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The map label for this gene is pncB [H]

Identifier: 55980586

GI number: 55980586

Start: 586086

End: 587606

Strand: Reverse

Name: pncB [H]

Synonym: TTHA0617

Alternate gene names: 55980586

Gene position: 587606-586086 (Counterclockwise)

Preceding gene: 55980588

Following gene: 55980581

Centisome position: 31.77

GC content: 69.36

Gene sequence:

>1521_bases
ATGGACCCCTTCGGCATCCTCTACACCGACCTCTACCAGCTCACCATGGGCCAGGTCTACTTCCGCATGGGCCTCCACGA
GAAGGAGGCCCTCTTTGAGGCCTTCTACCGGAGAAACCCCGACTACGGGGCCCACCAGGCGGGCTACACCGTCTTCGCCG
GGCTGGACCCCCTCCTAAGCTGGATGGAGGAAGCCCGCTTCGGCGAGGAGGAGATCGCGGCCCTCCGCAACCTCAAAAGC
CGCTCGGGGAAGCCCCTCTTCGCCGAGGACTACCTCCGCTACCTCAAGGCGATGGGCGGGTTTTCCGGCCTCACCCTAAG
GGCCCTCCCCGAGGGGCGCGTGGCCCACCCCCAGGTGCCCCTGGTGAGCGTGGAGGGCCCCCTCCTCCAGGCCCAGCTCC
TGGAGACCGCCCTCCTGAACCGCCTCAACTACGAGACCCTCATCGCCACCAAGGCGAGCCGGGTGCGGGAGGCGGCGGGG
GAGGCCGTGGTCCTGGAGTTCGGCCTCCGCCGCGCCCCCGCCAAGGGCGGGGAGAGCGCCACCCGGGCGAGCCTCATCGG
GGGGGCGAACCGCTCTAGCGCCGTGAGCCTCTCCCACCTCCTGGGCCTTCCCGCCTCCGGCACCCACGCCCACAGCCTGG
TCCAGGCCTTCATGGCCCTGGGGTACAGCGAGGAGGACGCCTTCCGGGCCTTCGCCGAGGTCTTCCCCGACGACGCCATC
CTCCTTCTGGACACCGTGGACACCCTCCACTCAGGGCTTCCCCACGCCATCCGGGTCTTTGAGGAGCTTAGGCGCAAGGG
GCACAGGCCCGTAGGGGTGCGCATAGACTCCGGGGACCTGGCCCACCTCGCCATCCAGGTGGCCAGGGAGCTGGACAGGG
CGGGGTTTCCCGAGGTCCTCATCGTCCTCTCCGGGGACCTGGACGAGCTCGTCATCTGGCAGATCAAAAGCCAGATCCTG
GAGGAGGCCCCCCGCTACGGGGTGGACCCCGACCGCCTCCTCAAGCGCCTGGTCTACGGGGTGGGGACGAGGATGGTGGT
CTCCTGGGGCGCCCCGGCCCTGGGCGGGGTCTACAAGCTGGTGGCGGTGCGGGAAAACGGCACCTGGGCCCCGGCGATGA
AGGTCTCCAACTCCCTGGAGAAGGTCTTAAACCCGGGGCACAAGCGGGTCTATCGGGTCTACGACGAGCGGGGCCTCGCC
ACCGCCGACCTTTTGGCCCTGGCCGAGGAGGAGGTGCGGGAGGACGCCCCCCTCACCCTCCGCCACCCCACGGACCCCAC
CAAAAGGCGCACCTTAAGGCCGGGAAGCTTCCGGCTCGAGCCCCTCCTGGAGGAGGTCTACCGGGGAAGGAGGCTCTTCC
CCCCCCTTCCCCTGGAAGAACTCAGGAAGCGCCGGGACCGGGACGTGGCCCTCCTGGACCCCGGGGTGCGGCGGCTCGTG
AACCCCCACGTCTACCACGTCTCCCTCACGGAGAGGCTTTTCGCCCTGAAGGAGGAATTGGTGCGGCGGCTCGAGGGCTA
A

