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The map label for this gene is ald [H]

Identifier: 55980185

GI number: 55980185

Start: 211656

End: 212765

Strand: Reverse

Name: ald [H]

Synonym: TTHA0216

Alternate gene names: 55980185

Gene position: 212765-211656 (Counterclockwise)

Preceding gene: 55980186

Following gene: 55980184

Centisome position: 11.5

GC content: 70.81

Gene sequence:

>1110_bases
ATGGTGATCGGCGTGCCGAAGGAGATCAAGACCTTGGAGAACCGGGTGGCCCTCACGCCCGGCGGGGTGGAGAGCCTGGT
CAGGCGCGGCCACACCGTGCTGGTGGAGCGGGGGGCCGGGGAGGGCTCGGGGCTTTCCGACGCGGAGTACGCCCGGGCCG
GGGCCGAGCTCGTGGGCCGGGAGGAGGCCTGGGGTGCGGAGATGGTGGTGAAGGTGAAGGAGCCCCTACCCGAGGAGTAC
GGCTTCCTGCGGGAGGGCCTCATCCTCTTCACCTACCTTCACCTGGCCGCGGACCGCGGCCTCACCGAGGCCATGCTCCG
TAGCGGGGTCACGGGCATCGCCTACGAGACCGTCCAGCTTCCCGACGGCACCCTCCCCCTCCTCGTCCCCATGAGCGAGG
TGGCGGGGCGGATGGCCCCCCAGGTGGGGGCCCAGTTCCTGGAGAAGCCCAAGGGGGGCCGGGGGGTCCTCCTCGGGGGG
GTGCCGGGGGTGGCCCCGGCCAGCGTGGTGATCCTCGGGGGCGGGACCGTGGGCACCAACGCGGCCAAGATCGCCCTGGG
GATGGGGGCCCAGGTGACCATCCTGGACGTGAACCACAAGCGCCTCCAGTATCTGGACGACGTCTTCGGCGGGCGGGTGA
TCACCCTCACCGCCACCGAGGCCAACATCAAAAAGAGCGTCCAGCACGCGGACCTCCTCATCGGGGCCGTCCTCGTCCCC
GGGGCCAAGGCCCCCAAGCTCGTCACCCGGGACATGCTCTCTCTGATGAAGGAGGGAGCGGTGATCGTGGACGTGGCCGT
GGACCAGGGGGGGTGCGTGGAGACCATCCGGCCCACCACCCACGCCGAGCCCACCTACGTGGTGGACGGGGTGGTCCACT
ACGGGGTGGCCAACATGCCCGGGGCGGTGCCCAGGACCAGCACCTTCGCCCTCACCAACCAGACCCTGCCCTACGTGTTG
AAGCTCGCGGAGAAGGGGCTGGACGCCCTTCTGGAGGACGCGGCCCTTCTCAAGGGGCTCAACACCCACAAAGGCCGCCT
CACCCACCCCGGGGTGGCCGAGGCCTTCGGCCTGCCCTACACGCCTCCCGAGGAGGCCTTGAGGGGGTGA

Upstream 100 bases:

>100_bases
ACGTGACCCTGGTGGACTCCAAGCGGCGCCTCTTGGCCATCGCCGAGGGGGACGGCTTCAAGCTTAAAATACGGCGCGTG
TTTGCGAAGGAGGCGTAGCC

Downstream 100 bases:

>100_bases
GGGTGCCGGGACGGGTGGTCCTCACGGAGGCGGCCTTGGCGAGCCTCCTCGCCCTGGTGGCCCACGAGGTCCCGGGGGTG
GTGGGCATGGCCCCCGCGGG

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MVIGVPKEIKTLENRVALTPGGVESLVRRGHTVLVERGAGEGSGLSDAEYARAGAELVGREEAWGAEMVVKVKEPLPEEY
GFLREGLILFTYLHLAADRGLTEAMLRSGVTGIAYETVQLPDGTLPLLVPMSEVAGRMAPQVGAQFLEKPKGGRGVLLGG
VPGVAPASVVILGGGTVGTNAAKIALGMGAQVTILDVNHKRLQYLDDVFGGRVITLTATEANIKKSVQHADLLIGAVLVP
GAKAPKLVTRDMLSLMKEGAVIVDVAVDQGGCVETIRPTTHAEPTYVVDGVVHYGVANMPGAVPRTSTFALTNQTLPYVL
KLAEKGLDALLEDAALLKGLNTHKGRLTHPGVAEAFGLPYTPPEEALRG

Sequences:

>Translated_369_residues
MVIGVPKEIKTLENRVALTPGGVESLVRRGHTVLVERGAGEGSGLSDAEYARAGAELVGREEAWGAEMVVKVKEPLPEEY
GFLREGLILFTYLHLAADRGLTEAMLRSGVTGIAYETVQLPDGTLPLLVPMSEVAGRMAPQVGAQFLEKPKGGRGVLLGG
VPGVAPASVVILGGGTVGTNAAKIALGMGAQVTILDVNHKRLQYLDDVFGGRVITLTATEANIKKSVQHADLLIGAVLVP
GAKAPKLVTRDMLSLMKEGAVIVDVAVDQGGCVETIRPTTHAEPTYVVDGVVHYGVANMPGAVPRTSTFALTNQTLPYVL
KLAEKGLDALLEDAALLKGLNTHKGRLTHPGVAEAFGLPYTPPEEALRG
>Mature_369_residues
MVIGVPKEIKTLENRVALTPGGVESLVRRGHTVLVERGAGEGSGLSDAEYARAGAELVGREEAWGAEMVVKVKEPLPEEY
GFLREGLILFTYLHLAADRGLTEAMLRSGVTGIAYETVQLPDGTLPLLVPMSEVAGRMAPQVGAQFLEKPKGGRGVLLGG
VPGVAPASVVILGGGTVGTNAAKIALGMGAQVTILDVNHKRLQYLDDVFGGRVITLTATEANIKKSVQHADLLIGAVLVP
GAKAPKLVTRDMLSLMKEGAVIVDVAVDQGGCVETIRPTTHAEPTYVVDGVVHYGVANMPGAVPRTSTFALTNQTLPYVL
KLAEKGLDALLEDAALLKGLNTHKGRLTHPGVAEAFGLPYTPPEEALRG

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=344, Percent_Identity=31.3953488372093, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI122939153, Length=344, Percent_Identity=31.3953488372093, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1787887, Length=377, Percent_Identity=30.7692307692308, Blast_Score=141, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17550456, Length=349, Percent_Identity=30.0859598853868, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38633; Mature: 38633

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIGVPKEIKTLENRVALTPGGVESLVRRGHTVLVERGAGEGSGLSDAEYARAGAELVGR
CCCCCCHHHHHHHHCEEECCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCC
EEAWGAEMVVKVKEPLPEEYGFLREGLILFTYLHLAADRGLTEAMLRSGVTGIAYETVQL
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEC
PDGTLPLLVPMSEVAGRMAPQVGAQFLEKPKGGRGVLLGGVPGVAPASVVILGGGTVGTN
CCCCCEEEEEHHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCC
AAKIALGMGAQVTILDVNHKRLQYLDDVFGGRVITLTATEANIKKSVQHADLLIGAVLVP
CEEEEECCCCEEEEEECCHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHHHCCC
GAKAPKLVTRDMLSLMKEGAVIVDVAVDQGGCVETIRPTTHAEPTYVVDGVVHYGVANMP
CCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCCCCCCEEEHHHHHHCCCCCC
GAVPRTSTFALTNQTLPYVLKLAEKGLDALLEDAALLKGLNTHKGRLTHPGVAEAFGLPY
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCC
TPPEEALRG
CCHHHHHCC
>Mature Secondary Structure
MVIGVPKEIKTLENRVALTPGGVESLVRRGHTVLVERGAGEGSGLSDAEYARAGAELVGR
CCCCCCHHHHHHHHCEEECCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCC
EEAWGAEMVVKVKEPLPEEYGFLREGLILFTYLHLAADRGLTEAMLRSGVTGIAYETVQL
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEC
PDGTLPLLVPMSEVAGRMAPQVGAQFLEKPKGGRGVLLGGVPGVAPASVVILGGGTVGTN
CCCCCEEEEEHHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCC
AAKIALGMGAQVTILDVNHKRLQYLDDVFGGRVITLTATEANIKKSVQHADLLIGAVLVP
CEEEEECCCCEEEEEECCHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHHHCCC
GAKAPKLVTRDMLSLMKEGAVIVDVAVDQGGCVETIRPTTHAEPTYVVDGVVHYGVANMP
CCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCCCCCCEEEHHHHHHCCCCCC
GAVPRTSTFALTNQTLPYVLKLAEKGLDALLEDAALLKGLNTHKGRLTHPGVAEAFGLPY
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCC
TPPEEALRG
CCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA