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The map label for this gene is ubiA

Identifier: 54297340

GI number: 54297340

Start: 1543279

End: 1544127

Strand: Direct

Name: ubiA

Synonym: lpp1385

Alternate gene names: 54297340

Gene position: 1543279-1544127 (Clockwise)

Preceding gene: 54297339

Following gene: 54297352

Centisome position: 44.05

GC content: 33.8

Gene sequence:

>849_bases
ATGATTCCCTGGAATGCCTATGTCAGATTATTACGCTTAAATAAACCAATAGGAATTTTATTACTTTGGTATCCCACCGC
ATGGGCACTTTGGATGGCAAATCAGGGCTTTCCTTCTATTGATTTGCTTATGATTTTTTTATTAGGTACAGTATTCATGC
GTTCCGCAGGTTGTGTTATTAACGATATTGCTGACAGGCATATTGATAGGCATGTAGCCCGAACCCAATTTCGCCCCTTG
ACTTCTGGAGAGGTCAGCTTGTCTGAGGCATTTATTTTATTGTTTATATTACTTTGTGCCTCATTGCTTTTATTATTAAA
ACTTCCAATCAATTGTTTTTATTTTGCGGTTATTTCCGTGCTAATTACTTTTGTATACCCATTTTGTAAACGATTTTTGA
ATGCTCCACAACTGATATTAGGTTTGGCTTTTTCCATGGGTATTCCTATGGCATTTATTGCCTCAGGGAAAAATTTAAAT
AGCGATTTTGTTGTATTGTTTTTAATTAATTTTACCTGGATTATCGCTTATGACACGATGTATGCGATGACTGACAAAGC
CGATGATTTAAAAATAGGAGTCAAATCGACTGCAATATATTTTGCAAGTTATGATAGATTAATTATTGCCTTGTTACTGA
TTTTTCTGCATTCTTTATGGTTGGTATGGGCAATAAATAAGAACGCAGAATGGTTTTTTTATTTGTTATGGTGTACCGCT
GCTGGAATATTGACTTATCAACTAAAATTAATTTATGCAAGAATACCTAAAAATTGTTTTAAAGCATTTTTAGTGAGTGG
TTATTATGGATTAGTGATGTGGTTTGCCGTTGGATTAGCATTGATTTAA

Upstream 100 bases:

>100_bases
AATACTCTCAGATGTGGGTCAGGTTTACGGAGCTAGTATTTCAGGAAAAGAGTTCTTTTTATTTGGTTGAAATCTTGTTA
CCGGAGTTGGAAAGTTTATT

Downstream 100 bases:

>100_bases
ATAATATGTCCTCTCAACCCTAATAGAAAATTTGTTGTGCCAAGAGATTGTGGGTGTCGGAAAATTCCTTCATAAGACAG
ACTTTAGAAGAAAAAATCCA

Product: 4-hydroxybenzoate polyprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MIPWNAYVRLLRLNKPIGILLLWYPTAWALWMANQGFPSIDLLMIFLLGTVFMRSAGCVINDIADRHIDRHVARTQFRPL
TSGEVSLSEAFILLFILLCASLLLLLKLPINCFYFAVISVLITFVYPFCKRFLNAPQLILGLAFSMGIPMAFIASGKNLN
SDFVVLFLINFTWIIAYDTMYAMTDKADDLKIGVKSTAIYFASYDRLIIALLLIFLHSLWLVWAINKNAEWFFYLLWCTA
AGILTYQLKLIYARIPKNCFKAFLVSGYYGLVMWFAVGLALI

Sequences:

>Translated_282_residues
MIPWNAYVRLLRLNKPIGILLLWYPTAWALWMANQGFPSIDLLMIFLLGTVFMRSAGCVINDIADRHIDRHVARTQFRPL
TSGEVSLSEAFILLFILLCASLLLLLKLPINCFYFAVISVLITFVYPFCKRFLNAPQLILGLAFSMGIPMAFIASGKNLN
SDFVVLFLINFTWIIAYDTMYAMTDKADDLKIGVKSTAIYFASYDRLIIALLLIFLHSLWLVWAINKNAEWFFYLLWCTA
AGILTYQLKLIYARIPKNCFKAFLVSGYYGLVMWFAVGLALI
>Mature_282_residues
MIPWNAYVRLLRLNKPIGILLLWYPTAWALWMANQGFPSIDLLMIFLLGTVFMRSAGCVINDIADRHIDRHVARTQFRPL
TSGEVSLSEAFILLFILLCASLLLLLKLPINCFYFAVISVLITFVYPFCKRFLNAPQLILGLAFSMGIPMAFIASGKNLN
SDFVVLFLINFTWIIAYDTMYAMTDKADDLKIGVKSTAIYFASYDRLIIALLLIFLHSLWLVWAINKNAEWFFYLLWCTA
AGILTYQLKLIYARIPKNCFKAFLVSGYYGLVMWFAVGLALI

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=279, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1790473, Length=275, Percent_Identity=44, Blast_Score=225, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17553718, Length=272, Percent_Identity=32.7205882352941, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32565247, Length=276, Percent_Identity=31.1594202898551, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17553720, Length=181, Percent_Identity=36.4640883977901, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=40.4255319148936, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32565243, Length=138, Percent_Identity=40.5797101449275, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324370, Length=269, Percent_Identity=33.8289962825279, Blast_Score=146, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21355567, Length=282, Percent_Identity=34.3971631205674, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_LEGPA (Q5X5D5)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123709.1
- STRING:   Q5X5D5
- GeneID:   3118928
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1385
- LegioList:   lpp1385
- eggNOG:   COG0382
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- ProtClustDB:   PRK12847
- BioCyc:   LPNE297246:LPP1385-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 32224; Mature: 32224

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x176deac8)-; HASH(0x1763d9d4)-; HASH(0x17bfe780)-; HASH(0x17e3bd2c)-; HASH(0x17451e2c)-; HASH(0x17e484dc)-; HASH(0x17c93b0c)-; HASH(0x17c38b24)-; HASH(0x17593664)-;

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPWNAYVRLLRLNKPIGILLLWYPTAWALWMANQGFPSIDLLMIFLLGTVFMRSAGCVI
CCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHH
NDIADRHIDRHVARTQFRPLTSGEVSLSEAFILLFILLCASLLLLLKLPINCFYFAVISV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LITFVYPFCKRFLNAPQLILGLAFSMGIPMAFIASGKNLNSDFVVLFLINFTWIIAYDTM
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
YAMTDKADDLKIGVKSTAIYFASYDRLIIALLLIFLHSLWLVWAINKNAEWFFYLLWCTA
HHHCCCCCCCEEEHHHHEEEHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHH
AGILTYQLKLIYARIPKNCFKAFLVSGYYGLVMWFAVGLALI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MIPWNAYVRLLRLNKPIGILLLWYPTAWALWMANQGFPSIDLLMIFLLGTVFMRSAGCVI
CCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHH
NDIADRHIDRHVARTQFRPLTSGEVSLSEAFILLFILLCASLLLLLKLPINCFYFAVISV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LITFVYPFCKRFLNAPQLILGLAFSMGIPMAFIASGKNLNSDFVVLFLINFTWIIAYDTM
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
YAMTDKADDLKIGVKSTAIYFASYDRLIIALLLIFLHSLWLVWAINKNAEWFFYLLWCTA
HHHCCCCCCCEEEHHHHEEEHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHH
AGILTYQLKLIYARIPKNCFKAFLVSGYYGLVMWFAVGLALI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA