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The map label for this gene is acuC [H]

Identifier: 55980444

GI number: 55980444

Start: 444268

End: 445392

Strand: Direct

Name: acuC [H]

Synonym: TTHA0475

Alternate gene names: 55980444

Gene position: 444268-445392 (Clockwise)

Preceding gene: 55980443

Following gene: 55980445

Centisome position: 24.02

GC content: 69.07

Gene sequence:

>1125_bases
ATGGTGATCTACCGGGAGGAGTACCGCCTCTACAACTTCGGGCCCGACCACCCCTTTAGCCCCGTCCGCCTGGAAATGCT
CACCTCCCTCCTCCAGGCCCTCGGGGTGTGGCGGGCGCCCCTTAGCCCCCCTGAGGCCTCGAGGGAGGAGGTGCTTTCGG
TCCACTCCGAGCGCCTGGTAAAGCGGGTGGAGGCGGCGAGCCGGGGAGAGCTTTACCCCGACCTGGAGCACTACCTGGGC
ACGGGGGACACCCCCGTCTTCCCCGGCATGGACCGGGCGGCCCGGATCCTGGTGGGGGGGACCCTGGAGGGGGCGAGAAG
GATTATGGCCGGGGAAAAGCGGGTCTTGCAGCTGGGCGGGGGTCTCCACCACGCCCAGTACGACCGCGCCTCGGGGTTTT
GCGTCTACAACGACCTCTCCGTGGCTATCCGCCACATGACCCAGGTTGGGCTTCGCGTGGCCTACGTGGACATTGACGTC
CACCACGGGGACGGGGTGCAGTGGATCCACTACGAGGAGGGGGAGGTCCTCACCCTAAGCCTCCACGAGTCGGGACGCTA
CCTCTTCCCGGGGACGGGGCACGTCTACGAGATCGGCCGGGGGGCGGGCCTGGGGAAGAAGCTCAACCTCCCCCTGGAGC
CCTTCACCGAGGACGAAAGCTACCTCGAGGTCTTTGAGGCCCTGGTGCCCTGGGCCCTTAAGGCCTTCCGCCCCGACGTC
CTCGTGGTCCAGGCGGGGGCGGACGCCCACTACCTGGACCCCTTGGCCGACCTCCTCCTCACCGCCCGGGCCTACGAGAG
GCTTTTCCGCCTCCTCCTGGAGTACGCCGAGGCCTACGCCGGGGGAAGGGTCCTCTTCACCTTGGGGGGCGGGTACAGCC
TGGACGGGACGGTGAGGGTCTGGGCCCTCCTCTACCACCTCTTCCACGGCCTTCCCCTGCCCGAGCGCCTTCCCGAGGGG
TGGCTTAGGACCTGGGAGGCGCGGCTCGGCAGGCCCCTCACCCCCACCCTCCACGACCCCGAAGGGGCCTACCCGGAGAT
CCCCAGGCGGGAGGAGATCGCGAAGCGGAACCGCCTGACCTTGCAGCGGCTCACGGAGCTCGTGGCCCCCCACCTGCTAC
ACTAG

Upstream 100 bases:

>100_bases
TCGTGCGGGCGGTGGTGCGGGTGAACACCCTGGAGACCCACCTCCTGGCGGAGGCCCTCCGCCGGGAGGGGTTTGACGTC
CTCTGGCCCCCCAAAAAGCC

Downstream 100 bases:

>100_bases
CGGGGTGAGGGTCGTTCTGCGCCTGCCCGAGCGCAAGGAGGTGGAGGTCAAGGGGAACCGGCCCTTAAGGGAGGTTCTGG
AGGAGCTTGGCCTGAACCCG

Product: acetoin utilization protein AcuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MVIYREEYRLYNFGPDHPFSPVRLEMLTSLLQALGVWRAPLSPPEASREEVLSVHSERLVKRVEAASRGELYPDLEHYLG
TGDTPVFPGMDRAARILVGGTLEGARRIMAGEKRVLQLGGGLHHAQYDRASGFCVYNDLSVAIRHMTQVGLRVAYVDIDV
HHGDGVQWIHYEEGEVLTLSLHESGRYLFPGTGHVYEIGRGAGLGKKLNLPLEPFTEDESYLEVFEALVPWALKAFRPDV
LVVQAGADAHYLDPLADLLLTARAYERLFRLLLEYAEAYAGGRVLFTLGGGYSLDGTVRVWALLYHLFHGLPLPERLPEG
WLRTWEARLGRPLTPTLHDPEGAYPEIPRREEIAKRNRLTLQRLTELVAPHLLH

Sequences:

>Translated_374_residues
MVIYREEYRLYNFGPDHPFSPVRLEMLTSLLQALGVWRAPLSPPEASREEVLSVHSERLVKRVEAASRGELYPDLEHYLG
TGDTPVFPGMDRAARILVGGTLEGARRIMAGEKRVLQLGGGLHHAQYDRASGFCVYNDLSVAIRHMTQVGLRVAYVDIDV
HHGDGVQWIHYEEGEVLTLSLHESGRYLFPGTGHVYEIGRGAGLGKKLNLPLEPFTEDESYLEVFEALVPWALKAFRPDV
LVVQAGADAHYLDPLADLLLTARAYERLFRLLLEYAEAYAGGRVLFTLGGGYSLDGTVRVWALLYHLFHGLPLPERLPEG
WLRTWEARLGRPLTPTLHDPEGAYPEIPRREEIAKRNRLTLQRLTELVAPHLLH
>Mature_374_residues
MVIYREEYRLYNFGPDHPFSPVRLEMLTSLLQALGVWRAPLSPPEASREEVLSVHSERLVKRVEAASRGELYPDLEHYLG
TGDTPVFPGMDRAARILVGGTLEGARRIMAGEKRVLQLGGGLHHAQYDRASGFCVYNDLSVAIRHMTQVGLRVAYVDIDV
HHGDGVQWIHYEEGEVLTLSLHESGRYLFPGTGHVYEIGRGAGLGKKLNLPLEPFTEDESYLEVFEALVPWALKAFRPDV
LVVQAGADAHYLDPLADLLLTARAYERLFRLLLEYAEAYAGGRVLFTLGGGYSLDGTVRVWALLYHLFHGLPLPERLPEG
WLRTWEARLGRPLTPTLHDPEGAYPEIPRREEIAKRNRLTLQRLTELVAPHLLH

Specific function: Role in growth and sporulation on acetoin or butanediol. Involved in the breakdown of these compounds used as a carbon source [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128862, Length=314, Percent_Identity=32.484076433121, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI13128860, Length=314, Percent_Identity=31.2101910828025, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI293336691, Length=314, Percent_Identity=31.2101910828025, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI8923769, Length=305, Percent_Identity=32.1311475409836, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI262073088, Length=199, Percent_Identity=34.1708542713568, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI262073092, Length=218, Percent_Identity=33.9449541284404, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI17158039, Length=216, Percent_Identity=35.1851851851852, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI30795202, Length=216, Percent_Identity=35.1851851851852, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI30795204, Length=216, Percent_Identity=35.1851851851852, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI13128864, Length=297, Percent_Identity=31.6498316498317, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI153085395, Length=244, Percent_Identity=34.4262295081967, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI20070354, Length=288, Percent_Identity=34.0277777777778, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI169234807, Length=182, Percent_Identity=35.7142857142857, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI148539870, Length=182, Percent_Identity=35.7142857142857, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI62750349, Length=219, Percent_Identity=36.986301369863, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI62750347, Length=217, Percent_Identity=37.3271889400922, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI226529806, Length=290, Percent_Identity=31.7241379310345, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI217272877, Length=310, Percent_Identity=26.4516129032258, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI209862883, Length=316, Percent_Identity=27.5316455696203, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534739, Length=351, Percent_Identity=32.1937321937322, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17508561, Length=304, Percent_Identity=32.8947368421053, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17561978, Length=314, Percent_Identity=31.2101910828025, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17540334, Length=324, Percent_Identity=27.7777777777778, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17540332, Length=324, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI193206283, Length=324, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI193209491, Length=217, Percent_Identity=31.3364055299539, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17537347, Length=262, Percent_Identity=29.0076335877863, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25154020, Length=325, Percent_Identity=23.6923076923077, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25154022, Length=325, Percent_Identity=23.3846153846154, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321244, Length=316, Percent_Identity=31.9620253164557, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323999, Length=314, Percent_Identity=31.8471337579618, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324307, Length=335, Percent_Identity=29.2537313432836, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6325325, Length=254, Percent_Identity=27.5590551181102, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24644244, Length=380, Percent_Identity=30.2631578947368, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24657891, Length=314, Percent_Identity=30.8917197452229, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24642144, Length=311, Percent_Identity=29.5819935691318, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24642146, Length=311, Percent_Identity=29.5819935691318, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI281360899, Length=311, Percent_Identity=29.5819935691318, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24642142, Length=311, Percent_Identity=29.5819935691318, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI281360799, Length=217, Percent_Identity=34.1013824884793, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281360801, Length=217, Percent_Identity=34.1013824884793, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24641720, Length=217, Percent_Identity=34.1013824884793, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24649807, Length=200, Percent_Identity=31, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003085
- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 42133; Mature: 42133

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIYREEYRLYNFGPDHPFSPVRLEMLTSLLQALGVWRAPLSPPEASREEVLSVHSERLV
CEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
KRVEAASRGELYPDLEHYLGTGDTPVFPGMDRAARILVGGTLEGARRIMAGEKRVLQLGG
HHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHCEEEECCCHHHHHHHHHCCHHHHHHCC
GLHHAQYDRASGFCVYNDLSVAIRHMTQVGLRVAYVDIDVHHGDGVQWIHYEEGEVLTLS
CCCHHHCCCCCCCEEECHHHHHHHHHHHHCEEEEEEEEEEECCCCEEEEEECCCCEEEEE
LHESGRYLFPGTGHVYEIGRGAGLGKKLNLPLEPFTEDESYLEVFEALVPWALKAFRPDV
EECCCCEECCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCE
LVVQAGADAHYLDPLADLLLTARAYERLFRLLLEYAEAYAGGRVLFTLGGGYSLDGTVRV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHH
WALLYHLFHGLPLPERLPEGWLRTWEARLGRPLTPTLHDPEGAYPEIPRREEIAKRNRLT
HHHHHHHHHCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LQRLTELVAPHLLH
HHHHHHHHHHHHCC
>Mature Secondary Structure
MVIYREEYRLYNFGPDHPFSPVRLEMLTSLLQALGVWRAPLSPPEASREEVLSVHSERLV
CEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
KRVEAASRGELYPDLEHYLGTGDTPVFPGMDRAARILVGGTLEGARRIMAGEKRVLQLGG
HHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHCEEEECCCHHHHHHHHHCCHHHHHHCC
GLHHAQYDRASGFCVYNDLSVAIRHMTQVGLRVAYVDIDVHHGDGVQWIHYEEGEVLTLS
CCCHHHCCCCCCCEEECHHHHHHHHHHHHCEEEEEEEEEEECCCCEEEEEECCCCEEEEE
LHESGRYLFPGTGHVYEIGRGAGLGKKLNLPLEPFTEDESYLEVFEALVPWALKAFRPDV
EECCCCEECCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCE
LVVQAGADAHYLDPLADLLLTARAYERLFRLLLEYAEAYAGGRVLFTLGGGYSLDGTVRV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHH
WALLYHLFHGLPLPERLPEGWLRTWEARLGRPLTPTLHDPEGAYPEIPRREEIAKRNRLT
HHHHHHHHHCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LQRLTELVAPHLLH
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]