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The map label for this gene is nqo13

Identifier: 55980065

GI number: 55980065

Start: 95002

End: 96411

Strand: Direct

Name: nqo13

Synonym: TTHA0096

Alternate gene names: 55980065

Gene position: 95002-96411 (Clockwise)

Preceding gene: 55980064

Following gene: 55980066

Centisome position: 5.14

GC content: 69.22

Gene sequence:

>1410_bases
GTGGTAGTCCTGGCGGTCCTTCTACCGGTGGTCTTCGGGGCCCTGCTCCTTTTGGGCCTGCCCCGGGCCCTCGGGGTTTT
GGGGGCGGGGCTTTCCTTCCTCCTCAACCTCTACCTCTTCCTCACCCACCCGGGCGGGGTGGCCCACGCCTTCCAAGCCC
CCCTCCTCCCCGGGGCGGGGGTGTACTGGGCCTTCGGTCTAGACGGGCTTTCCGCGCTTTTCTTCCTCACCATCGCCCTC
ACCGTTTTCTTAGGGGCTTTGGTGGCGAGGGTGGAAGGGCGCTTCCTGGGCCTCGCCCTCCTCATGGAGGGGCTTCTCCT
CGGCCTCTTCGCCGCCCGGGACCTCCTCGTCTTCTACGTCTTCTTTGAGGCCGCCCTCATCCCCGCCCTCCTCATGCTCT
ACCTCTACGGGGGGGAGGGGCGGACGCGGGCCCTCTACACCTTCGTCCTCTTCACCCTGGTGGGCTCCTTGCCCATGCTC
GCCGCCGTCCTCGGGGCCAGGCTCCTCTCGGGCAGCCCCACCTTCCTCCTGGAGGACCTCCTCGCCCACCCCCTCCAGGA
AGAGGCCGCCTTCTGGGTCTTCCTGGGCTTCGCCCTGGCCTTCGCCATCAAGACGCCCCTCTTCCCCCTCCACGCCTGGC
TTCCCCCCTTCCACCAGGAAAACCACCCTTCGGGCCTCGCCGACGCCCTCGGCACCCTTTACAAGGTGGGGGTCTTCGCC
TTCTTCCGCTTCGCCATCCCCTTGGCCCCTGAGGGCTTCGCCCAGGCCCAGGGCCTCCTCCTCTTCCTGGCGGCCCTCTC
CGCCCTCTACGGCGCCTGGGTGGCCTTCGCCGCCAAGGACTTCAAGACCCTCCTGGCCTACGCCGGGCTTTCCCACATGG
GGGTGGCGGCCCTGGGGGTCTTCTCGGGCACGCCGGAAGGGGCCATGGGGGGGCTATACCTCCTGGCGGCAAGCGGGGTC
TACACCGGGGGGCTCTTCCTCCTCGCGGGAAGGCTTTACGAGCGGACGGGCACCCTGGAGATCGGGCGCTACCGGGGCCT
GGCACAAAGCGCCCCGGGCCTCGCCGCCTTGGCCCTCATCCTCTTCCTCGCCATGGTGGGCCTCCCCGGGCTTTCCGGCT
TCCCCGGGGAGTTTCTGACCCTCCTCGGGGCCTACAAGGCAAGCCCCTGGCTTGCCGCCTTGGCCTTCCTCTCCGTGATC
GCCTCCGCGGCCTACGCCCTCACCGCCTTCCAGAAGACCTTCTGGGAGGAGGGAGGGTCCGGGGTGAAGGACCTCGCGGG
GGCGGAGTGGGGCTTCGCCCTGCTTAGCGTCCTCGCCCTCCTCCTCATGGGGGTCTTCCCCGGCTACTTCGCCCGGGGGC
TCCACCCTCTGGCGGAGGCCTTCGCCAAGCTTCTTGGAGGTGGCGCATGA

Upstream 100 bases:

>100_bases
GGAGCCTGGGGCAGGGCCTCGCCCGGTTGCAGACCGGCTACCTTAGGGTTTACGCCCTCCTCTTCGTGCTGGGGGCGCTT
CTCCTTCTGGGGGTGATGCG

Downstream 100 bases:

>100_bases
CCCTGGCGATCCTCGCGGTCTTCTCCGTGGCCTTGACCCTTCTCGGTTTCGTCCTCCCGCCCCAGGGCGTGAAGCGGGCC
ACGCTCCTGGGCCTGGCCCT

Product: NADH-quinone oxidoreductase subunit 13

Products: NA

Alternate protein names: NADH dehydrogenase I chain 13; NDH-1 subunit 13

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MVVLAVLLPVVFGALLLLGLPRALGVLGAGLSFLLNLYLFLTHPGGVAHAFQAPLLPGAGVYWAFGLDGLSALFFLTIAL
TVFLGALVARVEGRFLGLALLMEGLLLGLFAARDLLVFYVFFEAALIPALLMLYLYGGEGRTRALYTFVLFTLVGSLPML
AAVLGARLLSGSPTFLLEDLLAHPLQEEAAFWVFLGFALAFAIKTPLFPLHAWLPPFHQENHPSGLADALGTLYKVGVFA
FFRFAIPLAPEGFAQAQGLLLFLAALSALYGAWVAFAAKDFKTLLAYAGLSHMGVAALGVFSGTPEGAMGGLYLLAASGV
YTGGLFLLAGRLYERTGTLEIGRYRGLAQSAPGLAALALILFLAMVGLPGLSGFPGEFLTLLGAYKASPWLAALAFLSVI
ASAAYALTAFQKTFWEEGGSGVKDLAGAEWGFALLSVLALLLMGVFPGYFARGLHPLAEAFAKLLGGGA

Sequences:

>Translated_469_residues
MVVLAVLLPVVFGALLLLGLPRALGVLGAGLSFLLNLYLFLTHPGGVAHAFQAPLLPGAGVYWAFGLDGLSALFFLTIAL
TVFLGALVARVEGRFLGLALLMEGLLLGLFAARDLLVFYVFFEAALIPALLMLYLYGGEGRTRALYTFVLFTLVGSLPML
AAVLGARLLSGSPTFLLEDLLAHPLQEEAAFWVFLGFALAFAIKTPLFPLHAWLPPFHQENHPSGLADALGTLYKVGVFA
FFRFAIPLAPEGFAQAQGLLLFLAALSALYGAWVAFAAKDFKTLLAYAGLSHMGVAALGVFSGTPEGAMGGLYLLAASGV
YTGGLFLLAGRLYERTGTLEIGRYRGLAQSAPGLAALALILFLAMVGLPGLSGFPGEFLTLLGAYKASPWLAALAFLSVI
ASAAYALTAFQKTFWEEGGSGVKDLAGAEWGFALLSVLALLLMGVFPGYFARGLHPLAEAFAKLLGGGA
>Mature_469_residues
MVVLAVLLPVVFGALLLLGLPRALGVLGAGLSFLLNLYLFLTHPGGVAHAFQAPLLPGAGVYWAFGLDGLSALFFLTIAL
TVFLGALVARVEGRFLGLALLMEGLLLGLFAARDLLVFYVFFEAALIPALLMLYLYGGEGRTRALYTFVLFTLVGSLPML
AAVLGARLLSGSPTFLLEDLLAHPLQEEAAFWVFLGFALAFAIKTPLFPLHAWLPPFHQENHPSGLADALGTLYKVGVFA
FFRFAIPLAPEGFAQAQGLLLFLAALSALYGAWVAFAAKDFKTLLAYAGLSHMGVAALGVFSGTPEGAMGGLYLLAASGV
YTGGLFLLAGRLYERTGTLEIGRYRGLAQSAPGLAALALILFLAMVGLPGLSGFPGEFLTLLGAYKASPWLAALAFLSVI
ASAAYALTAFQKTFWEEGGSGVKDLAGAEWGFALLSVLALLLMGVFPGYFARGLHPLAEAFAKLLGGGA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family

Homologues:

Organism=Homo sapiens, GI251831116, Length=342, Percent_Identity=29.8245614035088, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI1788613, Length=431, Percent_Identity=30.8584686774942, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1788827, Length=195, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788831, Length=299, Percent_Identity=25.0836120401338, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693160, Length=260, Percent_Identity=27.6923076923077, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NQO13_THET8 (Q56228)

Other databases:

- EMBL:   U52917
- EMBL:   AP008226
- PIR:   T11910
- RefSeq:   YP_143362.1
- ProteinModelPortal:   Q56228
- STRING:   Q56228
- GeneID:   3169618
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA0096
- NMPDR:   fig|300852.3.peg.127
- eggNOG:   COG1008
- HOGENOM:   HBG643593
- OMA:   WIERFHI
- ProtClustDB:   CLSK445095
- BioCyc:   TTHE300852:TTHA0096-MONOMER
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- PRINTS:   PR01437
- TIGRFAMs:   TIGR01972

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 49219; Mature: 49219

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc8159f4)-; HASH(0x1257c634)-; HASH(0x126b06f4)-; HASH(0x12574660)-; HASH(0x125252ec)-; HASH(0x12580750)-; HASH(0x12255c8c)-; HASH(0x12e07350)-; HASH(0x120e8828)-; HASH(0x1222f684)-; HASH(0x1256c340)-; HASH(0x125724bc)-; HASH(0x1257e5f4)-; HASH(0x1217cebc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVLAVLLPVVFGALLLLGLPRALGVLGAGLSFLLNLYLFLTHPGGVAHAFQAPLLPGAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCC
VYWAFGLDGLSALFFLTIALTVFLGALVARVEGRFLGLALLMEGLLLGLFAARDLLVFYV
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFEAALIPALLMLYLYGGEGRTRALYTFVLFTLVGSLPMLAAVLGARLLSGSPTFLLEDL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LAHPLQEEAAFWVFLGFALAFAIKTPLFPLHAWLPPFHQENHPSGLADALGTLYKVGVFA
HHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FFRFAIPLAPEGFAQAQGLLLFLAALSALYGAWVAFAAKDFKTLLAYAGLSHMGVAALGV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FSGTPEGAMGGLYLLAASGVYTGGLFLLAGRLYERTGTLEIGRYRGLAQSAPGLAALALI
HCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEHHHHCCCCCCCCCHHHHHHH
LFLAMVGLPGLSGFPGEFLTLLGAYKASPWLAALAFLSVIASAAYALTAFQKTFWEEGGS
HHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVKDLAGAEWGFALLSVLALLLMGVFPGYFARGLHPLAEAFAKLLGGGA
CHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure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CHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9020134