BacMap

Definition	Thermus thermophilus HB8 chromosome, complete genome.
Accession	NC_006461
Length	1,849,742

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The map label for this gene is fabG [H]

Identifier: 55980430

GI number: 55980430

Start: 431482

End: 432186

Strand: Direct

Name: fabG [H]

Synonym: TTHA0461

Alternate gene names: 55980430

Gene position: 431482-432186 (Clockwise)

Preceding gene: 55980429

Following gene: 55980431

Centisome position: 23.33

GC content: 68.51

Gene sequence:

>705_bases
ATGAGGACCGCGTTGGTGACGGGGAGCGCCAAGGGCATCGGCCGGGCCATCCTCTTGGCCCTCGCCCGGGAGGGCTACGC
CGTGGCCGTCCACTACCGCACCTCCGAGGCCTTGGCCGAGGCCACCCGTCAAGAGGCGGAGGCCCTGGGCGTCAAGGCCA
TCAAGGTCCGGGCCGACCTCACCCGGGAGGAGGAGGTGGACCGGCTGGTGGAGGAGGTCCGCTACCACCTGGGGGGGGTG
GGCGTCCTGGTGAACAACGTGGGGGACTACCTCTACAAGCCCATAGAGGAGGTGAGCCTCGAGGAGTGGCGCTGGATCCT
GGACACCAACCTCACGGCCACCTTCCTCCTCACCCAAAGGGTCCTCCCCCTCATGGTGGCCCAGGGCTTTGGCCGCATCG
TGAACCTGGGCTACGCCGGGGCGGGGAACCTCCTCGCCCGGACCCACATCACCCCCTACGTCATCGCCAAGACGGGGGTC
ATCCTCTACACCAAGGCCATCGCCAAACGCTTCGCCGCAAGCGGCATCACCGCCAACGTGGTGGCCCCGGGGGTGGCGGA
AAACTCCGTCTCCAAGCCCCTCCACGAGATCCCCATGGGGAGGCTCGCCCTCCTTCAGGAGATCGCCCAGGCGGTGCTCT
TCTTCGTCCGCGAGCCCTACCTCACGGGGCAGGTGCTGGAGGTGGCCGGGGGGTGGAACCTCTAG

Upstream 100 bases:

>100_bases
AGGAGATCCTGGAGTGGGCCTGGGTGGAGCCCGAGAAGGGGCTCGCCTACCCTTTGAACGCCTTTACCCGGGCCCTCTTG
GTGCGCTATCTGGAGGGGAG

Downstream 100 bases:

>100_bases
GGGCCCCACCGCGGCGTTCGCCAGGGGCTTGGGCGCAAAAAGCCCCGGCTCGAGGCCGGGGCGGGTGGTGGGCCGTGCAG
GATTCGAACCTGCAACCTAC

Product: dihydropteridine/dihydrofolate reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MRTALVTGSAKGIGRAILLALAREGYAVAVHYRTSEALAEATRQEAEALGVKAIKVRADLTREEEVDRLVEEVRYHLGGV
GVLVNNVGDYLYKPIEEVSLEEWRWILDTNLTATFLLTQRVLPLMVAQGFGRIVNLGYAGAGNLLARTHITPYVIAKTGV
ILYTKAIAKRFAASGITANVVAPGVAENSVSKPLHEIPMGRLALLQEIAQAVLFFVREPYLTGQVLEVAGGWNL

Sequences:

>Translated_234_residues
MRTALVTGSAKGIGRAILLALAREGYAVAVHYRTSEALAEATRQEAEALGVKAIKVRADLTREEEVDRLVEEVRYHLGGV
GVLVNNVGDYLYKPIEEVSLEEWRWILDTNLTATFLLTQRVLPLMVAQGFGRIVNLGYAGAGNLLARTHITPYVIAKTGV
ILYTKAIAKRFAASGITANVVAPGVAENSVSKPLHEIPMGRLALLQEIAQAVLFFVREPYLTGQVLEVAGGWNL
>Mature_234_residues
MRTALVTGSAKGIGRAILLALAREGYAVAVHYRTSEALAEATRQEAEALGVKAIKVRADLTREEEVDRLVEEVRYHLGGV
GVLVNNVGDYLYKPIEEVSLEEWRWILDTNLTATFLLTQRVLPLMVAQGFGRIVNLGYAGAGNLLARTHITPYVIAKTGV
ILYTKAIAKRFAASGITANVVAPGVAENSVSKPLHEIPMGRLALLQEIAQAVLFFVREPYLTGQVLEVAGGWNL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=33.8912133891213, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI19923817, Length=252, Percent_Identity=30.5555555555556, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI32483357, Length=246, Percent_Identity=30.8943089430894, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI15277342, Length=250, Percent_Identity=31.6, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=31.8367346938775, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI66933014, Length=234, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=28.2786885245902, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI59889578, Length=205, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI40254986, Length=190, Percent_Identity=24.7368421052632, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI33667109, Length=193, Percent_Identity=30.5699481865285, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI109715829, Length=233, Percent_Identity=25.7510729613734, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI7705855, Length=186, Percent_Identity=27.4193548387097, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4557649, Length=203, Percent_Identity=29.5566502463054, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI4504505, Length=237, Percent_Identity=26.1603375527426, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=34.7107438016529, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=33.0612244897959, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790717, Length=243, Percent_Identity=29.6296296296296, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=29.8387096774194, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=30.9917355371901, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=26.530612244898, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=27.3809523809524, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082160, Length=244, Percent_Identity=26.2295081967213, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787820, Length=169, Percent_Identity=31.3609467455621, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1786701, Length=187, Percent_Identity=26.7379679144385, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=27.4509803921569, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786812, Length=251, Percent_Identity=26.2948207171315, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=31.8007662835249, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=30.188679245283, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=30.1960784313725, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=29.296875, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=248, Percent_Identity=27.8225806451613, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17538486, Length=264, Percent_Identity=30.6818181818182, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=25.968992248062, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=28.735632183908, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=262, Percent_Identity=29.7709923664122, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=24.0458015267176, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=28.3524904214559, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=29.6577946768061, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=268, Percent_Identity=28.3582089552239, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=265, Percent_Identity=26.4150943396226, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=27.9352226720648, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=28.3524904214559, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=260, Percent_Identity=27.6923076923077, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=27.0992366412214, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=26.6409266409266, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71982365, Length=193, Percent_Identity=27.979274611399, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=26.2548262548263, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=26.8199233716475, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=188, Percent_Identity=28.7234042553192, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=188, Percent_Identity=28.7234042553192, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=27.9352226720648, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534660, Length=187, Percent_Identity=28.3422459893048, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=27.7153558052434, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560176, Length=204, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=250, Percent_Identity=25.2, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=246, Percent_Identity=24.390243902439, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI25152911, Length=203, Percent_Identity=31.0344827586207, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=24.6153846153846, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17536651, Length=247, Percent_Identity=25.9109311740891, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=185, Percent_Identity=25.4054054054054, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=26.984126984127, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=195, Percent_Identity=29.2307692307692, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322861, Length=240, Percent_Identity=25.8333333333333, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=33.4645669291339, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=28.9156626506024, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=29.9212598425197, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571526, Length=244, Percent_Identity=30.327868852459, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=28.1124497991968, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=31.0756972111554, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24584744, Length=234, Percent_Identity=29.4871794871795, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574402, Length=234, Percent_Identity=29.4871794871795, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24584748, Length=235, Percent_Identity=29.7872340425532, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161076933, Length=235, Percent_Identity=29.7872340425532, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357673, Length=247, Percent_Identity=24.2914979757085, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859837, Length=237, Percent_Identity=27.0042194092827, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640492, Length=202, Percent_Identity=26.7326732673267, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25407; Mature: 25407

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTALVTGSAKGIGRAILLALAREGYAVAVHYRTSEALAEATRQEAEALGVKAIKVRADL
CCCEEECCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCHHEEEEECCC
TREEEVDRLVEEVRYHLGGVGVLVNNVGDYLYKPIEEVSLEEWRWILDTNLTATFLLTQR
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHCCCCHHHHHHHHH
VLPLMVAQGFGRIVNLGYAGAGNLLARTHITPYVIAKTGVILYTKAIAKRFAASGITANV
HHHHHHHHHHHHHEECCCCCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEE
VAPGVAENSVSKPLHEIPMGRLALLQEIAQAVLFFVREPYLTGQVLEVAGGWNL
ECCCCCCCHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCC
>Mature Secondary Structure
MRTALVTGSAKGIGRAILLALAREGYAVAVHYRTSEALAEATRQEAEALGVKAIKVRADL
CCCEEECCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHCHHEEEEECCC
TREEEVDRLVEEVRYHLGGVGVLVNNVGDYLYKPIEEVSLEEWRWILDTNLTATFLLTQR
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHCCCCHHHHHHHHH
VLPLMVAQGFGRIVNLGYAGAGNLLARTHITPYVIAKTGVILYTKAIAKRFAASGITANV
HHHHHHHHHHHHHEECCCCCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEE
VAPGVAENSVSKPLHEIPMGRLALLQEIAQAVLFFVREPYLTGQVLEVAGGWNL
ECCCCCCCHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA