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The map label for this gene is pntB [H]

Identifier: 55980177

GI number: 55980177

Start: 204566

End: 205918

Strand: Direct

Name: pntB [H]

Synonym: TTHA0208

Alternate gene names: 55980177

Gene position: 204566-205918 (Clockwise)

Preceding gene: 55980176

Following gene: 55980178

Centisome position: 11.06

GC content: 66.96

Gene sequence:

>1353_bases
ATGGACCTCATCCAGGCGGCCTACTTCGTGGTGGCCATCCTCTTCATCGTGGGCCTGAAGCGCATGGCCCACCCCACCAC
GGCCAAAAGCGGCATCGTCTGGGCGGGCTGGGGCATGGTCCTCGCCGTGCTCGCCACCTTCTTCTGGCCGGGGATGGGGA
ACTTCGCCCTCATCCTCCTCGCCCTTCTCCTTGGCTCGGCGGTGGCCTGGTGGGCGGCGGTGCGGGTGGCCATGACGGAC
ATGCCCCAGATGGTGGCCATCTACAACGGCATGGGAGGCGGGGCGGCCGCCACCATCGCCGCCGTGGAACTCCTCAAGGG
GGCCTTTGAGAACACGGGGCTCATGGCCTTGGCCATCCTGGGCGGCCTCATCGGGAGCGTGGCCTTCACGGGAAGCCTCA
TCGCCTTCGCCAAGCTCCAGGGGATCATGAAGAGCCGCCCCATCCTCTTCCCCGGGCAGAAGGCAGTAAACGCCCTGGTC
CTGGCCCTCACCCTCGTGCTCGGGCTTTCCCTCCTCTGGAACGACGCCACGGCGAGCATCGTCCTCTTCTTCCTCCTCGC
TCTTCTCTTCGGCGTCCTCATGACCCTCCCCATCGGCGGCGGGGACATGCCCGTGGCCATCTCCTTCTACAACGCCTTCA
CGGGGATGGCCGTGGGCTTTGAGGGCTTCGCCGTGGGAAACCCGGCCCTCATGGTGGCGGGCACCCTGGTGGGGGCGGCG
GGCACCCTCCTCACCGTGCTCATGGCGAGGGCCATGAACCGCTCGGTGTGGAGCGTCCTGGTGGGGGGCTTCGGCGTGGA
GCAGGAGGCGGGCGAGGTCAAGGGGAGCCTCAAGCCCATTGACGTGGAGGACGCCGCCGTGATGCTCGCCTACGCGGGCA
AGGTGGTCTTCGTCCCCGGCTACGGCATGGCCCTCTCCCAGGCGCAACACAAGCTGAAGGAGCTTGCGGACCTCCTCGAG
GCCCGCGGGGTGGAGGTGAAGTTCGCCATCCACCCGGTGGCGGGGCGGATGCCCGGGCACATGAACGTCCTCCTGGCCGA
GGCCGGGGTGGACTACGACAAGCTCAAGGACCTGGAGGAGATCAACCCCGAGTTCCCCACGGTGGACGTGGCCGTGGTCA
TCGGGGCGAACGACGTGGTGAACCCCGCCGCCCGCCGTCCGGGAAGCCCGCTTTACGGCATGCCCATCCTGGACGTGGAC
AAGGCCAAGAACGTCATCGTCATCAAGCGGGGACAGGGGAAGGGCTTCGCCGGGGTGGAGAACGAGCTCTTCTACGCCGA
AAACACAAGGATGCTCTACGGGGACGCGCAAAAGGTCCTCACCGAGCTCATCCAGGCCCTGAAAAGGCTTTAG

Upstream 100 bases:

>100_bases
GGGTCATCCTGGGGGCGGCCAACGCCGCCGGGGGGTACGCGGTCACGGTGCGCATGCTGGAGATGTTTGAAAGGAAGCCC
GGCCAAGGGGGTGGTCGGTA

Downstream 100 bases:

>100_bases
GCCTTGACGACACAAGGCCCCTCGCTTAGACTCCAGGGTGGCACCCCGGGCGCGCCAGCGCCCAGGCCAAAGACAGCGGG
GGGCCTTCGGGCCTTAAAAA

Product: nicotinamide nucleotide transhydrogenase subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MDLIQAAYFVVAILFIVGLKRMAHPTTAKSGIVWAGWGMVLAVLATFFWPGMGNFALILLALLLGSAVAWWAAVRVAMTD
MPQMVAIYNGMGGGAAATIAAVELLKGAFENTGLMALAILGGLIGSVAFTGSLIAFAKLQGIMKSRPILFPGQKAVNALV
LALTLVLGLSLLWNDATASIVLFFLLALLFGVLMTLPIGGGDMPVAISFYNAFTGMAVGFEGFAVGNPALMVAGTLVGAA
GTLLTVLMARAMNRSVWSVLVGGFGVEQEAGEVKGSLKPIDVEDAAVMLAYAGKVVFVPGYGMALSQAQHKLKELADLLE
ARGVEVKFAIHPVAGRMPGHMNVLLAEAGVDYDKLKDLEEINPEFPTVDVAVVIGANDVVNPAARRPGSPLYGMPILDVD
KAKNVIVIKRGQGKGFAGVENELFYAENTRMLYGDAQKVLTELIQALKRL

Sequences:

>Translated_450_residues
MDLIQAAYFVVAILFIVGLKRMAHPTTAKSGIVWAGWGMVLAVLATFFWPGMGNFALILLALLLGSAVAWWAAVRVAMTD
MPQMVAIYNGMGGGAAATIAAVELLKGAFENTGLMALAILGGLIGSVAFTGSLIAFAKLQGIMKSRPILFPGQKAVNALV
LALTLVLGLSLLWNDATASIVLFFLLALLFGVLMTLPIGGGDMPVAISFYNAFTGMAVGFEGFAVGNPALMVAGTLVGAA
GTLLTVLMARAMNRSVWSVLVGGFGVEQEAGEVKGSLKPIDVEDAAVMLAYAGKVVFVPGYGMALSQAQHKLKELADLLE
ARGVEVKFAIHPVAGRMPGHMNVLLAEAGVDYDKLKDLEEINPEFPTVDVAVVIGANDVVNPAARRPGSPLYGMPILDVD
KAKNVIVIKRGQGKGFAGVENELFYAENTRMLYGDAQKVLTELIQALKRL
>Mature_450_residues
MDLIQAAYFVVAILFIVGLKRMAHPTTAKSGIVWAGWGMVLAVLATFFWPGMGNFALILLALLLGSAVAWWAAVRVAMTD
MPQMVAIYNGMGGGAAATIAAVELLKGAFENTGLMALAILGGLIGSVAFTGSLIAFAKLQGIMKSRPILFPGQKAVNALV
LALTLVLGLSLLWNDATASIVLFFLLALLFGVLMTLPIGGGDMPVAISFYNAFTGMAVGFEGFAVGNPALMVAGTLVGAA
GTLLTVLMARAMNRSVWSVLVGGFGVEQEAGEVKGSLKPIDVEDAAVMLAYAGKVVFVPGYGMALSQAQHKLKELADLLE
ARGVEVKFAIHPVAGRMPGHMNVLLAEAGVDYDKLKDLEEINPEFPTVDVAVVIGANDVVNPAARRPGSPLYGMPILDVD
KAKNVIVIKRGQGKGFAGVENELFYAENTRMLYGDAQKVLTELIQALKRL

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=419, Percent_Identity=41.2887828162291, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI122939153, Length=419, Percent_Identity=41.2887828162291, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI1787886, Length=465, Percent_Identity=42.7956989247312, Blast_Score=352, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI17550456, Length=466, Percent_Identity=38.6266094420601, Blast_Score=296, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 47323; Mature: 47323

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLIQAAYFVVAILFIVGLKRMAHPTTAKSGIVWAGWGMVLAVLATFFWPGMGNFALILL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCHHHHHHH
ALLLGSAVAWWAAVRVAMTDMPQMVAIYNGMGGGAAATIAAVELLKGAFENTGLMALAIL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
GGLIGSVAFTGSLIAFAKLQGIMKSRPILFPGQKAVNALVLALTLVLGLSLLWNDATASI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VLFFLLALLFGVLMTLPIGGGDMPVAISFYNAFTGMAVGFEGFAVGNPALMVAGTLVGAA
HHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHH
GTLLTVLMARAMNRSVWSVLVGGFGVEQEAGEVKGSLKPIDVEDAAVMLAYAGKVVFVPG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCEEEECC
YGMALSQAQHKLKELADLLEARGVEVKFAIHPVAGRMPGHMNVLLAEAGVDYDKLKDLEE
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHH
INPEFPTVDVAVVIGANDVVNPAARRPGSPLYGMPILDVDKAKNVIVIKRGQGKGFAGVE
CCCCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCC
NELFYAENTRMLYGDAQKVLTELIQALKRL
CCEEEECCCEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLIQAAYFVVAILFIVGLKRMAHPTTAKSGIVWAGWGMVLAVLATFFWPGMGNFALILL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCHHHHHHH
ALLLGSAVAWWAAVRVAMTDMPQMVAIYNGMGGGAAATIAAVELLKGAFENTGLMALAIL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
GGLIGSVAFTGSLIAFAKLQGIMKSRPILFPGQKAVNALVLALTLVLGLSLLWNDATASI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VLFFLLALLFGVLMTLPIGGGDMPVAISFYNAFTGMAVGFEGFAVGNPALMVAGTLVGAA
HHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHH
GTLLTVLMARAMNRSVWSVLVGGFGVEQEAGEVKGSLKPIDVEDAAVMLAYAGKVVFVPG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCEEEECC
YGMALSQAQHKLKELADLLEARGVEVKFAIHPVAGRMPGHMNVLLAEAGVDYDKLKDLEE
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHH
INPEFPTVDVAVVIGANDVVNPAARRPGSPLYGMPILDVDKAKNVIVIKRGQGKGFAGVE
CCCCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCC
NELFYAENTRMLYGDAQKVLTELIQALKRL
CCEEEECCCEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]