BacMap

Definition	Thermus thermophilus HB8 chromosome, complete genome.
Accession	NC_006461
Length	1,849,742

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The map label for this gene is paaG [H]

Identifier: 55980259

GI number: 55980259

Start: 283093

End: 283857

Strand: Direct

Name: paaG [H]

Synonym: TTHA0290

Alternate gene names: 55980259

Gene position: 283093-283857 (Clockwise)

Preceding gene: 55980255

Following gene: 55980260

Centisome position: 15.3

GC content: 70.72

Gene sequence:

>765_bases
ATGGTCCTGAAGGAACGCCAAGACGGGGTTTTGGTCCTCACCCTGAACCGGCCCGAGAAGCTCAACGCCATCACCGGGGA
GCTCCTAGACGCCCTTTACGCCGCCCTCAAGGAGGGGGAGGAGGACCGGGAGGTGCGCGCCCTCCTCCTCACGGGAGCGG
GCCGGGCCTTCTCCGCCGGGCAGGACCTCACGGAGTTCGGCGACCGGAAGCCCGACTACGAGGCCCACCTGCGCCGCTAC
AACCGGGTGGTGGAGGCCTTGAGCGGCTTGGAGAAGCCCCTCGTGGTGGCGGTGAACGGGGTGGCGGCCGGGGCGGGGAT
GAGCCTCGCCCTATGGGGGGATCTCCGCCTCGCCGCCGTGGGGGCGAGCTTCACTACGGCCTTCGTCAGGATCGGCCTGG
TGCCGGACTCGGGGCTGAGCTTCCTCCTCCCCCGGCTCGTGGGCCTCGCCAAGGCCCAGGAGCTCCTCCTCCTCTCCCCA
AGGCTTTCCGCCGAGGAGGCCCTGGCCCTGGGGCTCGTGCACCGGGTGGTGCCCGCGGAAAAGCTCATGGAGGAGGCCCT
CTCCTTGGCCAAAGAGCTCGCCCAGGGCCCCACCCGGGCCTACGCCCTCACCAAGAAGCTCCTCCTGGAGACCTACCGCC
TCTCCCTCACCGAGGCTTTGGCCCTCGAGGCCGTCCTCCAGGGCCAGGCCGGCCAGACCCAGGACCACGAGGAGGGGGTC
CGGGCCTTTAGGGAGAAGCGGCCGCCCCGCTTCCAGGGCCGATGA

Upstream 100 bases:

>100_bases
GGCTTTCCAGCGTGAGCTCCATGGCGCCTCCGGGGGGTTACCCCCTACCTAAGCTACACCAAAAAGCGGTGTGGTGCGCC
ACGCCCCGTACAATGGGGGC

Downstream 100 bases:

>100_bases
TCCGCTACCTCCGGGGCCTGGTCCTCAAGAAGGAGGCGGGCGGCTTCGTCCTTCTCGCCGGGGGGGTGGGGTTCTTCCTC
CAGGCCCCCACGCCCTTCCT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MVLKERQDGVLVLTLNRPEKLNAITGELLDALYAALKEGEEDREVRALLLTGAGRAFSAGQDLTEFGDRKPDYEAHLRRY
NRVVEALSGLEKPLVVAVNGVAAGAGMSLALWGDLRLAAVGASFTTAFVRIGLVPDSGLSFLLPRLVGLAKAQELLLLSP
RLSAEEALALGLVHRVVPAEKLMEEALSLAKELAQGPTRAYALTKKLLLETYRLSLTEALALEAVLQGQAGQTQDHEEGV
RAFREKRPPRFQGR

Sequences:

>Translated_254_residues
MVLKERQDGVLVLTLNRPEKLNAITGELLDALYAALKEGEEDREVRALLLTGAGRAFSAGQDLTEFGDRKPDYEAHLRRY
NRVVEALSGLEKPLVVAVNGVAAGAGMSLALWGDLRLAAVGASFTTAFVRIGLVPDSGLSFLLPRLVGLAKAQELLLLSP
RLSAEEALALGLVHRVVPAEKLMEEALSLAKELAQGPTRAYALTKKLLLETYRLSLTEALALEAVLQGQAGQTQDHEEGV
RAFREKRPPRFQGR
>Mature_254_residues
MVLKERQDGVLVLTLNRPEKLNAITGELLDALYAALKEGEEDREVRALLLTGAGRAFSAGQDLTEFGDRKPDYEAHLRRY
NRVVEALSGLEKPLVVAVNGVAAGAGMSLALWGDLRLAAVGASFTTAFVRIGLVPDSGLSFLLPRLVGLAKAQELLLLSP
RLSAEEALALGLVHRVVPAEKLMEEALSLAKELAQGPTRAYALTKKLLLETYRLSLTEALALEAVLQGQAGQTQDHEEGV
RAFREKRPPRFQGR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=247, Percent_Identity=35.6275303643725, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI45643119, Length=229, Percent_Identity=33.6244541484716, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI260275230, Length=229, Percent_Identity=33.6244541484716, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI260274832, Length=229, Percent_Identity=33.6244541484716, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI70995211, Length=255, Percent_Identity=32.156862745098, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=31.3953488372093, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI31542718, Length=251, Percent_Identity=29.4820717131474, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI37594469, Length=193, Percent_Identity=32.6424870466321, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4757968, Length=200, Percent_Identity=31.5, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI49355787, Length=200, Percent_Identity=31.5, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI37594471, Length=193, Percent_Identity=32.6424870466321, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI221136756, Length=252, Percent_Identity=27.3809523809524, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI221136753, Length=252, Percent_Identity=27.3809523809524, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI150378541, Length=252, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI221307494, Length=240, Percent_Identity=28.3333333333333, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI4757966, Length=200, Percent_Identity=31, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI51538581, Length=200, Percent_Identity=31, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI25453481, Length=200, Percent_Identity=31, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI51538573, Length=200, Percent_Identity=31, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI68989263, Length=201, Percent_Identity=32.8358208955224, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI116235487, Length=199, Percent_Identity=29.1457286432161, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI157694516, Length=234, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI62530384, Length=209, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI213417737, Length=234, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI20127408, Length=220, Percent_Identity=28.6363636363636, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI295842266, Length=207, Percent_Identity=31.4009661835749, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787660, Length=262, Percent_Identity=45.0381679389313, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1787659, Length=262, Percent_Identity=34.7328244274809, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI221142681, Length=255, Percent_Identity=34.9019607843137, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1788597, Length=255, Percent_Identity=29.4117647058824, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI87082183, Length=255, Percent_Identity=28.2352941176471, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1788682, Length=198, Percent_Identity=32.8282828282828, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790281, Length=231, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25145438, Length=245, Percent_Identity=35.9183673469388, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17554946, Length=253, Percent_Identity=32.4110671936759, Blast_Score=130, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17535521, Length=252, Percent_Identity=29.3650793650794, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17560910, Length=198, Percent_Identity=32.3232323232323, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17549921, Length=189, Percent_Identity=32.8042328042328, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17540714, Length=230, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17540306, Length=251, Percent_Identity=27.8884462151394, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17534483, Length=205, Percent_Identity=31.219512195122, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17536985, Length=223, Percent_Identity=27.8026905829596, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144157, Length=194, Percent_Identity=30.9278350515464, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144160, Length=194, Percent_Identity=30.9278350515464, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17558304, Length=214, Percent_Identity=27.5700934579439, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=193, Percent_Identity=27.979274611399, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20129971, Length=242, Percent_Identity=35.1239669421488, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653477, Length=242, Percent_Identity=35.1239669421488, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19922422, Length=252, Percent_Identity=26.984126984127, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24654903, Length=222, Percent_Identity=30.1801801801802, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653139, Length=263, Percent_Identity=30.4182509505703, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357171, Length=254, Percent_Identity=28.740157480315, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI19920382, Length=231, Percent_Identity=29.004329004329, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24650670, Length=249, Percent_Identity=27.3092369477912, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28571729, Length=140, Percent_Identity=34.2857142857143, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28571730, Length=140, Percent_Identity=34.2857142857143, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR011968 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27528; Mature: 27528

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLKERQDGVLVLTLNRPEKLNAITGELLDALYAALKEGEEDREVRALLLTGAGRAFSAG
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCC
QDLTEFGDRKPDYEAHLRRYNRVVEALSGLEKPLVVAVNGVAAGAGMSLALWGDLRLAAV
CCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECEECCCCCEEEEECCCHHHHH
GASFTTAFVRIGLVPDSGLSFLLPRLVGLAKAQELLLLSPRLSAEEALALGLVHRVVPAE
CHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHH
KLMEEALSLAKELAQGPTRAYALTKKLLLETYRLSLTEALALEAVLQGQAGQTQDHEEGV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
RAFREKRPPRFQGR
HHHHHCCCCCCCCC
>Mature Secondary Structure
MVLKERQDGVLVLTLNRPEKLNAITGELLDALYAALKEGEEDREVRALLLTGAGRAFSAG
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCC
QDLTEFGDRKPDYEAHLRRYNRVVEALSGLEKPLVVAVNGVAAGAGMSLALWGDLRLAAV
CCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECEECCCCCEEEEECCCHHHHH
GASFTTAFVRIGLVPDSGLSFLLPRLVGLAKAQELLLLSPRLSAEEALALGLVHRVVPAE
CHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHH
KLMEEALSLAKELAQGPTRAYALTKKLLLETYRLSLTEALALEAVLQGQAGQTQDHEEGV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
RAFREKRPPRFQGR
HHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]