Percent_Identity=29.9295774647887, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24585514, Length=284, Percent_Identity=29.9295774647887, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI28574282, Length=284, Percent_Identity=29.9295774647887, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45551003, Length=284, Percent_Identity=29.9295774647887, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI45552429, Length=284, Percent_Identity=29.9295774647887, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56847; Mature: 56847

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWRVLVSDDMRLGEVRYPGVILDYRPGIGREELLEIIPAYDALITRSRTRVDAELLQRGK
CEEEEECCCCCCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHCCHHHHHCCC
RLKVVGRGGVGVDNVDLEAASRLGILVVNVPEANTRSAAELAFGLLLAAARGIALSDRKL
EEEEEECCCCCCCCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCHH
RQGEWDRKFLGLELKGKTLGIVGLGRIGSQVARFAKGFEMRVLAYDPYIPKARAESLGVE
HCCCCCCEEEEEEECCCEEEEEECHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHH
LLENLEDLLRQSHFLTVHTPLTEETRGMIGRRELYLLPRGAVVVNAARGGIIDEKALLEV
HHHHHHHHHHCCCEEEEECCCCHHHHCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHH
LEEGHLFAVGLDVFAEEPPPKDHPLIHHPRVVHTAHLGANTLEAQERVGEAILERVVRTL
HHCCCEEEEEEEHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
EGDLSYALNTGFDPEALEALKGFLPLGEALGKLLAQITRGRPEALEVRFLGQFEKDPEPI
CCCHHEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
ASAVAKGLLARVLGEGAVNLVSARPLLKDRGIHLTTLRSEEAGEYTRLVEARLSTDQEER
HHHHHHHHHHHHHCCCCCEEHHCCCHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHH
RARGVVIGGRPRLVGIDDYALEVVPEGYMLVCVNYDRPGVVGQVGTLLGEAGVNIAGMQL
HHCCEEECCCCCEEECCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEHHH
GRDVPGGRALFVLTVDQKPSPEVLEALRALPVLERVDLVEL
CCCCCCCCEEEEEEECCCCCHHHHHHHHHCHHHHHCCHHCC
>Mature Secondary Structure
MWRVLVSDDMRLGEVRYPGVILDYRPGIGREELLEIIPAYDALITRSRTRVDAELLQRGK
CEEEEECCCCCCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHCCHHHHHCCC
RLKVVGRGGVGVDNVDLEAASRLGILVVNVPEANTRSAAELAFGLLLAAARGIALSDRKL
EEEEEECCCCCCCCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCHH
RQGEWDRKFLGLELKGKTLGIVGLGRIGSQVARFAKGFEMRVLAYDPYIPKARAESLGVE
HCCCCCCEEEEEEECCCEEEEEECHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHH
LLENLEDLLRQSHFLTVHTPLTEETRGMIGRRELYLLPRGAVVVNAARGGIIDEKALLEV
HHHHHHHHHHCCCEEEEECCCCHHHHCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHH
LEEGHLFAVGLDVFAEEPPPKDHPLIHHPRVVHTAHLGANTLEAQERVGEAILERVVRTL
HHCCCEEEEEEEHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
EGDLSYALNTGFDPEALEALKGFLPLGEALGKLLAQITRGRPEALEVRFLGQFEKDPEPI
CCCHHEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
ASAVAKGLLARVLGEGAVNLVSARPLLKDRGIHLTTLRSEEAGEYTRLVEARLSTDQEER
HHHHHHHHHHHHHCCCCCEEHHCCCHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHH
RARGVVIGGRPRLVGIDDYALEVVPEGYMLVCVNYDRPGVVGQVGTLLGEAGVNIAGMQL
HHCCEEECCCCCEEECCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEHHH
GRDVPGGRALFVLTVDQKPSPEVLEALRALPVLERVDLVEL
CCCCCCCCEEEEEEECCCCCHHHHHHHHHCHHHHHCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]