| Definition | Legionella pneumophila str. Paris, complete genome. |
|---|---|
| Accession | NC_006368 |
| Length | 3,503,610 |
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The map label for this gene is folC [H]
Identifier: 54297251
GI number: 54297251
Start: 1442879
End: 1444165
Strand: Direct
Name: folC [H]
Synonym: lpp1296
Alternate gene names: 54297251
Gene position: 1442879-1444165 (Clockwise)
Preceding gene: 54297250
Following gene: 54297252
Centisome position: 41.18
GC content: 38.62
Gene sequence:
>1287_bases TTGCACACGCCATGGAGTGAATGGGATTTAAATCACTGGTTGACTCATTTGGAAACCAGAAATACCCAGGAAATACAGCT TGGTTTGACCAGAGTTTTGACTGTAGCGCAGAAATTAAATTTGCAGCGACCAAATTGCAAGGTAATAACAGTTGCAGGAA CAAACGGTAAAGGTTCTACAGTCACAGCACTTGAAACCATCTATCACCAGTCAGGTTTTAGAGTTGGTACCTATACGTCG CCCCATCTTCTTGTGTTTAATGAACGTATTCGAATTAATTTAGCACCGATTCAAGATAAAGATTTATGTAAGGCTTTTTC TGTGATTGAAGAAGCACGTTACCCTACCAATTTAACCTATTTTGAAATGGCAACACTTGCTGCCTTATGGTATTTCAAAC AGCATGATCTGGATCTGATAATTCTTGAAGTAGGCTTGGGAGGACGGTTGGATGCTACAAACATTGTTGATACTGATTTA GCGATCATTACTACTATCGACTTCGATCATCAGAATTTTCTTGGTGATACACTTGAGTTGATAGGGTATGAGAAAGCTGG AATACTACGAAAAAATAAACCTTTTATCTACGCGGATCTCTCACTACCAAAAAGTGTCGTTGAGGTTGCGGTACAACTTG GAGCATTATCTTATTTATACGGTAAAGACTATTTTTATCAGGAGGAAGCTGACCATTGGGGGGTTACTTGTCAAGGTAAG CCATTTGAGCAATTGACCAGGCCAAAAATTCAACTTCGTTCTGCGGCAGCAGCTGTAATGGCTTGTCATTTGATGCAAAA TGATTTGCCTGTATCCTATGAGAACCTAAAGAAAGCGATGGATCTCACTGATATCCCGGGGCGATTGCAATTACAAAAAG GAAAAACTGATATTTTGTACGATGTATCTCATAATCCGCAGTCAGTTCGATTACTTGCAGATACAGTAAAAAAAATCAAT GTAAAAGGGCAAATTCATGCCGTTTTCTCCGCTTTAAAGGATAAAGATCTTTATGGATTGATTATGCCTTTAAAGGATTG TGTTAATCGATGGTATCCTGCACAATTACATAATAAGCGCGCTGCAAGTCAAGAGGAATTGCTTTCTGTATTCAGGGAAG CAGAAATTTTTGCAGATGTTTGCTATAATGACCCATTTGCTGCTTTTGAAAAGGCATTAAAGCAAGCATCAGATGACGAT TTAATTATTGTCTATGGTTCATTTTTTACGGTTAGTCATGTAATGGCTGCCCAACATAATCTTTTGGAGCAGAAGGAGAA TCAATGA
Upstream 100 bases:
>100_bases GAACATGGGCATATTGATATGATAGTTGAACGTAAACATCTTCGAGCAACTATATCCGAATTGGTTTCCAAATTGACTCA TAAAGGAGCGGAGAGTTTTT
Downstream 100 bases:
>100_bases AACTGATAATGGATGAGAAAGTTAAACATCGCTTGATAGGTTTGGCCGTTATTATTTCATTGGGGGCAATTTTTGCTCCT GCATTAATAAAAAAATCCAG
Product: hypothetical protein
Products: NA
Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]
Number of amino acids: Translated: 428; Mature: 428
Protein sequence:
>428_residues MHTPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGSTVTALETIYHQSGFRVGTYTS PHLLVFNERIRINLAPIQDKDLCKAFSVIEEARYPTNLTYFEMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDL AIITTIDFDHQNFLGDTLELIGYEKAGILRKNKPFIYADLSLPKSVVEVAVQLGALSYLYGKDYFYQEEADHWGVTCQGK PFEQLTRPKIQLRSAAAAVMACHLMQNDLPVSYENLKKAMDLTDIPGRLQLQKGKTDILYDVSHNPQSVRLLADTVKKIN VKGQIHAVFSALKDKDLYGLIMPLKDCVNRWYPAQLHNKRAASQEELLSVFREAEIFADVCYNDPFAAFEKALKQASDDD LIIVYGSFFTVSHVMAAQHNLLEQKENQ
Sequences:
>Translated_428_residues MHTPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGSTVTALETIYHQSGFRVGTYTS PHLLVFNERIRINLAPIQDKDLCKAFSVIEEARYPTNLTYFEMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDL AIITTIDFDHQNFLGDTLELIGYEKAGILRKNKPFIYADLSLPKSVVEVAVQLGALSYLYGKDYFYQEEADHWGVTCQGK PFEQLTRPKIQLRSAAAAVMACHLMQNDLPVSYENLKKAMDLTDIPGRLQLQKGKTDILYDVSHNPQSVRLLADTVKKIN VKGQIHAVFSALKDKDLYGLIMPLKDCVNRWYPAQLHNKRAASQEELLSVFREAEIFADVCYNDPFAAFEKALKQASDDD LIIVYGSFFTVSHVMAAQHNLLEQKENQ >Mature_428_residues MHTPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGSTVTALETIYHQSGFRVGTYTS PHLLVFNERIRINLAPIQDKDLCKAFSVIEEARYPTNLTYFEMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDL AIITTIDFDHQNFLGDTLELIGYEKAGILRKNKPFIYADLSLPKSVVEVAVQLGALSYLYGKDYFYQEEADHWGVTCQGK PFEQLTRPKIQLRSAAAAVMACHLMQNDLPVSYENLKKAMDLTDIPGRLQLQKGKTDILYDVSHNPQSVRLLADTVKKIN VKGQIHAVFSALKDKDLYGLIMPLKDCVNRWYPAQLHNKRAASQEELLSVFREAEIFADVCYNDPFAAFEKALKQASDDD LIIVYGSFFTVSHVMAAQHNLLEQKENQ
Specific function: Conversion of folates to polyglutamate derivatives [H]
COG id: COG0285
COG function: function code H; Folylpolyglutamate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the folylpolyglutamate synthase family [H]
Homologues:
Organism=Homo sapiens, GI66932984, Length=155, Percent_Identity=38.0645161290323, Blast_Score=108, Evalue=7e-24, Organism=Homo sapiens, GI66932990, Length=155, Percent_Identity=38.0645161290323, Blast_Score=108, Evalue=8e-24, Organism=Escherichia coli, GI1788654, Length=413, Percent_Identity=39.7094430992736, Blast_Score=295, Evalue=5e-81, Organism=Caenorhabditis elegans, GI17553150, Length=338, Percent_Identity=27.2189349112426, Blast_Score=117, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17553148, Length=338, Percent_Identity=27.2189349112426, Blast_Score=117, Evalue=1e-26, Organism=Caenorhabditis elegans, GI71984923, Length=371, Percent_Identity=26.4150943396226, Blast_Score=117, Evalue=1e-26, Organism=Saccharomyces cerevisiae, GI6323760, Length=419, Percent_Identity=26.7303102625298, Blast_Score=125, Evalue=1e-29, Organism=Saccharomyces cerevisiae, GI6324815, Length=300, Percent_Identity=28.3333333333333, Blast_Score=102, Evalue=2e-22, Organism=Drosophila melanogaster, GI24641571, Length=166, Percent_Identity=35.5421686746988, Blast_Score=99, Evalue=7e-21, Organism=Drosophila melanogaster, GI24581568, Length=174, Percent_Identity=35.0574712643678, Blast_Score=94, Evalue=1e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR018109 - InterPro: IPR001645 - InterPro: IPR004101 - InterPro: IPR013221 [H]
Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.17; =6.3.2.12 [H]
Molecular weight: Translated: 48491; Mature: 48491
Theoretical pI: Translated: 6.39; Mature: 6.39
Prosite motif: PS01012 FOLYLPOLYGLU_SYNT_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 3.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MHTPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGST CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC VTALETIYHQSGFRVGTYTSPHLLVFNERIRINLAPIQDKDLCKAFSVIEEARYPTNLTY HHHHHHHHHHCCCEEECCCCCEEEEEECEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHH FEMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDLAIITTIDFDHQNFLGDTLEL HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEECCCEEEEEEEECCCCHHHHHHHHH IGYEKAGILRKNKPFIYADLSLPKSVVEVAVQLGALSYLYGKDYFYQEEADHWGVTCQGK HCCCHHCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEECCC PFEQLTRPKIQLRSAAAAVMACHLMQNDLPVSYENLKKAMDLTDIPGRLQLQKGKTDILY CHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEECCCCEEEE DVSHNPQSVRLLADTVKKINVKGQIHAVFSALKDKDLYGLIMPLKDCVNRWYPAQLHNKR ECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHH AASQEELLSVFREAEIFADVCYNDPFAAFEKALKQASDDDLIIVYGSFFTVSHVMAAQHN CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHH LLEQKENQ HHHHCCCC >Mature Secondary Structure MHTPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGST CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC VTALETIYHQSGFRVGTYTSPHLLVFNERIRINLAPIQDKDLCKAFSVIEEARYPTNLTY HHHHHHHHHHCCCEEECCCCCEEEEEECEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHH FEMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDLAIITTIDFDHQNFLGDTLEL HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEECCCEEEEEEEECCCCHHHHHHHHH IGYEKAGILRKNKPFIYADLSLPKSVVEVAVQLGALSYLYGKDYFYQEEADHWGVTCQGK HCCCHHCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEECCC PFEQLTRPKIQLRSAAAAVMACHLMQNDLPVSYENLKKAMDLTDIPGRLQLQKGKTDILY CHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEECCCCEEEE DVSHNPQSVRLLADTVKKINVKGQIHAVFSALKDKDLYGLIMPLKDCVNRWYPAQLHNKR ECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHH AASQEELLSVFREAEIFADVCYNDPFAAFEKALKQASDDDLIIVYGSFFTVSHVMAAQHN CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHH LLEQKENQ HHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]