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The map label for this gene is umuC [H]

Identifier: 54296999

GI number: 54296999

Start: 1165398

End: 1166675

Strand: Direct

Name: umuC [H]

Synonym: lpp1040

Alternate gene names: 54296999

Gene position: 1165398-1166675 (Clockwise)

Preceding gene: 54296998

Following gene: 54297000

Centisome position: 33.26

GC content: 43.74

Gene sequence:

>1278_bases
ATGAGCTTGCCTGAGATGTTTGCCCTTATCGATTGCAACAATTTTTACGCCAGTTGTGAGCGTTTGTTTCGTCCTGATTT
AAAGGACGTCCCCATCGTGGTGCTATCCAATAATGATGGCTGTTGTATCGCACGCTCGAATGAAGCCAAAGCATTGGGCA
TTGCCATGGGCGAGCCGTACTTCAAAATTAAACATTTGTGCAAACAGCATGGAGTGAAAGCTTTTTCCTCAAATTATACG
CTGTATGGCAACATGAGTCATCGTGTGATGTGCACTATTGAAGAAGCCTGGCCCCATATAGAAGTTTACTCGATTGATGA
AGCGTTTCTTGATTTAAGGAGTTTACCGGTTGATAGCCATGATTCGTTTTGCGAGCAGTTACAAAAGAAAATCTTGAAGC
ACACAGGAATACCCACTTCCATCGGTATTGGACCTACTAAAACACTAGCTAAAGCCGCCAATCATTTATGCAAAAAAGTT
TATAAAATCCCTGTGTTTAATATCACCTCGAATCGTGGGCGGTTATTGCAACAGATTTCCGTTGGGGACATTTGGGGAGT
AGGGCGGCAATGGGCCAATAAATTAATTTCGCGAGGCATTCATACGGCTTATGATTTGGCAATGACCAATCCTCACCTTC
TGAAGAAATGTTTTAACGTCGTGTTGATGCGTACCGCCATGGAGCTTCAAGGAATTGCTTGTGGCGGTTTAGAGGCAATA
GAGCCTAAGCAAAGTATTATGTCATCTAAAAGTTTTGGTCAGATGCAAACTCAACTTGCTTCGATTGAGGAATCAATCAG
TAGCCATTGTGCCCGTGCGGTGGAGAAAATGCGTCGCCAGCAATTGGTGGCGAAGCGCCTGGTTGTATTTGTGCATACGA
ACCGATTTCGCGAAGATTTGGCACAGCACTTTCAGTCCATCGAATTTAAGCTGATTAATCCTACAGATGATTTGCGCTTA
ATTACCAAAATGGCCAAGCGATGTCTGCAACGCATTTTTAAACCAGGGTATTACTATAAAAAGGCAGGAGTATGTCTTGA
GGACTTAATTCCCAAAAACCCACGACAGCTGGATATGTTTTATCAACCAAGTGACGAGCATCTAAACCACACGGAACAAT
TGATGGCGGTCTTTGACCAAATCAATCAAAAATACGGACGAAGTACAATCCGCCTCGCGGCAGAGGGTTATTCAAAACCT
TGGGCGATGCGTGCTGAACTGAAATCGCCTGCCTATACCACACGATGGTCTGATTTACCTCGTGCAATCATTAGGTAA

Upstream 100 bases:

>100_bases
GGAAGGGTGCAATTACTTCCTGCTAATCCCAAATTTCAACCCATTGACATTACAGAGGACAGTGAGATGGTGATTTGGGG
AGTGGTGACTTTGGTTCTAC

Downstream 100 bases:

>100_bases
TTATAAATAGGGCAATTAATAACCTAATTTTGATACGCCTGTGGGTGTTTTTAATTAGCTTAAATCAGTCAGATGTATCT
CAAATTACTTAATTTTTAAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSLPEMFALIDCNNFYASCERLFRPDLKDVPIVVLSNNDGCCIARSNEAKALGIAMGEPYFKIKHLCKQHGVKAFSSNYT
LYGNMSHRVMCTIEEAWPHIEVYSIDEAFLDLRSLPVDSHDSFCEQLQKKILKHTGIPTSIGIGPTKTLAKAANHLCKKV
YKIPVFNITSNRGRLLQQISVGDIWGVGRQWANKLISRGIHTAYDLAMTNPHLLKKCFNVVLMRTAMELQGIACGGLEAI
EPKQSIMSSKSFGQMQTQLASIEESISSHCARAVEKMRRQQLVAKRLVVFVHTNRFREDLAQHFQSIEFKLINPTDDLRL
ITKMAKRCLQRIFKPGYYYKKAGVCLEDLIPKNPRQLDMFYQPSDEHLNHTEQLMAVFDQINQKYGRSTIRLAAEGYSKP
WAMRAELKSPAYTTRWSDLPRAIIR

Sequences:

>Translated_425_residues
MSLPEMFALIDCNNFYASCERLFRPDLKDVPIVVLSNNDGCCIARSNEAKALGIAMGEPYFKIKHLCKQHGVKAFSSNYT
LYGNMSHRVMCTIEEAWPHIEVYSIDEAFLDLRSLPVDSHDSFCEQLQKKILKHTGIPTSIGIGPTKTLAKAANHLCKKV
YKIPVFNITSNRGRLLQQISVGDIWGVGRQWANKLISRGIHTAYDLAMTNPHLLKKCFNVVLMRTAMELQGIACGGLEAI
EPKQSIMSSKSFGQMQTQLASIEESISSHCARAVEKMRRQQLVAKRLVVFVHTNRFREDLAQHFQSIEFKLINPTDDLRL
ITKMAKRCLQRIFKPGYYYKKAGVCLEDLIPKNPRQLDMFYQPSDEHLNHTEQLMAVFDQINQKYGRSTIRLAAEGYSKP
WAMRAELKSPAYTTRWSDLPRAIIR
>Mature_424_residues
SLPEMFALIDCNNFYASCERLFRPDLKDVPIVVLSNNDGCCIARSNEAKALGIAMGEPYFKIKHLCKQHGVKAFSSNYTL
YGNMSHRVMCTIEEAWPHIEVYSIDEAFLDLRSLPVDSHDSFCEQLQKKILKHTGIPTSIGIGPTKTLAKAANHLCKKVY
KIPVFNITSNRGRLLQQISVGDIWGVGRQWANKLISRGIHTAYDLAMTNPHLLKKCFNVVLMRTAMELQGIACGGLEAIE
PKQSIMSSKSFGQMQTQLASIEESISSHCARAVEKMRRQQLVAKRLVVFVHTNRFREDLAQHFQSIEFKLINPTDDLRLI
TKMAKRCLQRIFKPGYYYKKAGVCLEDLIPKNPRQLDMFYQPSDEHLNHTEQLMAVFDQINQKYGRSTIRLAAEGYSKPW
AMRAELKSPAYTTRWSDLPRAIIR

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=423, Percent_Identity=44.4444444444444, Blast_Score=340, Evalue=8e-95,
Organism=Escherichia coli, GI1786425, Length=357, Percent_Identity=23.5294117647059, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 48449; Mature: 48318

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPEMFALIDCNNFYASCERLFRPDLKDVPIVVLSNNDGCCIARSNEAKALGIAMGEPY
CCCCHHEEEEECHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCEEEEECCCCH
FKIKHLCKQHGVKAFSSNYTLYGNMSHRVMCTIEEAWPHIEVYSIDEAFLDLRSLPVDSH
HHHHHHHHHCCCHHHCCCEEEEECCCCEEEEEEHHCCCCEEEEEHHHHHHHHHHCCCCCC
DSFCEQLQKKILKHTGIPTSIGIGPTKTLAKAANHLCKKVYKIPVFNITSNRGRLLQQIS
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHC
VGDIWGVGRQWANKLISRGIHTAYDLAMTNPHLLKKCFNVVLMRTAMELQGIACGGLEAI
CCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
EPKQSIMSSKSFGQMQTQLASIEESISSHCARAVEKMRRQQLVAKRLVVFVHTNRFREDL
CHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQHFQSIEFKLINPTDDLRLITKMAKRCLQRIFKPGYYYKKAGVCLEDLIPKNPRQLDMF
HHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCHHHHCCCCCCCEEEE
YQPSDEHLNHTEQLMAVFDQINQKYGRSTIRLAAEGYSKPWAMRAELKSPAYTTRWSDLP
ECCCHHHCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCEEHHHHCCCCCCCCHHHHH
RAIIR
HHHCC
>Mature Secondary Structure 
SLPEMFALIDCNNFYASCERLFRPDLKDVPIVVLSNNDGCCIARSNEAKALGIAMGEPY
CCCHHEEEEECHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCEEEEECCCCH
FKIKHLCKQHGVKAFSSNYTLYGNMSHRVMCTIEEAWPHIEVYSIDEAFLDLRSLPVDSH
HHHHHHHHHCCCHHHCCCEEEEECCCCEEEEEEHHCCCCEEEEEHHHHHHHHHHCCCCCC
DSFCEQLQKKILKHTGIPTSIGIGPTKTLAKAANHLCKKVYKIPVFNITSNRGRLLQQIS
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHC
VGDIWGVGRQWANKLISRGIHTAYDLAMTNPHLLKKCFNVVLMRTAMELQGIACGGLEAI
CCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
EPKQSIMSSKSFGQMQTQLASIEESISSHCARAVEKMRRQQLVAKRLVVFVHTNRFREDL
CHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQHFQSIEFKLINPTDDLRLITKMAKRCLQRIFKPGYYYKKAGVCLEDLIPKNPRQLDMF
HHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCHHHHCCCCCCCEEEE
YQPSDEHLNHTEQLMAVFDQINQKYGRSTIRLAAEGYSKPWAMRAELKSPAYTTRWSDLP
ECCCHHHCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCEEHHHHCCCCCCCCHHHHH
RAIIR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609 [H]