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The map label for this gene is moaA [H]

Identifier: 55979980

GI number: 55979980

Start: 12493

End: 13503

Strand: Direct

Name: moaA [H]

Synonym: TTHA0011

Alternate gene names: 55979980

Gene position: 12493-13503 (Clockwise)

Preceding gene: 55979979

Following gene: 55979982

Centisome position: 0.68

GC content: 67.66

Gene sequence:

>1011_bases
GTGGTATTAAGATGGGCAGCAAAGGGGGATAAGGTGAAGCTTCTAGACAACTACGGGCGCGTGATCAAGGACCTCCGCAT
CTCCGTCACCCCCCGGTGCAACCTCCACTGCCTCTACTGCCATCCCCTGGGCCTGGAGATGCGGGAGCCCCCGGGTACCC
TCACCGTGGAGGAGGTGGACCGCTTCCTCGAGGCCGCCTCCCTCCTCGGCCTCTCCTCCGTGCGCTTCACCGGGGGCGAG
CCCCTGGTGCGCAAGGAGCTTCCCGAGATGATCGCCCGGGCCCGGGCGAAGGAGGGGGTGGAGGACGTGGCCATCACGAC
CAACGGCCTCCTCTTCGCCAGGCGGGCAAAGGAGCTCGTGGAGGCGGGGCTCAACCGGGTGAACATCTCCTTAGACGCCC
TCACCCCCGAGGTCTTCGCCCGCATCACCCGGGGGGGGAAGGTGGAGCGGGTCCTCGAGGCCATAGAGAAGGCCCTAGAG
CTCGGCCTCCACCCGGTGAAGCTCAACGCCGTGGTGATCCGGGGGATGAACGAGGAGGAGGTGGTGCCCCTAGCGGGGCT
TTCCCTGGACCGCCCCCTCCACGTGCGCTTCATTGAGTACATGCACCTGGACAACTCCGACCCCGAGGCCTACCGCCGCC
GCTTCGTCCCCGGAAAAGAGACCCGGGCCCGGATTGAGGCGGTCTACGGCCCCCTGGAGCCCGTCCCCCACGACCCCACC
TCCCCGGCCCGGGTCTTCAAGATCCCCGGGGCCCAGGGCACGGTGGGCTTCATCAACCCGGTGACGGAGCCTTTTTGCAC
CCACTGCTCCAGGCTCCGCCTCACCTCGGACAAGAAGCTCAGGCCCTGCCTGCTTACGGACCTGGAGATGGACATCGCCT
GGGCCTTCGCCGCCCCCGAGCCCGTGGAGGCCCTGGTGGACGCCATCCTCATCGCCACGAACCGTAAACCCGCCTTCGGC
AACACCCTTCCCACCCTGCGCAAGCGGGTCATGCTGGGGATCGGCGGATAG

Upstream 100 bases:

>100_bases
GACCTTGCCAAGGTCGGGGTCGCGGGTTCAAGTCCCGTCTCCCGCTCCAATACCCAAACCCCCCAGGACAAAAACCTGGG
GGGTTTTGCTTTGCCCCCCG

Downstream 100 bases:

>100_bases
CGAGGAGGGTCGCGAGAAGCACCAGGAGGGCCCCGAGGAGCCCGGAAGGGCTTAGGCGCTCCCCCAAGGCGAGGTAGGCG
AAGAAGGCGGCCCAGACGGG

Product: molybdenum cofactor biosynthesis protein A MoaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MVLRWAAKGDKVKLLDNYGRVIKDLRISVTPRCNLHCLYCHPLGLEMREPPGTLTVEEVDRFLEAASLLGLSSVRFTGGE
PLVRKELPEMIARARAKEGVEDVAITTNGLLFARRAKELVEAGLNRVNISLDALTPEVFARITRGGKVERVLEAIEKALE
LGLHPVKLNAVVIRGMNEEEVVPLAGLSLDRPLHVRFIEYMHLDNSDPEAYRRRFVPGKETRARIEAVYGPLEPVPHDPT
SPARVFKIPGAQGTVGFINPVTEPFCTHCSRLRLTSDKKLRPCLLTDLEMDIAWAFAAPEPVEALVDAILIATNRKPAFG
NTLPTLRKRVMLGIGG

Sequences:

>Translated_336_residues
MVLRWAAKGDKVKLLDNYGRVIKDLRISVTPRCNLHCLYCHPLGLEMREPPGTLTVEEVDRFLEAASLLGLSSVRFTGGE
PLVRKELPEMIARARAKEGVEDVAITTNGLLFARRAKELVEAGLNRVNISLDALTPEVFARITRGGKVERVLEAIEKALE
LGLHPVKLNAVVIRGMNEEEVVPLAGLSLDRPLHVRFIEYMHLDNSDPEAYRRRFVPGKETRARIEAVYGPLEPVPHDPT
SPARVFKIPGAQGTVGFINPVTEPFCTHCSRLRLTSDKKLRPCLLTDLEMDIAWAFAAPEPVEALVDAILIATNRKPAFG
NTLPTLRKRVMLGIGG
>Mature_336_residues
MVLRWAAKGDKVKLLDNYGRVIKDLRISVTPRCNLHCLYCHPLGLEMREPPGTLTVEEVDRFLEAASLLGLSSVRFTGGE
PLVRKELPEMIARARAKEGVEDVAITTNGLLFARRAKELVEAGLNRVNISLDALTPEVFARITRGGKVERVLEAIEKALE
LGLHPVKLNAVVIRGMNEEEVVPLAGLSLDRPLHVRFIEYMHLDNSDPEAYRRRFVPGKETRARIEAVYGPLEPVPHDPT
SPARVFKIPGAQGTVGFINPVTEPFCTHCSRLRLTSDKKLRPCLLTDLEMDIAWAFAAPEPVEALVDAILIATNRKPAFG
NTLPTLRKRVMLGIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=38.5321100917431, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=38.5321100917431, Blast_Score=223, Evalue=1e-58,
Organism=Escherichia coli, GI1786999, Length=275, Percent_Identity=34.1818181818182, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI32566329, Length=332, Percent_Identity=37.3493975903614, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=311, Percent_Identity=37.620578778135, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17561210, Length=339, Percent_Identity=35.9882005899705, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI28574488, Length=328, Percent_Identity=38.109756097561, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI28574490, Length=306, Percent_Identity=39.2156862745098, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37225; Mature: 37225

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLRWAAKGDKVKLLDNYGRVIKDLRISVTPRCNLHCLYCHPLGLEMREPPGTLTVEEVD
CEEEEECCCCEEEEHHHHHHHHHHHEEEECCCCCEEEEEEECCCCEECCCCCCEEHHHHH
RFLEAASLLGLSSVRFTGGEPLVRKELPEMIARARAKEGVEDVAITTNGLLFARRAKELV
HHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHEEEECCCHHHHHHHHHHH
EAGLNRVNISLDALTPEVFARITRGGKVERVLEAIEKALELGLHPVKLNAVVIRGMNEEE
HCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCC
VVPLAGLSLDRPLHVRFIEYMHLDNSDPEAYRRRFVPGKETRARIEAVYGPLEPVPHDPT
CCEEECCCCCCCHHHEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
SPARVFKIPGAQGTVGFINPVTEPFCTHCSRLRLTSDKKLRPCLLTDLEMDIAWAFAAPE
CCCEEEECCCCCCCEEECCCCCHHHHHHHHHEEECCCCCCCCCEEECCCEEEEEEECCCC
PVEALVDAILIATNRKPAFGNTLPTLRKRVMLGIGG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLRWAAKGDKVKLLDNYGRVIKDLRISVTPRCNLHCLYCHPLGLEMREPPGTLTVEEVD
CEEEEECCCCEEEEHHHHHHHHHHHEEEECCCCCEEEEEEECCCCEECCCCCCEEHHHHH
RFLEAASLLGLSSVRFTGGEPLVRKELPEMIARARAKEGVEDVAITTNGLLFARRAKELV
HHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHEEEECCCHHHHHHHHHHH
EAGLNRVNISLDALTPEVFARITRGGKVERVLEAIEKALELGLHPVKLNAVVIRGMNEEE
HCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCC
VVPLAGLSLDRPLHVRFIEYMHLDNSDPEAYRRRFVPGKETRARIEAVYGPLEPVPHDPT
CCEEECCCCCCCHHHEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
SPARVFKIPGAQGTVGFINPVTEPFCTHCSRLRLTSDKKLRPCLLTDLEMDIAWAFAAPE
CCCEEEECCCCCCCEEECCCCCHHHHHHHHHEEECCCCCCCCCEEECCCEEEEEEECCCC
PVEALVDAILIATNRKPAFGNTLPTLRKRVMLGIGG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA