Click here to switch to the map view.

The map label for this gene is nrdR

Identifier: 55980103

GI number: 55980103

Start: 130735

End: 131196

Strand: Direct

Name: nrdR

Synonym: TTHA0134

Alternate gene names: 55980103

Gene position: 130735-131196 (Clockwise)

Preceding gene: 55980102

Following gene: 55980104

Centisome position: 7.07

GC content: 66.23

Gene sequence:

>462_bases
ATGAAGTGCCCCTACTGCGGCCACCCCGACACCCGGGTGGTGGACTCGAGGCCCTCCGACGAGGGCATGGCCATCCGCAG
GCGGCGGGAGTGCCCCTCCTGCGGACGCCGCTTCACCACCTACGAGCGCACCCAGCTTGAGCCCCTCATGGTGGTCAAGC
GGGACGGGCGCAAGGAGCCCTTCAACCCCGACAAGCTCCTAAGGGGCCTCCTCCTCGCCTGCGAGAAGCGCCCCGTGAGC
GAGGAGGTCCTGCGCCGCTTCGCCTACACCTTTGAGGACCAGGTCTCGGGCCCGGAGATCACCTCGGAGGAGATCGGGCT
CAAGGCCCTGGCCTTCCTCAAGGAGCTGGACCACGTGGCCTACATCCGCTTCGCCTCCGTCTACCGCGAGTTTGACTCGG
TGGAGCGCTTCATTGAGGAGATCCGCTCCCTCGCAAGCCTTGACAAAAAGGAGGGGGATTGA

Upstream 100 bases:

>100_bases
GGTCCATGGTCTCCGAGGGGATCCGGGGGGTGGTCCTCGAGGTCCAGCTCCCCGAGCCCCCCTTGGAGTTTGAACCCTAC
GCCGCCTTGAGGGAGCTGCC

Downstream 100 bases:

>100_bases
TAGCATGGCTTTTGCTGCGCGGGCGAAAGCCCAAGCAGGGGGATCTTGAAAAGGGGAGAAGGCAGGCCAAGCATCTGAGC
TCTACGCCCGTTTAGGGCGT

Product: NrdR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MKCPYCGHPDTRVVDSRPSDEGMAIRRRRECPSCGRRFTTYERTQLEPLMVVKRDGRKEPFNPDKLLRGLLLACEKRPVS
EEVLRRFAYTFEDQVSGPEITSEEIGLKALAFLKELDHVAYIRFASVYREFDSVERFIEEIRSLASLDKKEGD

Sequences:

>Translated_153_residues
MKCPYCGHPDTRVVDSRPSDEGMAIRRRRECPSCGRRFTTYERTQLEPLMVVKRDGRKEPFNPDKLLRGLLLACEKRPVS
EEVLRRFAYTFEDQVSGPEITSEEIGLKALAFLKELDHVAYIRFASVYREFDSVERFIEEIRSLASLDKKEGD
>Mature_153_residues
MKCPYCGHPDTRVVDSRPSDEGMAIRRRRECPSCGRRFTTYERTQLEPLMVVKRDGRKEPFNPDKLLRGLLLACEKRPVS
EEVLRRFAYTFEDQVSGPEITSEEIGLKALAFLKELDHVAYIRFASVYREFDSVERFIEEIRSLASLDKKEGD

Specific function: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes

COG id: COG1327

COG function: function code K; Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain

Homologues:

Organism=Escherichia coli, GI1786615, Length=147, Percent_Identity=46.2585034013605, Blast_Score=122, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NRDR_THET2 (Q72GI8)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_005829.1
- ProteinModelPortal:   Q72GI8
- STRING:   Q72GI8
- GeneID:   2775208
- GenomeReviews:   AE017221_GR
- eggNOG:   COG1327
- HOGENOM:   HBG351755
- OMA:   FASVYRD
- PhylomeDB:   Q72GI8
- ProtClustDB:   PRK00464
- BioCyc:   TTHE262724:TT_C1860-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00440
- InterPro:   IPR005144
- InterPro:   IPR003796
- TIGRFAMs:   TIGR00244

Pfam domain/function: PF03477 ATP-cone

EC number: NA

Molecular weight: Translated: 17793; Mature: 17793

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCPYCGHPDTRVVDSRPSDEGMAIRRRRECPSCGRRFTTYERTQLEPLMVVKRDGRKEP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHCCCHHHHCCCHHHEECCCCCCCC
FNPDKLLRGLLLACEKRPVSEEVLRRFAYTFEDQVSGPEITSEEIGLKALAFLKELDHVA
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
YIRFASVYREFDSVERFIEEIRSLASLDKKEGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKCPYCGHPDTRVVDSRPSDEGMAIRRRRECPSCGRRFTTYERTQLEPLMVVKRDGRKEP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHCCCHHHHCCCHHHEECCCCCCCC
FNPDKLLRGLLLACEKRPVSEEVLRRFAYTFEDQVSGPEITSEEIGLKALAFLKELDHVA
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
YIRFASVYREFDSVERFIEEIRSLASLDKKEGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA