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The map label for this gene is fabD [H]

Identifier: 55980385

GI number: 55980385

Start: 394671

End: 395588

Strand: Reverse

Name: fabD [H]

Synonym: TTHA0416

Alternate gene names: 55980385

Gene position: 395588-394671 (Counterclockwise)

Preceding gene: 55980386

Following gene: 55980384

Centisome position: 21.39

GC content: 70.15

Gene sequence:

>918_bases
ATGTACGCCGCCCTCTTCCCCGGGCAGGGCTCCCACCGGGTGGGGATGGGCAGGGCCCTCTACGAGGCCTCCCCCGCCGC
CAAGGAGGTCCTGGACCGGGCCGAGGCCGCCCTACCCGGCCTCCTTAAGCTCATGTGGGAGGGCCCGGAGGAGGCCCTGA
CCCTCACGGAGAACCAGCAGCCCGCCCTCCTCGCCGCAGGCTACGCCGCCTACCGGGCCTTTTTGGAGGCGGGCGGAAAG
CCCCCTGCCCTCGCCGCGGGCCACTCCTTAGGGGAGTGGACGGCCCACGTGGCCGCGGGCACCTTGGAGCTGGAAGACGC
CCTAAGGCTCGTGCGCCTTAGGGGCAGGTACATGCAGGAGGCCGTCCCCGTGGGGGAAGGGGCCATGGCCGCCGTGCTGA
AGCTCCCCCTGGAGGAAATCCAAAAGGCCCTGGAGGGCCTTGAGGGGGTGGAGATCGCCAACCTCAACGCCCCGGAGCAG
ACGGTGATCTCCGGGAGGAGGCAAGCGGTGGAGGAGGCCGCGGAAAGGCTCAAGGAGCGGCGGGCCCGCGTGGTCTTCCT
CCCCGTCTCCGCCCCCTTCCACTCCTCCCTCATGGCCCCCGCGCGAAAGCGGCTGGCCGAGGACCTGGCCCAGGTTCCCC
TGAGAAGGCCCCGCTTCCCCGTCTACTCCAACGTCACCGCGAGGCCCGAGGAGGACCCGGAGAGGATCCGGGCGCTCCTC
CTGGAGCAGATCACCGCCCCGGTACGCTGGGTGGAGATCCTACGGGACATGGAGGCGAGGGGCGTCAAGCGCTTCTTGGA
GTTCGGAAGCGGAGAGGTGCTCAAAGGCCTCGTCCTCCGCACCCTGAAGGAGGCGGAGGCCTTGAGCGTCCAGGACCCGG
ATAGCCTGAGGAAGGCGCTGGAGGTGGAGCGTGCGTAA

Upstream 100 bases:

>100_bases
TGGACGCGGGCCGGATCCGGGAGGGGGACCACGTCCTTTTGGTCTCCTTCGGGGCGGGGCTCACCTGGGCCGCCGCCGTC
CTCACCTGGGGAGGTGCCTG

Downstream 100 bases:

>100_bases
GGCCCTGATCACCGGAGCAAGCCGCGGCATCGGTCGGGCCATCGCCCTGAGGCTGGCGGAGGACGGCTTCGCCCTGGCCA
TCCACTACGGCCAGAACCGG

Product: malonyl CoA-[acyl carrier protein] transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MYAALFPGQGSHRVGMGRALYEASPAAKEVLDRAEAALPGLLKLMWEGPEEALTLTENQQPALLAAGYAAYRAFLEAGGK
PPALAAGHSLGEWTAHVAAGTLELEDALRLVRLRGRYMQEAVPVGEGAMAAVLKLPLEEIQKALEGLEGVEIANLNAPEQ
TVISGRRQAVEEAAERLKERRARVVFLPVSAPFHSSLMAPARKRLAEDLAQVPLRRPRFPVYSNVTARPEEDPERIRALL
LEQITAPVRWVEILRDMEARGVKRFLEFGSGEVLKGLVLRTLKEAEALSVQDPDSLRKALEVERA

Sequences:

>Translated_305_residues
MYAALFPGQGSHRVGMGRALYEASPAAKEVLDRAEAALPGLLKLMWEGPEEALTLTENQQPALLAAGYAAYRAFLEAGGK
PPALAAGHSLGEWTAHVAAGTLELEDALRLVRLRGRYMQEAVPVGEGAMAAVLKLPLEEIQKALEGLEGVEIANLNAPEQ
TVISGRRQAVEEAAERLKERRARVVFLPVSAPFHSSLMAPARKRLAEDLAQVPLRRPRFPVYSNVTARPEEDPERIRALL
LEQITAPVRWVEILRDMEARGVKRFLEFGSGEVLKGLVLRTLKEAEALSVQDPDSLRKALEVERA
>Mature_305_residues
MYAALFPGQGSHRVGMGRALYEASPAAKEVLDRAEAALPGLLKLMWEGPEEALTLTENQQPALLAAGYAAYRAFLEAGGK
PPALAAGHSLGEWTAHVAAGTLELEDALRLVRLRGRYMQEAVPVGEGAMAAVLKLPLEEIQKALEGLEGVEIANLNAPEQ
TVISGRRQAVEEAAERLKERRARVVFLPVSAPFHSSLMAPARKRLAEDLAQVPLRRPRFPVYSNVTARPEEDPERIRALL
LEQITAPVRWVEILRDMEARGVKRFLEFGSGEVLKGLVLRTLKEAEALSVQDPDSLRKALEVERA

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=314, Percent_Identity=34.3949044585987, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1787334, Length=306, Percent_Identity=43.1372549019608, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71984332, Length=293, Percent_Identity=29.3515358361775, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=292, Percent_Identity=29.1095890410959, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24665753, Length=298, Percent_Identity=37.248322147651, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 33385; Mature: 33385

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYAALFPGQGSHRVGMGRALYEASPAAKEVLDRAEAALPGLLKLMWEGPEEALTLTENQQ
CCEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCC
PALLAAGYAAYRAFLEAGGKPPALAAGHSLGEWTAHVAAGTLELEDALRLVRLRGRYMQE
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
AVPVGEGAMAAVLKLPLEEIQKALEGLEGVEIANLNAPEQTVISGRRQAVEEAAERLKER
HCCCCCHHHHHHHHCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
RARVVFLPVSAPFHSSLMAPARKRLAEDLAQVPLRRPRFPVYSNVTARPEEDPERIRALL
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LEQITAPVRWVEILRDMEARGVKRFLEFGSGEVLKGLVLRTLKEAEALSVQDPDSLRKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EVERA
HHCCC
>Mature Secondary Structure
MYAALFPGQGSHRVGMGRALYEASPAAKEVLDRAEAALPGLLKLMWEGPEEALTLTENQQ
CCEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCC
PALLAAGYAAYRAFLEAGGKPPALAAGHSLGEWTAHVAAGTLELEDALRLVRLRGRYMQE
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
AVPVGEGAMAAVLKLPLEEIQKALEGLEGVEIANLNAPEQTVISGRRQAVEEAAERLKER
HCCCCCHHHHHHHHCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
RARVVFLPVSAPFHSSLMAPARKRLAEDLAQVPLRRPRFPVYSNVTARPEEDPERIRALL
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LEQITAPVRWVEILRDMEARGVKRFLEFGSGEVLKGLVLRTLKEAEALSVQDPDSLRKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EVERA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]