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The map label for this gene is lysK [H]

Identifier: 55980266

GI number: 55980266

Start: 287247

End: 288317

Strand: Direct

Name: lysK [H]

Synonym: TTHA0297

Alternate gene names: 55980266

Gene position: 287247-288317 (Clockwise)

Preceding gene: 55980265

Following gene: 55980267

Centisome position: 15.53

GC content: 74.7

Gene sequence:

>1071_bases
GTGGACTGGGTCAGGCTCCTCTCCCGCCTCGTCCAGGCGGAAAGCCTCCCCGGGGAGGAAGGGGAGGCGGCGGGGCTCCT
CCTCGAGGCCCTGAAGGGGATGGGCCTCGAGGCCACCCTGGACGAGGCGGGGAACATCGAGGCCCTCCTCGGCGAGAAGG
GGCCCGAGGTGGTCCTCACCGGGCACATGGACGTGGTGCCCGTGGGCGACCCCGCCCGCTGGCCCTACCCCCAGGGGGCC
GTGGCCGAAGGGTCCCTCTGGGGCCGGGGGGCGGTGGACATGAAGGGGAGCCTGGTGGCCATGCTCCTCGCCCTGGAGAC
CCTGGCGCGGGGGGCCTTAAAAGGGCGGGTCCGCTTCCTCGCCGTGGTCCAGGAGGAGGTGGGGGGCCTCGGGAGCCGCT
TCGCCGCGGAAAGGCTTTCCCCCCTGGCCTTCGTCCTGGGGGAGCCCTCCTCGGGGCGGCTCATGCGGGGGCACCGCGGG
CGGGCGGAGGTGTGGGCCGACTTTGAGGGCAGGGAGACCCACGCCGCCCTCGCCGGGCCGGAAAACCCCCTCTTTGACCT
AGGGGCCTACCTCCTCGCCCTCCAGGACCTCCCCCTGCCCCCCGGGGTGAAGCTCACCCCCACCCGGGTGGACACCCACC
CCGGGGCCCGGAACCAGACCCCCGGGGTGGTGCGGCTCTACCTGGACGTGCGCTACGAGCCCGAGGCCGACCTGGACGGG
CTCCTCGCCGCCTTGCGCACCCTGGGCCCGGCCTCGGTCTACCTGCCCGAGGAGGAGAGGGCCTCCGGGGAGGTGCGGAT
GACCCTCCCCGCCCTCTGGCCCCCCTACCGCCTCCCGGAGGACCACCCTCTCCTGCAGGCGGCCCTCCAAGCCCTGGGGC
AGGAGGAGGCGGGGCTTTGGCCCTTCACCACCGACGCCCCCTACCTCGGGGCCAAGGCCCCCGTCCTGGGCCTGGGCCCG
GGGGACCCCGCCTTGGCCCACACCCCCATGGAGCACGTCCCCTTGCGGGCCGTGGAGGAGGCGGCCCAGGCCTACGTGCG
GCTGGTGGAGGCCCTATGGAACGCCGCTTGA

Upstream 100 bases:

>100_bases
CGCATCCCCATCCGGGAGGAGGCGGAGTCCCTGAACGCCTCCGTGGCCCTGGGGATCGCCCTCTACCAGGCGAGGCTCGC
CCGGGGTGTAGGATAGGGGC

Downstream 100 bases:

>100_bases
TCGCAGGGAAACCCTACCGCAGGCTTCTCGTGGCCCCGAGGCCCGTGGCCGAGGGGATGAAGGCCCGCCTCGAGGCCCGG
GGCCTCCCGGTCTACCTGGA

Product: acetylornithine deacetylase ArgE

Products: Acetate; Ornithine [C]

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MDWVRLLSRLVQAESLPGEEGEAAGLLLEALKGMGLEATLDEAGNIEALLGEKGPEVVLTGHMDVVPVGDPARWPYPQGA
VAEGSLWGRGAVDMKGSLVAMLLALETLARGALKGRVRFLAVVQEEVGGLGSRFAAERLSPLAFVLGEPSSGRLMRGHRG
RAEVWADFEGRETHAALAGPENPLFDLGAYLLALQDLPLPPGVKLTPTRVDTHPGARNQTPGVVRLYLDVRYEPEADLDG
LLAALRTLGPASVYLPEEERASGEVRMTLPALWPPYRLPEDHPLLQAALQALGQEEAGLWPFTTDAPYLGAKAPVLGLGP
GDPALAHTPMEHVPLRAVEEAAQAYVRLVEALWNAA

Sequences:

>Translated_356_residues
MDWVRLLSRLVQAESLPGEEGEAAGLLLEALKGMGLEATLDEAGNIEALLGEKGPEVVLTGHMDVVPVGDPARWPYPQGA
VAEGSLWGRGAVDMKGSLVAMLLALETLARGALKGRVRFLAVVQEEVGGLGSRFAAERLSPLAFVLGEPSSGRLMRGHRG
RAEVWADFEGRETHAALAGPENPLFDLGAYLLALQDLPLPPGVKLTPTRVDTHPGARNQTPGVVRLYLDVRYEPEADLDG
LLAALRTLGPASVYLPEEERASGEVRMTLPALWPPYRLPEDHPLLQAALQALGQEEAGLWPFTTDAPYLGAKAPVLGLGP
GDPALAHTPMEHVPLRAVEEAAQAYVRLVEALWNAA
>Mature_356_residues
MDWVRLLSRLVQAESLPGEEGEAAGLLLEALKGMGLEATLDEAGNIEALLGEKGPEVVLTGHMDVVPVGDPARWPYPQGA
VAEGSLWGRGAVDMKGSLVAMLLALETLARGALKGRVRFLAVVQEEVGGLGSRFAAERLSPLAFVLGEPSSGRLMRGHRG
RAEVWADFEGRETHAALAGPENPLFDLGAYLLALQDLPLPPGVKLTPTRVDTHPGARNQTPGVVRLYLDVRYEPEADLDG
LLAALRTLGPASVYLPEEERASGEVRMTLPALWPPYRLPEDHPLLQAALQALGQEEAGLWPFTTDAPYLGAKAPVLGLGP
GDPALAHTPMEHVPLRAVEEAAQAYVRLVEALWNAA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. LysK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790395, Length=371, Percent_Identity=26.9541778975741, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1789236, Length=363, Percent_Identity=25.3443526170799, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788816, Length=259, Percent_Identity=27.7992277992278, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010175
- InterPro:   IPR002933 [H]

Pfam domain/function: PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 37990; Mature: 37990

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWVRLLSRLVQAESLPGEEGEAAGLLLEALKGMGLEATLDEAGNIEALLGEKGPEVVLT
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEECCCCCCEEEE
GHMDVVPVGDPARWPYPQGAVAEGSLWGRGAVDMKGSLVAMLLALETLARGALKGRVRFL
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVVQEEVGGLGSRFAAERLSPLAFVLGEPSSGRLMRGHRGRAEVWADFEGRETHAALAGP
HHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCCEECCCCCCCEEEECCCCCCCEEECCCC
ENPLFDLGAYLLALQDLPLPPGVKLTPTRVDTHPGARNQTPGVVRLYLDVRYEPEADLDG
CCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCHHH
LLAALRTLGPASVYLPEEERASGEVRMTLPALWPPYRLPEDHPLLQAALQALGQEEAGLW
HHHHHHHCCCCEEECCCHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
PFTTDAPYLGAKAPVLGLGPGDPALAHTPMEHVPLRAVEEAAQAYVRLVEALWNAA
CCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDWVRLLSRLVQAESLPGEEGEAAGLLLEALKGMGLEATLDEAGNIEALLGEKGPEVVLT
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEECCCCCCEEEE
GHMDVVPVGDPARWPYPQGAVAEGSLWGRGAVDMKGSLVAMLLALETLARGALKGRVRFL
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVVQEEVGGLGSRFAAERLSPLAFVLGEPSSGRLMRGHRGRAEVWADFEGRETHAALAGP
HHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCCEECCCCCCCEEEECCCCCCCEEECCCC
ENPLFDLGAYLLALQDLPLPPGVKLTPTRVDTHPGARNQTPGVVRLYLDVRYEPEADLDG
CCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCHHH
LLAALRTLGPASVYLPEEERASGEVRMTLPALWPPYRLPEDHPLLQAALQALGQEEAGLW
HHHHHHHCCCCEEECCCHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
PFTTDAPYLGAKAPVLGLGPGDPALAHTPMEHVPLRAVEEAAQAYVRLVEALWNAA
CCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA