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The map label for this gene is fadA [H]

Identifier: 55980659

GI number: 55980659

Start: 653261

End: 654415

Strand: Direct

Name: fadA [H]

Synonym: TTHA0690

Alternate gene names: 55980659

Gene position: 653261-654415 (Clockwise)

Preceding gene: 55980649

Following gene: 55980660

Centisome position: 35.32

GC content: 69.44

Gene sequence:

>1155_bases
ATGGGAGAGCCGGTGATCCTCGAGGCGGTGCGCACGCCCATCGGCAAGCGGAACGGGGCCCTGAGGGCCTACAGGCCCGA
TGCCCTCTACGCCAAGGTCCTGGACGCCCTCTTGGAGCGGACGGGCATAGACCCCGGCCTCATCGGGGACGTGGTCACGG
GGTGCGTGACCCAGGTGGGGGAGCAGGGGGCGAACGTGGGGCGGCTTGGGGTGCTCCTCTCCAGGCTTCCCAAGGAGGTC
CCCGCGGTGAGCTTGAACCGCATGTGCGGCTCCAGCCAGCAGGCCGTCCACTTCGCCGCCCAGGCCATCGCCGCAGGGGA
TGTGGACTTCGCCATCGCCGGCGGGGTGGAGAGCATGACCCGGGTGCCCATGTTCGCGGACATCGGCGGGGGCTTCCACA
CCCTGAACCCCGAGCTTGGGAAGAGGTACGAGCTCGTCCACCAGGGGGAAAGCGCCGAGCGGATCGCTGAGCGCTACGGG
TTTTGCCGCGAGGAGCTGGACGAGTGGGGGTACCTCTCCCACAAAAGGGCCGCCCGGGCCACGGAGGAGGGGCGGTTTTC
TGCCCAGATCCTCCCCCTCGAGGGGCTGGACGCCGAGGGGAGGCCCTTCCTCCTCACCCGGGACGAGGGGGTCCGCCCCG
ATGTGGACTACGAGAAGATGCTCGCCCTGAAACCCGTCTTCCGGGAAGACGGGGTGGTGACGGCGGGGAACTCCAGCCAG
ATCTCCGACGGCGCCGCGGCCCTCCTCCTCGGGGACCGGGAAAAGGCCCTGGCCTTGGGCCTGAGGCCCAGGGCCCGCTT
CCTCGCCCGGGTGGTGGTGGCGGGGGACCCTACCCTGCAGCTTCTTGAGGTCATCCCCGCCGCGAAAAAGGCCCTGGAGC
GGGCGGGGCTCTCCTTGCGGGACGTGGACGTCATAGAGGTCAACGAGGCCTTCGCCAGCGTGGTCCTCGCCTTCCTGCGG
GAGCTTGGGGCGGACCCCGAAAAGGTGAACCCCAACGGCGGGGCCATCGCCCACGGGCATCCCTTGGGGGCCACGGGGGC
CGTGCTCATGACCAAGCTCCTTTATGAGCTAGAGCGCACGGGAAGCGAGTTCGGCCTCCAGGTGATGTGCATCGGCCACG
GCCAGGCCACGGCCACGGTGATCCAGAGGCTATAG

Upstream 100 bases:

>100_bases
CCGCGCGCTCCTTAGTTCGTTCCCAGGTCTAACTAAAGCACGCGCCCCCCCAAGGCGTCAAGGGGGTATACTGGGAAGCC
CGCAGGGAAGGGAGGAACGG

Downstream 100 bases:

>100_bases
GGAGGGGAGGATGGAGCGGAGCGCCTTGGTGACGGGCGGGGCCTCGGGCCTCGGGCGGGCGGCGGCCCTCGCCTTGAAGG
CGAGGGGCTACCGGGTGGTG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MGEPVILEAVRTPIGKRNGALRAYRPDALYAKVLDALLERTGIDPGLIGDVVTGCVTQVGEQGANVGRLGVLLSRLPKEV
PAVSLNRMCGSSQQAVHFAAQAIAAGDVDFAIAGGVESMTRVPMFADIGGGFHTLNPELGKRYELVHQGESAERIAERYG
FCREELDEWGYLSHKRAARATEEGRFSAQILPLEGLDAEGRPFLLTRDEGVRPDVDYEKMLALKPVFREDGVVTAGNSSQ
ISDGAAALLLGDREKALALGLRPRARFLARVVVAGDPTLQLLEVIPAAKKALERAGLSLRDVDVIEVNEAFASVVLAFLR
ELGADPEKVNPNGGAIAHGHPLGATGAVLMTKLLYELERTGSEFGLQVMCIGHGQATATVIQRL

Sequences:

>Translated_384_residues
MGEPVILEAVRTPIGKRNGALRAYRPDALYAKVLDALLERTGIDPGLIGDVVTGCVTQVGEQGANVGRLGVLLSRLPKEV
PAVSLNRMCGSSQQAVHFAAQAIAAGDVDFAIAGGVESMTRVPMFADIGGGFHTLNPELGKRYELVHQGESAERIAERYG
FCREELDEWGYLSHKRAARATEEGRFSAQILPLEGLDAEGRPFLLTRDEGVRPDVDYEKMLALKPVFREDGVVTAGNSSQ
ISDGAAALLLGDREKALALGLRPRARFLARVVVAGDPTLQLLEVIPAAKKALERAGLSLRDVDVIEVNEAFASVVLAFLR
ELGADPEKVNPNGGAIAHGHPLGATGAVLMTKLLYELERTGSEFGLQVMCIGHGQATATVIQRL
>Mature_383_residues
GEPVILEAVRTPIGKRNGALRAYRPDALYAKVLDALLERTGIDPGLIGDVVTGCVTQVGEQGANVGRLGVLLSRLPKEVP
AVSLNRMCGSSQQAVHFAAQAIAAGDVDFAIAGGVESMTRVPMFADIGGGFHTLNPELGKRYELVHQGESAERIAERYGF
CREELDEWGYLSHKRAARATEEGRFSAQILPLEGLDAEGRPFLLTRDEGVRPDVDYEKMLALKPVFREDGVVTAGNSSQI
SDGAAALLLGDREKALALGLRPRARFLARVVVAGDPTLQLLEVIPAAKKALERAGLSLRDVDVIEVNEAFASVVLAFLRE
LGADPEKVNPNGGAIAHGHPLGATGAVLMTKLLYELERTGSEFGLQVMCIGHGQATATVIQRL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=387, Percent_Identity=40.5684754521964, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=38.7179487179487, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI167614485, Length=387, Percent_Identity=33.8501291989664, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=35.3689567430025, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=32.2352941176471, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI194353979, Length=381, Percent_Identity=29.6587926509186, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI302344767, Length=321, Percent_Identity=24.9221183800623, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI302344760, Length=321, Percent_Identity=24.9221183800623, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19923233, Length=321, Percent_Identity=24.9221183800623, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=42.7860696517413, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI48994986, Length=391, Percent_Identity=43.4782608695652, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=40.4522613065327, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=38.1679389312977, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1788683, Length=407, Percent_Identity=31.4496314496315, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=35.8056265984655, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI133906874, Length=396, Percent_Identity=36.6161616161616, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=34.1902313624679, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=31.6279069767442, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=30, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=36.8020304568528, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=32, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=36.1323155216285, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=34.4387755102041, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=34.0966921119593, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=30.9133489461358, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24585051, Length=320, Percent_Identity=23.125, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41003; Mature: 40871

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEPVILEAVRTPIGKRNGALRAYRPDALYAKVLDALLERTGIDPGLIGDVVTGCVTQVG
CCCCEEHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
EQGANVGRLGVLLSRLPKEVPAVSLNRMCGSSQQAVHFAAQAIAAGDVDFAIAGGVESMT
HCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
RVPMFADIGGGFHTLNPELGKRYELVHQGESAERIAERYGFCREELDEWGYLSHKRAARA
HCCCEEECCCCCEECCHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHCCCHHHHHHHHH
TEEGRFSAQILPLEGLDAEGRPFLLTRDEGVRPDVDYEKMLALKPVFREDGVVTAGNSSQ
HHCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCHHHHHHHCCHHHCCCEEECCCCCC
ISDGAAALLLGDREKALALGLRPRARFLARVVVAGDPTLQLLEVIPAAKKALERAGLSLR
CCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
DVDVIEVNEAFASVVLAFLRELGADPEKVNPNGGAIAHGHPLGATGAVLMTKLLYELERT
CCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHC
GSEFGLQVMCIGHGQATATVIQRL
CHHCCEEEEEEECCCHHHHHHHHC
>Mature Secondary Structure 
GEPVILEAVRTPIGKRNGALRAYRPDALYAKVLDALLERTGIDPGLIGDVVTGCVTQVG
CCCEEHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
EQGANVGRLGVLLSRLPKEVPAVSLNRMCGSSQQAVHFAAQAIAAGDVDFAIAGGVESMT
HCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
RVPMFADIGGGFHTLNPELGKRYELVHQGESAERIAERYGFCREELDEWGYLSHKRAARA
HCCCEEECCCCCEECCHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHCCCHHHHHHHHH
TEEGRFSAQILPLEGLDAEGRPFLLTRDEGVRPDVDYEKMLALKPVFREDGVVTAGNSSQ
HHCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCHHHHHHHCCHHHCCCEEECCCCCC
ISDGAAALLLGDREKALALGLRPRARFLARVVVAGDPTLQLLEVIPAAKKALERAGLSLR
CCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
DVDVIEVNEAFASVVLAFLRELGADPEKVNPNGGAIAHGHPLGATGAVLMTKLLYELERT
CCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHC
GSEFGLQVMCIGHGQATATVIQRL
CHHCCEEEEEEECCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA