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The map label for this gene is glmU [H]

Identifier: 55980354

GI number: 55980354

Start: 366353

End: 367723

Strand: Direct

Name: glmU [H]

Synonym: TTHA0385

Alternate gene names: 55980354

Gene position: 366353-367723 (Clockwise)

Preceding gene: 55980353

Following gene: 55980355

Centisome position: 19.81

GC content: 70.61

Gene sequence:

>1371_bases
ATGGGAGGCATGCACGCCCACGTGATCCTGGCCGCGGGGCAGGGGACCAGGATGCGGTCCCGCCTGCCCAAGGTGCTCCA
CCCCCTTTTGGGGAAGCCCATGCTCCTTTACGCCCTCGAGGCCGCCTTAGCCCTCAAGCCGGAAAGGCTCGTGGTGGTGG
TGGGCCACGGGGGGGAGAAGGTGGTGGAGGCCCTGGAGGGCTACCCCGTGGAGGTGGCGTGGCAAAAGGAGCAGCTCGGG
ACCGCCCACGCCCTCCTCCAGGCGGAAGGCCTCCTCCGGGACTTCCCCGGGCCCTTCCTCGTGACCCAGGGGGACACCCC
CCTCCTTTCCCCGAGGACCCTGGAGGCCCTTCTCCGGAGGGTGCGGGAGGGGGCGGGGATGGCCCTCCTCACCGCGGAGC
TCCCTGACCCCACGGGCTACGGCCGGATCCTCCGCGAGGGGGAGGAGGTCTTGGGGAACGTGGAGGAGAAGGACGCGCCT
CCTGAGGTCCGGGCCATCCGGGAGGTGAACGCCGGGGCCTACGCCTTTGACGGCTTCCTCTTCCAGGCCCTCAAAGAGGT
GAGGAACGAAAACGCCGCCCGGGAGTACTACCTCCCGGACCTTATCGCCATCTACCGCGCCCACGGCAGGCGGGTCTTGG
CCGTGCGGGGCGTGGCGGAGGAGGCCTTGGGCGTGAACACCCGCGAGGAGCTCGCCCGGGTGGAGGGGGTGCTTCTTAGG
AGGCTTCGCGCCGAGTGGATGGGGAAGGGGGTGCGGATGATCCTCCCCGAGACCATCTACCTGGAGCCCTCGGTGGAGCT
CGCCCCCGACGTTACCCTCTGGCCCGGGGCGGTCCTCAAGGGAAAGACCCGGATCGGCGAGGGGTGCGAGGTGGGGCCTT
ACGCCGTCCTCGAGGACACGGTGCTGGAACCCGGGGCCAAGGTCCTCGCCCACACCGTGGCCCAGGGGGCCCACCTCCAC
CCCGGGGCCTCCGCCGGGCCCTTCGCCAGGCTCCGCCCGGGGGCGGTCCTCATGGAGGAGGTCCACGTGGGGAACTTCGT
GGAGGTGAAGAACAGCCTCCTCCACAAGGGGGTGAAGGCGGGCCACCTCGCCTACCTCGGGGACGCCGAGGTGGGGGAGG
GGACCAACATCGGCGCCGGGGTCATCACCGCGAACTACGACGGCAAGCGGAAGCACAAGACCGAGATCGGCAAGAAGGCC
TTCATCGGCTCCAACAGCGTCCTCGTGGCCCCGGTGCGGGTGGGGGACCGCGCCCTGGTGGGGGCGGGGAGCGTCATCAC
CCAGGACGTGCCCGAGGGCGCCTTGGCCGTGGCCCGGGAGAGGCAGAAGAACCTCGAGGGGTACGCCCTCAGGAAGCTCG
GGGAAGGGTAG

Upstream 100 bases:

>100_bases
GGCCTCTTCACCGCCACCCAGGTGGTGAGCCTGCCCCTCGTCCTCCTCTCCCTTTACATGCTGCGCCGGCTGGGCAAGGG
GGAGGCGTCTCGGCGCTAAG

Downstream 100 bases:

>100_bases
CCCTCTCCTCCCTTCAGCCCCGGGGTGCTAGACTTAGGGCATGAACCTCGGCATGCCGGAGATCCTCGTCATCCTCCTCG
TCGCCCTCCTCATCTTCGGG

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MGGMHAHVILAAGQGTRMRSRLPKVLHPLLGKPMLLYALEAALALKPERLVVVVGHGGEKVVEALEGYPVEVAWQKEQLG
TAHALLQAEGLLRDFPGPFLVTQGDTPLLSPRTLEALLRRVREGAGMALLTAELPDPTGYGRILREGEEVLGNVEEKDAP
PEVRAIREVNAGAYAFDGFLFQALKEVRNENAAREYYLPDLIAIYRAHGRRVLAVRGVAEEALGVNTREELARVEGVLLR
RLRAEWMGKGVRMILPETIYLEPSVELAPDVTLWPGAVLKGKTRIGEGCEVGPYAVLEDTVLEPGAKVLAHTVAQGAHLH
PGASAGPFARLRPGAVLMEEVHVGNFVEVKNSLLHKGVKAGHLAYLGDAEVGEGTNIGAGVITANYDGKRKHKTEIGKKA
FIGSNSVLVAPVRVGDRALVGAGSVITQDVPEGALAVARERQKNLEGYALRKLGEG

Sequences:

>Translated_456_residues
MGGMHAHVILAAGQGTRMRSRLPKVLHPLLGKPMLLYALEAALALKPERLVVVVGHGGEKVVEALEGYPVEVAWQKEQLG
TAHALLQAEGLLRDFPGPFLVTQGDTPLLSPRTLEALLRRVREGAGMALLTAELPDPTGYGRILREGEEVLGNVEEKDAP
PEVRAIREVNAGAYAFDGFLFQALKEVRNENAAREYYLPDLIAIYRAHGRRVLAVRGVAEEALGVNTREELARVEGVLLR
RLRAEWMGKGVRMILPETIYLEPSVELAPDVTLWPGAVLKGKTRIGEGCEVGPYAVLEDTVLEPGAKVLAHTVAQGAHLH
PGASAGPFARLRPGAVLMEEVHVGNFVEVKNSLLHKGVKAGHLAYLGDAEVGEGTNIGAGVITANYDGKRKHKTEIGKKA
FIGSNSVLVAPVRVGDRALVGAGSVITQDVPEGALAVARERQKNLEGYALRKLGEG
>Mature_455_residues
GGMHAHVILAAGQGTRMRSRLPKVLHPLLGKPMLLYALEAALALKPERLVVVVGHGGEKVVEALEGYPVEVAWQKEQLGT
AHALLQAEGLLRDFPGPFLVTQGDTPLLSPRTLEALLRRVREGAGMALLTAELPDPTGYGRILREGEEVLGNVEEKDAPP
EVRAIREVNAGAYAFDGFLFQALKEVRNENAAREYYLPDLIAIYRAHGRRVLAVRGVAEEALGVNTREELARVEGVLLRR
LRAEWMGKGVRMILPETIYLEPSVELAPDVTLWPGAVLKGKTRIGEGCEVGPYAVLEDTVLEPGAKVLAHTVAQGAHLHP
GASAGPFARLRPGAVLMEEVHVGNFVEVKNSLLHKGVKAGHLAYLGDAEVGEGTNIGAGVITANYDGKRKHKTEIGKKAF
IGSNSVLVAPVRVGDRALVGAGSVITQDVPEGALAVARERQKNLEGYALRKLGEG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=443, Percent_Identity=43.5665914221219, Blast_Score=330, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48917; Mature: 48786

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGMHAHVILAAGQGTRMRSRLPKVLHPLLGKPMLLYALEAALALKPERLVVVVGHGGEK
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCHHH
VVEALEGYPVEVAWQKEQLGTAHALLQAEGLLRDFPGPFLVTQGDTPLLSPRTLEALLRR
HHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHH
VREGAGMALLTAELPDPTGYGRILREGEEVLGNVEEKDAPPEVRAIREVNAGAYAFDGFL
HHCCCCEEEEEECCCCCCCHHHHHHCCHHHHCCCHHCCCCHHHHHHHHCCCCCCHHHHHH
FQALKEVRNENAAREYYLPDLIAIYRAHGRRVLAVRGVAEEALGVNTREELARVEGVLLR
HHHHHHHHCCCCCHHHCCHHHHHHHHHCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHH
RLRAEWMGKGVRMILPETIYLEPSVELAPDVTLWPGAVLKGKTRIGEGCEVGPYAVLEDT
HHHHHHHCCCCEEECCCEEEECCCCCCCCCCEECCCCCEECCCCCCCCCCCCCCHHHHHH
VLEPGAKVLAHTVAQGAHLHPGASAGPFARLRPGAVLMEEVHVGNFVEVKNSLLHKGVKA
HHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCC
GHLAYLGDAEVGEGTNIGAGVITANYDGKRKHKTEIGKKAFIGSNSVLVAPVRVGDRALV
CCEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCEEEECCCCEEEEEEEECCEEEE
GAGSVITQDVPEGALAVARERQKNLEGYALRKLGEG
CCCCHHHCCCCCHHHHHHHHHHHCCCHHHHHHCCCC
>Mature Secondary Structure 
GGMHAHVILAAGQGTRMRSRLPKVLHPLLGKPMLLYALEAALALKPERLVVVVGHGGEK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCHHH
VVEALEGYPVEVAWQKEQLGTAHALLQAEGLLRDFPGPFLVTQGDTPLLSPRTLEALLRR
HHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHH
VREGAGMALLTAELPDPTGYGRILREGEEVLGNVEEKDAPPEVRAIREVNAGAYAFDGFL
HHCCCCEEEEEECCCCCCCHHHHHHCCHHHHCCCHHCCCCHHHHHHHHCCCCCCHHHHHH
FQALKEVRNENAAREYYLPDLIAIYRAHGRRVLAVRGVAEEALGVNTREELARVEGVLLR
HHHHHHHHCCCCCHHHCCHHHHHHHHHCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHH
RLRAEWMGKGVRMILPETIYLEPSVELAPDVTLWPGAVLKGKTRIGEGCEVGPYAVLEDT
HHHHHHHCCCCEEECCCEEEECCCCCCCCCCEECCCCCEECCCCCCCCCCCCCCHHHHHH
VLEPGAKVLAHTVAQGAHLHPGASAGPFARLRPGAVLMEEVHVGNFVEVKNSLLHKGVKA
HHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCC
GHLAYLGDAEVGEGTNIGAGVITANYDGKRKHKTEIGKKAFIGSNSVLVAPVRVGDRALV
CCEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCEEEECCCCEEEEEEEECCEEEE
GAGSVITQDVPEGALAVARERQKNLEGYALRKLGEG
CCCCHHHCCCCCHHHHHHHHHHHCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA