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The map label for this gene is tdh [H]

Identifier: 55980538

GI number: 55980538

Start: 537023

End: 538054

Strand: Direct

Name: tdh [H]

Synonym: TTHA0569

Alternate gene names: 55980538

Gene position: 537023-538054 (Clockwise)

Preceding gene: 55980537

Following gene: 55980539

Centisome position: 29.03

GC content: 70.54

Gene sequence:

>1032_bases
ATGCGCGCTTTGGCCAAGCTGGCCCCGGAGGAGGGCCTGACCCTGGTGGACCGCCCCGTGCCCGAGCCGGGCCCCGGGGA
GATCCTGGTGCGGGTGGAGGCGGCGAGCATCTGCGGCACCGACCTCCACATCTGGAAGTGGGACGCCTGGGCCCGGGGCA
GGATCCGCCCTCCCCTCGTCACCGGGCACGAGTTCAGCGGGGTGGTGGAGGCCGTGGGCCCCGGGGTGAGGCGACCCCAG
GTGGGGGACCACGTGAGCCTGGAAAGCCACATCGTCTGCCACGCCTGCCCCGCCTGCCGCACGGGGAACTACCACGTTTG
CCTCAACACCCAGATCCTCGGCGTGGACCGGGACGGCGGCTTCGCCGAGTACGTGGTGGTGCCGGCGGAGAACGCCTGGG
TGAACCCCAAGGACCTTCCCTTTGAGGTGGCGGCCATCCTGGAGCCCTTCGGCAACGCCGTGCACACCGTCTACGCGGGA
AGCGGGGTTTCGGGGAAGAGCGTCCTCATCACGGGGGCGGGGCCCATCGGCCTCATGGCGGCCATGGTGGTCCGGGCGAG
CGGGGCGGGGCCCATCCTGGTCTCCGACCCGAACCCCTACCGCCTGGCCTTCGCCAGGCCCTACGCCGACCGGCTGGTGA
ACCCCTTGGAGGAGGACCTCCTGGAGGTGGTGCGCCGGGTGACGGGAAGCGGGGTGGAGGTGCTTTTGGAGTTTTCTGGG
AACGAGGCCGCCATCCACCAGGGCCTCATGGCCCTCATCCCCGGGGGGGAGGCGAGGATCTTGGGGATCCCTTCCGACCC
CATCCGCTTTGACCTCGCCGGGGAGCTCGTCATGCGGGGGATCACCGCCTTCGGCATCGCCGGGCGCAGGCTCTGGCAGA
CCTGGATGCAGGGCACCGCCTTGGTCTACTCGGGTAGGGTGGACCTAAGCCCCCTCCTCACCCACCGCCTCCCCTTGAGC
CGCTACCGGGAGGCCTTCGGCCTTCTGGCCTCGGGCCAGGCGGTGAAGGTGATCCTGGACCCGAAGGCCTAA

Upstream 100 bases:

>100_bases
CGACCTCACCGACGCCCTTTCCCTGACCCTCACCCTGGAGACGGGGGACGACACCCGCTTCAGCGTGGGCGCGGCCTACC
GGTGGTAGCATGGCGCCGGT

Downstream 100 bases:

>100_bases
AGGGGGTTTCCGGTACCCTGTCGGGGAAGGGGGTGGCTGGTGGACCGGAGGCGCTTTCTCGTGGGGCTCCTCGGCCTGGG
ACTCGCCCGGGGGCAGGGGC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRALAKLAPEEGLTLVDRPVPEPGPGEILVRVEAASICGTDLHIWKWDAWARGRIRPPLVTGHEFSGVVEAVGPGVRRPQ
VGDHVSLESHIVCHACPACRTGNYHVCLNTQILGVDRDGGFAEYVVVPAENAWVNPKDLPFEVAAILEPFGNAVHTVYAG
SGVSGKSVLITGAGPIGLMAAMVVRASGAGPILVSDPNPYRLAFARPYADRLVNPLEEDLLEVVRRVTGSGVEVLLEFSG
NEAAIHQGLMALIPGGEARILGIPSDPIRFDLAGELVMRGITAFGIAGRRLWQTWMQGTALVYSGRVDLSPLLTHRLPLS
RYREAFGLLASGQAVKVILDPKA

Sequences:

>Translated_343_residues
MRALAKLAPEEGLTLVDRPVPEPGPGEILVRVEAASICGTDLHIWKWDAWARGRIRPPLVTGHEFSGVVEAVGPGVRRPQ
VGDHVSLESHIVCHACPACRTGNYHVCLNTQILGVDRDGGFAEYVVVPAENAWVNPKDLPFEVAAILEPFGNAVHTVYAG
SGVSGKSVLITGAGPIGLMAAMVVRASGAGPILVSDPNPYRLAFARPYADRLVNPLEEDLLEVVRRVTGSGVEVLLEFSG
NEAAIHQGLMALIPGGEARILGIPSDPIRFDLAGELVMRGITAFGIAGRRLWQTWMQGTALVYSGRVDLSPLLTHRLPLS
RYREAFGLLASGQAVKVILDPKA
>Mature_343_residues
MRALAKLAPEEGLTLVDRPVPEPGPGEILVRVEAASICGTDLHIWKWDAWARGRIRPPLVTGHEFSGVVEAVGPGVRRPQ
VGDHVSLESHIVCHACPACRTGNYHVCLNTQILGVDRDGGFAEYVVVPAENAWVNPKDLPFEVAAILEPFGNAVHTVYAG
SGVSGKSVLITGAGPIGLMAAMVVRASGAGPILVSDPNPYRLAFARPYADRLVNPLEEDLLEVVRRVTGSGVEVLLEFSG
NEAAIHQGLMALIPGGEARILGIPSDPIRFDLAGELVMRGITAFGIAGRRLWQTWMQGTALVYSGRVDLSPLLTHRLPLS
RYREAFGLLASGQAVKVILDPKA

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=31.7647058823529, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI4501929, Length=357, Percent_Identity=28.0112044817927, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI34577061, Length=361, Percent_Identity=26.0387811634349, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4501933, Length=354, Percent_Identity=25.9887005649718, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI71743840, Length=351, Percent_Identity=26.4957264957265, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI262073058, Length=351, Percent_Identity=26.4957264957265, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI156523966, Length=358, Percent_Identity=24.0223463687151, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71565152, Length=388, Percent_Identity=25.5154639175258, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI4501939, Length=352, Percent_Identity=23.8636363636364, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=42.8152492668622, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1788075, Length=361, Percent_Identity=31.3019390581717, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1787863, Length=355, Percent_Identity=30.4225352112676, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788407, Length=310, Percent_Identity=30, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI226510992, Length=329, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=28.0453257790368, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788073, Length=327, Percent_Identity=27.82874617737, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790718, Length=326, Percent_Identity=26.0736196319018, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1786825, Length=388, Percent_Identity=27.0618556701031, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=28.494623655914, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=27.8846153846154, Blast_Score=78, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=339, Percent_Identity=30.3834808259587, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17562878, Length=337, Percent_Identity=29.080118694362, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17562582, Length=278, Percent_Identity=28.0575539568345, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=256, Percent_Identity=27.34375, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=282, Percent_Identity=28.0141843971631, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=379, Percent_Identity=26.6490765171504, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71997431, Length=330, Percent_Identity=27.5757575757576, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=326, Percent_Identity=28.8343558282209, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=319, Percent_Identity=31.0344827586207, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=339, Percent_Identity=25.6637168141593, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6322619, Length=339, Percent_Identity=25.6637168141593, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319257, Length=290, Percent_Identity=30, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6319621, Length=289, Percent_Identity=29.0657439446367, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=254, Percent_Identity=29.9212598425197, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=26.6129032258064, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=257, Percent_Identity=28.4046692607004, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=258, Percent_Identity=27.906976744186, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737897, Length=342, Percent_Identity=29.5321637426901, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17137530, Length=341, Percent_Identity=28.7390029325513, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=26.790450928382, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45550770, Length=319, Percent_Identity=23.8244514106583, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551930, Length=319, Percent_Identity=23.8244514106583, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221457811, Length=319, Percent_Identity=23.8244514106583, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 36639; Mature: 36639

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALAKLAPEEGLTLVDRPVPEPGPGEILVRVEAASICGTDLHIWKWDAWARGRIRPPLV
CCCHHHCCCCCCCEEEECCCCCCCCCCEEEEEEEHHCCCCCEEEEEECCCCCCCCCCCEE
TGHEFSGVVEAVGPGVRRPQVGDHVSLESHIVCHACPACRTGNYHVCLNTQILGVDRDGG
CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEEEEEEEECCCC
FAEYVVVPAENAWVNPKDLPFEVAAILEPFGNAVHTVYAGSGVSGKSVLITGAGPIGLMA
EEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCHHHHHH
AMVVRASGAGPILVSDPNPYRLAFARPYADRLVNPLEEDLLEVVRRVTGSGVEVLLEFSG
HHHHHCCCCCCEEEECCCCEEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECC
NEAAIHQGLMALIPGGEARILGIPSDPIRFDLAGELVMRGITAFGIAGRRLWQTWMQGTA
CHHHHHCCEEEEECCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
LVYSGRVDLSPLLTHRLPLSRYREAFGLLASGQAVKVILDPKA
EEEECCCCCCHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MRALAKLAPEEGLTLVDRPVPEPGPGEILVRVEAASICGTDLHIWKWDAWARGRIRPPLV
CCCHHHCCCCCCCEEEECCCCCCCCCCEEEEEEEHHCCCCCEEEEEECCCCCCCCCCCEE
TGHEFSGVVEAVGPGVRRPQVGDHVSLESHIVCHACPACRTGNYHVCLNTQILGVDRDGG
CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEEEEEEEECCCC
FAEYVVVPAENAWVNPKDLPFEVAAILEPFGNAVHTVYAGSGVSGKSVLITGAGPIGLMA
EEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCHHHHHH
AMVVRASGAGPILVSDPNPYRLAFARPYADRLVNPLEEDLLEVVRRVTGSGVEVLLEFSG
HHHHHCCCCCCEEEECCCCEEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECC
NEAAIHQGLMALIPGGEARILGIPSDPIRFDLAGELVMRGITAFGIAGRRLWQTWMQGTA
CHHHHHCCEEEEECCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
LVYSGRVDLSPLLTHRLPLSRYREAFGLLASGQAVKVILDPKA
EEEECCCCCCHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA