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The map label for this gene is purD [H]

Identifier: 55980781

GI number: 55980781

Start: 774831

End: 776084

Strand: Direct

Name: purD [H]

Synonym: TTHA0812

Alternate gene names: 55980781

Gene position: 774831-776084 (Clockwise)

Preceding gene: 55980780

Following gene: 55980797

Centisome position: 41.89

GC content: 72.01

Gene sequence:

>1254_bases
ATGAAGGTCCTCGTGGTGGGCAGCGGGGGGCGGGAGCACGCCCTCCTTTGGAAGGCGGCCCAAAGCCCAAGGGTGAAGCG
GCTTTACGCCGCCCCCGGAAACGCCGGGATGGAGGCCCTGGCCGAGCTCGTCCCCTGGAACGGCGACGTGGAGGCCCTGG
CGGACTGGGCCCTGGCCGAGGGCATAGACCTCACCCTGGTGGGCCCGGAGGCCCCCCTGGTGGAGGGGATCGCCGACGCC
TTCCAGGCCCGGGGGCTATTGCTCTTCGGCCCCACGCAGAAGGCGGCCATGATTGAGGGCTCCAAGGCCTTCGCCAAGGG
CCTGATGGAGCGCTACGGCATCCCCACGGCCCGCTACCGGGTCTTCCGGGAGCCCCTGGAGGCCCTGGCGTACCTGGAGG
AGGTGGGGGTGCCCGTGGTGGTCAAGGACTCGGGGCTTGCCGCGGGAAAGGGGGTCACGGTGGCCTTTGACCTGCACCAG
GCCAAGCAGGCCGTGGCCAACATCCTGAACCGGGCCGAGGGGGGGGAGGTGGTCGTAGAGGAGTACCTGGAGGGGGAGGA
GGCCACGGTCCTCGCCCTCACCGACGGCGAGACGATCCTCCCCCTCCTCCCTTCCCAGGACCACAAGCGCCTTTTGGACG
GGGACCAGGGCCCCATGACGGGGGGGATGGGGGCCGTGGCCCCTTACCCCATGGACGAGGCCACCCTGAGGCGGGTGGAG
GAGGAGATCCTCGGGCCCCTCGTCCGGGGCCTCCGGGCGGAGGGGGTGGTCTACCGGGGGGTGGTCTACGCCGGCCTCAT
GCTCACCCGGGAGGGCCCCAAGGTCCTGGAGTTCAACGCCCGCTTCGGCGACCCCGAGGCCCAGGCGCTCCTGCCCCTTT
TGGAGAACGACCTGGTGGAGCTCGCCCTGAGGGTGGCCGAGGGGAGGCTTGCGGGGACGAGGCTTTCCTGGAAGGAGGGG
GCGGCCGCCTGCGTGGTCCTCGCCGCCCCAGGCTACCCCGAAAGCCCCAGGAAGGGGATCCCCCTCCACGTCCCCGAGCC
CCCGGAGGGGGTCTTGGTCTTCCACGCGGGGACGCGGCGGGAAGGGGGGCGCCTGGTGAGCGCCGGGGGGCGGGTCTTGA
ACGTGGTGGGCCTGGGGAGGGACCTCAAGGAGGCCCTGGAGCGGGCCTACGCCTACATCCCCCAGGTGGGCTTCCCCGGG
GCGGTGTACCGGAGGGACATCGGCCGAAGGGCCCTCGCCCGGCTCAGTACCTGA

Upstream 100 bases:

>100_bases
TCCTCGCCGAGCCCAGCCCCGTCCTCCTGGAGGAGGTGGCGGGGCTTCCCGGGGAGGTCCGGGCCCGGGTGGAGGAGGCG
TTGCGGGTAGAATCCTCACC

Downstream 100 bases:

>100_bases
GCCGGGCCAAGGGGAGGCGGCGGCAGGCTTCCACCACGTCCCATAGCCGCTTAAGCCCCCGCTCAAAGAGGAGGGGCTGC
ATTCTCACGAAGACCTCCGC

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKVLVVGSGGREHALLWKAAQSPRVKRLYAAPGNAGMEALAELVPWNGDVEALADWALAEGIDLTLVGPEAPLVEGIADA
FQARGLLLFGPTQKAAMIEGSKAFAKGLMERYGIPTARYRVFREPLEALAYLEEVGVPVVVKDSGLAAGKGVTVAFDLHQ
AKQAVANILNRAEGGEVVVEEYLEGEEATVLALTDGETILPLLPSQDHKRLLDGDQGPMTGGMGAVAPYPMDEATLRRVE
EEILGPLVRGLRAEGVVYRGVVYAGLMLTREGPKVLEFNARFGDPEAQALLPLLENDLVELALRVAEGRLAGTRLSWKEG
AAACVVLAAPGYPESPRKGIPLHVPEPPEGVLVFHAGTRREGGRLVSAGGRVLNVVGLGRDLKEALERAYAYIPQVGFPG
AVYRRDIGRRALARLST

Sequences:

>Translated_417_residues
MKVLVVGSGGREHALLWKAAQSPRVKRLYAAPGNAGMEALAELVPWNGDVEALADWALAEGIDLTLVGPEAPLVEGIADA
FQARGLLLFGPTQKAAMIEGSKAFAKGLMERYGIPTARYRVFREPLEALAYLEEVGVPVVVKDSGLAAGKGVTVAFDLHQ
AKQAVANILNRAEGGEVVVEEYLEGEEATVLALTDGETILPLLPSQDHKRLLDGDQGPMTGGMGAVAPYPMDEATLRRVE
EEILGPLVRGLRAEGVVYRGVVYAGLMLTREGPKVLEFNARFGDPEAQALLPLLENDLVELALRVAEGRLAGTRLSWKEG
AAACVVLAAPGYPESPRKGIPLHVPEPPEGVLVFHAGTRREGGRLVSAGGRVLNVVGLGRDLKEALERAYAYIPQVGFPG
AVYRRDIGRRALARLST
>Mature_417_residues
MKVLVVGSGGREHALLWKAAQSPRVKRLYAAPGNAGMEALAELVPWNGDVEALADWALAEGIDLTLVGPEAPLVEGIADA
FQARGLLLFGPTQKAAMIEGSKAFAKGLMERYGIPTARYRVFREPLEALAYLEEVGVPVVVKDSGLAAGKGVTVAFDLHQ
AKQAVANILNRAEGGEVVVEEYLEGEEATVLALTDGETILPLLPSQDHKRLLDGDQGPMTGGMGAVAPYPMDEATLRRVE
EEILGPLVRGLRAEGVVYRGVVYAGLMLTREGPKVLEFNARFGDPEAQALLPLLENDLVELALRVAEGRLAGTRLSWKEG
AAACVVLAAPGYPESPRKGIPLHVPEPPEGVLVFHAGTRREGGRLVSAGGRVLNVVGLGRDLKEALERAYAYIPQVGFPG
AVYRRDIGRRALARLST

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=426, Percent_Identity=46.4788732394366, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI209869995, Length=426, Percent_Identity=46.4788732394366, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI209869993, Length=426, Percent_Identity=46.4788732394366, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI28416899, Length=426, Percent_Identity=46.4788732394366, Blast_Score=360, Evalue=1e-99,
Organism=Escherichia coli, GI1790438, Length=426, Percent_Identity=50, Blast_Score=381, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17567511, Length=420, Percent_Identity=41.4285714285714, Blast_Score=294, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6321203, Length=439, Percent_Identity=39.4077448747153, Blast_Score=312, Evalue=8e-86,
Organism=Drosophila melanogaster, GI62471619, Length=431, Percent_Identity=45.2436194895592, Blast_Score=320, Evalue=8e-88,
Organism=Drosophila melanogaster, GI24582400, Length=431, Percent_Identity=45.2436194895592, Blast_Score=319, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 44463; Mature: 44463

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVVGSGGREHALLWKAAQSPRVKRLYAAPGNAGMEALAELVPWNGDVEALADWALAE
CEEEEEECCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHC
GIDLTLVGPEAPLVEGIADAFQARGLLLFGPTQKAAMIEGSKAFAKGLMERYGIPTARYR
CCEEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCEEECCHHHHHHHHHHHHCCCHHHHH
VFREPLEALAYLEEVGVPVVVKDSGLAAGKGVTVAFDLHQAKQAVANILNRAEGGEVVVE
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCHHH
EYLEGEEATVLALTDGETILPLLPSQDHKRLLDGDQGPMTGGMGAVAPYPMDEATLRRVE
HHHCCCCEEEEEEECCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
EEILGPLVRGLRAEGVVYRGVVYAGLMLTREGPKVLEFNARFGDPEAQALLPLLENDLVE
HHHHHHHHHHHHHCCEEEHHHHHHCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
LALRVAEGRLAGTRLSWKEGAAACVVLAAPGYPESPRKGIPLHVPEPPEGVLVFHAGTRR
HHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEECCCCCCCEEEEECCCCC
EGGRLVSAGGRVLNVVGLGRDLKEALERAYAYIPQVGFPGAVYRRDIGRRALARLST
CCCEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVLVVGSGGREHALLWKAAQSPRVKRLYAAPGNAGMEALAELVPWNGDVEALADWALAE
CEEEEEECCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHC
GIDLTLVGPEAPLVEGIADAFQARGLLLFGPTQKAAMIEGSKAFAKGLMERYGIPTARYR
CCEEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCEEECCHHHHHHHHHHHHCCCHHHHH
VFREPLEALAYLEEVGVPVVVKDSGLAAGKGVTVAFDLHQAKQAVANILNRAEGGEVVVE
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCHHH
EYLEGEEATVLALTDGETILPLLPSQDHKRLLDGDQGPMTGGMGAVAPYPMDEATLRRVE
HHHCCCCEEEEEEECCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
EEILGPLVRGLRAEGVVYRGVVYAGLMLTREGPKVLEFNARFGDPEAQALLPLLENDLVE
HHHHHHHHHHHHHCCEEEHHHHHHCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
LALRVAEGRLAGTRLSWKEGAAACVVLAAPGYPESPRKGIPLHVPEPPEGVLVFHAGTRR
HHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEECCCCCCCEEEEECCCCC
EGGRLVSAGGRVLNVVGLGRDLKEALERAYAYIPQVGFPGAVYRRDIGRRALARLST
CCCEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]