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The map label for this gene is pyrD [H]

Identifier: 55980748

GI number: 55980748

Start: 747888

End: 748928

Strand: Direct

Name: pyrD [H]

Synonym: TTHA0779

Alternate gene names: 55980748

Gene position: 747888-748928 (Clockwise)

Preceding gene: 55980746

Following gene: 55980760

Centisome position: 40.43

GC content: 69.45

Gene sequence:

>1041_bases
ATGCACCGCTTCCTCTTCGCCCTGGACCCCGAGGCCGCCCACGGGCTCGCCTTGGGGCTTCTCGCCTTATGGTCGGAAAG
GGGGCCCTTGCTGGAGGTTCCCGCGAGGCTTCTTCGGGTGGAGGACCCCCGCTTAAGGGTGGAGGCCTTTGGGGTCTCCT
TTCCCAACCCCTTGGGCCTTGCCGCGGGGATGGACAAGGACGCGAGGGCCCTAGGGGCCTGGTGGGCCTTGGGCTTCGGC
TTCGCCGAGGTGGGGACCCTCACCCCGAGGCCCCAGGTGGGAAACCCAAAGCCGAGGCTTTTCCGCCTGGTGGAAGACCG
CGCCCTCATCAACCGCATGGGCTTCAACAACCGGGGGGCGGAGGAGGCCGCCAGGCGCCTAAAGCGCTCCCGCCAGAGGG
GGCTTCCCCTGCCCATTGGGGTCAACCTGGGGAAGAACCGGGACACGCCCTTGGGGCGGGCGGCGGAGGACTACCTAAAG
GCCCTCCGCCTCCTGGAGCCTTTTGGGGACTACTTCGTCTTGAACGTGAGCTCCCCCAACACCCCGGGCCTTCGCGCCCT
CCAGGAAGGCCCCTTCCTGGACGAGCTCCTCGCCCGCCTTCGCCCGGCCACAAAGAAGCCCCTCCTCCTCAAGGTGGCCC
CGGACCTCTCCCCGAAGGCCTTGGACGAGGTCCTCGCCCTGGCCAAGAAGCACCGCCTCCAGGGCCTGGTGGCGGTGAAC
ACCACCCTTGCCCGGGAGGGCCTAAAAAGCCCCTGGGCTAAGGAGGCCGGGGGGCTTTCGGGAAGGCCCCTGAAGGGGAG
GGCCTTGGAGGTCCTCCGCCACCTGGCGGAGGGCGCGGAGGGGCTTGCCCTGGTGAGCGTGGGGGGCGTGGAGACCCCTC
TGGACCTCTGGGAGAGGCTCAAGGCCGGGGCGAGCCTGGTCCAGGTCTACACGGGCTTCGTCTACGGGGGGCCCCTCTTC
CCCAGGAGGCTCCTCCTGGGGCTTCTCCGCCTTATGGAGGCCGAGGGGGTTTCCTCCCTGGGGGAGCTTCGCCGCGCGTG
A

Upstream 100 bases:

>100_bases
GAGCCCAGGTCCAGGGTGAGGGTGGCGGAGCAGGCGGCGAGGAAGAGGGCCAGGAGAAAAGGCGGGCGGCGCACGAAGGG
GAGTCTATCATGGGTGGGGG

Downstream 100 bases:

>100_bases
GTCCGGGGAAAGGGCCTTCACCGGGGCCTCCAGGCTGGCGAAGCCAGCATGGGGTTCAGACGGTGAGGAGGCAGCCCGCC
TCGAGCTCCAGTTCCACAGG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MHRFLFALDPEAAHGLALGLLALWSERGPLLEVPARLLRVEDPRLRVEAFGVSFPNPLGLAAGMDKDARALGAWWALGFG
FAEVGTLTPRPQVGNPKPRLFRLVEDRALINRMGFNNRGAEEAARRLKRSRQRGLPLPIGVNLGKNRDTPLGRAAEDYLK
ALRLLEPFGDYFVLNVSSPNTPGLRALQEGPFLDELLARLRPATKKPLLLKVAPDLSPKALDEVLALAKKHRLQGLVAVN
TTLAREGLKSPWAKEAGGLSGRPLKGRALEVLRHLAEGAEGLALVSVGGVETPLDLWERLKAGASLVQVYTGFVYGGPLF
PRRLLLGLLRLMEAEGVSSLGELRRA

Sequences:

>Translated_346_residues
MHRFLFALDPEAAHGLALGLLALWSERGPLLEVPARLLRVEDPRLRVEAFGVSFPNPLGLAAGMDKDARALGAWWALGFG
FAEVGTLTPRPQVGNPKPRLFRLVEDRALINRMGFNNRGAEEAARRLKRSRQRGLPLPIGVNLGKNRDTPLGRAAEDYLK
ALRLLEPFGDYFVLNVSSPNTPGLRALQEGPFLDELLARLRPATKKPLLLKVAPDLSPKALDEVLALAKKHRLQGLVAVN
TTLAREGLKSPWAKEAGGLSGRPLKGRALEVLRHLAEGAEGLALVSVGGVETPLDLWERLKAGASLVQVYTGFVYGGPLF
PRRLLLGLLRLMEAEGVSSLGELRRA
>Mature_346_residues
MHRFLFALDPEAAHGLALGLLALWSERGPLLEVPARLLRVEDPRLRVEAFGVSFPNPLGLAAGMDKDARALGAWWALGFG
FAEVGTLTPRPQVGNPKPRLFRLVEDRALINRMGFNNRGAEEAARRLKRSRQRGLPLPIGVNLGKNRDTPLGRAAEDYLK
ALRLLEPFGDYFVLNVSSPNTPGLRALQEGPFLDELLARLRPATKKPLLLKVAPDLSPKALDEVLALAKKHRLQGLVAVN
TTLAREGLKSPWAKEAGGLSGRPLKGRALEVLRHLAEGAEGLALVSVGGVETPLDLWERLKAGASLVQVYTGFVYGGPLF
PRRLLLGLLRLMEAEGVSSLGELRRA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=325, Percent_Identity=41.2307692307692, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1787177, Length=331, Percent_Identity=42.2960725075529, Blast_Score=259, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17509475, Length=319, Percent_Identity=41.0658307210031, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI281361352, Length=322, Percent_Identity=42.2360248447205, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17137316, Length=322, Percent_Identity=42.2360248447205, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37663; Mature: 37663

Theoretical pI: Translated: 10.93; Mature: 10.93

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRFLFALDPEAAHGLALGLLALWSERGPLLEVPARLLRVEDPRLRVEAFGVSFPNPLGL
CCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCH
AAGMDKDARALGAWWALGFGFAEVGTLTPRPQVGNPKPRLFRLVEDRALINRMGFNNRGA
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
EEAARRLKRSRQRGLPLPIGVNLGKNRDTPLGRAAEDYLKALRLLEPFGDYFVLNVSSPN
HHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
TPGLRALQEGPFLDELLARLRPATKKPLLLKVAPDLSPKALDEVLALAKKHRLQGLVAVN
CCCHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
TTLAREGLKSPWAKEAGGLSGRPLKGRALEVLRHLAEGAEGLALVSVGGVETPLDLWERL
HHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHH
KAGASLVQVYTGFVYGGPLFPRRLLLGLLRLMEAEGVSSLGELRRA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MHRFLFALDPEAAHGLALGLLALWSERGPLLEVPARLLRVEDPRLRVEAFGVSFPNPLGL
CCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCH
AAGMDKDARALGAWWALGFGFAEVGTLTPRPQVGNPKPRLFRLVEDRALINRMGFNNRGA
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
EEAARRLKRSRQRGLPLPIGVNLGKNRDTPLGRAAEDYLKALRLLEPFGDYFVLNVSSPN
HHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
TPGLRALQEGPFLDELLARLRPATKKPLLLKVAPDLSPKALDEVLALAKKHRLQGLVAVN
CCCHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
TTLAREGLKSPWAKEAGGLSGRPLKGRALEVLRHLAEGAEGLALVSVGGVETPLDLWERL
HHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHH
KAGASLVQVYTGFVYGGPLFPRRLLLGLLRLMEAEGVSSLGELRRA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA