Click here to switch to the map view.

The map label for this gene is dapL [H]

Identifier: 55980311

GI number: 55980311

Start: 323734

End: 324864

Strand: Direct

Name: dapL [H]

Synonym: TTHA0342

Alternate gene names: 55980311

Gene position: 323734-324864 (Clockwise)

Preceding gene: 55980310

Following gene: 55980316

Centisome position: 17.5

GC content: 69.41

Gene sequence:

>1131_bases
ATGAGTAGGGTGCCGGAGCCCTCGGTTTTTCTGGTGGTGGACGAGGCCAAGCGGAAGGCCCGGGAACGGGGCGTGGGGCT
CATTGACCTCTCCATCGGCTCCACCGACCTCCCGCCCCCCGAGGCCCCCCTGAAGGCCCTCGCCGAGGCCTTGAACGACC
CCACCACCTACGGCTACTGCCTGAAGAGCTGTACCCTCCCCTTCCTGGAGGAGGCGGCCCGCTGGTACGAGGGCCGCTAC
GGGGTGGGCCTGGACCCCAGGCGGGAGGCCCTGGCCCTCATCGGAAGCCAAGAGGGCTTAGCCCACCTCCTCCTCGCCCT
CACGGAGCCCGAAGACCTCCTCCTCCTCCCCGAGGTGGCCTACCCCAGCTACTTCGGGGCGGCCCGGGTGGCCTCCTTGA
GGACCTTCCTCATCCCCCTAAGGGAGGACGGCCTCGCCGACCTGAAGGCGGTGCCGGAAGGCGTGTGGCGGGAGGCCAAG
GTCCTCCTCCTCAACTACCCCAACAACCCCACGGGGGCCGTGGCCGACTGGGGCTACTTTGAGGAGGCCCTGGGCTTGGC
CCGGAAGCACGGCCTCTGGCTCATCCACGACAACCCCTACGTGGACCAGGTCTACGAGGGAGAGGCCCCCTCCCCCCTGG
CCCTCCCCGGGGCCAAGGAGCGGGTGGTGGAGCTCTTCTCCCTCTCCAAGAGCTACAACCTCGCGGGCTTTCGCCTGGGC
TTCGCCCTGGGGAGCGAGGAGGCCCTCGCCCGCCTGGAGCGGGTGAAGGGGGTCATAGACTTCAACCAGTACGCCGGGGT
CCTGCGCATGGGGGTGGAGGCCCTGAAGACCCCTAAGGAGGTGGTCCGAGGCTACGCCCGGGTCTACCGGGAAAGGGCCC
TGGGGATGGCCGAGGCCCTAAAGGGGGTCCTAAGCCTCCTCCCCCCCAGGGCCACCATGTACCTCTGGGGGCGGCTTCCC
GAGGGGGTGGACGACCTGGAGTTCGGCCTCAGGTTGGTGGAAAGGGGCGTGGCCCTGGCCCCGGGAAGGGGCTTTGGCCC
TGGAGGAAAAGGGTTCGTCCGCATCGCCCTGGTGCGGCCCCTGGAAGAGCTCCTCGAGGCGGCCAAGCGCATCCGCGAGG
CCCTGGACTAA

Upstream 100 bases:

>100_bases
GGAAGCCCCAAGGGGGCGAGGGAGTCCTTGGAGGCCGTGCTCCCCGTTTTGCCCCACGCCCTCTCCCTGGTGACGGGCAA
GCCCTGGAAGGAGGGGCACC

Downstream 100 bases:

>100_bases
GCGCCCAGCCTACTGCCAACGCTCCTCGGCGGGAAGCCCCTCAAGGCGGCGGAGAACCTCCCCCACCAGGTAGAGGCTTC
CCGCCACCACCACCCGGCCC

Product: N-succinyldiaminopimelate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MSRVPEPSVFLVVDEAKRKARERGVGLIDLSIGSTDLPPPEAPLKALAEALNDPTTYGYCLKSCTLPFLEEAARWYEGRY
GVGLDPRREALALIGSQEGLAHLLLALTEPEDLLLLPEVAYPSYFGAARVASLRTFLIPLREDGLADLKAVPEGVWREAK
VLLLNYPNNPTGAVADWGYFEEALGLARKHGLWLIHDNPYVDQVYEGEAPSPLALPGAKERVVELFSLSKSYNLAGFRLG
FALGSEEALARLERVKGVIDFNQYAGVLRMGVEALKTPKEVVRGYARVYRERALGMAEALKGVLSLLPPRATMYLWGRLP
EGVDDLEFGLRLVERGVALAPGRGFGPGGKGFVRIALVRPLEELLEAAKRIREALD

Sequences:

>Translated_376_residues
MSRVPEPSVFLVVDEAKRKARERGVGLIDLSIGSTDLPPPEAPLKALAEALNDPTTYGYCLKSCTLPFLEEAARWYEGRY
GVGLDPRREALALIGSQEGLAHLLLALTEPEDLLLLPEVAYPSYFGAARVASLRTFLIPLREDGLADLKAVPEGVWREAK
VLLLNYPNNPTGAVADWGYFEEALGLARKHGLWLIHDNPYVDQVYEGEAPSPLALPGAKERVVELFSLSKSYNLAGFRLG
FALGSEEALARLERVKGVIDFNQYAGVLRMGVEALKTPKEVVRGYARVYRERALGMAEALKGVLSLLPPRATMYLWGRLP
EGVDDLEFGLRLVERGVALAPGRGFGPGGKGFVRIALVRPLEELLEAAKRIREALD
>Mature_375_residues
SRVPEPSVFLVVDEAKRKARERGVGLIDLSIGSTDLPPPEAPLKALAEALNDPTTYGYCLKSCTLPFLEEAARWYEGRYG
VGLDPRREALALIGSQEGLAHLLLALTEPEDLLLLPEVAYPSYFGAARVASLRTFLIPLREDGLADLKAVPEGVWREAKV
LLLNYPNNPTGAVADWGYFEEALGLARKHGLWLIHDNPYVDQVYEGEAPSPLALPGAKERVVELFSLSKSYNLAGFRLGF
ALGSEEALARLERVKGVIDFNQYAGVLRMGVEALKTPKEVVRGYARVYRERALGMAEALKGVLSLLPPRATMYLWGRLPE
GVDDLEFGLRLVERGVALAPGRGFGPGGKGFVRIALVRPLEELLEAAKRIREALD

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507369, Length=392, Percent_Identity=25.5102040816327, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI95147551, Length=250, Percent_Identity=26, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI169881279, Length=250, Percent_Identity=26, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI56713254, Length=250, Percent_Identity=26, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI56713256, Length=250, Percent_Identity=26, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788722, Length=381, Percent_Identity=35.1706036745407, Blast_Score=230, Evalue=9e-62,
Organism=Escherichia coli, GI1788627, Length=359, Percent_Identity=26.4623955431755, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786816, Length=313, Percent_Identity=24.2811501597444, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=359, Percent_Identity=25.3481894150418, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994472, Length=351, Percent_Identity=25.0712250712251, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71994476, Length=343, Percent_Identity=25.0728862973761, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=197, Percent_Identity=23.8578680203046, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI18859735, Length=384, Percent_Identity=26.0416666666667, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 41229; Mature: 41098

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVPEPSVFLVVDEAKRKARERGVGLIDLSIGSTDLPPPEAPLKALAEALNDPTTYGYC
CCCCCCCCEEEEECHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHH
LKSCTLPFLEEAARWYEGRYGVGLDPRREALALIGSQEGLAHLLLALTEPEDLLLLPEVA
HHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCC
YPSYFGAARVASLRTFLIPLREDGLADLKAVPEGVWREAKVLLLNYPNNPTGAVADWGYF
CCCHHHHHHHHHHHHHHEECCCCCCHHHHHCCHHHCCCEEEEEEECCCCCCCCCCCHHHH
EEALGLARKHGLWLIHDNPYVDQVYEGEAPSPLALPGAKERVVELFSLSKSYNLAGFRLG
HHHHHHHHHCCEEEEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEE
FALGSEEALARLERVKGVIDFNQYAGVLRMGVEALKTPKEVVRGYARVYRERALGMAEAL
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHH
KGVLSLLPPRATMYLWGRLPEGVDDLEFGLRLVERGVALAPGRGFGPGGKGFVRIALVRP
HHHHHHCCCCHHEEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEEHHHHHH
LEELLEAAKRIREALD
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRVPEPSVFLVVDEAKRKARERGVGLIDLSIGSTDLPPPEAPLKALAEALNDPTTYGYC
CCCCCCCEEEEECHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHH
LKSCTLPFLEEAARWYEGRYGVGLDPRREALALIGSQEGLAHLLLALTEPEDLLLLPEVA
HHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCC
YPSYFGAARVASLRTFLIPLREDGLADLKAVPEGVWREAKVLLLNYPNNPTGAVADWGYF
CCCHHHHHHHHHHHHHHEECCCCCCHHHHHCCHHHCCCEEEEEEECCCCCCCCCCCHHHH
EEALGLARKHGLWLIHDNPYVDQVYEGEAPSPLALPGAKERVVELFSLSKSYNLAGFRLG
HHHHHHHHHCCEEEEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEE
FALGSEEALARLERVKGVIDFNQYAGVLRMGVEALKTPKEVVRGYARVYRERALGMAEAL
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHH
KGVLSLLPPRATMYLWGRLPEGVDDLEFGLRLVERGVALAPGRGFGPGGKGFVRIALVRP
HHHHHHCCCCHHEEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEEHHHHHH
LEELLEAAKRIREALD
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]