Upstream 100 bases:

>100_bases
AGCCCGCCCCCCCGAGGTGGTGGCGGCATCCGGGGCTGCAGGCGTGGACCTCCACCATATCCCGCTAGTGTAGCGAACCG
GGCGGGGCTATGCTAGGCCC

Downstream 100 bases:

>100_bases
GCCCCCCAAAAGGGGCTTGGTCGCCCTTAGGAGGCCTGCCGGAGCCTGGCCTCCTCGAGGGCCTTCAGGGGGTGGTCCAG
GTGGGGGAGGTCAAAGACGA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MDPFGILYTDLYQLTMGQVYFRMGLHEKEALFEAFYRRNPDYGAHQAGYTVFAGLDPLLSWMEEARFGEEEIAALRNLKS
RSGKPLFAEDYLRYLKAMGGFSGLTLRALPEGRVAHPQVPLVSVEGPLLQAQLLETALLNRLNYETLIATKASRVREAAG
EAVVLEFGLRRAPAKGGESATRASLIGGANRSSAVSLSHLLGLPASGTHAHSLVQAFMALGYSEEDAFRAFAEVFPDDAI
LLLDTVDTLHSGLPHAIRVFEELRRKGHRPVGVRIDSGDLAHLAIQVARELDRAGFPEVLIVLSGDLDELVIWQIKSQIL
EEAPRYGVDPDRLLKRLVYGVGTRMVVSWGAPALGGVYKLVAVRENGTWAPAMKVSNSLEKVLNPGHKRVYRVYDERGLA
TADLLALAEEEVREDAPLTLRHPTDPTKRRTLRPGSFRLEPLLEEVYRGRRLFPPLPLEELRKRRDRDVALLDPGVRRLV
NPHVYHVSLTERLFALKEELVRRLEG

Sequences:

>Translated_506_residues
MDPFGILYTDLYQLTMGQVYFRMGLHEKEALFEAFYRRNPDYGAHQAGYTVFAGLDPLLSWMEEARFGEEEIAALRNLKS
RSGKPLFAEDYLRYLKAMGGFSGLTLRALPEGRVAHPQVPLVSVEGPLLQAQLLETALLNRLNYETLIATKASRVREAAG
EAVVLEFGLRRAPAKGGESATRASLIGGANRSSAVSLSHLLGLPASGTHAHSLVQAFMALGYSEEDAFRAFAEVFPDDAI
LLLDTVDTLHSGLPHAIRVFEELRRKGHRPVGVRIDSGDLAHLAIQVARELDRAGFPEVLIVLSGDLDELVIWQIKSQIL
EEAPRYGVDPDRLLKRLVYGVGTRMVVSWGAPALGGVYKLVAVRENGTWAPAMKVSNSLEKVLNPGHKRVYRVYDERGLA
TADLLALAEEEVREDAPLTLRHPTDPTKRRTLRPGSFRLEPLLEEVYRGRRLFPPLPLEELRKRRDRDVALLDPGVRRLV
NPHVYHVSLTERLFALKEELVRRLEG
>Mature_506_residues
MDPFGILYTDLYQLTMGQVYFRMGLHEKEALFEAFYRRNPDYGAHQAGYTVFAGLDPLLSWMEEARFGEEEIAALRNLKS
RSGKPLFAEDYLRYLKAMGGFSGLTLRALPEGRVAHPQVPLVSVEGPLLQAQLLETALLNRLNYETLIATKASRVREAAG
EAVVLEFGLRRAPAKGGESATRASLIGGANRSSAVSLSHLLGLPASGTHAHSLVQAFMALGYSEEDAFRAFAEVFPDDAI
LLLDTVDTLHSGLPHAIRVFEELRRKGHRPVGVRIDSGDLAHLAIQVARELDRAGFPEVLIVLSGDLDELVIWQIKSQIL
EEAPRYGVDPDRLLKRLVYGVGTRMVVSWGAPALGGVYKLVAVRENGTWAPAMKVSNSLEKVLNPGHKRVYRVYDERGLA
TADLLALAEEEVREDAPLTLRHPTDPTKRRTLRPGSFRLEPLLEEVYRGRRLFPPLPLEELRKRRDRDVALLDPGVRRLV
NPHVYHVSLTERLFALKEELVRRLEG

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=548, Percent_Identity=35.948905109489, Blast_Score=229, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI71997947, Length=546, Percent_Identity=32.2344322344322, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71997952, Length=546, Percent_Identity=32.2344322344322, Blast_Score=275, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI71997955, Length=213, Percent_Identity=41.3145539906103, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24581587, Length=550, Percent_Identity=33.0909090909091, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI161076680, Length=217, Percent_Identity=40.5529953917051, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24581595, Length=217, Percent_Identity=40.5529953917051, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI28574709, Length=217, Percent_Identity=40.5529953917051, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24581593, Length=217, Percent_Identity=40.5529953917051, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24581591, Length=217, Percent_Identity=40.5529953917051, Blast_Score=139, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 56467; Mature: 56467

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPFGILYTDLYQLTMGQVYFRMGLHEKEALFEAFYRRNPDYGAHQAGYTVFAGLDPLLS
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHH
WMEEARFGEEEIAALRNLKSRSGKPLFAEDYLRYLKAMGGFSGLTLRALPEGRVAHPQVP
HHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
LVSVEGPLLQAQLLETALLNRLNYETLIATKASRVREAAGEAVVLEFGLRRAPAKGGESA
EEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCHH
TRASLIGGANRSSAVSLSHLLGLPASGTHAHSLVQAFMALGYSEEDAFRAFAEVFPDDAI
HHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCE
LLLDTVDTLHSGLPHAIRVFEELRRKGHRPVGVRIDSGDLAHLAIQVARELDRAGFPEVL
EEEECHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEE
IVLSGDLDELVIWQIKSQILEEAPRYGVDPDRLLKRLVYGVGTRMVVSWGAPALGGVYKL
EEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHCCCEEE
VAVRENGTWAPAMKVSNSLEKVLNPGHKRVYRVYDERGLATADLLALAEEEVREDAPLTL
EEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEE
RHPTDPTKRRTLRPGSFRLEPLLEEVYRGRRLFPPLPLEELRKRRDRDVALLDPGVRRLV
ECCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEECHHHHHHC
NPHVYHVSLTERLFALKEELVRRLEG
CCCEEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDPFGILYTDLYQLTMGQVYFRMGLHEKEALFEAFYRRNPDYGAHQAGYTVFAGLDPLLS
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHH
WMEEARFGEEEIAALRNLKSRSGKPLFAEDYLRYLKAMGGFSGLTLRALPEGRVAHPQVP
HHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
LVSVEGPLLQAQLLETALLNRLNYETLIATKASRVREAAGEAVVLEFGLRRAPAKGGESA
EEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCHH
TRASLIGGANRSSAVSLSHLLGLPASGTHAHSLVQAFMALGYSEEDAFRAFAEVFPDDAI
HHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCE
LLLDTVDTLHSGLPHAIRVFEELRRKGHRPVGVRIDSGDLAHLAIQVARELDRAGFPEVL
EEEECHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEE
IVLSGDLDELVIWQIKSQILEEAPRYGVDPDRLLKRLVYGVGTRMVVSWGAPALGGVYKL
EEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHCCCEEE
VAVRENGTWAPAMKVSNSLEKVLNPGHKRVYRVYDERGLATADLLALAEEEVREDAPLTL
EEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEE
RHPTDPTKRRTLRPGSFRLEPLLEEVYRGRRLFPPLPLEELRKRRDRDVALLDPGVRRLV
ECCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEECHHHHHHC
NPHVYHVSLTERLFALKEELVRRLEG
CCCEEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]