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The map label for this gene is purM [H]

Identifier: 55980336

GI number: 55980336

Start: 347164

End: 348165

Strand: Direct

Name: purM [H]

Synonym: TTHA0367

Alternate gene names: 55980336

Gene position: 347164-348165 (Clockwise)

Preceding gene: 55980335

Following gene: 55980337

Centisome position: 18.77

GC content: 71.46

Gene sequence:

>1002_bases
ATGCGCTACGAGGAGGCCGGGGTCCACATCGAGGCCAAGGCCGAGGCCCTAAGGCGGGCCAGGGAGGCCATCGCCGCCAC
CTACACCCCCGAGGTCCTGCGGGGCATGGGGGCCTTCGGCGGGCTTTACGCCGCAAGCCGGCTCAAGGCCCTAGAGGAAC
CGGTTTTGGTGGCCACCACGGACGGCGTGGGCACCAAAACCCTCCTGGCCCTGGAAGCAGGGGACGTCTCGGGGCTCGGC
TTTGACCTGGTCAACCACTCGGTCAACGACCTCCTGGCCCAGGGGGCGGAGCCCCTTTTCTTCCTGGACTACCTGGCGGC
AAGCCACCTGGACGAAGGGGTGTTGGCCGCCCTCCTCGCCTCCCTGGCCGAGGCCTGCCGCGCGCACGGCATCCCCCTCT
TAGGGGGGGAAACCGCCGAGATGCCCGGCGTCTACCGGGAAGGCGCCTGGGATATCGCCGGCACCCTGGTGGGCGTGGTG
GAGCGGAGCCGCATCCTCGGGCCCGAGCGGGTGCGGGAAGGGGACGCGCTCCTCGCCCTCCCCTCCTCCGGCCCCCACAC
CAACGGCTACTCCCTCATCCGCAAGGTGGTGGCGGGCCAGGACCTCTCCGCCCCCGTCCCCGAACTCGGCGAAAGCCTTA
AAGAAGCCCTCCTCCGCCCCCACCGGGCCTACCTGAAGGAGTTCCGCCTCCTTTGGGAGGCGGGGGTGGAGCTCCACGCC
GCCGCCCACATCACCGGCGGGGGCCTCCCGGAGAACCTGCCCCGGGCCCTGCCCCCGGGCCTCGGCGCGGAGGTCCGGCG
GGGAAGCTGGCCCATCCCCCCCGTCTTCCCCTACCTCCAACGCCTGGGGGGCATCCCCGAGGAGGAGATGTACCGGGTGT
TCAACATGGGCTTGGGCATGGTCCTCGTCCTCCCCCAGGAAGCGGCCGAGGAGGCCCTGAAGCTGGTGGAGGGCTTCCTG
GTGGGCCGGGTGGTCCCGGGAGAGGGCGTCCGCCTGGTATGA

Upstream 100 bases:

>100_bases
ACGCCCTCGTGGGCCAGGTGATGCGCAAGACCCGGGGCCAAGCCCGGCCCGACCTGGTGCGCCGCCTCCTCCTCGAGGCC
CTTGGGGTAGGATAGGGCCG

Downstream 100 bases:

>100_bases
AGGAGATCTGGTACGTCCGCCACGGGGAGACGGAGTGGAACGCCCAGCGGCGCTTCCAGGGGCACCTGGACATCCCCCTC
TCCCCCGTGGGTATCGGGCA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MRYEEAGVHIEAKAEALRRAREAIAATYTPEVLRGMGAFGGLYAASRLKALEEPVLVATTDGVGTKTLLALEAGDVSGLG
FDLVNHSVNDLLAQGAEPLFFLDYLAASHLDEGVLAALLASLAEACRAHGIPLLGGETAEMPGVYREGAWDIAGTLVGVV
ERSRILGPERVREGDALLALPSSGPHTNGYSLIRKVVAGQDLSAPVPELGESLKEALLRPHRAYLKEFRLLWEAGVELHA
AAHITGGGLPENLPRALPPGLGAEVRRGSWPIPPVFPYLQRLGGIPEEEMYRVFNMGLGMVLVLPQEAAEEALKLVEGFL
VGRVVPGEGVRLV

Sequences:

>Translated_333_residues
MRYEEAGVHIEAKAEALRRAREAIAATYTPEVLRGMGAFGGLYAASRLKALEEPVLVATTDGVGTKTLLALEAGDVSGLG
FDLVNHSVNDLLAQGAEPLFFLDYLAASHLDEGVLAALLASLAEACRAHGIPLLGGETAEMPGVYREGAWDIAGTLVGVV
ERSRILGPERVREGDALLALPSSGPHTNGYSLIRKVVAGQDLSAPVPELGESLKEALLRPHRAYLKEFRLLWEAGVELHA
AAHITGGGLPENLPRALPPGLGAEVRRGSWPIPPVFPYLQRLGGIPEEEMYRVFNMGLGMVLVLPQEAAEEALKLVEGFL
VGRVVPGEGVRLV
>Mature_333_residues
MRYEEAGVHIEAKAEALRRAREAIAATYTPEVLRGMGAFGGLYAASRLKALEEPVLVATTDGVGTKTLLALEAGDVSGLG
FDLVNHSVNDLLAQGAEPLFFLDYLAASHLDEGVLAALLASLAEACRAHGIPLLGGETAEMPGVYREGAWDIAGTLVGVV
ERSRILGPERVREGDALLALPSSGPHTNGYSLIRKVVAGQDLSAPVPELGESLKEALLRPHRAYLKEFRLLWEAGVELHA
AAHITGGGLPENLPRALPPGLGAEVRRGSWPIPPVFPYLQRLGGIPEEEMYRVFNMGLGMVLVLPQEAAEEALKLVEGFL
VGRVVPGEGVRLV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=43.620178041543, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=43.620178041543, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=43.620178041543, Blast_Score=245, Evalue=5e-65,
Organism=Escherichia coli, GI1788845, Length=318, Percent_Identity=46.2264150943396, Blast_Score=274, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17567511, Length=348, Percent_Identity=33.3333333333333, Blast_Score=190, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6321203, Length=324, Percent_Identity=41.0493827160494, Blast_Score=235, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24582400, Length=268, Percent_Identity=37.6865671641791, Blast_Score=174, Evalue=8e-44,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 35404; Mature: 35404

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYEEAGVHIEAKAEALRRAREAIAATYTPEVLRGMGAFGGLYAASRLKALEEPVLVATT
CCCCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
DGVGTKTLLALEAGDVSGLGFDLVNHSVNDLLAQGAEPLFFLDYLAASHLDEGVLAALLA
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHH
SLAEACRAHGIPLLGGETAEMPGVYREGAWDIAGTLVGVVERSRILGPERVREGDALLAL
HHHHHHHHCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEE
PSSGPHTNGYSLIRKVVAGQDLSAPVPELGESLKEALLRPHRAYLKEFRLLWEAGVELHA
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHEE
AAHITGGGLPENLPRALPPGLGAEVRRGSWPIPPVFPYLQRLGGIPEEEMYRVFNMGLGM
EEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCE
VLVLPQEAAEEALKLVEGFLVGRVVPGEGVRLV
EEEECHHHHHHHHHHHHHHHHHEECCCCCCCCC
>Mature Secondary Structure
MRYEEAGVHIEAKAEALRRAREAIAATYTPEVLRGMGAFGGLYAASRLKALEEPVLVATT
CCCCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
DGVGTKTLLALEAGDVSGLGFDLVNHSVNDLLAQGAEPLFFLDYLAASHLDEGVLAALLA
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHH
SLAEACRAHGIPLLGGETAEMPGVYREGAWDIAGTLVGVVERSRILGPERVREGDALLAL
HHHHHHHHCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEE
PSSGPHTNGYSLIRKVVAGQDLSAPVPELGESLKEALLRPHRAYLKEFRLLWEAGVELHA
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHEE
AAHITGGGLPENLPRALPPGLGAEVRRGSWPIPPVFPYLQRLGGIPEEEMYRVFNMGLGM
EEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCE
VLVLPQEAAEEALKLVEGFLVGRVVPGEGVRLV
EEEECHHHHHHHHHHHHHHHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]