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The map label for this gene is infB

Identifier: 55980668

GI number: 55980668

Start: 662361

End: 664076

Strand: Reverse

Name: infB

Synonym: TTHA0699

Alternate gene names: 55980668

Gene position: 664076-662361 (Counterclockwise)

Preceding gene: 55980669

Following gene: 55980667

Centisome position: 35.9

GC content: 68.18

Gene sequence:

>1716_bases
ATGGCCAAGGTAAGGATCTACCAGCTGGCTAAGGAGCTGGGCATGGAAACCCAGGAGCTTTTGGAGCTCCTGGACCAGAT
GGGGGTGGCCTACAAGTCCCACGCCTCCACCCTGGAGGAGAAGGACGCGGAGGCGGTGCGGGAGCTCGTGAAGGAGCAGC
GGGGACTTCAGGAGAAGCTCGCCGAGGAGGAGCGCCGCAAGAGCCTCCCCCGGCGCCCCCCCGTGGTGGTCATCATGGGC
CACGTGGACCACGGGAAGACGACCCTCCTGGACTACCTCCGCAAAAGCCGCATCGCCGAGAAGGAGGCCGGGGGGATCAC
CCAGCACGTGGGCGCCTTTGAGGTGAAGACGCCCCAGGGCACCGTGGTCTTCATTGACACGCCGGGGCACGAGGCCTTCA
CCACCATCCGGCAGCGCGGGGCCAAGGTGGCGGACATCGCCGTCATCGTCATCGCCGCCGACGACGGCATCATGCCCCAG
ACGGAGGAGGCCATCGCCCACGCCAAGGCCGCGGGGGCCAAGCTCATCTTTGCCATCAACAAGATTGACCTGCCCCAGGC
GGACCCCGAGAAGGTGAAGCGGCAGCTCATGGAGCGGGGCTTCGTCCCCGAGGAGTACGGCGGCGACGCCATCGTCATCC
CCATCAGCGCCAAGACGGGGCAGGGGGTCCAGGACCTCCTGGAGATGATCCTCCTCCTCGCCGAGCTGGAGGACTACCGG
GCCGACCCCAACGCCGAGCCCCGGGGGGTGATCCTGGAGTCCAAGCTGGACAAGCAGGCGGGCATCATCGCCAACATGCT
CGTCCAGGAGGGGACCTTCCGGGTGGGGGACTATGTGGTGGCCGGGGAGGCCTACGGCCGCATCCGCGCCATGATGGACG
CCGACGGCAACCAGCGCAAGGAGGCGGGGCCGGGAAGCGCCGTCCAGGTTTTGGGCTTCCAGGAGCTCCCCCACGCCGGG
GACGTGGTGGAGTGGGTGCCGGACCTCGAGGCCGCCAAGGAGATCGCCGAGGAGCGCAAGGAGGAGAGGAAGGCGCGGGA
GGAGGAGGAGAAGGCCCGCCGCCCCCGGACCATGGCCGAGCTCCTCCGGGCCATGCAGGAGGAGGGGAGGAAGGAGCTCA
ACCTCATCCTCCGGGCCGACACCCAGGGCTCCCTCGAGGCCATCCAGCACATCCTGGCCCGGGAGAGCACCGAGGACGTG
AAGATCAACATCCTCCTCGCCCAGGTGGGCGCCCCCACGGAGTCCGACGTCCTCCTCGCCCAGACGGCGAACGCGGCCAT
CCTGGCCTTCGGCGTGAACCCGCCGGGCTCGGTGAAGAAGAAGGCGGAGGAGAAGGGCGTCCTCCTCAAGACCTTCCGCA
TCATCTACGACCTGGTGGACGAGGTCCGCAACATGGTCAAGGGGCAGAGGGAGCCCCAGTACAAGGAGGAGGTCCTGGGC
CAGGCCGAGGTGCGGGCCATCTTCCGCCTTCCCACGGGCAAGCAGGTGGCGGGGTGCATGGTCACCCAGGGCCGGATCCC
GCGGAACGCCGAGGTGCGGGTCCTGAGGGACGGCCAGGTGATCTGGCAAGGGCGCATCGCCAGCCTCAAGCGCTTCAAGG
AGGACGTGCGCGAGGTGGCCCAGGGCTACGAGTGCGGCATCGGCCTGGACGGGTTTGACGACTTCCGGGAAGGGGACGTG
ATCGAGGCCTTCCAGATGGTGGAGGTCCCCGCCTAA

Upstream 100 bases:

>100_bases
GACAGCCCCGAGTGCCGCTCGGAAAAGCGGCTCCGGCGCTTCGCCGGGGCCAAGGCCAGGGCCTTGGCCGAGGCCCTGGC
CGCTTATCTAGGAGGTGAGG

Downstream 100 bases:

>100_bases
GGCCATGCTCCGCCTCCTGGCCCTCCTCGCCCTTTGCCTCTACGGGGCCGAGCGCCTCCCAGAGGCCCCCAAGGGCGCGG
AGGGCCTCTTCGCCCCGGGG

Product: translation initiation factor IF-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MAKVRIYQLAKELGMETQELLELLDQMGVAYKSHASTLEEKDAEAVRELVKEQRGLQEKLAEEERRKSLPRRPPVVVIMG
HVDHGKTTLLDYLRKSRIAEKEAGGITQHVGAFEVKTPQGTVVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQ
TEEAIAHAKAAGAKLIFAINKIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGVQDLLEMILLLAELEDYR
ADPNAEPRGVILESKLDKQAGIIANMLVQEGTFRVGDYVVAGEAYGRIRAMMDADGNQRKEAGPGSAVQVLGFQELPHAG
DVVEWVPDLEAAKEIAEERKEERKAREEEEKARRPRTMAELLRAMQEEGRKELNLILRADTQGSLEAIQHILARESTEDV
KINILLAQVGAPTESDVLLAQTANAAILAFGVNPPGSVKKKAEEKGVLLKTFRIIYDLVDEVRNMVKGQREPQYKEEVLG
QAEVRAIFRLPTGKQVAGCMVTQGRIPRNAEVRVLRDGQVIWQGRIASLKRFKEDVREVAQGYECGIGLDGFDDFREGDV
IEAFQMVEVPA

Sequences:

>Translated_571_residues
MAKVRIYQLAKELGMETQELLELLDQMGVAYKSHASTLEEKDAEAVRELVKEQRGLQEKLAEEERRKSLPRRPPVVVIMG
HVDHGKTTLLDYLRKSRIAEKEAGGITQHVGAFEVKTPQGTVVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQ
TEEAIAHAKAAGAKLIFAINKIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGVQDLLEMILLLAELEDYR
ADPNAEPRGVILESKLDKQAGIIANMLVQEGTFRVGDYVVAGEAYGRIRAMMDADGNQRKEAGPGSAVQVLGFQELPHAG
DVVEWVPDLEAAKEIAEERKEERKAREEEEKARRPRTMAELLRAMQEEGRKELNLILRADTQGSLEAIQHILARESTEDV
KINILLAQVGAPTESDVLLAQTANAAILAFGVNPPGSVKKKAEEKGVLLKTFRIIYDLVDEVRNMVKGQREPQYKEEVLG
QAEVRAIFRLPTGKQVAGCMVTQGRIPRNAEVRVLRDGQVIWQGRIASLKRFKEDVREVAQGYECGIGLDGFDDFREGDV
IEAFQMVEVPA
>Mature_570_residues
AKVRIYQLAKELGMETQELLELLDQMGVAYKSHASTLEEKDAEAVRELVKEQRGLQEKLAEEERRKSLPRRPPVVVIMGH
VDHGKTTLLDYLRKSRIAEKEAGGITQHVGAFEVKTPQGTVVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQT
EEAIAHAKAAGAKLIFAINKIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGVQDLLEMILLLAELEDYRA
DPNAEPRGVILESKLDKQAGIIANMLVQEGTFRVGDYVVAGEAYGRIRAMMDADGNQRKEAGPGSAVQVLGFQELPHAGD
VVEWVPDLEAAKEIAEERKEERKAREEEEKARRPRTMAELLRAMQEEGRKELNLILRADTQGSLEAIQHILARESTEDVK
INILLAQVGAPTESDVLLAQTANAAILAFGVNPPGSVKKKAEEKGVLLKTFRIIYDLVDEVRNMVKGQREPQYKEEVLGQ
AEVRAIFRLPTGKQVAGCMVTQGRIPRNAEVRVLRDGQVIWQGRIASLKRFKEDVREVAQGYECGIGLDGFDDFREGDVI
EAFQMVEVPA

Specific function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 7

COG id: COG0532

COG function: function code J; Translation initiation factor 2 (IF-2; GTPase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IF-2 family

Homologues:

Organism=Homo sapiens, GI53729339, Length=544, Percent_Identity=37.5, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI53729337, Length=544, Percent_Identity=37.5, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI84043963, Length=474, Percent_Identity=26.7932489451477, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI157426893, Length=227, Percent_Identity=29.5154185022026, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1789559, Length=499, Percent_Identity=47.0941883767535, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI2367247, Length=226, Percent_Identity=33.1858407079646, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788922, Length=235, Percent_Identity=30.6382978723404, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI48994988, Length=280, Percent_Identity=28.9285714285714, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790412, Length=123, Percent_Identity=35.7723577235772, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1789737, Length=123, Percent_Identity=35.7723577235772, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71994658, Length=555, Percent_Identity=35.3153153153153, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI212656558, Length=565, Percent_Identity=25.8407079646018, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17557151, Length=218, Percent_Identity=33.0275229357798, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25141371, Length=193, Percent_Identity=32.1243523316062, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324550, Length=537, Percent_Identity=39.1061452513966, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319282, Length=461, Percent_Identity=26.6811279826464, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6323320, Length=232, Percent_Identity=31.0344827586207, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324761, Length=167, Percent_Identity=35.3293413173653, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28572034, Length=528, Percent_Identity=39.0151515151515, Blast_Score=345, Evalue=6e-95,
Organism=Drosophila melanogaster, GI24656849, Length=534, Percent_Identity=27.9026217228464, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI160714833, Length=70, Percent_Identity=65.7142857142857, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI78706572, Length=214, Percent_Identity=29.4392523364486, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19921738, Length=154, Percent_Identity=34.4155844155844, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363316, Length=154, Percent_Identity=35.0649350649351, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17864358, Length=154, Percent_Identity=35.0649350649351, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 1150 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): IF2_THET2 (Q72KE8)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_004322.1
- ProteinModelPortal:   Q72KE8
- STRING:   Q72KE8
- GeneID:   2776475
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0532
- HOGENOM:   HBG635083
- OMA:   QYGRIRS
- BioCyc:   TTHE262724:TT_C0347-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00100_B
- InterPro:   IPR006847
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000178
- InterPro:   IPR015760
- InterPro:   IPR023115
- InterPro:   IPR004161
- InterPro:   IPR009000
- Gene3D:   G3DSA:3.40.50.10050
- PANTHER:   PTHR23115:SF41
- TIGRFAMs:   TIGR00487
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF11987 IF-2; PF04760 IF2_N; SSF52156 TIF_IF2_dom3; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 63179; Mature: 63048

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS01176 IF2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVRIYQLAKELGMETQELLELLDQMGVAYKSHASTLEEKDAEAVRELVKEQRGLQEKL
CCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
AEEERRKSLPRRPPVVVIMGHVDHGKTTLLDYLRKSRIAEKEAGGITQHVGAFEVKTPQG
HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCC
TVVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQTEEAIAHAKAAGAKLIFAIN
EEEEEECCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEE
KIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGVQDLLEMILLLAELEDYR
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
ADPNAEPRGVILESKLDKQAGIIANMLVQEGTFRVGDYVVAGEAYGRIRAMMDADGNQRK
CCCCCCCCCEEECCHHCHHHHHHHHHHHHCCCEEECCEEEECCHHHHHHHHHCCCCCCCC
EAGPGSAVQVLGFQELPHAGDVVEWVPDLEAAKEIAEERKEERKAREEEEKARRPRTMAE
CCCCCCCEEEECHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LLRAMQEEGRKELNLILRADTQGSLEAIQHILARESTEDVKINILLAQVGAPTESDVLLA
HHHHHHHCCHHHEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCEEEE
QTANAAILAFGVNPPGSVKKKAEEKGVLLKTFRIIYDLVDEVRNMVKGQREPQYKEEVLG
ECCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCC
QAEVRAIFRLPTGKQVAGCMVTQGRIPRNAEVRVLRDGQVIWQGRIASLKRFKEDVREVA
HHHHHHHEECCCCCHHHCEEEECCCCCCCCCEEEEECCCEEECHHHHHHHHHHHHHHHHH
QGYECGIGLDGFDDFREGDVIEAFQMVEVPA
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
AKVRIYQLAKELGMETQELLELLDQMGVAYKSHASTLEEKDAEAVRELVKEQRGLQEKL
CCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
AEEERRKSLPRRPPVVVIMGHVDHGKTTLLDYLRKSRIAEKEAGGITQHVGAFEVKTPQG
HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCC
TVVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQTEEAIAHAKAAGAKLIFAIN
EEEEEECCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEE
KIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGVQDLLEMILLLAELEDYR
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
ADPNAEPRGVILESKLDKQAGIIANMLVQEGTFRVGDYVVAGEAYGRIRAMMDADGNQRK
CCCCCCCCCEEECCHHCHHHHHHHHHHHHCCCEEECCEEEECCHHHHHHHHHCCCCCCCC
EAGPGSAVQVLGFQELPHAGDVVEWVPDLEAAKEIAEERKEERKAREEEEKARRPRTMAE
CCCCCCCEEEECHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LLRAMQEEGRKELNLILRADTQGSLEAIQHILARESTEDVKINILLAQVGAPTESDVLLA
HHHHHHHCCHHHEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCEEEE
QTANAAILAFGVNPPGSVKKKAEEKGVLLKTFRIIYDLVDEVRNMVKGQREPQYKEEVLG
ECCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCC
QAEVRAIFRLPTGKQVAGCMVTQGRIPRNAEVRVLRDGQVIWQGRIASLKRFKEDVREVA
HHHHHHHEECCCCCHHHCEEEECCCCCCCCCEEEEECCCEEECHHHHHHHHHHHHHHHHH
QGYECGIGLDGFDDFREGDVIEAFQMVEVPA
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA