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The map label for this gene is sir1 [H]

Identifier: 55980641

GI number: 55980641

Start: 637640

End: 639397

Strand: Reverse

Name: sir1 [H]

Synonym: TTHA0672

Alternate gene names: 55980641

Gene position: 639397-637640 (Counterclockwise)

Preceding gene: 55980642

Following gene: 55980640

Centisome position: 34.57

GC content: 70.31

Gene sequence:

>1758_bases
ATGGCAGGGCTTGTGGACAGGGTAAGCGGCGCGCGCCTGGACCCGGCGGCGGAGGCGGAGATCCGGTACCTGGAGGCCAT
GATCGCCCGCCTCGAGGCCGGGGAGGAAGACCCCGAGGACTTCCGGGTCTTCCGGCTCAAAAACGGCATCTACGGCATCC
GGGGCCGCCCCGAGCACCACATGATCCGCATCAAGCTCCCCGTGGGGCGGATCACCCCCGAGGGCCTCAGGGTTCTCGCG
GACGTGGCCGAGCGCTACGCGGAAAACCGCCTGGCCCACGTGACCACCCGCCAGGCGGTCCAGCTCCACCACGTCCACCG
CCGGGACGTGCCCAAGGTCTTAAGGGCGGTGAACGCCGTGGGCCTCACCACGAGGGAGGCCTGCGGCCACTCCATCCGGG
CCATCACCTGCTGCCCCTACGCCGGGGTCTCCCCCGAGGAACCCTTTGACGTGACCCCCTACGCCGAGGCCGCCTACCGC
TACTTCCTCCGCCACCCCGTGGGGCAGAACCTCCCCCGGAAGTTCAAGATCGCCTTTGAGGGGTGCGCCGCGGACCACGC
CCGCACCCCCATCCACGACATCGGGGTGGTGGCGGCCTTGGAAGGGGGAAAACGGGGGTTCCGCGTCTACGTGGGCGGGG
GCTTAGGGGCCGCCCCCATGAGCGCCGAGCTTCTGGAGGCCTTCACCCCCGAGGAGGACCTCCTCCCCACCATGCTCGCC
ATCGTCCGCCTCTTTGACCGCTACGGAAACCGCAAGGTCTTGACCCAGGCCCGGCTCAAGTTCCTGGTGAAGAAGTGGGG
GATCGCCGCCTTCCGGGAGGCGGTGCGGGAGGAGAGGCGCCTCGTCAAGCTCACGGCGAGCGGCGAGGACCTCGAGGCCT
GGGCCCCGCCCCCAGAGCCCGAGCCCCCAAGGCTTCCCAGCCCGCCCAAAAAGCCCTTCTCCTTTGCCCCAGGCTTTGAC
GCCTGGCGGCGCACCAACCTCTTCAAGCAAAAGCAGGAGGGCTTCTATACCGTCACCGTCCGCCTCCCCTTGGGGGACAT
CACCCCGGAAGGCCTCAGGGCCCTGGCGGCCATCGCCGAGACCTACGCCGCCGAGGTCCGGAGCGCCATCAGCCAGAACC
TCCTCCTCCGCTTCGTCCCCGAGGAGGCCCTGGGTGGGCTTTACGAGGCCCTCTTGGAGGCGGGGCTCGCTCTCCCTGAG
GCCCACACCCTCCTGGACATCACCCGCTGCCCCGGGGCCGACACCTGCAACCTGGCCATCACCCGCTCCCGGGGGCTCGC
CCAGGCCCTCGAGGCCCACCTCGCCACGCTCCCCCTGGCCCAGGACCCGGGGGCCAAGGCCATCGGCGTCAAGATCTCCG
GCTGCCCCAACTCCTGCGGCCAGCACCACATCGCCGACATCGGCTTCTACGGTTCAAGCCGCAAGGTGGGAGAAAGGGAG
GTGCCCCACTACGTCCTCCTCCTGGGCGGGCGCACCCGGGAGGGGGAGGCTCGCTTCGGCCAGGTGGTGGGGAGGCTCCC
GGCGCGGCGGGTCCCCGAGGCGGTGGAAAGGATCCTCAAGCGCTACCTGGAGGAGCGGCAAAACGGGGAGAGCTTCCAGG
CCTACCTGGACCGGGTGGGGGCGGCCTCCTTCAAGCCCCTCCTCCAGGAGCTCCAGGAGGTCCCTCCCTACGAGGAGGCC
CCCGAGTTCTACCAGGACCTGGGGGCGGAAGGGGAGGCCTTCAGCGTGCAGCTCGGGCGCGGGGAGTGCGCCGTCTAG

Upstream 100 bases:

>100_bases
CGGCGGGGTCCGGGGCCAGGGTGCCCCATACCCTTGACTTTCATAGGCTCAATGGTATACCATCCCCACCAACCCCCGGA
CCGGGGGTCGGAGGTGAGGG

Downstream 100 bases:

>100_bases
AGGAGGACGCCGTGCGCGTGGCCTACGCGGGACTCAGACGGAAGGAAGCGTTTAAGGCCCTGGCGGAGAAGCTCGGCTTC
ACCCCCCTCCTCTTCCCCGT

Product: sulfite reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MAGLVDRVSGARLDPAAEAEIRYLEAMIARLEAGEEDPEDFRVFRLKNGIYGIRGRPEHHMIRIKLPVGRITPEGLRVLA
DVAERYAENRLAHVTTRQAVQLHHVHRRDVPKVLRAVNAVGLTTREACGHSIRAITCCPYAGVSPEEPFDVTPYAEAAYR
YFLRHPVGQNLPRKFKIAFEGCAADHARTPIHDIGVVAALEGGKRGFRVYVGGGLGAAPMSAELLEAFTPEEDLLPTMLA
IVRLFDRYGNRKVLTQARLKFLVKKWGIAAFREAVREERRLVKLTASGEDLEAWAPPPEPEPPRLPSPPKKPFSFAPGFD
AWRRTNLFKQKQEGFYTVTVRLPLGDITPEGLRALAAIAETYAAEVRSAISQNLLLRFVPEEALGGLYEALLEAGLALPE
AHTLLDITRCPGADTCNLAITRSRGLAQALEAHLATLPLAQDPGAKAIGVKISGCPNSCGQHHIADIGFYGSSRKVGERE
VPHYVLLLGGRTREGEARFGQVVGRLPARRVPEAVERILKRYLEERQNGESFQAYLDRVGAASFKPLLQELQEVPPYEEA
PEFYQDLGAEGEAFSVQLGRGECAV

Sequences:

>Translated_585_residues
MAGLVDRVSGARLDPAAEAEIRYLEAMIARLEAGEEDPEDFRVFRLKNGIYGIRGRPEHHMIRIKLPVGRITPEGLRVLA
DVAERYAENRLAHVTTRQAVQLHHVHRRDVPKVLRAVNAVGLTTREACGHSIRAITCCPYAGVSPEEPFDVTPYAEAAYR
YFLRHPVGQNLPRKFKIAFEGCAADHARTPIHDIGVVAALEGGKRGFRVYVGGGLGAAPMSAELLEAFTPEEDLLPTMLA
IVRLFDRYGNRKVLTQARLKFLVKKWGIAAFREAVREERRLVKLTASGEDLEAWAPPPEPEPPRLPSPPKKPFSFAPGFD
AWRRTNLFKQKQEGFYTVTVRLPLGDITPEGLRALAAIAETYAAEVRSAISQNLLLRFVPEEALGGLYEALLEAGLALPE
AHTLLDITRCPGADTCNLAITRSRGLAQALEAHLATLPLAQDPGAKAIGVKISGCPNSCGQHHIADIGFYGSSRKVGERE
VPHYVLLLGGRTREGEARFGQVVGRLPARRVPEAVERILKRYLEERQNGESFQAYLDRVGAASFKPLLQELQEVPPYEEA
PEFYQDLGAEGEAFSVQLGRGECAV
>Mature_584_residues
AGLVDRVSGARLDPAAEAEIRYLEAMIARLEAGEEDPEDFRVFRLKNGIYGIRGRPEHHMIRIKLPVGRITPEGLRVLAD
VAERYAENRLAHVTTRQAVQLHHVHRRDVPKVLRAVNAVGLTTREACGHSIRAITCCPYAGVSPEEPFDVTPYAEAAYRY
FLRHPVGQNLPRKFKIAFEGCAADHARTPIHDIGVVAALEGGKRGFRVYVGGGLGAAPMSAELLEAFTPEEDLLPTMLAI
VRLFDRYGNRKVLTQARLKFLVKKWGIAAFREAVREERRLVKLTASGEDLEAWAPPPEPEPPRLPSPPKKPFSFAPGFDA
WRRTNLFKQKQEGFYTVTVRLPLGDITPEGLRALAAIAETYAAEVRSAISQNLLLRFVPEEALGGLYEALLEAGLALPEA
HTLLDITRCPGADTCNLAITRSRGLAQALEAHLATLPLAQDPGAKAIGVKISGCPNSCGQHHIADIGFYGSSRKVGEREV
PHYVLLLGGRTREGEARFGQVVGRLPARRVPEAVERILKRYLEERQNGESFQAYLDRVGAASFKPLLQELQEVPPYEEAP
EFYQDLGAEGEAFSVQLGRGECAV

Specific function: This Enzyme Catalyzes The 6-Electron Reduction Of Sulfite To Sulfide. This Is One Of Several Activities Required For The Biosynthesis Of L-Cysteine From Sulfate. [C]

COG id: COG0155

COG function: function code P; Sulfite reductase, beta subunit (hemoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

Organism=Escherichia coli, GI1789122, Length=553, Percent_Identity=23.869801084991, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322597, Length=613, Percent_Identity=23.3278955954323, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005117
- InterPro:   IPR006067
- InterPro:   IPR006066 [H]

Pfam domain/function: PF01077 NIR_SIR; PF03460 NIR_SIR_ferr [H]

EC number: =1.8.7.1 [H]

Molecular weight: Translated: 64466; Mature: 64334

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00365 NIR_SIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLVDRVSGARLDPAAEAEIRYLEAMIARLEAGEEDPEDFRVFRLKNGIYGIRGRPEHH
CCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEEEEECCEEECCCCCCCC
MIRIKLPVGRITPEGLRVLADVAERYAENRLAHVTTRQAVQLHHVHRRDVPKVLRAVNAV
EEEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GLTTREACGHSIRAITCCPYAGVSPEEPFDVTPYAEAAYRYFLRHPVGQNLPRKFKIAFE
CCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEE
GCAADHARTPIHDIGVVAALEGGKRGFRVYVGGGLGAAPMSAELLEAFTPEEDLLPTMLA
CCCCCCCCCCHHHCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHH
IVRLFDRYGNRKVLTQARLKFLVKKWGIAAFREAVREERRLVKLTASGEDLEAWAPPPEP
HHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCC
EPPRLPSPPKKPFSFAPGFDAWRRTNLFKQKQEGFYTVTVRLPLGDITPEGLRALAAIAE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHH
TYAAEVRSAISQNLLLRFVPEEALGGLYEALLEAGLALPEAHTLLDITRCPGADTCNLAI
HHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCCCCCEEE
TRSRGLAQALEAHLATLPLAQDPGAKAIGVKISGCPNSCGQHHIADIGFYGSSRKVGERE
ECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCC
VPHYVLLLGGRTREGEARFGQVVGRLPARRVPEAVERILKRYLEERQNGESFQAYLDRVG
CCEEEEEECCCCCCCHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
AASFKPLLQELQEVPPYEEAPEFYQDLGAEGEAFSVQLGRGECAV
CHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
AGLVDRVSGARLDPAAEAEIRYLEAMIARLEAGEEDPEDFRVFRLKNGIYGIRGRPEHH
CCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEEEEECCEEECCCCCCCC
MIRIKLPVGRITPEGLRVLADVAERYAENRLAHVTTRQAVQLHHVHRRDVPKVLRAVNAV
EEEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GLTTREACGHSIRAITCCPYAGVSPEEPFDVTPYAEAAYRYFLRHPVGQNLPRKFKIAFE
CCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEE
GCAADHARTPIHDIGVVAALEGGKRGFRVYVGGGLGAAPMSAELLEAFTPEEDLLPTMLA
CCCCCCCCCCHHHCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHH
IVRLFDRYGNRKVLTQARLKFLVKKWGIAAFREAVREERRLVKLTASGEDLEAWAPPPEP
HHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCC
EPPRLPSPPKKPFSFAPGFDAWRRTNLFKQKQEGFYTVTVRLPLGDITPEGLRALAAIAE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHH
TYAAEVRSAISQNLLLRFVPEEALGGLYEALLEAGLALPEAHTLLDITRCPGADTCNLAI
HHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCCCCCEEE
TRSRGLAQALEAHLATLPLAQDPGAKAIGVKISGCPNSCGQHHIADIGFYGSSRKVGERE
ECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCC
VPHYVLLLGGRTREGEARFGQVVGRLPARRVPEAVERILKRYLEERQNGESFQAYLDRVG
CCEEEEEECCCCCCCHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
AASFKPLLQELQEVPPYEEAPEFYQDLGAEGEAFSVQLGRGECAV
CHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA