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The map label for this gene is norA [H]

Identifier: 55980232

GI number: 55980232

Start: 250524

End: 251696

Strand: Direct

Name: norA [H]

Synonym: TTHA0263

Alternate gene names: 55980232

Gene position: 250524-251696 (Clockwise)

Preceding gene: 55980231

Following gene: 55980233

Centisome position: 13.54

GC content: 71.36

Gene sequence:

>1173_bases
ATGTCGCCCCTTGCCCTCCTCTTCCTCACCCTCTTCAACAGCGTCCTGGGCCTCTCCATCCTCTTCCCCATCCTGGGGCC
TTTGGGCAGGGCGCTGGGCCTCACCGAGGTCCAGGTGGGCCTCTTCTCCACGGGCTACGCCCTCATGCAGTTCCTCCTTT
CCCCCTACTGGGGCAGGCGGAGCGAACGGGGCCGGAAGCCCGTCCTCCTCGTGGGCATCCTGGGCTTCGCGGCAAGCTTC
CTCCTCTTCGGCGTCTTCGCCCTCCTGGGGGAGCGGGGCCTCGTGCCCCCGGGGCTCCTCTTTTTCCTGCTCCTCCTCGC
GCGGCTTCTCGGCGGGGCCTTCAGCTCCGCCACCCTGCCCACGGCCCAGGCCTACGTGGCCGACGTTACGGGGCGGGAGA
ACCGCACCGCGGGGATGGCCCTCCTGGGGGCGGCCTTTGGCCTCGCGGTGATCCTAGGGCCCGCCCTGGGGGCGGGGCTT
GCCGCCCTCTTCGGCCTCCTCGCCCCCGTCTTCTTCTCGGCGGGGATCGCCCTCCTAAACGCCCTTTTCGTTTACCTGGT
CCTCCCCGAGTCCAGACCCCGGGGGCAGGAAGCCGGGGCGCGGCTTTCCCCCTTTGACCCCAGGGTCTTCCCCCTCCTCC
TCCTCGGCCTCGCCCTCAACCTTTCCAGCGTGGCCCTGGAGCAGACCATCGCCTTCTACTTCCAGGACCGGCTTCTCCTC
GGCGGGGTGGAGACGGCCCAGAAGGTGGGCCTGGCCCTGGTCTTCTACGGGGTCGTGGCCGTCTTCGTCCAGGGCGTCCT
GGTGCGCAAGACCGGCTGGCCCCCGAGGGTCCTCCTCTCCCTGGGCCTGCCTCTGGGGATCCTGGGCTTCGTCCTCCTGG
TCTACGCCAAGACCTTCTGGGCCCTGGCCCTGGGCCTCGCCCTCCAGGGGGTGGGGCAGGGGCTCGCCCTCCCCGGGGTC
ACGGCGGCCCTCTCCCTGGCCGTGGGCGAGGGGGAGCAGGGCCTGGTGGCGGGGCTCAACAGTTCCGCCCAGGCCCTGGG
GAGGATGCTCGGGCCCATCGTGGGCACGGGGCTCTACCGCCTGGCCCCCGAGGGGCCCTACGTCCTCGGGGCCTCCCTCC
TCCTCCTCGCCCTCCTCTTCCTTCCCGCCCTCTTCCGCCGGGCGAGGCTTTAG

Upstream 100 bases:

>100_bases
GGTCCTGGTGGAGGAAGGCCCCACCGAGGTGATCTTCACCAAGCCCAAGCACCCTTACACCGAGGCCTACATCACCGGGC
GCTTCGGCTAAAATCGGCCC

Downstream 100 bases:

>100_bases
CATGCGGCTTCTCCTCTTCCGGCAACGGAACTTCCGCAACCTGGCCCTGGAGGCCTACCGCCCCCCGCCGGGCCTTTCCG
CCCTGGTGGGGGCCAACGCC

Product: multidrug-efflux transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSPLALLFLTLFNSVLGLSILFPILGPLGRALGLTEVQVGLFSTGYALMQFLLSPYWGRRSERGRKPVLLVGILGFAASF
LLFGVFALLGERGLVPPGLLFFLLLLARLLGGAFSSATLPTAQAYVADVTGRENRTAGMALLGAAFGLAVILGPALGAGL
AALFGLLAPVFFSAGIALLNALFVYLVLPESRPRGQEAGARLSPFDPRVFPLLLLGLALNLSSVALEQTIAFYFQDRLLL
GGVETAQKVGLALVFYGVVAVFVQGVLVRKTGWPPRVLLSLGLPLGILGFVLLVYAKTFWALALGLALQGVGQGLALPGV
TAALSLAVGEGEQGLVAGLNSSAQALGRMLGPIVGTGLYRLAPEGPYVLGASLLLLALLFLPALFRRARL

Sequences:

>Translated_390_residues
MSPLALLFLTLFNSVLGLSILFPILGPLGRALGLTEVQVGLFSTGYALMQFLLSPYWGRRSERGRKPVLLVGILGFAASF
LLFGVFALLGERGLVPPGLLFFLLLLARLLGGAFSSATLPTAQAYVADVTGRENRTAGMALLGAAFGLAVILGPALGAGL
AALFGLLAPVFFSAGIALLNALFVYLVLPESRPRGQEAGARLSPFDPRVFPLLLLGLALNLSSVALEQTIAFYFQDRLLL
GGVETAQKVGLALVFYGVVAVFVQGVLVRKTGWPPRVLLSLGLPLGILGFVLLVYAKTFWALALGLALQGVGQGLALPGV
TAALSLAVGEGEQGLVAGLNSSAQALGRMLGPIVGTGLYRLAPEGPYVLGASLLLLALLFLPALFRRARL
>Mature_389_residues
SPLALLFLTLFNSVLGLSILFPILGPLGRALGLTEVQVGLFSTGYALMQFLLSPYWGRRSERGRKPVLLVGILGFAASFL
LFGVFALLGERGLVPPGLLFFLLLLARLLGGAFSSATLPTAQAYVADVTGRENRTAGMALLGAAFGLAVILGPALGAGLA
ALFGLLAPVFFSAGIALLNALFVYLVLPESRPRGQEAGARLSPFDPRVFPLLLLGLALNLSSVALEQTIAFYFQDRLLLG
GVETAQKVGLALVFYGVVAVFVQGVLVRKTGWPPRVLLSLGLPLGILGFVLLVYAKTFWALALGLALQGVGQGLALPGVT
AALSLAVGEGEQGLVAGLNSSAQALGRMLGPIVGTGLYRLAPEGPYVLGASLLLLALLFLPALFRRARL

Specific function: Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Drosophila melanogaster, GI17738085, Length=389, Percent_Identity=26.2210796915167, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40676; Mature: 40545

Theoretical pI: Translated: 10.81; Mature: 10.81

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLALLFLTLFNSVLGLSILFPILGPLGRALGLTEVQVGLFSTGYALMQFLLSPYWGRR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SERGRKPVLLVGILGFAASFLLFGVFALLGERGLVPPGLLFFLLLLARLLGGAFSSATLP
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
TAQAYVADVTGRENRTAGMALLGAAFGLAVILGPALGAGLAALFGLLAPVFFSAGIALLN
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFVYLVLPESRPRGQEAGARLSPFDPRVFPLLLLGLALNLSSVALEQTIAFYFQDRLLL
HHHHHHHCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGVETAQKVGLALVFYGVVAVFVQGVLVRKTGWPPRVLLSLGLPLGILGFVLLVYAKTFW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
ALALGLALQGVGQGLALPGVTAALSLAVGEGEQGLVAGLNSSAQALGRMLGPIVGTGLYR
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHCCHHH
LAPEGPYVLGASLLLLALLFLPALFRRARL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPLALLFLTLFNSVLGLSILFPILGPLGRALGLTEVQVGLFSTGYALMQFLLSPYWGRR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SERGRKPVLLVGILGFAASFLLFGVFALLGERGLVPPGLLFFLLLLARLLGGAFSSATLP
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
TAQAYVADVTGRENRTAGMALLGAAFGLAVILGPALGAGLAALFGLLAPVFFSAGIALLN
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFVYLVLPESRPRGQEAGARLSPFDPRVFPLLLLGLALNLSSVALEQTIAFYFQDRLLL
HHHHHHHCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGVETAQKVGLALVFYGVVAVFVQGVLVRKTGWPPRVLLSLGLPLGILGFVLLVYAKTFW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
ALALGLALQGVGQGLALPGVTAALSLAVGEGEQGLVAGLNSSAQALGRMLGPIVGTGLYR
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHCCHHH
LAPEGPYVLGASLLLLALLFLPALFRRARL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA