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The map label for this gene is ispD

Identifier: 55980140

GI number: 55980140

Start: 165254

End: 165895

Strand: Reverse

Name: ispD

Synonym: TTHA0171

Alternate gene names: 55980140

Gene position: 165895-165254 (Counterclockwise)

Preceding gene: 55980142

Following gene: 55980139

Centisome position: 8.97

GC content: 74.45

Gene sequence:

>642_bases
GTGGAGGTTTCCGTCCTCATCCCCGCCGCGGGGAACGGCCTTCGCCTGGGCCGAGGCCCCAAGGCCTTTCTCCAGGTGGG
GGGGCGGACGCTTCTGGAGTGGACCCTCGCCGCCTTCCGGGACGCGGCGGAGGTCCTGGTGGCCCTGCCCCCCGGGGCGG
AGCCCCCGAAGGGGCTTGGGGCCGTCTTCTTAGAGGGGGGCGCCACCCGGCAGGCCTCGGTGGCCCGGCTTCTGGAGGCG
GCGAGCCTGCCCCTCGTCCTGGTCCACGACGTGGCCCGTCCCTTCGTCAGCCGGGGCCTGGTGGCGCGGGTCCTCGAGGC
CGCCCAAAGAAGCGGCGCCGCCGTCCCCGTCCTCCCCGTGCCCGACACCCTCATGGCCCCGGAGGGGGAGGCCTACGGCC
GGGTGGTGCCCCGGGAGGCCTTCCGCCTGGTGCAGACCCCCCAGGGGTTTTTCACCGCCCTCCTCCGGGAGGCCCACGCC
TACGCCCGGAGGAAGGGGCTCGAGGCCAGCGACGACGCCCAGCTGGTCCAGGCCCTGGGTTACCCCGTGGCCCTGGTGGA
AGGGGAGGCCACGGCCTTCAAGATCACCCACCCTCAGGACCTCGTCTTGGCGGAGGCCCTGGCCCGGGTATGGAGCGCCT
AG

Upstream 100 bases:

>100_bases
TGGCCGGTGGAGGAGACGGGCAGGAACTCCGTGAGCCCCTCAACCACCCCGAGCAGAAGGGCTTCCCAAGCGCTCACGCG
GCCCATGCTACCATGGGGGC

Downstream 100 bases:

>100_bases
CCCCTGCGAAGGTCAACCTCGGGCTTTCCGTCCGCTTCCGGCGGGAGGACGGGTACCACGAGCTCCACACCCTCTTCGCC
CCCTTCTCCCTGGCGGACCG

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MEVSVLIPAAGNGLRLGRGPKAFLQVGGRTLLEWTLAAFRDAAEVLVALPPGAEPPKGLGAVFLEGGATRQASVARLLEA
ASLPLVLVHDVARPFVSRGLVARVLEAAQRSGAAVPVLPVPDTLMAPEGEAYGRVVPREAFRLVQTPQGFFTALLREAHA
YARRKGLEASDDAQLVQALGYPVALVEGEATAFKITHPQDLVLAEALARVWSA

Sequences:

>Translated_213_residues
MEVSVLIPAAGNGLRLGRGPKAFLQVGGRTLLEWTLAAFRDAAEVLVALPPGAEPPKGLGAVFLEGGATRQASVARLLEA
ASLPLVLVHDVARPFVSRGLVARVLEAAQRSGAAVPVLPVPDTLMAPEGEAYGRVVPREAFRLVQTPQGFFTALLREAHA
YARRKGLEASDDAQLVQALGYPVALVEGEATAFKITHPQDLVLAEALARVWSA
>Mature_213_residues
MEVSVLIPAAGNGLRLGRGPKAFLQVGGRTLLEWTLAAFRDAAEVLVALPPGAEPPKGLGAVFLEGGATRQASVARLLEA
ASLPLVLVHDVARPFVSRGLVARVLEAAQRSGAAVPVLPVPDTLMAPEGEAYGRVVPREAFRLVQTPQGFFTALLREAHA
YARRKGLEASDDAQLVQALGYPVALVEGEATAFKITHPQDLVLAEALARVWSA

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=233, Percent_Identity=29.1845493562232, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1789104, Length=222, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD_THET2 (Q72GN3)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_005784.1
- ProteinModelPortal:   Q72GN3
- SMR:   Q72GN3
- STRING:   Q72GN3
- GeneID:   2775059
- GenomeReviews:   AE017221_GR
- eggNOG:   COG1211
- HOGENOM:   HBG672839
- OMA:   PSNIKVT
- PhylomeDB:   Q72GN3
- ProtClustDB:   CLSK445685
- BioCyc:   TTHE262724:TT_C1815-MONOMER
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294
- TIGRFAMs:   TIGR00453

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 22423; Mature: 22423

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVSVLIPAAGNGLRLGRGPKAFLQVGGRTLLEWTLAAFRDAAEVLVALPPGAEPPKGLG
CCEEEEEECCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCC
AVFLEGGATRQASVARLLEAASLPLVLVHDVARPFVSRGLVARVLEAAQRSGAAVPVLPV
EEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
PDTLMAPEGEAYGRVVPREAFRLVQTPQGFFTALLREAHAYARRKGLEASDDAQLVQALG
CCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
YPVALVEGEATAFKITHPQDLVLAEALARVWSA
CCEEEEECCCEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEVSVLIPAAGNGLRLGRGPKAFLQVGGRTLLEWTLAAFRDAAEVLVALPPGAEPPKGLG
CCEEEEEECCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCC
AVFLEGGATRQASVARLLEAASLPLVLVHDVARPFVSRGLVARVLEAAQRSGAAVPVLPV
EEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
PDTLMAPEGEAYGRVVPREAFRLVQTPQGFFTALLREAHAYARRKGLEASDDAQLVQALG
CCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
YPVALVEGEATAFKITHPQDLVLAEALARVWSA
CCEEEEECCCEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA